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Acta Universitatis Palackianae Olomucensis Facultatis Medicae最新文献

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Constructs for production of a probe for monitoring of CHS3 expression in Saccharomyces cerevisiae. 构建用于监测CHS3在酿酒酵母中表达的探针。
Acta Universitatis Palackianae Olomucensis Facultatis Medicae Pub Date : 2000-07-01 DOI: 10.5507/bp.2000.009
L. Kafková, V. Raclavský
{"title":"Constructs for production of a probe for monitoring of CHS3 expression in Saccharomyces cerevisiae.","authors":"L. Kafková, V. Raclavský","doi":"10.5507/bp.2000.009","DOIUrl":"https://doi.org/10.5507/bp.2000.009","url":null,"abstract":"Constructs for production of a probe for monitoring of CHS3 expression in saccharomyces cerevisiae","PeriodicalId":75423,"journal":{"name":"Acta Universitatis Palackianae Olomucensis Facultatis Medicae","volume":"143 1","pages":"63-9"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70742850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrastructure of synapses in the supraoptic nucleus of the cat after induced hypothermia. 低温诱导后猫视上核突触的超微结构。
Acta Universitatis Palackianae Olomucensis Facultatis Medicae Pub Date : 2000-07-01 DOI: 10.5507/bp.2000.008
J. Malinska, J. Malínský
{"title":"Ultrastructure of synapses in the supraoptic nucleus of the cat after induced hypothermia.","authors":"J. Malinska, J. Malínský","doi":"10.5507/bp.2000.008","DOIUrl":"https://doi.org/10.5507/bp.2000.008","url":null,"abstract":"Ultrastructure of axosomatic (AS) and axodendritic (AD) synapses in the supraoptic nucleus (NSO) was investigated in a group of normothermic cats and compared with another group of cats after short-term induced hypothermia. Quantitative analysis demonstrated a significant decrease of number of AS synapses, smaller size of AD synaptic knobs, shorter length of the synaptic contact and an increase of the active zone. Evaluation of the shape of the synaptic cleft demonstrated an increase of both positive (P) and negative (N) types in hypothermic animals. The observed morphological changes can be ascribed to the decreased synaptic activity in a greater part of the synaptic population and to the increased activity in a smaller portion of synapses.","PeriodicalId":75423,"journal":{"name":"Acta Universitatis Palackianae Olomucensis Facultatis Medicae","volume":"143 1","pages":"59-62"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70742488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decreased copper level in the blood serum of male stutterers and the occurrence of the vibratio brevis phenomenon. 男性口吃者血清铜水平降低与短暂振动现象的发生。
Acta Universitatis Palackianae Olomucensis Facultatis Medicae Pub Date : 2000-07-01 DOI: 10.5507/bp.2000.010
J. Pešák, J. Opavský
{"title":"Decreased copper level in the blood serum of male stutterers and the occurrence of the vibratio brevis phenomenon.","authors":"J. Pešák, J. Opavský","doi":"10.5507/bp.2000.010","DOIUrl":"https://doi.org/10.5507/bp.2000.010","url":null,"abstract":"The blood serum copper level and the phonation start were investigated in sixteen male subjects with developmental stuttering (mean age = 25.8 years). A statistically significant decrease in blood serum copper level was revealed in the stutterers under study. The differences between their mode and mean values and that of the control group were 4.6 mumol/l and 3.1 mumol/l, respectively. The negative linear regression between the copper level in serum and the vibratio brevis phenomenon was registered in the stutterers under study. A decreased copper level can be involved in the biochemical abnormalities of male developmental stutterers and it can be included among the factors participating in pathophysiology of an uncertain phonation start.","PeriodicalId":75423,"journal":{"name":"Acta Universitatis Palackianae Olomucensis Facultatis Medicae","volume":"143 1","pages":"71-4"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70742871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Interleukin-1 family: from genes to human disease. 白细胞介素-1家族:从基因到人类疾病。
Acta Universitatis Palackianae Olomucensis Facultatis Medicae Pub Date : 2000-07-01 DOI: 10.5507/bp.2000.002
Beáta Laurincová
{"title":"Interleukin-1 family: from genes to human disease.","authors":"Beáta Laurincová","doi":"10.5507/bp.2000.002","DOIUrl":"https://doi.org/10.5507/bp.2000.002","url":null,"abstract":"Interleukin-1 (IL-1) is one of the most potent proinflammatory cytokines involved both in physiological immune responses and in the development of various immunopathological disorders. The members of IL-1 family form a complex system with tight regulatory mechanisms and clarifying their role in disease remains in the centre of research interests. This review article except of summarising recent findings about IL-1 family members focuses on associations of IL-1 gene complex polymorphisms with human diseases.","PeriodicalId":75423,"journal":{"name":"Acta Universitatis Palackianae Olomucensis Facultatis Medicae","volume":"143 1","pages":"19-29"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70742415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 34
Effect of colchicine and its derivatives on the expression of selected isoforms of cytochrome P450 in primary cultures of human hepatocytes. 秋水仙碱及其衍生物对人肝细胞原代培养细胞色素P450特定亚型表达的影响。
Acta Universitatis Palackianae Olomucensis Facultatis Medicae Pub Date : 2000-07-01 DOI: 10.5507/bp.2000.006
Z. Dvořák, J. Ulrichová, M. Modriansky, P. Maurel
{"title":"Effect of colchicine and its derivatives on the expression of selected isoforms of cytochrome P450 in primary cultures of human hepatocytes.","authors":"Z. Dvořák, J. Ulrichová, M. Modriansky, P. Maurel","doi":"10.5507/bp.2000.006","DOIUrl":"https://doi.org/10.5507/bp.2000.006","url":null,"abstract":"The study addressed the effect of colchicine and its derivatives on the protein levels of cytochrome P450 (CYP) 1A2, 2A6, 3A4, 2C9/19, and 2E1 isoforms. Primary human hepatocyte culture was the model of choice. Levels of individual CYP isoforms were detected using immunoblotting. Colchicine caused an increase of CYP2E1 protein content, colchiceine and N-deacetylcolchiceine induced isoforms CYP2C9, 2E1 and 3A4 whereas colchicoside induced CYP2C9 and 2E1. The levels of CYP1A2 and 2A6 were unaffected by any of tested compounds. Demecolcine and 3-demethylcolchicine had no effect on any studied P450 isoform. Since colchicine is an exclusive substrate of CYP3A4 whereas it induces CYP2E1, there is a suspicion rather at protein stabilization than at gene induction concerning induction origin.","PeriodicalId":75423,"journal":{"name":"Acta Universitatis Palackianae Olomucensis Facultatis Medicae","volume":"143 1","pages":"47-50"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70742335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Gene therapy strategies for liver tumours. 肝脏肿瘤的基因治疗策略。
Acta Universitatis Palackianae Olomucensis Facultatis Medicae Pub Date : 2000-01-01
R Havlík
{"title":"Gene therapy strategies for liver tumours.","authors":"R Havlík","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75423,"journal":{"name":"Acta Universitatis Palackianae Olomucensis Facultatis Medicae","volume":"143 ","pages":"83"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21965013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiofrequency thermal ablation in liver tumours. 肝肿瘤的射频热消融。
Acta Universitatis Palackianae Olomucensis Facultatis Medicae Pub Date : 2000-01-01
R Havlík, P Vojácek, N Habib
{"title":"Radiofrequency thermal ablation in liver tumours.","authors":"R Havlík, P Vojácek, N Habib","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75423,"journal":{"name":"Acta Universitatis Palackianae Olomucensis Facultatis Medicae","volume":"143 ","pages":"84-5"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21965015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk of metastasization of bronchogenic carcinoma. 支气管源性癌转移的风险。
Acta Universitatis Palackianae Olomucensis Facultatis Medicae Pub Date : 2000-01-01
J Klein, T Bohanes, T Tichý, J Skarda, V Král, V Kolek, C Neoral, R Aujeský
{"title":"Risk of metastasization of bronchogenic carcinoma.","authors":"J Klein, T Bohanes, T Tichý, J Skarda, V Král, V Kolek, C Neoral, R Aujeský","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75423,"journal":{"name":"Acta Universitatis Palackianae Olomucensis Facultatis Medicae","volume":"143 ","pages":"87"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21965017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Total removal of thyroid gland at the patients with malignant goiter, importance, problems and subsequent therapy. 甲状腺全切除对恶性甲状腺肿患者的重要性、问题及后续治疗。
Acta Universitatis Palackianae Olomucensis Facultatis Medicae Pub Date : 2000-01-01
J Klofanda, Z Krska, S Trca, M Krenek
{"title":"Total removal of thyroid gland at the patients with malignant goiter, importance, problems and subsequent therapy.","authors":"J Klofanda, Z Krska, S Trca, M Krenek","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75423,"journal":{"name":"Acta Universitatis Palackianae Olomucensis Facultatis Medicae","volume":"143 ","pages":"89"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21965020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The long-term survival aspects in patients with pancreatic carcinoma. 胰腺癌患者的长期生存。
Acta Universitatis Palackianae Olomucensis Facultatis Medicae Pub Date : 2000-01-01
M Ryska, R Strnad, F Bĕlina
{"title":"The long-term survival aspects in patients with pancreatic carcinoma.","authors":"M Ryska, R Strnad, F Bĕlina","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75423,"journal":{"name":"Acta Universitatis Palackianae Olomucensis Facultatis Medicae","volume":"143 ","pages":"100"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21965057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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