Advances in shock research最新文献_第8页

The influence of megadose methylprednisolone on experimental myocardial infarct size. 大剂量甲基强的松龙对实验性心肌梗死面积的影响。

Advances in shock research Pub Date : 1982-01-01

C H Shatney, R C Lillehei

{"title":"The influence of megadose methylprednisolone on experimental myocardial infarct size.","authors":"C H Shatney, R C Lillehei","doi":"","DOIUrl":"","url":null,"abstract":"Prior work in our laboratory demonstrated a significant reduction of infarct size following early or late administration of 30 mg/kg of methylprednisolone sodium succinate (MP). This study was designed to determine the influence of larger doses of MP on infarct volume. Healthy anesthetized mongrel dogs with similar cardiac anatomy underwent ligation of the distal third of the LAD coronary artery. Following ligation, animals were randomly placed into control or treatment groups. Treated dogs received an IV bolus of either 50 mg/kg MP at 15 minutes (MP-50) or 30 mg/kg MP at 15 minutes and 1 hour later (2MP-30). Animals were then monitored for 6 hours, sacrificed, and the heart removed. The left ventricle was dissected from the heart, weighed, sectioned, and incubated in nitro-blue tetrazolium solution, an LDH stain. Unstained tissue (infarct) was dissected from the slices and weighed, and infarct volume was calculated. Among 20 untreated animals the infarct size was 14.5% +/- 4.3% of the left ventricle. Treatment with 2MP-30 or MP-50 significantly reduced infarct volume to a similar degree (9.1%-9.6%). There was no difference in the effect on infarct size by \"megadose\" MP compared to previous results with one injection of 30 mg/kg MP. Therefore, the early use of MP at doses above 30 mg/kg confers no additional protection to the ischemic myocardium.","PeriodicalId":75453,"journal":{"name":"Advances in shock research","volume":"8 ","pages":"187-93"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18152726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An experimental model of intraabdominal abscess in the rat. 大鼠腹腔内脓肿的实验模型。

Advances in shock research Pub Date : 1982-01-01

D E Fry, R N Garrison, R D Rink, J Casey, M M DeCamp, J D Richardson

引用次数: 0

Studies of the mechanism of hypoxic pulmonary vasoconstriction. 缺氧肺血管收缩机制的研究。

Advances in shock research Pub Date : 1982-01-01

I F McMurtry, S Rounds, H S Stanbrook

引用次数: 0

Neurogenic shock syndrome after experimental subarachnoid hemorrhage in cats. 猫实验性蛛网膜下腔出血后的神经源性休克综合征。

Advances in shock research Pub Date : 1982-01-01

T Shigeno, E Fritschka, S Shigeno, M Brock

引用次数: 0

Respiratory monitoring in acute multiple organ system failure. 急性多器官系统衰竭的呼吸监测。

Advances in shock research Pub Date : 1982-01-01

C A Guenter

引用次数: 0

A review of the skin and muscle hemodynamics during hemorrhagic hypotension and shock. 失血性低血压和休克时皮肤和肌肉血流动力学的综述。

Advances in shock research Pub Date : 1982-01-01

R F Bond

{"title":"A review of the skin and muscle hemodynamics during hemorrhagic hypotension and shock.","authors":"R F Bond","doi":"","DOIUrl":"","url":null,"abstract":"The primary objective of this study was to compare the hemodynamic responses in a vascular bed known to exhibit decompensation (ie, skeletal muscle) with a nondecompensating bed such as the cutaneous vascular bed during systemic and local reductions in perfusion pressure induced by hemorrhage and sequential inflow arterial occlusion. The secondary objective was to examine the mechanisms which may be responsible for skeletal muscle vascular decompensation. Systemic hypotension was produced by a stepwise hemorrhage of 5 ml/kg body weight with 5-minute intervals between bleedings. The carotid sinus impact was examined during bilateral carotid artery occlusion. The intrinsic effects were evaluated during reductions in local perfusion pressure. The data show that skeletal muscle vasculature exhibits autoregulation but skin vasculature does not. Both vascular beds respond to acute hemorrhage by vasoconstriction; however, the vasoconstriction in the skin occurs as a result of increased plasma levels of catecholamines acting on alpha receptors with no neural component, whereas the vasoconstriction in skeletal muscle occurs as a result of both neural and humoral hyperactivity. The data presented also suggest that the skeletal muscle vascular decompensation occurring late in shock is the result of prostaglandin inhibition of a hyperactive sympathetic nervous system.","PeriodicalId":75453,"journal":{"name":"Advances in shock research","volume":"8 ","pages":"53-70"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17806323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma fibronectin and resistance to thrombosis during sepsis. 血浆纤维连接蛋白与败血症时血栓形成的抵抗。

Advances in shock research Pub Date : 1982-01-01

J E Kaplan

{"title":"Plasma fibronectin and resistance to thrombosis during sepsis.","authors":"J E Kaplan","doi":"","DOIUrl":"","url":null,"abstract":"Previous studies have suggested that plasma fibronectin is a component of the physiological antithrombotic mechanism and is related to resistance to cardiopulmonary failure during sepsis. The current study addresses the hypothesis that fibronectin deficiency results in increased sensitivity to thrombosis during sepsis, whereas increased fibronectin results in enhanced resistance. Rats were injected with purified fibronectin, antiserum to fibronectin, antiserum to albumin or vehicle prior to intraaortic infusion of saline, live Escherichia coli (10(7)--10(8)/100 gm) or E coli endotoxin (0.001--0.1 mg/100 gm). Infusion of the higher doses was associated with greater mortality in antifibronectin groups than the other groups. Mean arterial blood pressure fell transiently in all groups following injection of antifibronectin but not following the other pretreatment. Both endotoxin and bacterial infusion resulted in severe thrombocytopenia in antifibronectin-treated animals and to a lesser extent following antialbumin. Fibrinogen consumption was increased in all groups after antifibronectin treatment in bacteria infused animals after pretreatment with antialbumin or fibronectin. Fibrin degradation products were increased by bacterial infusion in animals treated with either antiserum. The current data support a relationship between plasma fibronectin and resistance to thrombosis. The relationship was not as clear-cut as that previously observed for nonseptic thrombotic states.","PeriodicalId":75453,"journal":{"name":"Advances in shock research","volume":"7 ","pages":"159-72"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17806551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of phentolamine on insulin levels and insulin responsiveness in endotoxicosis. 酚妥拉明对内毒素中毒患者胰岛素水平和胰岛素反应性的影响。

Advances in shock research Pub Date : 1982-01-01

J P Filkins

引用次数: 0

The improvement in endotoxin-induced redistribution of organ blood flow by inhibition of thromboxane and prostaglandin synthesis. 通过抑制血栓素和前列腺素的合成改善内毒素诱导的器官血流再分配。

Advances in shock research Pub Date : 1982-01-01

G E Tempel, J A Cook, W C Wise, P V Halushka

引用次数: 0

Inhibition of endogenous thromboxane synthesis by exogenous prostacyclin during endotoxemia in conscious sheep. 外源性前列环素对有意识绵羊内毒素血症时内源性血栓素合成的抑制作用。

Advances in shock research Pub Date : 1982-01-01

J T Flynn, R H Demling

引用次数: 0