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Annual review of pharmacology最新文献

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Chemical reactions of sulfonamides with carbonic anhydrase. 磺胺类化合物与碳酸酐酶的化学反应。
Annual review of pharmacology Pub Date : 1975-01-01 DOI: 10.1146/annurev.pa.15.040175.001253
J E Coleman
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引用次数: 66
In vitro models in the study of structure-activity relationships of narcotic analgesics. 麻醉镇痛药构效关系的体外模型研究。
Annual review of pharmacology Pub Date : 1975-01-01 DOI: 10.1146/annurev.pa.15.040175.000333
H W Kosterlitz, A A Waterfield
{"title":"In vitro models in the study of structure-activity relationships of narcotic analgesics.","authors":"H W Kosterlitz,&nbsp;A A Waterfield","doi":"10.1146/annurev.pa.15.040175.000333","DOIUrl":"https://doi.org/10.1146/annurev.pa.15.040175.000333","url":null,"abstract":"<p><p>Evidence has been adduced for the view that the morphiness receptor or receptors in the myenteric plexus of guinea pig ileum are very similar to the brain receptors that mediate the analgesic action of the narcotic alagesics. Such an in vitro model is very suitable for the study of structure-activity relationships because the angonist and antagonist activities of compounds can readily be assessed. One example is the investigation of the effects of changes at the N atom. Another point of interest is the role of substitutions at the C14 atom in morphine and morphinans. Such alterations in structure may have a profound effect on the relative agonist and antagonist activities and may convert a drug with dual agonist and antagonist actions into an antagonist devoid of agonist action.</p>","PeriodicalId":75521,"journal":{"name":"Annual review of pharmacology","volume":"15 ","pages":"29-47"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev.pa.15.040175.000333","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11452335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 265
Review of reviews. 审查的审查。
Annual review of pharmacology Pub Date : 1975-01-01 DOI: 10.1146/annurev.pa.15.040175.002341
C D Leake
{"title":"Review of reviews.","authors":"C D Leake","doi":"10.1146/annurev.pa.15.040175.002341","DOIUrl":"https://doi.org/10.1146/annurev.pa.15.040175.002341","url":null,"abstract":"","PeriodicalId":75521,"journal":{"name":"Annual review of pharmacology","volume":"15 ","pages":"465-72"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev.pa.15.040175.002341","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12277034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical relevance of drugs affecting tryptophan transport. 影响色氨酸转运的药物的临床意义。
Annual review of pharmacology Pub Date : 1975-01-01 DOI: 10.1146/annurev.pa.15.040175.000445
R Paoletti, C Sirtori, P F Spano
{"title":"Clinical relevance of drugs affecting tryptophan transport.","authors":"R Paoletti,&nbsp;C Sirtori,&nbsp;P F Spano","doi":"10.1146/annurev.pa.15.040175.000445","DOIUrl":"https://doi.org/10.1146/annurev.pa.15.040175.000445","url":null,"abstract":"","PeriodicalId":75521,"journal":{"name":"Annual review of pharmacology","volume":"15 ","pages":"73-81"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev.pa.15.040175.000445","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12277035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Pharmacology of marijuana. 大麻药理学。
Annual review of pharmacology Pub Date : 1975-01-01 DOI: 10.1146/annurev.pa.15.040175.001203
W D Paton
{"title":"Pharmacology of marijuana.","authors":"W D Paton","doi":"10.1146/annurev.pa.15.040175.001203","DOIUrl":"https://doi.org/10.1146/annurev.pa.15.040175.001203","url":null,"abstract":"","PeriodicalId":75521,"journal":{"name":"Annual review of pharmacology","volume":"15 ","pages":"191-220"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev.pa.15.040175.001203","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11994908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 164
How I became a pharmacologist. 我是如何成为药理学家的。
Annual review of pharmacology Pub Date : 1975-01-01 DOI: 10.1146/annurev.pa.15.040175.000245
S V Anichkov
{"title":"How I became a pharmacologist.","authors":"S V Anichkov","doi":"10.1146/annurev.pa.15.040175.000245","DOIUrl":"https://doi.org/10.1146/annurev.pa.15.040175.000245","url":null,"abstract":"","PeriodicalId":75521,"journal":{"name":"Annual review of pharmacology","volume":"15 ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev.pa.15.040175.000245","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12276148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of drugs on uric acid in man. 药物对人体尿酸的影响。
Annual review of pharmacology Pub Date : 1975-01-01 DOI: 10.1146/annurev.pa.15.040175.001551
W N Kelley
{"title":"Effects of drugs on uric acid in man.","authors":"W N Kelley","doi":"10.1146/annurev.pa.15.040175.001551","DOIUrl":"https://doi.org/10.1146/annurev.pa.15.040175.001551","url":null,"abstract":"<p><p>In this review the drugs capable of increasing or lowering the serum urate concentration are considered with regard to mechanism of action and significance of the effect, where known. Several hypouricemic agents, probenecid, sulfinpyrazone, and allopurinol, are considered in further detail because of their major clinical importance. No effort has been made, however, to summarize the relative clinical indications for each agent. In addition, in those cases where specific details could not be included because of limitation of space, the appropiate reference has been given.</p>","PeriodicalId":75521,"journal":{"name":"Annual review of pharmacology","volume":"15 ","pages":"327-50"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev.pa.15.040175.001551","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12277027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 54
Oral contraceptives: relations to mammary cancer, benign breast lesions, and cervical cancer. 口服避孕药:与乳腺癌、乳腺良性病变、宫颈癌的关系。
Annual review of pharmacology Pub Date : 1975-01-01 DOI: 10.1146/annurev.pa.15.040175.002055
V A Drill
{"title":"Oral contraceptives: relations to mammary cancer, benign breast lesions, and cervical cancer.","authors":"V A Drill","doi":"10.1146/annurev.pa.15.040175.002055","DOIUrl":"https://doi.org/10.1146/annurev.pa.15.040175.002055","url":null,"abstract":"<p><p>The results of experimental studies on the relationship of estrogens and oral contraceptives to mammary lesions demonstrate that the type of response obtained depends largely on the species and strain of animal that is employed. A variety of clinical studies has failed to demonstrate that estrogen can cause mammary cancer, this lack of effort correlates with the results obtained in various studies in animals. Similar relationships exist for oral contraceptives, and the clinical data show good agreement in demonstrating that the contraceptive steroids do not have a tumorigenic effect on the human mammary gland. Estrogen can increase the occurrence of cervical cancer in certain strains of mice, but apparently this effect is not observed in other species of animals, including man. The preponderance of data shows that oral contraceptives do not adversely affect the occurence of abnormal Papanicolaou smears, cervical dysplasia, cervical cancer in situ, or invasive cervical cancer.</p>","PeriodicalId":75521,"journal":{"name":"Annual review of pharmacology","volume":"15 ","pages":"367-85"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev.pa.15.040175.002055","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12277029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
The cholinergic receptor protein in its membrane environment. 胆碱能受体蛋白在膜环境中的作用。
Annual review of pharmacology Pub Date : 1975-01-01 DOI: 10.1146/annurev.pa.15.040175.000503
J B Cohen, J P Changeux
{"title":"The cholinergic receptor protein in its membrane environment.","authors":"J B Cohen,&nbsp;J P Changeux","doi":"10.1146/annurev.pa.15.040175.000503","DOIUrl":"https://doi.org/10.1146/annurev.pa.15.040175.000503","url":null,"abstract":"","PeriodicalId":75521,"journal":{"name":"Annual review of pharmacology","volume":"15 ","pages":"83-103"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev.pa.15.040175.000503","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12277036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 85
Amino acids as central neurotransmitters. 氨基酸作为中枢神经递质。
Annual review of pharmacology Pub Date : 1975-01-01 DOI: 10.1146/annurev.pa.15.040175.000541
F V DeFeudis
{"title":"Amino acids as central neurotransmitters.","authors":"F V DeFeudis","doi":"10.1146/annurev.pa.15.040175.000541","DOIUrl":"https://doi.org/10.1146/annurev.pa.15.040175.000541","url":null,"abstract":"","PeriodicalId":75521,"journal":{"name":"Annual review of pharmacology","volume":"15 ","pages":"105-30"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev.pa.15.040175.000541","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11452332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 101
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