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Advances in cytopharmacology最新文献

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Immunochemical analysis of acetylcholine receptor and its relevance to specific treatment of experimental autoimmune myasthenia gravis. 乙酰胆碱受体的免疫化学分析及其与实验性自身免疫性重症肌无力特异性治疗的相关性。
Advances in cytopharmacology Pub Date : 1979-01-01
S Fuchs
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引用次数: 0
Biochemical studies on the ionic channel of Torpedo acetylcholine receptor. 鱼雷乙酰胆碱受体离子通道的生化研究。
Advances in cytopharmacology Pub Date : 1979-01-01
M E Eldefrawi, A T Eldefrawi
{"title":"Biochemical studies on the ionic channel of Torpedo acetylcholine receptor.","authors":"M E Eldefrawi,&nbsp;A T Eldefrawi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>1. [3H]H12-HTX binding to Torpedo electric organ membranes is saturable and inhibited by ligands that modulate EPCs. There is a small proportion of nonspecific binding to the membrane. 2. The validity of utilizing [3H]H12-HTX as a specific label for the ionic channel of the nicotinic receptor is extablished by the good correlation between the potency of HTX analogues in reducing EPC amplitudes and their inhibition of [3H]H12-HTX binding. 3. Receptor drugs and toxins inhibit [3H]ACh binding to the ACh receptor, but do not inhibit significantly [3h]h12-htx binding to the ionic channel at similar concentrations. 4. Various drugs and toxins with different modes of action modulate EPCs and inhibit [3H]H12-HTX binding to the ionic channel of the nicotinic receptor. Most such drugs and toxins, at similar concentrations, do not inhibit [3H]ACh binding to the ACh receptor, but some do, such as quinacrine and TEA. 5. The ionic channel of the nicotinic receptor is a protein which is solubilized by cholate and retains its affinity for H12-HTX as well as its drug sensitivity. 6. The ACh receptor is separated from its ionic channel, and different conditions affect the proportion of separated molecules.</p>","PeriodicalId":75440,"journal":{"name":"Advances in cytopharmacology","volume":"3 ","pages":"213-23"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11589606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sea anemone toxins: tools in the study of excitable membranes. 海葵毒素:可兴奋膜研究的工具。
Advances in cytopharmacology Pub Date : 1979-01-01
W Rathmayer
{"title":"Sea anemone toxins: tools in the study of excitable membranes.","authors":"W Rathmayer","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75440,"journal":{"name":"Advances in cytopharmacology","volume":"3 ","pages":"335-44"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11589613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibodies against muscle and brain nicotinic acetylcholine receptors in IgA-deficient patients with epilepsy. iga缺乏癫痫患者抗肌肉和脑烟碱乙酰胆碱受体的抗体。
Advances in cytopharmacology Pub Date : 1979-01-01
A Fontana, B W Fulpius, S Cuénoud
{"title":"Antibodies against muscle and brain nicotinic acetylcholine receptors in IgA-deficient patients with epilepsy.","authors":"A Fontana,&nbsp;B W Fulpius,&nbsp;S Cuénoud","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75440,"journal":{"name":"Advances in cytopharmacology","volume":"3 ","pages":"287-92"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11679470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acetylcholine receptor-enriched membranes from Torpedo marmorata electroplax, prepared by liquid partitioning. 液体分划法制备了富含乙酰胆碱受体的电鳗膜。
Advances in cytopharmacology Pub Date : 1979-01-01
E Heilbronn, C Björk, L Elfman, A Hartman, C Mattsson
{"title":"Acetylcholine receptor-enriched membranes from Torpedo marmorata electroplax, prepared by liquid partitioning.","authors":"E Heilbronn,&nbsp;C Björk,&nbsp;L Elfman,&nbsp;A Hartman,&nbsp;C Mattsson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75440,"journal":{"name":"Advances in cytopharmacology","volume":"3 ","pages":"151-8"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11589601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scorpion toxins: chemistry and mode of action. 蝎子毒素:化学和作用方式。
Advances in cytopharmacology Pub Date : 1979-01-01
H Rochat, P Bernard, F Couraud
{"title":"Scorpion toxins: chemistry and mode of action.","authors":"H Rochat,&nbsp;P Bernard,&nbsp;F Couraud","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75440,"journal":{"name":"Advances in cytopharmacology","volume":"3 ","pages":"325-34"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11589612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurotoxins and the ganglionic (C6) type of nicotinic receptor. 神经毒素和神经节(C6)型尼古丁受体。
Advances in cytopharmacology Pub Date : 1979-01-01
D A Brown
{"title":"Neurotoxins and the ganglionic (C6) type of nicotinic receptor.","authors":"D A Brown","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75440,"journal":{"name":"Advances in cytopharmacology","volume":"3 ","pages":"225-30"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11589607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in chemistry and pharmacology of snake toxins. 蛇毒素的化学和药理学研究进展。
Advances in cytopharmacology Pub Date : 1979-01-01
C Y Lee
{"title":"Recent advances in chemistry and pharmacology of snake toxins.","authors":"C Y Lee","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75440,"journal":{"name":"Advances in cytopharmacology","volume":"3 ","pages":"1-16"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11375222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studies on the mechanism of action of botulinum toxin. 肉毒毒素作用机理的研究。
Advances in cytopharmacology Pub Date : 1979-01-01
L L Simpson
{"title":"Studies on the mechanism of action of botulinum toxin.","authors":"L L Simpson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75440,"journal":{"name":"Advances in cytopharmacology","volume":"3 ","pages":"27-34"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11589610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
alpha-Bungarotoxin and anti-acetylcholine receptor antibody binding to the human acetylcholine receptor. 甲鼠毒素和抗乙酰胆碱受体抗体结合人乙酰胆碱受体。
Advances in cytopharmacology Pub Date : 1979-01-01
A Vincent, J Newsom-Davis
{"title":"alpha-Bungarotoxin and anti-acetylcholine receptor antibody binding to the human acetylcholine receptor.","authors":"A Vincent,&nbsp;J Newsom-Davis","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75440,"journal":{"name":"Advances in cytopharmacology","volume":"3 ","pages":"269-78"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11679469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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