Artery Pub Date : 1994-01-01

A Ohshige, M Ito, H Koyama, T Maeda, T Yoshimura, H Okamura

引用次数: 0

The involvement of perivascular innervation in acetylcholine-induced endothelium-dependent vascular relaxation in the rat superior mesenteric arterial bed. 大鼠肠系膜上动脉床血管周围神经支配参与乙酰胆碱诱导的内皮依赖性血管舒张。

Artery Pub Date : 1994-01-01

T M Scott, L Chafe

{"title":"The involvement of perivascular innervation in acetylcholine-induced endothelium-dependent vascular relaxation in the rat superior mesenteric arterial bed.","authors":"T M Scott, L Chafe","doi":"","DOIUrl":"","url":null,"abstract":"The distribution of the ability of perivascular peptidergic innervation to influence acetylcholine-induced relaxation in the arterial bed has been investigated using the superior mesenteric arterial bed of the rat. The superior mesenteric artery was denervated by freezing, under pentobarbital anaesthesia (40 mg/kg i.p.), at one of two different points and the animals allowed to survive for 7, 14, 21 or 28 days following freezing. This produced a range of denervation along the superior mesenteric artery and its branches. The ability to respond to acetylcholine in an endothelium-dependent fashion was determined pharmacologically in isolated perfused superior mesenteric artery preparations. The extent of the denervation was determined by immunohistochemistry. It was found that the ability of the arterial bed to relax in a concentration-dependent manner to increasing concentrations of acetylcholine was little altered by denervation of the superior mesenteric artery alone. However when a short piece of the superior mesenteric artery and its primary branches were denervated the response to acetylcholine was reduced. It is concluded that the innervation of the primary branches of the mesenteric artery, the jejunal and ileal branches, contributes to the ability of acetylcholine to cause endothelium-dependent relaxation.","PeriodicalId":75564,"journal":{"name":"Artery","volume":"21 1","pages":"51-62"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18974924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ubiquitin expression in atherosclerotic lesions of wistar fatty and wistar lean rats. 泛素在wistar脂肪大鼠和wistar瘦肉大鼠动脉粥样硬化病变中的表达。

Artery Pub Date : 1994-01-01

M Igarashi, T Kato, H Ohnuma, Y Morita, T Kawanami, H Sasaki

{"title":"Ubiquitin expression in atherosclerotic lesions of wistar fatty and wistar lean rats.","authors":"M Igarashi, T Kato, H Ohnuma, Y Morita, T Kawanami, H Sasaki","doi":"","DOIUrl":"","url":null,"abstract":"To clarify whether ubiquitin is expressed in atherosclerotic lesions, and, if so, the expression is influenced by diabetes mellitus, we examined atherosclerotic (AS) lesions from Wistar fatty (WF) and Wistar lean (WL) rats immunohistochemically using an antibody against ubiquitin (AUb). Ten-week-old male WF and WL rats were treated to cannulize a silicon tube from the left carotid artery (LCA) to the descending aorta under chloral hydrate anesthesia and the tube was fixed. Age-matched WF and WL rats without cannulization were served as controls. Eight weeks after operation, 1 ml of 0.1% Evans blue solution was injected to all rats from the tail vein. 15 min latter, the aortae were removed, fixed with 4% paraformaldehyde and embedded in paraffin. Immunohistochemical staining with AUb by the ABC method, hematoxylin and eosin (HE) and elastica-Goldner (EG) stains were performed. In the cannulized group, focal areas of the luminal surface of the aorta were stained blue with Evans blue and these areas were microscopically confirmed as AS lesions in all WF and WL rats. In the control group, no Evans blue staining or AS lesions were observed. The destruction of the internal elastic lamina in AS lesions were seen with EG stain in the cannulized aorta of both WF and WL rats. No significant difference of the area ratio of intima/media was present between WF and WL rats in the cannulized group. Ubiquitin immunoreactivity was observed in the nucleus and cytoplasm of cells in AS lesions of both WF and WL rats. The present study suggests that ubiquitin plays a role in the formation of AS, and the condition of diabetes mellitus has little influence on ubiquitin expression and AS formation in this experimental model.","PeriodicalId":75564,"journal":{"name":"Artery","volume":"21 5","pages":"256-70"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19793722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of sustained release diltiazem (Diltiazem-R) in patients with stable effort angina. 缓释地尔硫卓(diltiazem - r)治疗稳定型心绞痛的疗效。

Artery Pub Date : 1994-01-01

T Kaku, E Himeno, Y Nakashima, A Kuroiwa

{"title":"Effect of sustained release diltiazem (Diltiazem-R) in patients with stable effort angina.","authors":"T Kaku, E Himeno, Y Nakashima, A Kuroiwa","doi":"","DOIUrl":"","url":null,"abstract":"Ca++-antagonist is effective not only for variant angina but also for effort angina. The effects of sustained release diltiazem (diltiazem-R) and beta 1-blocker (atenolol) on exercise tolerance were studied in seven patients with stable effort angina in a cross over trial. Diltiazem-R (100mg) or atenolol (50mg) was given once a day, each treatment period lasting for two weeks after a two-week control period. The treadmill exercise test was performed on the last day of each protocol. Both diltiazem-R and atenolol decreased heart rate at rest and the decrease with atenolol was greater than that with diltiazem-R. The systolic blood pressure was unchanged at rest by both drugs. At maximal work levels, atenolol decreased the heart rate and pressure rate product significantly but diltiazem-R did not. Both diltiazem-R and atenolol significantly prolonged the exercise time (average 137 and 165 seconds respectively), time to onset of 1mm ST depression (240 and 288 seconds respectively). There was no significant difference in exercise tolerance between diltiazem-R and atenolol. These findings suggest that diltiazem-R, a sustained release Ca++-antagonist, provides beneficial effects in patients with stable effort angina.","PeriodicalId":75564,"journal":{"name":"Artery","volume":"21 4","pages":"193-207"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19799532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

XbaI polymorphism of the apolipoprotein B gene in patients with hyperlipidemia and echo-Doppler evidence of arterial lesions. 高脂血症患者载脂蛋白B基因XbaI多态性及动脉病变的超声多普勒证据。

Artery Pub Date : 1993-01-01

F De Lorenzo, P Rubba, A Monticelli, C Cortese, H M Bond, B De Simone, P Mastranzo, A Perrotta, G Mossetti, S Cocozza

引用次数: 0

Vitamin E: the evidence for an anti-atherogenic role. 维生素E:抗动脉粥样硬化作用的证据。

Artery Pub Date : 1993-01-01

G A Ferns, M Konneh, E E Anggård

引用次数: 0

Angiotensin II forming activity of vascular endothelial and smooth muscle cells. 血管内皮细胞和平滑肌细胞的血管紧张素II形成活性。

Artery Pub Date : 1993-01-01

M Ideishi, K Noda, M Sasaguri, M Ikeda, K Arakawa