Advances in pharmacology and chemotherapy最新文献

Biochemical pharmacology, metabolism, and mechanism of action of L-alanosine, a novel, natural antitumor agent. 新型天然抗肿瘤药物l -丙氨酸的生化药理学、代谢及作用机制。

Advances in pharmacology and chemotherapy Pub Date : 1984-01-01 DOI: 10.1016/s1054-3589(08)60265-3

A K Tyagi, D A Cooney

引用次数: 19

The pharmacology of prodrugs of 5-fluorouracil and 1-beta-D-arabinofuranosylcytosine. 5-氟尿嘧啶和1- β - d -阿拉伯糖脲基胞嘧啶前药的药理学研究。

Advances in pharmacology and chemotherapy Pub Date : 1984-01-01 DOI: 10.1016/s1054-3589(08)60264-1

A F Hadfield, A C Sartorelli

引用次数: 26

Computer-assisted structure-activity correlations. 计算机辅助构效关系。

Advances in pharmacology and chemotherapy Pub Date : 1984-01-01 DOI: 10.1016/s1054-3589(08)60266-5

M Nasr, K D Paull, V L Narayanan

{"title":"Computer-assisted structure-activity correlations.","authors":"M Nasr, K D Paull, V L Narayanan","doi":"10.1016/s1054-3589(08)60266-5","DOIUrl":"https://doi.org/10.1016/s1054-3589(08)60266-5","url":null,"abstract":"<p><p>Several types of Michael acceptors, including alpha,beta-unsaturated ketones, lactones, and lactams, have been extensively studied as potential anticancer agents. A concerted effort was made to explore the relationship between the structures of these compounds and their antitumor activity against P388 and L1210 leukemias. This article describes the computer-assisted structure-activity evaluation of more than 14,000 compounds, representing different classes of Michael acceptors, in the NCI file. In this study, advantage has been taken of the computer's ability to search substructures according to precise definitions and to manipulate these substructures utilizing Boolean logic. Olefinic conjugated Michael-type acceptors, e.g., styrenes with different activating groups, cinnamic acid derivatives, and alpha,beta-unsaturated nitro, cyano, sulfone, sulfoxide, and acetylenic compounds, have shown appreciable activity against P388 lymphocytic leukemia. The analysis of lactones and lactams includes substructures representing a wide variety of exocyclic and endocyclic alpha,beta-unsaturated compounds. The analysis describes the effect of certain groups, such as an --OH, --OR, alpha,beta-unsaturated ester, or epoxide, adjacent to the alpha,beta-unsaturated center, on the antitumor activity of these compounds. A combination of one or more of these activating groups with an alpha-methylene-gamma-lactone moiety significantly enhanced the activity against P388. In general, many of the classes of compounds studied have shown poor activity against the more stringent L1210 lymphoid leukemia.</p>","PeriodicalId":75449,"journal":{"name":"Advances in pharmacology and chemotherapy","volume":"20 ","pages":"123-90"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1054-3589(08)60266-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17458214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Current NCI preclinical antitumor screening in vivo: results of tumor panel screening, 1976-1982, and future directions. 当前NCI临床前体内抗肿瘤筛查:1976-1982年肿瘤组筛查结果及未来方向。

Advances in pharmacology and chemotherapy Pub Date : 1984-01-01 DOI: 10.1016/s1054-3589(08)60263-x

J M Venditti, R A Wesley, J Plowman

引用次数: 96

Praziquantel. 吡喹酮。

Advances in pharmacology and chemotherapy Pub Date : 1984-01-01 DOI: 10.1016/s1054-3589(08)60268-9

E Groll

引用次数: 2

The sugar alcohols: a profile. 糖醇:简介。

Advances in pharmacology and chemotherapy Pub Date : 1984-01-01 DOI: 10.1016/s1054-3589(08)60267-7

A Jori

引用次数: 3

The interaction of cancer chemotherapy agents with mononuclear phagocytes. 肿瘤化疗药物与单核吞噬细胞的相互作用。

Advances in pharmacology and chemotherapy Pub Date : 1982-01-01 DOI: 10.1016/s1054-3589(08)60020-4

A Mantovani

引用次数: 23

Development of radiosensitizers: a medicinal chemistry perspective. 放射增敏剂的发展:药物化学的观点。

Advances in pharmacology and chemotherapy Pub Date : 1982-01-01 DOI: 10.1016/s1054-3589(08)60023-x

V L Narayanan, W W Lee

引用次数: 15

The effects of antineoplastic therapy on growth and development in children. 抗肿瘤治疗对儿童生长发育的影响。

Advances in pharmacology and chemotherapy Pub Date : 1982-01-01 DOI: 10.1016/s1054-3589(08)60024-1

U Bode, A Oliff

引用次数: 2

Chloroethylnitrosourea cancer chemotherapeutic agents. 氯乙基亚硝基脲类癌症化疗药物。

Advances in pharmacology and chemotherapy Pub Date : 1982-01-01 DOI: 10.1016/s1054-3589(08)60019-8

R J Weinkam, H S Lin

引用次数: 30