Artery最新文献_第8页

Long-term administration of probucol and QTc interval prolongation. 长期服用probucol和QTc间隔延长。

Artery Pub Date : 1993-01-01

N Sasaki, K Saku, K Moroe, B Zhang, K Hirata, R Liu, K Arakawa

引用次数: 0

Human parathyroid hormone dilates both pig coronary and human inferior epigastric arteries by a cyclic AMP-dependent pathway. 人甲状旁腺激素扩张猪冠状动脉和人腹壁下动脉的循环amp依赖途径。

Artery Pub Date : 1993-01-01

M R Schulze, A Mügge, H M Harms, J Cremer, R Frombach, P R Lichtlen

{"title":"Human parathyroid hormone dilates both pig coronary and human inferior epigastric arteries by a cyclic AMP-dependent pathway.","authors":"M R Schulze, A Mügge, H M Harms, J Cremer, R Frombach, P R Lichtlen","doi":"","DOIUrl":"","url":null,"abstract":"Human parathyroid hormone (hPTH (1-38)) induced concentration-dependent relaxations in prostaglandin F2 alpha-preconstricted pig coronary arteries in vitro. Removal of endothelial cells or pretreatment with nitro-L-arginine, a specific inhibitor of the endothelium-derived relaxing factor (EDRF) synthesis, impaired, although to a small extent, hPTH-induced relaxations. Human PTH-, but not bradykinin- or nitroglycerin-induced relaxations were potentiated in the presence of the cyclic AMP phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX). Human PTH also relaxed preconstricted human inferior epigastric arteries in vitro. In accordance to pig coronary arteries, this relaxation was potentiated in the presence of IBMX. However, the human internal thoracic (mammary) artery did not respond to hPTH (1-100 nM). Thus, acute vasodilatory effects of hPTH may not be present in all human arteries. The physiological significance of this phenomenon is not known. This relaxation, at least in pig arteries, is mediated to a small extent by the release of EDRF. In addition, this relaxation appears to be mainly mediated in both pig and human arteries by a smooth muscle cyclic AMP pathway.","PeriodicalId":75564,"journal":{"name":"Artery","volume":"20 3","pages":"147-62"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19230127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcranial Doppler evaluation of cerebrovascular reactivity to acetazolamide in normal subjects. 经颅多普勒评价正常人对乙酰唑胺的脑血管反应性。

Artery Pub Date : 1993-01-01

M Mancini, S De Chiara, A Postiglione, L A Ferrara

{"title":"Transcranial Doppler evaluation of cerebrovascular reactivity to acetazolamide in normal subjects.","authors":"M Mancini, S De Chiara, A Postiglione, L A Ferrara","doi":"","DOIUrl":"","url":null,"abstract":"Acetazolamide (AZ), the selective inhibitor of carbonic anhydrase, was proved by intravenous Xenon 133 technique to increase cerebral blood flow (CBF). In this study cerebrovascular reactivity to AZ was evaluated in 10 normal subjects by transcranial Doppler (TCD) within the middle cerebral artery (MCA), since several reports have demonstrated that velocity of cerebral blood flow is well correlated to CBF. After 1 gr AZ injection blood flow velocity markedly increased in all subjects, with a peak in both systolic and diastolic velocity 20 min after drug administration. At that time systolic velocity increased by 35% and diastolic velocity by 50% in comparison to basal values. In contrast with Xenon 133 technique which gives one measurement only for each investigation, TCD allows a continuous monitoring of haemodynamic change following AZ infusion. MCA diastolic velocity at rest was inversely related to age (r = -.804, p < 0.01); baseline diastolic velocity was inversely related to the maximum percentage increment (r = -.745 p < .05). No change in blood pressure and heart rate was observed under experimental conditions. These results, confirm the usefulness of the AZ test in the evaluation of cerebrovascular reactivity and strongly support the use of TCD technique applied to AZ in order to investigate cerebrovascular haemodynamics in normal healthy subjects and in patients at risk of cerebrovascular insufficiency.","PeriodicalId":75564,"journal":{"name":"Artery","volume":"20 4","pages":"231-41"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19238896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced degradation of high density lipoprotein by peritoneal macrophages from nude mice is attenuated by interleukin-1. 白细胞介素-1可减弱裸鼠腹腔巨噬细胞对高密度脂蛋白的增强降解。

Artery Pub Date : 1993-01-01

S Keidar, A Gilhar, M Kaplan, J G Brook, M Aviram

{"title":"Enhanced degradation of high density lipoprotein by peritoneal macrophages from nude mice is attenuated by interleukin-1.","authors":"S Keidar, A Gilhar, M Kaplan, J G Brook, M Aviram","doi":"","DOIUrl":"","url":null,"abstract":"Athymic nude mice are characterized by deficient cellular immunity due to almost complete absence of functional mature T-lymphocytes. Plasma HDL (the major cholesterol carrier in mice) cholesterol levels in nude mice were found to be reduced by 1.7 fold in comparison to control Balb/c mice. Cellular degradation of HDL by peritoneal macrophages (MPM) that were obtained from nude mice, was 2.5 fold greater in comparison to MPM obtained from Balb/c mice. Since nude mice lack cytokines that can affect lipid metabolism, intravenous administration of 10 micrograms/100g body weight of interleukin-1 (IL-1), tumor necrosis factor (TNF), or transforming growth factor (TGF) on HDL degradation by their PM, were investigated. IL-1 (but not TNF) reduced HDL (50 micrograms of protein/ml) cellular degradation from 810 +/- 34 to 350 +/- 12 ng/mg cell protein (p < 0.01) in nude mice. In control Balb/c mice, however, IL-1 as well as TNF enhanced macrophage degradation of HDL by 56% and 280%, respectively. TGF injection into nude mice (but not control mice) decreased HDL degradation by their MPM by 50%. We, thus, suggest that in nude mice the reduced plasma and HDL cholesterol levels are probably due to increased HDL degradation, which may be secondary to IL-1 and TGF deficiency.","PeriodicalId":75564,"journal":{"name":"Artery","volume":"20 5","pages":"268-79"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19132690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethanol induced hypertension in rats: reversibility and role of intracellular cytosolic calcium. 乙醇诱导大鼠高血压:细胞内胞质钙的可逆性和作用。

Artery Pub Date : 1993-01-01

S Vasdev, I P Gupta, C A Sampson, L Longerich, S Parai

{"title":"Ethanol induced hypertension in rats: reversibility and role of intracellular cytosolic calcium.","authors":"S Vasdev, I P Gupta, C A Sampson, L Longerich, S Parai","doi":"","DOIUrl":"","url":null,"abstract":"This study examined the reversibility of chronic ethanol induced increase in systolic blood pressure, elevated platelet cytosolic free calcium and aortic calcium uptake in rats and the effect of a calcium channel blocker on these changes. Twenty-four male Wistar-Kyoto rats, age 7 weeks, were divided into 4 groups of 6 animals each. Animals in group I were given water and group II, III and IV, 5% ethanol in drinking water for the next 7 weeks. Systolic blood pressure in the ethanol treated rats was significantly higher (p < 0.01) than in controls after 1 week and remained higher. After 7 weeks, group I was continued on water, group II on ethanol, group III was continued on ethanol but with the addition of verapamil 5 mg/100 ml in their drinking water and group IV was returned to normal drinking water for the next 7 weeks. After 14 weeks, systolic blood pressure, platelet cytosolic free calcium and aortic calcium uptake was significantly higher (p < 0.01) in rats given ethanol for 14 weeks and also in rats given ethanol for 7 weeks followed by water for 7 weeks as compared to controls. These two groups also showed smooth muscle cell hyperplasia with some thickening of the wall and narrowing of the lumen in small arteries and arterioles of kidney. Verapamil given to the ethanol treated rats normalized their blood pressure, platelet cytosolic free calcium, aortic calcium uptake and attenuated renal vascular changes. Discontinuation of ethanol treatment for 7 weeks did not reverse the hypertension or the adverse renal vascular changes in ethanol induced hypertensive rats.","PeriodicalId":75564,"journal":{"name":"Artery","volume":"20 1","pages":"19-43"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19431760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid peroxide levels in type II hyperlipoproteinemic subjects. II型高脂血症患者的脂质过氧化水平。

Artery Pub Date : 1993-01-01

K Kameda-Takemura, C N Corder, D M Lee

{"title":"Lipid peroxide levels in type II hyperlipoproteinemic subjects.","authors":"K Kameda-Takemura, C N Corder, D M Lee","doi":"","DOIUrl":"","url":null,"abstract":"The purpose of this study was to evaluate, under the most rigorous precautionary measures against in vitro oxidation, whether the baseline lipid peroxide levels in hypercholesterolemic subjects were higher than those in normolipidemic subjects. Two methods were employed: thiobarbituric acid (TBA), and hemoglobin-methylene blue (HbMB). Blood was collected into EDTA tube and centrifuged at 4 degrees C for 30 min to collect plasma, then protected from in vitro oxidation with preservatives and N2. Serum was from blood samples allowed to clot at 20 degrees C for 1 h, then protected from oxidation. Determination of lipid peroxide was carried out within 2 h of blood collection. Results from 35 hypercholesterolemic and 34 control subjects showed that lipid peroxide levels obtained from both methods were significantly higher in serum than in plasma for both groups, suggesting a greater rate of lipid peroxidation occurred in serum during clot formation. However, no significant difference in lipid peroxide levels was found between patients and controls in either serum or plasma by either assay method. No correlation existed between lipid peroxide values and plasma cholesterol or LDL-cholesterol levels. These results suggest that the mechanism for a higher tendency towards atherosclerosis in hypercholesterolemic subjects is not related to baseline levels of plasma lipid peroxide.","PeriodicalId":75564,"journal":{"name":"Artery","volume":"20 4","pages":"189-200"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19238893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences in LDL receptor-mediated metabolism of three low density lipoprotein subfractions by human monocyte-derived macrophages: impact on the risk for atherosclerosis. 人单核细胞源性巨噬细胞LDL受体介导的三种低密度脂蛋白亚组分代谢的差异:对动脉粥样硬化风险的影响

Artery Pub Date : 1993-01-01

J de Graaf, J C Hendriks, D W Swinkels, P N Demacker, A F Stalenhoef

{"title":"Differences in LDL receptor-mediated metabolism of three low density lipoprotein subfractions by human monocyte-derived macrophages: impact on the risk for atherosclerosis.","authors":"J de Graaf, J C Hendriks, D W Swinkels, P N Demacker, A F Stalenhoef","doi":"","DOIUrl":"","url":null,"abstract":"The metabolism of three low density lipoprotein (LDL) subfractions by human monocyte-derived macrophages (HMDM) through the LDL receptor pathway was studied. The three LDL subfractions, very light LDL1, light LDL2 and heavy LDL3, were isolated from serum pools of normolipidemic subjects by density gradient ultracentrifugation. The LDL subfractions were shown to differ in molecular size and chemical composition but not in electrophoretic mobility on agarose gel. Cell specific association, cell specific degradation and stimulation of cholesteryl esterification were determined in parallel after incubation of HMDM with increasing amounts of LDL-protein of the three LDL subfractions. The experiments were repeated four times with freshly prepared LDL subfractions. Both the cell specific association and degradation increased more with increasing LDL-protein concentration for LDL1 than for LDL3 (p < 0.001). The results for LDL2 were intermediate between those for LDL1 and LDL3 and differed significantly from both (p < 0.05). For the stimulation of cholesteryl ester formation, the curves for LDL1 and LDL2 increased more with increasing LDL-protein concentration than that for LDL3 (p < 0.001); the results for LDL1 and LDL2 did not differ significantly from each other. These differences between LDL subfractions in cholesteryl esterification were independent of the cholesterol content of the LDL subfractions. The results show that LDL subfractions have different rates of LDL receptor-mediated catabolism by HMDM. As HMDM play an important role in the formation of atherosclerotic plaques, the differences between the LDL subfractions in catabolism by HMDM, may result in differences in atherogenicity between LDL subfractions isolated from normolipidemic subjects.","PeriodicalId":75564,"journal":{"name":"Artery","volume":"20 4","pages":"201-30"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19238894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of parenteral lipid emulsion-induced hyperlipidemia on prostaglandin E1 modulation of platelet function. 脂质乳剂诱导的高脂血症对前列腺素E1调节血小板功能的影响。

Artery Pub Date : 1993-01-01

C F Saladino, C Kosacolsky-Singer, R Fox, V Nethala, S E Feffer, E A Jonas

{"title":"The effect of parenteral lipid emulsion-induced hyperlipidemia on prostaglandin E1 modulation of platelet function.","authors":"C F Saladino, C Kosacolsky-Singer, R Fox, V Nethala, S E Feffer, E A Jonas","doi":"","DOIUrl":"","url":null,"abstract":"The purpose of this study is to better understand how hyperlipidemia alters the modulating action of prostaglandin E1 (PGE1) on platelet function. Using our previously characterized rat model of atherogenesis, we demonstrate that the parenteral lipid emulsions, Lipofundin-S and Liposyn, significantly (p < or = 0.05) enhance baseline platelet aggregation. In addition, dose response curves show that in all animals, PGE1 substantially inhibits platelet aggregation at 10(-7) to 10(-6) M, while significantly stimulating platelet function at lower doses. However, at all PGE1 concentrations, aggregation values are higher in platelets from lipid-treated vs. control rats, showing that hyperlipidemia significantly reduces the ability of high concentrations of PGE1 to inhibit platelet activity, based on the absolute values of the controls. Also, dose response curves for PGE1 on platelet aggregation show a marked similarity in shape for control ratsvs. normal humans. Thus, this study demonstrates that hyperlipidemia significantly alters the platelet modulating action of prostaglandin E1, and it shows that PGE1 can either inhibit or stimulate platelet activity in both rat and human platelets.","PeriodicalId":75564,"journal":{"name":"Artery","volume":"20 6","pages":"303-13"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19004857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum cholesterol levels of nondiabetic and streptozotocin-diabetic rats fed a high cholesterol diet. 高胆固醇饮食对非糖尿病大鼠和链脲佐菌素糖尿病大鼠血清胆固醇水平的影响。

Artery Pub Date : 1993-01-01

P R Holmgren, A C Brown

引用次数: 0

Effect of aspirin on the contractility of aortic smooth muscle in female spontaneously hypertensive rats. 阿司匹林对雌性自发性高血压大鼠主动脉平滑肌收缩力的影响。

Artery Pub Date : 1992-01-01

M A Rahmani, T Mangroo, M Bienaime, S Wiggins, J Williams

引用次数: 0