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Acta paediatrica Scandinavica. Supplement最新文献

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Parental heights of children with idiopathic growth hormone deficiency: analysis from the Kabi International Growth Study. 特发性生长激素缺乏儿童的父母身高:来自Kabi国际生长研究的分析。
Acta paediatrica Scandinavica. Supplement Pub Date : 1989-01-01
{"title":"Parental heights of children with idiopathic growth hormone deficiency: analysis from the Kabi International Growth Study.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In an international study of children treated with growth hormone (GH), parental heights of 554 children with idiopathic growth hormone deficiency (IGHD) and of 248 children with secondary or 'organic' growth hormone deficiency (OGHD) were ascertained. The maternal height SDS of IGHD children was -0.41 +/- 1.26 (mean +/- SD) and the maternal height SDS of OGHD children was 0.03 +/- 1.11 (p less than 0.006). Paternal height SDS of IGHD children was -0.19 +/- 1.08, and paternal height SDS of OGHD children was 0.15 +/- 1.08 (p less than 0.006). Adverse deliveries were associated with significantly shorter mothers (p = 0.04) and a greater discrepancy between paternal and maternal heights (p less than 0.006).</p>","PeriodicalId":75408,"journal":{"name":"Acta paediatrica Scandinavica. Supplement","volume":"356 ","pages":"178-80"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13824185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A three-dimensional representation of linear growth and skeletal maturation. 线性生长和骨骼成熟的三维表现。
Acta paediatrica Scandinavica. Supplement Pub Date : 1989-01-01 DOI: 10.1111/j.1651-2227.1989.tb11240.x
C R Rudlin
{"title":"A three-dimensional representation of linear growth and skeletal maturation.","authors":"C R Rudlin","doi":"10.1111/j.1651-2227.1989.tb11240.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1989.tb11240.x","url":null,"abstract":"<p><p>Traditional two-dimensional (2-D) growth charts do not distinguish between the effects of a particular pathology or therapy on skeletal maturation and the effects on linear growth. In this study, longitudinal data from two growth studies on children were analysed using a computer technique to produce a growth chart in three dimensions. The three-dimensional (3-D) surface of the graph represents both the linear growth and the skeletal maturation of the patients. If the height and the chronological and bone ages of an individual patient are plotted to give a line in 3-D space, the line can be compared with the 3-D surface of the graph. This permits qualitative assessment of the relative effect of a pathology or treatment on skeletal maturation as compared with linear growth. Quantitative assessment is also possible by expressing the data in polar coordinates. The technique can be applied to clinical trials as well as to individual patients.</p>","PeriodicalId":75408,"journal":{"name":"Acta paediatrica Scandinavica. Supplement","volume":"356 ","pages":"46-50; discussion 51"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1989.tb11240.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13955221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Quality of life of adults with growth hormone deficiency: a controlled study. 生长激素缺乏症成人的生活质量:一项对照研究。
Acta paediatrica Scandinavica. Supplement Pub Date : 1989-01-01 DOI: 10.1111/j.1651-2227.1989.tb11242.x
S Björk, B Jönsson, O Westphal, J E Levin
{"title":"Quality of life of adults with growth hormone deficiency: a controlled study.","authors":"S Björk,&nbsp;B Jönsson,&nbsp;O Westphal,&nbsp;J E Levin","doi":"10.1111/j.1651-2227.1989.tb11242.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1989.tb11242.x","url":null,"abstract":"<p><p>The quality of life of 23 adults with growth hormone deficiency (GHD) who had received growth hormone (GH) therapy was compared with that of 47 normal individuals in a control group. The GHD group had a poorer quality of life than the control group. Statistically significant differences were found between the groups for social isolation, physical mobility, sleep, and emotional status. More individuals in the control group had a driving licence and were married than in the GHD group.</p>","PeriodicalId":75408,"journal":{"name":"Acta paediatrica Scandinavica. Supplement","volume":"356 ","pages":"55-9; discussion 60, 73-4"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1989.tb11242.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13955223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 142
Prediction of outcome in 164 infants born after 24 to 28 weeks gestation. 164例妊娠24 ~ 28周新生儿结局预测。
Acta paediatrica Scandinavica. Supplement Pub Date : 1989-01-01
G Eg-Andersen
{"title":"Prediction of outcome in 164 infants born after 24 to 28 weeks gestation.","authors":"G Eg-Andersen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Between 1984 and 1987 164 infants born after 24 to 28 completed weeks were admitted to our unit. In 6 children respirator treatment was withdrawn between days 6 and 57 mainly on the basis of severe intracranial bleeding and periventricular leucomalacia. Among 102 (62%) surviving infants, 18 (18%) had a major handicap (cerebral palsy, IQ less than 50, blindness) at follow-up, in 6 of the 18 (6%) there was a combination of several major handicaps. We conclude that we can still not reliably predict serious handicap and we are therefore faced with a serious ethical dilemma which we think can best be approached in a trust-relationship between parents and staff.</p>","PeriodicalId":75408,"journal":{"name":"Acta paediatrica Scandinavica. Supplement","volume":"360 ","pages":"56-61"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13679669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstracts of the XXII Nordic Paediatric Congress. Reykjavík, Iceland, June 12-16, 1988. 第22届北欧儿科大会摘要。Reykjavík，冰岛，1988年6月12-16日。
Acta paediatrica Scandinavica. Supplement Pub Date : 1989-01-01
{"title":"Abstracts of the XXII Nordic Paediatric Congress. Reykjavík, Iceland, June 12-16, 1988.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75408,"journal":{"name":"Acta paediatrica Scandinavica. Supplement","volume":"359 ","pages":"1-30"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13719871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Growth hormone secretion and growth hormone treatment in children with intrauterine growth retardation. Swedish Paediatric Study Group for Growth Hormone Treatment. 宫内发育迟缓患儿生长激素分泌及生长激素治疗。瑞典儿科生长激素治疗研究小组。
Acta paediatrica Scandinavica. Supplement Pub Date : 1989-01-01 DOI: 10.1111/j.1651-2227.1989.tb17166.x
K Albertsson-Wikland
{"title":"Growth hormone secretion and growth hormone treatment in children with intrauterine growth retardation. Swedish Paediatric Study Group for Growth Hormone Treatment.","authors":"K Albertsson-Wikland","doi":"10.1111/j.1651-2227.1989.tb17166.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1989.tb17166.x","url":null,"abstract":"<p><p>Few children with intrauterine growth retardation (IUGR) fail to show catch-up growth during the first year of life. There may be many reasons for this, ranging from disturbances of hormone production to hormonal unresponsiveness of target cells. This report presents preliminary data on growth hormone (GH) secretion and responses to GH treatment in 16 children with IUGR and poor catch-up growth, six of whom had Silver-Russell stigmata. GH secretion was assessed by measurement of the GH response to an arginine-insulin test and determination of spontaneous GH secretion over 24 hours. GH production was heterogeneous but, more often than expected, children showed both a low response to GH provocation and low spontaneous secretion of GH. Five out of six of the children with Silver-Russell syndrome and seven out of 10 of the children with non-Silver-Russell IUGR gained more than 2 cm in height during 1 year of treatment with GH at a dose of 0.1 IU/kg/day. These results clearly demonstrate that some children with IUGR and poor catch-up growth secrete insufficient amounts of GH, and that many of these very short children show an improvement in growth rate during treatment with physiological doses of GH.</p>","PeriodicalId":75408,"journal":{"name":"Acta paediatrica Scandinavica. Supplement","volume":"349 ","pages":"35-41; discussion 53-4"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1989.tb17166.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13889091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 79
Incidence of neurosecretory dysfunction among children aged 6-14 years in Rehovot, Israel. 以色列Rehovot 6-14岁儿童神经分泌功能障碍发生率
Acta paediatrica Scandinavica. Supplement Pub Date : 1989-01-01 DOI: 10.1111/j.1651-2227.1989.tb17173.x
Z Zadik, A Kowarski
{"title":"Incidence of neurosecretory dysfunction among children aged 6-14 years in Rehovot, Israel.","authors":"Z Zadik,&nbsp;A Kowarski","doi":"10.1111/j.1651-2227.1989.tb17173.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1989.tb17173.x","url":null,"abstract":"<p><p>Screening of 7500 children aged between 5.8 and 14.4 years, out of a total population of 39,690 in this age group in the Rehovot region, revealed 111 children with heights 2.5 SD below the mean for their age, according to the Tanner-Whitehouse standards. Included among these short children were eight with hypochondroplastic skeletal disease, two with Down's syndrome, four with thalassaemia, four with Turner's syndrome, three with coeliac disease, four with classical growth hormone (GH) deficiency, four with intrauterine growth retardation, four with systemic disease and 78 without obvious underlying causes. In 35 of the 78 children in the last group, the 24-hour integrated concentration of GH was in the hypopituitary range (less than 3.2 ng/ml), and GH neurosecretory dysfunction (NSD) was accordingly diagnosed. This represents an incidence of GH neurosecretory dysfunction of 45% among abnormally short children without underlying pathology, and is consistent with the authors' previous findings. The overall frequency of GH neurosecretory dysfunction in the screened population was 4/1000.</p>","PeriodicalId":75408,"journal":{"name":"Acta paediatrica Scandinavica. Supplement","volume":"349 ","pages":"77-80; discussion 81-3"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1989.tb17173.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13889095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
From basic defect to symptoms in cystic fibrosis. Proceedings of a symposium on the occasion of the 20th anniversary of the Dutch Cystic Fibrosis Association. 21-22 April 1989. 从基本缺陷到囊性纤维化的症状1989年4月21日至22日，荷兰囊性纤维化协会成立20周年纪念座谈会纪要。
Acta paediatrica Scandinavica. Supplement Pub Date : 1989-01-01
{"title":"From basic defect to symptoms in cystic fibrosis. Proceedings of a symposium on the occasion of the 20th anniversary of the Dutch Cystic Fibrosis Association. 21-22 April 1989.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75408,"journal":{"name":"Acta paediatrica Scandinavica. Supplement","volume":"363 ","pages":"5-85"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13784492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastrointestinal dysfunction and its effects on nutrition in CF. CF患者胃肠功能障碍及其对营养的影响。
Acta paediatrica Scandinavica. Supplement Pub Date : 1989-01-01 DOI: 10.1111/apa.1989.78.s363.74
H S Heymans
{"title":"Gastrointestinal dysfunction and its effects on nutrition in CF.","authors":"H S Heymans","doi":"10.1111/apa.1989.78.s363.74","DOIUrl":"https://doi.org/10.1111/apa.1989.78.s363.74","url":null,"abstract":"<p><p>Prevention of malnutrition, a consequence of elevated energy requirements, increased losses and low caloric intake, is one of the main goals in the treatment of cystic fibrosis. Caloric stool losses, catch-up growth and an elevated energy expenditure, even in the absence of overt lung disease and malabsorption, have led to recommendations for a caloric intake of 120-150% of the recommended daily allowances. A high energy intake with a fat content of at least 40 calorie % and adequate pancreatic supplementation has shown to improve growth and median age of survival. As a rational treatment of the fundamental disturbance in cystic fibrosis, a decrease in chloride permeability across epithelia, is not yet available, treatment should be concentrated on adequate nutritional support in combination with optimal correction of those gastrointestinal abnormalities including faecal bile acid loss, small intestinal abnormalities, pancreatic insufficiency, hormonal abnormalities and disturbances in gastrointestinal motility, which may aggravate maldigestion and malabsorption.</p>","PeriodicalId":75408,"journal":{"name":"Acta paediatrica Scandinavica. Supplement","volume":"363 ","pages":"74-8; discussion 78-9"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/apa.1989.78.s363.74","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13841005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Fetal growth: an endocrine perspective. 胎儿生长:内分泌视角。
Acta paediatrica Scandinavica. Supplement Pub Date : 1989-01-01 DOI: 10.1111/j.1651-2227.1989.tb17162.x
P D Gluckman
{"title":"Fetal growth: an endocrine perspective.","authors":"P D Gluckman","doi":"10.1111/j.1651-2227.1989.tb17162.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1989.tb17162.x","url":null,"abstract":"Fetal growth is generally considered in terms of birth weight and it is consequently often difficult to make comparisons with postnatal growth. Nevertheless, there are fundamental differences between the regulation of growth before and after birth, and the significance of endocrine regulators of growth differs greatly. Retardation of fetal growth is a major clinical concern: there is an exponential relationship between the degree of growth retardation and perinatal morbidity and mortality.","PeriodicalId":75408,"journal":{"name":"Acta paediatrica Scandinavica. Supplement","volume":"349 ","pages":"21-5; discussion 26"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1989.tb17162.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13807520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 30
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