{"title":"Mechanisms of endothelial injury in systemic vasculitis.","authors":"L Harper, C O Savage","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The precise etiology of primary systemic vasculitis remains unknown. However, recent advances in the understanding of the role of and interaction between the vascular endothelium, mediators, and immune effector cells have helped to further elucidate those specific processes that result in endothelial cell damage. In WG and MPA, the evidence favors an autoimmune inflammatory response characterized by specific mediators in which the endothelium is both target and active participant.</p>","PeriodicalId":75446,"journal":{"name":"Advances in nephrology from the Necker Hospital","volume":"29 ","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21421956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J F Mann, U Thomae, H C Gerstein, J Franke, M Lièvre
{"title":"Antihypertensive therapy in patients with type 2 diabetes mellitus: focus on nephropathy.","authors":"J F Mann, U Thomae, H C Gerstein, J Franke, M Lièvre","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75446,"journal":{"name":"Advances in nephrology from the Necker Hospital","volume":"29 ","pages":"241-55"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21421223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chloride channels in renal disease.","authors":"R V Thakker","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Recent studies of hereditary renal tubular disorders have facilitated the identification and roles of chloride channels and cotransporters in the regulation of the most abundant anion, Cl-, in the ECF. Thus, mutations that result in a loss of function of the voltage-gated chloride channel, CLC-5, are associated with Dent's disease, which is characterized by low-molecular weight proteinuria, hypercalciuria, nephrolithiasis, and renal failure. Mutations of another voltage-gated chloride channel, CLC-Kb, are associated with a form of Bartter's syndrome, whereas other forms of Bartter's syndrome are caused by mutations in the bumetanide-sensitive sodium-potassium-chloride cotransporter (NKCC2) and the potassium channel, ROMK. Finally, mutations of the thiazide-sensitive sodium-chloride cotransporter (NCCT) are associated with Gitelman's syndrome. These studies have helped to elucidate some of the renal tubular mechanisms regulating mineral homeostasis and the role of chloride channels.</p>","PeriodicalId":75446,"journal":{"name":"Advances in nephrology from the Necker Hospital","volume":"29 ","pages":"289-98"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21421226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nitric oxide in renal disease.","authors":"P Y Martin, E Féraille","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75446,"journal":{"name":"Advances in nephrology from the Necker Hospital","volume":"29 ","pages":"93-113"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21421960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J Bariéty, D Nochy, C Jacquot, C Mandet, P Callard, A Meyrier
{"title":"Diversity and unity of focal and segmental glomerular sclerosis.","authors":"J Bariéty, D Nochy, C Jacquot, C Mandet, P Callard, A Meyrier","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75446,"journal":{"name":"Advances in nephrology from the Necker Hospital","volume":"28 ","pages":"1-42"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20796780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Urea excretion revisited: physiology and transporters.","authors":"L Bankir, M M Trinh-Trang-Tan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75446,"journal":{"name":"Advances in nephrology from the Necker Hospital","volume":"28 ","pages":"83-135"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20796783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Early expression of all components of the renin-angiotensin system in human development.","authors":"P Corvol, S Schütz, J M Gasc","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75446,"journal":{"name":"Advances in nephrology from the Necker Hospital","volume":"28 ","pages":"195-212"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20796787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Treatment of chain amyloidosis (AL).","authors":"R A Kyle","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75446,"journal":{"name":"Advances in nephrology from the Necker Hospital","volume":"28 ","pages":"383-99"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20796796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pathophysiology of idiopathic hypercalciuria: recent advances.","authors":"P Houillier, M Paillard","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75446,"journal":{"name":"Advances in nephrology from the Necker Hospital","volume":"28 ","pages":"137-62"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20796784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Liver transplantation or liver and kidney transplantation?","authors":"D Samuel, H Bismuth","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75446,"journal":{"name":"Advances in nephrology from the Necker Hospital","volume":"28 ","pages":"163-9"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20796785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}