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Acta medica et biologica最新文献

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Basic Fibroblast Growth Factor Modulates the Expression of PDZ Domain-containing Proteins in Cultured Cortical Neurons. 碱性成纤维细胞生长因子调节皮层神经元中PDZ结构域蛋白的表达。
Acta medica et biologica Pub Date : 2002-01-01
Hussam Jourdi, Hiroyuki Nawa
{"title":"Basic Fibroblast Growth Factor Modulates the Expression of PDZ Domain-containing Proteins in Cultured Cortical Neurons.","authors":"Hussam Jourdi,&nbsp;Hiroyuki Nawa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Different cytokines and growth factors, together with their receptors, are expressed in brain tissue. One such molecule is the basic fibroblast growth factor (bFGF) that has recently been shown to promote survival following insults to neurons <i>in vivo</i> or <i>in vitro</i>. In this study, we found that repeated treatment of neocortical cultures with bFGF modulated the expression of various PDZ domain-containing proteins (SAP97, GRIP1, Pick1, and PSD-93) and that the patterns of their immunostaining matched the bFGF effects on their total protein expression. For instance, bFGF decreased the expression of SAP97, GRIP1, and Pick1 (PDZ proteins that interact with the AMPA-type glutamate receptor subunits GluR1 and GluR2/3). PSD-93, which associates with the NMDA-type glutamate receptor, was increased by bFGF. Moreover, the interactions of GluR1 with SAP97 and GluR2 with GRIP1 were down-regulated by the repeated bFGF stimulation, as revealed by co-immunoprecipitation. Together, these results describe a novel function of bFGF in the regulation of expression of PDZ proteins.</p>","PeriodicalId":75383,"journal":{"name":"Acta medica et biologica","volume":"50 3","pages":"107-115"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685851/pdf/nihms348356.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31528893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of prostagrandin F2alpha E1 and some spasmolytic agents on the exposed cat basilar artery. 前列腺素F2alpha E1和一些解痉剂对暴露的猫基底动脉的影响。
Acta medica et biologica Pub Date : 1975-04-01
N Miyazawa, K Aoki, R Ishii, T Koike, I Ihara
{"title":"The effect of prostagrandin F2alpha E1 and some spasmolytic agents on the exposed cat basilar artery.","authors":"N Miyazawa,&nbsp;K Aoki,&nbsp;R Ishii,&nbsp;T Koike,&nbsp;I Ihara","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75383,"journal":{"name":"Acta medica et biologica","volume":"22 3-4","pages":"133-41"},"PeriodicalIF":0.0,"publicationDate":"1975-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12376617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of antitumor agents on carcinoma cells: bleomycin's effects on Ehrlich's carcinoma. 抗肿瘤药物对癌细胞的作用:博莱霉素对埃利希癌的作用。
Acta medica et biologica Pub Date : 1975-04-01
T Sakashita
{"title":"The effects of antitumor agents on carcinoma cells: bleomycin's effects on Ehrlich's carcinoma.","authors":"T Sakashita","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75383,"journal":{"name":"Acta medica et biologica","volume":"22 3-4","pages":"143-52"},"PeriodicalIF":0.0,"publicationDate":"1975-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11276744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Double contrast examination with ingested barium. 摄入钡双重造影检查。
Acta medica et biologica Pub Date : 1975-04-01
S Niizuma, S Kobayashi
{"title":"Double contrast examination with ingested barium.","authors":"S Niizuma,&nbsp;S Kobayashi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75383,"journal":{"name":"Acta medica et biologica","volume":"22 3-4","pages":"103-17"},"PeriodicalIF":0.0,"publicationDate":"1975-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12376613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental esophageal carcinoma in mastomys. A preliminary report. 乳突癌的实验性食管癌。初步报告。
Acta medica et biologica Pub Date : 1975-04-01
J Soga, K Tajima, O Tanaka, M Kawaguchi, M Fujimaki
{"title":"Experimental esophageal carcinoma in mastomys. A preliminary report.","authors":"J Soga,&nbsp;K Tajima,&nbsp;O Tanaka,&nbsp;M Kawaguchi,&nbsp;M Fujimaki","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75383,"journal":{"name":"Acta medica et biologica","volume":"22 3-4","pages":"119-32"},"PeriodicalIF":0.0,"publicationDate":"1975-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12376616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new biomicrogonioscopy. A clinical approach to the functioning fine structure of the chamber angle. 一种新的生物显微镜检技术。心室角功能精细结构的临床研究。
Acta medica et biologica Pub Date : 1972-03-01
K Iwata
{"title":"A new biomicrogonioscopy. A clinical approach to the functioning fine structure of the chamber angle.","authors":"K Iwata","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75383,"journal":{"name":"Acta medica et biologica","volume":"19 3","pages":"165-71"},"PeriodicalIF":0.0,"publicationDate":"1972-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15726244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Survey on radioprotective attention in Japanese physicians. 日本医师放射防护注意情况调查。
Acta medica et biologica Pub Date : 1972-03-01
T Kitabatake, R Kayamori
{"title":"Survey on radioprotective attention in Japanese physicians.","authors":"T Kitabatake,&nbsp;R Kayamori","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75383,"journal":{"name":"Acta medica et biologica","volume":"19 3","pages":"173-80"},"PeriodicalIF":0.0,"publicationDate":"1972-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16133360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new chemotherapy as a preoperative treatment for esophageal cancer surgery. 食管癌手术前新的化疗方法。
Acta medica et biologica Pub Date : 1972-03-01
M Fujimaki, J Soga, K Wada, M Kawaguchi, M Maeda
{"title":"A new chemotherapy as a preoperative treatment for esophageal cancer surgery.","authors":"M Fujimaki,&nbsp;J Soga,&nbsp;K Wada,&nbsp;M Kawaguchi,&nbsp;M Maeda","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75383,"journal":{"name":"Acta medica et biologica","volume":"19 3","pages":"181-91"},"PeriodicalIF":0.0,"publicationDate":"1972-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15226044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stereometric reconstruction and quantitative measurement of elevation in the ocular fundus by means of stereo-photography. 用立体摄影技术进行眼底高程的立体重建和定量测量。
Acta medica et biologica Pub Date : 1972-03-01
M Mikuni, H Yaoeda, S Fujii, M Togano
{"title":"Stereometric reconstruction and quantitative measurement of elevation in the ocular fundus by means of stereo-photography.","authors":"M Mikuni,&nbsp;H Yaoeda,&nbsp;S Fujii,&nbsp;M Togano","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75383,"journal":{"name":"Acta medica et biologica","volume":"19 3","pages":"207-17"},"PeriodicalIF":0.0,"publicationDate":"1972-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16133050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studies on the cause of the Niigata episode of Minamata disease outbreak. 新泻期水俣病暴发原因研究。
Acta medica et biologica Pub Date : 1972-03-01
Y Takizawa, T Kosaka, R Sugai, I Sasagawa, C Sekiguchi
{"title":"Studies on the cause of the Niigata episode of Minamata disease outbreak.","authors":"Y Takizawa,&nbsp;T Kosaka,&nbsp;R Sugai,&nbsp;I Sasagawa,&nbsp;C Sekiguchi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75383,"journal":{"name":"Acta medica et biologica","volume":"19 3","pages":"193-206"},"PeriodicalIF":0.0,"publicationDate":"1972-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16133361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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