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Evaluation Series on Safety and Efficacy of Nutritional Supplements in Newly Diagnosed Hyperglycemia: A Placebo-Controlled, Randomized Study. 新诊断的高血糖患者服用营养补充剂的安全性和有效性评估系列：安慰剂对照随机研究》。
Archives of gynecology Pub Date : 2016-02-01 DOI: 10.4103/1947-2714.177320
Hemant Thacker, Ganapati Bantwal, Sunil Jain, Sanjay Kalra, Shailaja Kale, Banshi Saboo, Jugal B Gupta, Sakthivel Sivam
{"title":"Evaluation Series on Safety and Efficacy of Nutritional Supplements in Newly Diagnosed Hyperglycemia: A Placebo-Controlled, Randomized Study.","authors":"Hemant Thacker, Ganapati Bantwal, Sunil Jain, Sanjay Kalra, Shailaja Kale, Banshi Saboo, Jugal B Gupta, Sakthivel Sivam","doi":"10.4103/1947-2714.177320","DOIUrl":"10.4103/1947-2714.177320","url":null,"abstract":"<p><strong>Background: </strong>Diabetes is endemic with developing economies contributing to the bulk of this pandemic. Despite the evidence of incremental benefit of glycemic control starting early in life, acceptance of and adherence to modern medications remain suboptimal.</p><p><strong>Aims: </strong>To determine the hemoglobin A1c (HbA1c)-lowering efficacy and safety of nutritional supplement, PreCrea(®), in adult Indians with newly diagnosed hyperglycemia.</p><p><strong>Materials and methods: </strong>Double-blind, randomized study conducted in six diabetes centers in India. A total of 193 treatment-naïve subjects with newly diagnosed hyperglycemia and fasting plasma glucose (FPG) >100 mg/dL were randomized into either PreCrea(®) 600 mg (n = 90) or matched placebo (n = 89) capsules twice daily, along with lifestyle modification, for 12 weeks. The main outcomes were changes in HbA1c and FPG levels, attainment of the American Diabetes Association (ADA)-defined goals for HbA1c, and clinical and biochemical measures of safety.</p><p><strong>Results: </strong>At 12 weeks, mean HbA1c in PreCrea(®) group reduced by 0.91% compared with 0.08% increase in the placebo group (P < .001). The reductions in the mean FPG at week 4 (P < .001) and week 12 (P = 0.04) were significant compared to the baseline. ADA goal of HbA1c <7% increased from 15.5% at the baseline to 35.6% at week 12 in PreCrea(®) subjects. Clinical safety and biochemical safety did not change. Hypoglycemia and weight gain were not observed with PreCrea(®).</p><p><strong>Conclusions: </strong>Nearly 1% point reduction in HbA1c at week 12 with PreCrea(®) is comparable with most first-line glucose-lowering drugs. The safety and tolerability of PreCrea(®) highlights its potential as a first-line therapy in newly detected hyperglycemia.</p>","PeriodicalId":75541,"journal":{"name":"Archives of gynecology","volume":"232 1","pages":"106-13"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73253412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sitzung der Arbeitsgemeinschaft für Biochemie und Klinische Chemie an Frauenkliniken: Chemische Marker von Zellen Gynäkologischer Tumoren 我不知道if生物化学和临床化学委员会通过妇科医院，我不知道if
Archives of gynecology Pub Date : 2006-01-01 DOI: 10.1007/BF02427532
W. Eiermann, M. Groh, K. Prechtel, O. Scheiffarth, H. Schleich, W. Wiest, A. Keramopoullos, S. Michalas, P. Papapetrou, D. Kaskarelis, P. Braun, G. Leyendecker, J. Itzbicki, E. Neusel, H. Rjosk, J. Baltzer, J. Gokel, K. Holzmann, H. Mickan, E. Schneider, H. Würz, K. Schulz, P. Citoler, B. Sprenger, E. Wassner, P. Weymar, R. Kaiser, U. Eppenberger, A. Salokangas, P. Huber, W. Roos, W. Simon, F. Hölzel
{"title":"Sitzung der Arbeitsgemeinschaft für Biochemie und Klinische Chemie an Frauenkliniken: Chemische Marker von Zellen Gynäkologischer Tumoren","authors":"W. Eiermann, M. Groh, K. Prechtel, O. Scheiffarth, H. Schleich, W. Wiest, A. Keramopoullos, S. Michalas, P. Papapetrou, D. Kaskarelis, P. Braun, G. Leyendecker, J. Itzbicki, E. Neusel, H. Rjosk, J. Baltzer, J. Gokel, K. Holzmann, H. Mickan, E. Schneider, H. Würz, K. Schulz, P. Citoler, B. Sprenger, E. Wassner, P. Weymar, R. Kaiser, U. Eppenberger, A. Salokangas, P. Huber, W. Roos, W. Simon, F. Hölzel","doi":"10.1007/BF02427532","DOIUrl":"https://doi.org/10.1007/BF02427532","url":null,"abstract":"","PeriodicalId":75541,"journal":{"name":"Archives of gynecology","volume":"228 1","pages":"659-672"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02427532","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51604819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Posterpräsentationen 52 海报演示52
Archives of gynecology Pub Date : 2006-01-01 DOI: 10.1007/BF02428765
R. Briel, T. Lippert, S. Kunz
{"title":"Posterpräsentationen 52","authors":"R. Briel, T. Lippert, S. Kunz","doi":"10.1007/BF02428765","DOIUrl":"https://doi.org/10.1007/BF02428765","url":null,"abstract":"","PeriodicalId":75541,"journal":{"name":"Archives of gynecology","volume":"235 1","pages":"474"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02428765","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51617583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Posterpräsentationen 53 海报演示53
Archives of gynecology Pub Date : 2006-01-01 DOI: 10.1007/BF02428766
P. Brockerhoff, M. Höckel, A. Holzer, E. Schwenzer, G. Rathgen
{"title":"Posterpräsentationen 53","authors":"P. Brockerhoff, M. Höckel, A. Holzer, E. Schwenzer, G. Rathgen","doi":"10.1007/BF02428766","DOIUrl":"https://doi.org/10.1007/BF02428766","url":null,"abstract":"","PeriodicalId":75541,"journal":{"name":"Archives of gynecology","volume":"235 1","pages":"474-476"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02428766","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51617614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Posterpräsentationen 48 海报演示48
Archives of gynecology Pub Date : 2006-01-01 DOI: 10.1007/BF02428761
D. Kalogirou, K. Loghis, E. Papachristou, N. Vitoreatos, B. Contifaris
{"title":"Posterpräsentationen 48","authors":"D. Kalogirou, K. Loghis, E. Papachristou, N. Vitoreatos, B. Contifaris","doi":"10.1007/BF02428761","DOIUrl":"https://doi.org/10.1007/BF02428761","url":null,"abstract":"","PeriodicalId":75541,"journal":{"name":"Archives of gynecology","volume":"235 1","pages":"469"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02428761","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51617362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Posterpräsentationen 51 海报演示51
Archives of gynecology Pub Date : 2006-01-01 DOI: 10.1007/BF02428764
T. Öney, H. Kaulhausen
{"title":"Posterpräsentationen 51","authors":"T. Öney, H. Kaulhausen","doi":"10.1007/BF02428764","DOIUrl":"https://doi.org/10.1007/BF02428764","url":null,"abstract":"","PeriodicalId":75541,"journal":{"name":"Archives of gynecology","volume":"235 1","pages":"473"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02428764","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51617488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Posterpräsentationen 54 海报演示54
Archives of gynecology Pub Date : 2006-01-01 DOI: 10.1007/BF02428767
R. Knitza, M. Strowitzki, G. Bíró
{"title":"Posterpräsentationen 54","authors":"R. Knitza, M. Strowitzki, G. Bíró","doi":"10.1007/BF02428767","DOIUrl":"https://doi.org/10.1007/BF02428767","url":null,"abstract":"","PeriodicalId":75541,"journal":{"name":"Archives of gynecology","volume":"235 1","pages":"477"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02428767","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51617634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Posterpräsentationen 46 海报演示46
Archives of gynecology Pub Date : 2006-01-01 DOI: 10.1007/BF02428759
H. Woraschk, C. Gründig, W. Rumler
{"title":"Posterpräsentationen 46","authors":"H. Woraschk, C. Gründig, W. Rumler","doi":"10.1007/BF02428759","DOIUrl":"https://doi.org/10.1007/BF02428759","url":null,"abstract":"","PeriodicalId":75541,"journal":{"name":"Archives of gynecology","volume":"235 1","pages":"467"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02428759","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51617319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Posterpräsentationen 50 海报演示50
Archives of gynecology Pub Date : 2006-01-01 DOI: 10.1007/BF02428763
R. Gerner, E. Halberstadt
{"title":"Posterpräsentationen 50","authors":"R. Gerner, E. Halberstadt","doi":"10.1007/BF02428763","DOIUrl":"https://doi.org/10.1007/BF02428763","url":null,"abstract":"","PeriodicalId":75541,"journal":{"name":"Archives of gynecology","volume":"13 1","pages":"470-472"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02428763","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51617410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Posterpräsentationen 49 海报演示49
Archives of gynecology Pub Date : 2006-01-01 DOI: 10.1007/BF02428762
L. Spätling, P. Kunz, D. Vonderschmitt, R. Huch, A. Huch
{"title":"Posterpräsentationen 49","authors":"L. Spätling, P. Kunz, D. Vonderschmitt, R. Huch, A. Huch","doi":"10.1007/BF02428762","DOIUrl":"https://doi.org/10.1007/BF02428762","url":null,"abstract":"","PeriodicalId":75541,"journal":{"name":"Archives of gynecology","volume":"235 1","pages":"470"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02428762","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51617379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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