Saad J Taj-Aldeen, Maria N Gamaletsou, Blandine Rammaert, Nikolaos V Sipsas, Valerie Zeller, Emmanuel Roilides, Dimitrios P Kontoyiannis, Michael Henry, Vidmantas Petraitis, Brad Moriyama, David W Denning, Olivier Lortholary, Thomas J Walsh
{"title":"Bone and joint infections caused by mucormycetes: A challenging osteoarticular mycosis of the twenty-first century.","authors":"Saad J Taj-Aldeen, Maria N Gamaletsou, Blandine Rammaert, Nikolaos V Sipsas, Valerie Zeller, Emmanuel Roilides, Dimitrios P Kontoyiannis, Michael Henry, Vidmantas Petraitis, Brad Moriyama, David W Denning, Olivier Lortholary, Thomas J Walsh","doi":"10.1093/mmy/myw136","DOIUrl":"10.1093/mmy/myw136","url":null,"abstract":"<p><p>Osteomyelitis and arthritis caused by mucormycetes are rare diseases that rank among the most challenging complications in orthopedic and trauma surgery. The aim of this work is to review the epidemiological, clinical, diagnostic, and therapeutic aspects of the osteoarticular mucormycosis with particular emphasis on high-risk patients. A systematic review of osteoarticular mucormycosis was performed using PUBMED and EMBASE databases from 1978 to 2014. Among 34 patients with median age 41 (0.5-73 years), 24 (71%) were males. While 12 (35%) were immunocompromised patients, 14 (41%) had prior surgery, and seven (21%) suffered trauma. Other underlying conditions included diabetes mellitus, hematological malignancies, transplantation, and corticosteroid therapy. The median diagnostic delay from onset of symptoms and signs was 60 (10-180) days. The principal mechanism of the infection was direct inoculation (n = 19; 56%), and in immunocompromised patients was usually hematogenous disseminated. The long bones were infected by trauma or surgery, while a wide variety of bones were involved by hematogenous dissemination. Combined surgery and amphotericin B treatment were implemented in 28 (82%) and eight (23%) had an unfavorable outcome. Osteoarticular mucormycosis occurs most frequently after trauma or surgical procedures. These infections are progressively destructive and more virulent in individuals with impaired immune systems. Early diagnosis, timely administration of amphotericin B, control of underlying conditions, and surgical debridement of infected tissue are critical for successful management of osteoarticular mucormycosis.</p>","PeriodicalId":75496,"journal":{"name":"Annales chirurgiae et gynaecologiae Fenniae","volume":"44 1 1","pages":"691-704"},"PeriodicalIF":1.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89624664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Morton's metatarsalgia in rheumatoid arthritis.","authors":"V. Ritama, K. Vainio","doi":"10.1097/00003086-197907000-00013","DOIUrl":"https://doi.org/10.1097/00003086-197907000-00013","url":null,"abstract":"Findings in a follow-up study of 66 operations Morton's metatarsalgia performed on 52 patients suffering from rheumatoid arthritis during the years 1954-1977 were in many respects different from those described as \"classic\" Morton's neuroma. The incidence was one to 520 in rheumatoid patients. The ratio of females to males was 9.4 to one. Histology revealed inflammatory or degenerative changes of the walls of synovial cavities often in connection with typical rheumatoid nudules. The changes of the nerves were non-specific alterations caused by chronic compression. Surgical removal of the tumor-like formations gave uniformly good results. Early metatarsophalangeal synovectomy for rheumatoid arthritis decreased in need of operations for Morton's metatarsalgia from 4.5 to 0.6 operations per year and can be recommended as a prophylactic procedure.","PeriodicalId":75496,"journal":{"name":"Annales chirurgiae et gynaecologiae Fenniae","volume":"38 1","pages":"197-206"},"PeriodicalIF":0.0,"publicationDate":"1979-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00003086-197907000-00013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61381090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effect of systematic treatment of toxaemia of pregnancy upon fetal prognosis.","authors":"L. Rauramo, A. Kivikoski, T. Salmi","doi":"10.1097/00006254-197606000-00014","DOIUrl":"https://doi.org/10.1097/00006254-197606000-00014","url":null,"abstract":"Systematic therapy for pre-eclampsia including diuretics was investigated in 604 patients in whom therapy was begun immediately the first symptoms appeared and continued until delivery. The control group consisted of 368 patients with toxemia from the two previous years who received no systematic therapy but who also underwent delivery at either the Turku City Maternity Hospital or the Women's Clinic of Turku University Central Hospital. Cases of pre-eclampsia gravis were significantly reduced (2.3 as compared with 7.3%). A significant difference was seen in the percentage of premature deliveries. In the experimental group this was 4.3% and in the control group 11.2%, (p less than 0.001). There was also a significant difference in the perinatal mortality, the values being 2.3 and 4.6%, respectively (p less than 0.05). The overal premature birth rate during these two periods remained unchanged, at 5.5 and 5.7%. The difference between the overall perinatal mortality rates was also slight (1.8 and 2.2%).","PeriodicalId":75496,"journal":{"name":"Annales chirurgiae et gynaecologiae Fenniae","volume":"64 3 1","pages":"165-9"},"PeriodicalIF":0.0,"publicationDate":"1976-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00006254-197606000-00014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61912822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clonidine in the treatment of menopausal symptoms.","authors":"O. Ylikorkala","doi":"10.1097/00006254-197605000-00019","DOIUrl":"https://doi.org/10.1097/00006254-197605000-00019","url":null,"abstract":"Twenty-five women suffering from climacteric complaints after surgical castration were treated with clonidine in a placebo controlled trial. Clonidine in the dose of 75 to 150 mug daily diminished the attack rates of flushing and sweating significantly. It can be recommended as a safe therapy for climacteric patients, at least those with contra-indications to oestrogen therapy.","PeriodicalId":75496,"journal":{"name":"Annales chirurgiae et gynaecologiae Fenniae","volume":"64 4 1","pages":"242-5"},"PeriodicalIF":0.0,"publicationDate":"1976-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00006254-197605000-00019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61913133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The prognosis in pregnancy after threatened abortion.","authors":"P. Jouppila, M. Koivisto","doi":"10.1097/00006254-197508000-00005","DOIUrl":"https://doi.org/10.1097/00006254-197508000-00005","url":null,"abstract":"\u0000 A study of the outcome of pregnancy in 143 cases of threatened abortion is presented. Fetal life was confirmed by ultrasonic technique during the 1st half of pregnancy. 7% of the pregnancies terminated in abortion and the remainder ended in delivery. The frequency of preeclampsia (21%) and placenta praevia (3%) was significantly higher than in the control group, as was the case with the number of manual removals (6) of the placenta (p less than .001). Breech extractions were required in 5 cases. 13.2% of the deliveries occurred before Week 37 of pregnancy, and 8.1% of the infants weighed less than 2500 gm. The perinatal mortality rate (3.7%) and the frequency of infant malformation (5.2%) were not statistically significant compared with the control group. However, the frequency of respiratory difficulties (14.7%) and hyperbilirubinemia (8.1%) was significantly higher (p less than .001). It was concluded that a pregnancy continuing after threatened abortion does not noticeably increase the risk of severe infant malformations or perinatal death, though mothers with threatened abortion constitute a high-risk group that requires careful follow-up.\u0000","PeriodicalId":75496,"journal":{"name":"Annales chirurgiae et gynaecologiae Fenniae","volume":"63 6 1","pages":"439-44"},"PeriodicalIF":0.0,"publicationDate":"1975-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00006254-197508000-00005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61910171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The absorption of conjugated oestrogen and sodium oestrone sulphate from the vagina.","authors":"O. Widholm, E. Vartiainen","doi":"10.1097/00006254-197505000-00019","DOIUrl":"https://doi.org/10.1097/00006254-197505000-00019","url":null,"abstract":"","PeriodicalId":75496,"journal":{"name":"Annales chirurgiae et gynaecologiae Fenniae","volume":"63 3 1","pages":"186-90"},"PeriodicalIF":0.0,"publicationDate":"1975-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00006254-197505000-00019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61909401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of high-dose medroxyprogesterone given for endometrial carcinoma on serum proteins.","authors":"P. Ylöstalo, A. Vehaskari, A. Kauppila","doi":"10.1097/00006254-197504000-00026","DOIUrl":"https://doi.org/10.1097/00006254-197504000-00026","url":null,"abstract":"\u0000 29 women with endometrial cancer were treated with 50-mg medroxyprogesterone twice daily for 1 year and studied to determine what effect this dose of progesterone had on serum proteins. Total serum proteins were significantly (p less than .01) elevated at 3 months until 6 months after treatment. There was a transient decline in albumin at 1 month (p less than .01) which reelevated after 3 months. Alpha-1-globulin and alpha-2-globulin increased at the beginning of therapy (p less than .001 at 1 month) and returned to pretreatment levels at the end of therapy. Gamma globulin levels were significantly less after 1 year of therapy. Alpha-1-acid-glycoprotein was significantly elevated at 1 month and returned to normal after therapy ended. These protein levels are compared with those in pregnancy and during oral contraceptive therapy. It is concluded that these changes are smaller and even the reverse of those seen in pregnancy and oral contraceptive therapy; the changes are attributed to the effect of sex hormones on hepatic metabolic activities.\u0000","PeriodicalId":75496,"journal":{"name":"Annales chirurgiae et gynaecologiae Fenniae","volume":"63 2 1","pages":"86-92"},"PeriodicalIF":0.0,"publicationDate":"1975-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00006254-197504000-00026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61909278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A case of malignant arrhenoblastoma.","authors":"O Widholm, M Ikonen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The patient was a 72-year-old married woman from whom a recurrent arrhenoblastoma had been removed three time in the course of six years. She was clearly virilized and her voice had become deep. Endocrine studies before removal of the recurrences showed pronounced elevation of the serum testosterone values. The 17-KS values did not as clearly parallel growth of the tumour. Histochemical examination showed moderate 3beta-steroid dehydrogenase activity in limited areas. The histological features were those of so-called intermediate type of arrhenoblastoma with a very scanty tubular component. Histologically the tumour was malignant, but with a relatively low degree of malignancy. Regardless of the treatment there was twice a recurrence of the tumour. The increase of the serum testosterone values during the follow-up period reflected recurrence on of the tumour.</p>","PeriodicalId":75496,"journal":{"name":"Annales chirurgiae et gynaecologiae Fenniae","volume":"64 1","pages":"55-61"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11387177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Haemophilus influenzae as a cause of salpingitis.","authors":"E Herva, R Pokela, O Ylikorkala","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A case is reported of acute unilateral salpingitis, the cause of which was Haemophilus influenzae cultured from a pus sample taken from the infected Fallopian tube during laparotomy. The significance of the findings is discussed with reference to the literature.</p>","PeriodicalId":75496,"journal":{"name":"Annales chirurgiae et gynaecologiae Fenniae","volume":"64 5","pages":"317-9"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12262454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gastric retention following antrectomy and gastroduodenal anastomosis combined with truncal vagotomy.","authors":"T Monclair","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A clinical series of 208 patients who had elective operations for gastroduodenal ulcer in Surgical Department II, Oslo City Hospital, has been reviewed. The study concentrates on postoperative gastric retention, comparing the frequency of this complication following antrectomy and gastroduodenal anastomosis with and without vagotomy. The patients in the nonvagotomy group had no retention problem. In the vagotomy group, 19 patients (35%) of 54 operated had troublesome postoperative retention. 7 patients (13%) had to have a further operation for this complication, all within 1 year. We no longer use the combined operation as a routine procedure for duodenal ulcer.</p>","PeriodicalId":75496,"journal":{"name":"Annales chirurgiae et gynaecologiae Fenniae","volume":"64 2","pages":"78-81"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12316260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}