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Effect of furosemide on transperitoneal passage of uric acid--experimental studies. 速尿对尿酸经腹腔转运的影响——实验研究。
Acta medica Polona Pub Date : 1989-01-01
J Knapowski, A Breborowicz, K Czyzewska
{"title":"Effect of furosemide on transperitoneal passage of uric acid--experimental studies.","authors":"J Knapowski,&nbsp;A Breborowicz,&nbsp;K Czyzewska","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Application of furosemide (F) during peritoneal dialysis had been proposed for enlargement of peritoneal excretion of uric acid (UA), however, localization and mechanism of action of the drug remained obscure. To clarify the problem experimental studies on isolated peritoneum were performed with intention to establish whether and how transperitoneal flux of UA can be modified by F. Experiments were carried out in vitro on fragments of peritoneum taken from rabbits: parietal peritoneum and mesentery were isolated with single layer of mesothelium, and minimal amount of submesothelial tissue. Gradient of UA across the membranes was set up at 0.9-1.1 mmol/l, and flow estimated before and after addition of F (final conc. 10(-4) M) to the medium bathing either side of the membranes. Some differences in the flow between both types of the membranes as quantitative (greater flow in the parietal peritoneum), and qualitative (opposite succession of changes after F) were observed, however, the reaction for the diuretic was significant in both series of the experiments. The results confirm the suggestion that F can affect peritoneal excretion of UA during the dialysis, but at the same time they show that the mechanisms regulating the transperitoneal UA passage are complex.</p>","PeriodicalId":75384,"journal":{"name":"Acta medica Polona","volume":"30 1-2","pages":"31-5"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13633914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacterial capacity of blood platelets in patients suffering from pneumonia. 肺炎患者血小板的细菌容量。
Acta medica Polona Pub Date : 1989-01-01
H Kemona, J Wysocka, M Mantur, J Prokopowicz
{"title":"Bacterial capacity of blood platelets in patients suffering from pneumonia.","authors":"H Kemona,&nbsp;J Wysocka,&nbsp;M Mantur,&nbsp;J Prokopowicz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The percent of bacteria engulfed by blood platelets, surviving in them and killed was determined in these cells taken from 22 patients with pneumonia before the treatment and from 14 patients after the treatment. The mean percent of bacteria phagocytosed by platelets collected before the treatment was 6.28 and by those after the treatment 5.01, being considerably higher than in the control group (3.42). The mean percent of bacteria surviving in platelets taken before the treatment equalled 3.10 and after the treatment 2.36 being also higher than in the control group (1.32). The mean percent of bacteria killed by platelets taken before the treatment was 3.18 and by those taken after the treatment 2.65, being also higher than in the control group. These results seem to indicate that in cases of pneumonia the blood platelets are involved into the antibacterial activity.</p>","PeriodicalId":75384,"journal":{"name":"Acta medica Polona","volume":"30 1-2","pages":"45-50"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13633916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vasopressin-induced changes in permeability of peritoneal mesothelium for urea "in vitro". 抗利尿激素诱导的体外尿素腹膜间皮通透性的变化。
Acta medica Polona Pub Date : 1989-01-01
M Radkowski, A Breborowicz, J Knapowski
{"title":"Vasopressin-induced changes in permeability of peritoneal mesothelium for urea \"in vitro\".","authors":"M Radkowski,&nbsp;A Breborowicz,&nbsp;J Knapowski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Vasopressin (ADH) acts in humans mainly upon renal collecting tubules. By changing their water permeability it plays a key role in regulation of renal water excretion. Acting upon vascular smooth muscle cells, it causes vasoconstriction and raised arterial blood pressure. This hormone was also proven to cause constriction of cultured mesangial cels, it causes vasoconstriction and raised arterial blood pressure. This urea (Seldin, Giebisch 1985), to release the natriuretic hormone as well as to stimulate hepatic glycogenolysis (Abramov et al. 1987). The influence of vasopressin upon peritoneal transport of solutes was studied, too. ADH influenced the passage of phosphate and rubidium through the isolated rabbit mesentery (Berndt, Gosselin 1961) as well as sodium flux through isolated rabbit omentum (Shear et al. 1966). It caused the drop in urea dialysance in dogs subjected to peritoneal dialysis (Henderson et al. 1971). The subject of our study was the assessment of the action of the antidiuretic hormone under \"in vitro\" conditions upon the peritoneal transfer of urea, the solute present in human body fluids and removable by peritoneal dialysis.</p>","PeriodicalId":75384,"journal":{"name":"Acta medica Polona","volume":"30 1-2","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13633911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kinetics of destruction and regeneration of the haemopoietic system after administration of busulphan and cyclophosphamide followed by bone marrow transplantation. Peripheral blood parameters. 骨髓移植后给予布硫芬和环磷酰胺后造血系统破坏和再生的动力学。外周血参数。
Acta medica Polona Pub Date : 1989-01-01
C Szczylik, M Z Ratajczak, E Urbanowska, W W Jedrzejczak
{"title":"Kinetics of destruction and regeneration of the haemopoietic system after administration of busulphan and cyclophosphamide followed by bone marrow transplantation. Peripheral blood parameters.","authors":"C Szczylik,&nbsp;M Z Ratajczak,&nbsp;E Urbanowska,&nbsp;W W Jedrzejczak","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The kinetics of restoration of haemopoiesis was studied in 10 patients prepared for allogenic bone marrow transplantation with busulphan combined with cyclophosphamide. The morphology of peripheral blood after administration of these drugs and transplantation of allogenic bone marrow was similar to that reported elsewhere after irradiation, cyclophosphamide administration and bone marrow transplantation, the cell counts falling almost to zero within several days after the end of the pharmacological preparation, and later rising to normal values within the period from several weeks to several months after transplantation.</p>","PeriodicalId":75384,"journal":{"name":"Acta medica Polona","volume":"30 3-4","pages":"93-109"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13665591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Estimation of the size of myocardial infarct and its clinical application. 心肌梗死面积的估计及其临床应用。
Acta medica Polona Pub Date : 1989-01-01
A Szafranek, P Wojtek, S Pasyk
{"title":"Estimation of the size of myocardial infarct and its clinical application.","authors":"A Szafranek,&nbsp;P Wojtek,&nbsp;S Pasyk","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>CK-MB activity was estimated in 16 patients and infarct size was calculated on that basis using our own computer programme. The infarct size was confronted with ejection fraction calculated in haemodynamic studies (p = 0.01). In the next step the ejection fraction was determined basing exclusively on changes of CK-MB activity. Significant changes between the value of fractions defined in these ways appear in the case when myocardial necrosis simultaneously involves the right ventricle.</p>","PeriodicalId":75384,"journal":{"name":"Acta medica Polona","volume":"30 3-4","pages":"201-7"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13665590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of immunosuppressive therapy on humoral immune response in multiple sclerosis. 免疫抑制治疗对多发性硬化体液免疫反应的影响。
Acta medica Polona Pub Date : 1989-01-01
A Wajgt, M Górny, L Szczechowski, G Grzybowski, S Ochudło
{"title":"Effect of immunosuppressive therapy on humoral immune response in multiple sclerosis.","authors":"A Wajgt,&nbsp;M Górny,&nbsp;L Szczechowski,&nbsp;G Grzybowski,&nbsp;S Ochudło","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The purpose of this study was to evaluate the effect of various therapeutic regimens on: 1) intrathecal IgG synthesis on the basis of IgG Index value, 2) oligoclonal IgG spectrum visualized by SDS-PAGE of unconcentrated CSF, 3) CSF antibody specific activity against MBP estimated by solid phase RIA and expressed in cpm/micrograms IgG, and 4) immune complex (CIC) level in the CSF estimated by C1q binding solid phase RIA. CSF antibody against Gal-C and ganglioside was also estimated. Patients with clinically definite MS were selected according to 4 therapeutic regimens: group 1, subjected to Mega-dose prednisone therapy (4000 mg over 54 days), group 2, subjected to moderate dose prednisone therapy, group 3 subjected to Mega-dose Solu-Medrol therapy (7500 mg over 10 days), and group 4, subjected to intravenous Cyclophosphamide therapy (4000 mg over 10 days). This last group was characterized by chronic progressive course of disease. Intrathecal IgG production was significantly reduced in all 4 groups as a result of therapy. More pronounced reduction was obtained in Mega-dose prednisone (p below 0.001) and CY (p below 0.001) treated group. Therapeutic regimens did not influence the IgG oligoclonal pattern. The moderate dose prednisone therapy and Mega-dose Solu-Medrol therapy on CSF IgG anti-MBP antibody specific activity were less effective than the Mega-dose prednisone medication. CY therapy did not influence anti-MBP antibody specific activity in MS group characterized by chronic progressive course of disease. The influence of therapeutic regimens on elevated CIC level in the CSF was insignificant. In our study CSF the anti-galactocerebroside antibody appeared to be of IgM class.</p>","PeriodicalId":75384,"journal":{"name":"Acta medica Polona","volume":"30 3-4","pages":"121-8"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13632025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of extracellular fluid volume contraction and expansion on plasma atrial natriuretic peptide (ANP) concentration in patients with acromegaly. 细胞外液容量收缩和扩张对肢端肥大症患者血浆心房钠素(ANP)浓度的影响。
Acta medica Polona Pub Date : 1989-01-01
S Czekalski, K Widecka, J Goździk
{"title":"Effect of extracellular fluid volume contraction and expansion on plasma atrial natriuretic peptide (ANP) concentration in patients with acromegaly.","authors":"S Czekalski,&nbsp;K Widecka,&nbsp;J Goździk","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Atrial natriuretic peptide (ANP) is a hormone release into the circulation by atrial cardiocytes (Gutkowska et al. 1984). Extracellular fluid volume expansion acts as a powerful stimulus for ANP secretion and results in the augmentation of its plasma concentration (Lang et al. 1985). Patients with active acromegaly demonstrate the increased extracellular fluid volume (Falkheden et al. 1964), while a successful treatment of the disease results in the disappearance of hypervolemia (Strauch et al. 1977). We have recently demonstrated that in patients with active acromegaly the increased total body plasma volumes are accompanied by the elevated plasma ANP concentrations, whereas, in the successfully treated patients, both: total plasma volumes and plasma ANP levels do not differ significantly from these in healthy subjects (Czekalski et al. 1988b).</p>","PeriodicalId":75384,"journal":{"name":"Acta medica Polona","volume":"30 1-2","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13680235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of magnesium valproate on plasma ACTH concentrations in Nelson's syndrome. 丙戊酸镁对纳尔逊综合征患者血浆ACTH浓度的影响。
Acta medica Polona Pub Date : 1989-01-01
A Kasperlik-Załuska, B Migdalska, W Jeske, J Drac-Kaniewska, T Wiśniewska-Woźniak
{"title":"The effect of magnesium valproate on plasma ACTH concentrations in Nelson's syndrome.","authors":"A Kasperlik-Załuska,&nbsp;B Migdalska,&nbsp;W Jeske,&nbsp;J Drac-Kaniewska,&nbsp;T Wiśniewska-Woźniak","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Sodium valproate, a gamma-aminobutyric acid (GABA) agonist, was found to decrease plasma ACTH concentration in some cases of Cushing's disease and Nelson's syndrome. In this study we have investigated the influence of magnesium valproate (MV), a newly introduced salt of valproic acid, on plasma ACTH levels in 8 patients with Nelson's syndrome. The daily dose, 1200 mg of MV, significantly decreased plasma ACTH level at 10 p.m. compared with placebo. A single dose of 400 mg of MV, led to a reduction in plasma ACTH concentration only in two out of seven patients during a four-hour observation. The fall in plasma ACTH level in the same patients at 10 p.m., after the next two doses of this drug, suggests that single dose may be insufficient for introducing GABA-dependent reduction in ACTH release. During a long-term therapy with MV, in all three patients investigated a marked decrease in plasma ACTH was observed. Our results suggest that magnesium valproate may be useful during chronic therapy in some patients with ACTH hypersecretion.</p>","PeriodicalId":75384,"journal":{"name":"Acta medica Polona","volume":"30 1-2","pages":"9-15"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13704997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of prolonged inhibition of angiotensin converting enzyme by captopril on some hemodynamic parameters of pulmonary circulation in patients with secondary pulmonary hypertension. 卡托普利长期抑制血管紧张素转换酶对继发性肺动脉高压患者肺循环某些血流动力学参数的影响。
Acta medica Polona Pub Date : 1989-01-01
J P Dubiel, K Zmudka, T Brzostek, T Horzela
{"title":"Effect of prolonged inhibition of angiotensin converting enzyme by captopril on some hemodynamic parameters of pulmonary circulation in patients with secondary pulmonary hypertension.","authors":"J P Dubiel,&nbsp;K Zmudka,&nbsp;T Brzostek,&nbsp;T Horzela","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of prolonged treatment with captopril on some parameters of pulmonary circulation was studied in a group of 17 patients with secondary pulmonary hypertension due to mitral stenosis. Each patient received 25 mg of captopril four times daily for mean time of means = 12.5 +/- 2.1 days. A drop in pulmonary artery mean pressure of at least 20% was observed in 5 patients (29.4%). In 4 patients (23.5%) captopril had adverse effect on the hemodynamics of the pulmonary circulation, and in 8 patients no effect of captopril on the pulmonary hypertension was noticed. Our model of the experiment did not allow us to select before the treatment the group of patients in whom positive effects of captopril could be expected.</p>","PeriodicalId":75384,"journal":{"name":"Acta medica Polona","volume":"30 1-2","pages":"23-30"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13633913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Activity of urinary alpha-amylase isoenzymes in marathon runners. 马拉松运动员尿α -淀粉酶同工酶的活性。
Acta medica Polona Pub Date : 1989-01-01
E Bakońska-Pacoń, K A Sobiech
{"title":"Activity of urinary alpha-amylase isoenzymes in marathon runners.","authors":"E Bakońska-Pacoń,&nbsp;K A Sobiech","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The activity of urinary total alpha-amylase (EC 3.2.1.1) as well as of its pancreatic and salivary isoenzymes was determined in Marathon runners using the Labordiagnostica Gödecke \"Enz-Amyl-Isoamylase\" test set with specific inhibitor extracted from wheat germs. Initial total alpha-amylase activity equals about 20 U/l with the 56% share of type P isoenzyme. The correlation was found between the race score and changes in enzymatic activity after subgrouping the racers according to their scores in Marathon race. After the race total alpha-amylase activity rose respectively 3.14 and 8 times in particular groups, the proportion of isoenzymes being also changed. The activity of type P isoenzyme rose 16 times immediately after the race, and that of type S one 11 times 24 h after the race. The determination of the activity of these enzymes may be helpful in the evaluation of physical effort.</p>","PeriodicalId":75384,"journal":{"name":"Acta medica Polona","volume":"30 1-2","pages":"51-7"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13636017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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