Women's midlife health最新文献

{"title":"C-reactive protein gene rs1205 polymorphism is associated with low-grade chronic inflammation in postmenopausal women.","authors":"Iriane Prado de Santis,&nbsp;Juliana Dal-Ri Lindenau,&nbsp;Ramon Bossardi Ramos,&nbsp;Thais Rasia Silva,&nbsp;Gislaine Casanova,&nbsp;Karen Oppermann,&nbsp;Poli Mara Spritzer","doi":"10.1186/s40695-020-00051-2","DOIUrl":"https://doi.org/10.1186/s40695-020-00051-2","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease is the leading cause of death in postmenopausal women, and inflammation is a key mechanism involved in the pathogenesis of atherosclerosis. High-sensitivity C-reactive protein (hs-CRP) has been used as a biomarker of inflammation. Considering that <i>CRP</i> gene rs1205 polymorphism has been associated with hs-CRP circulating levels, we evaluated whether rs1205 genotypes influence the presence of low-grade chronic inflammation, acting as a marker of cardiovascular risk.</p><p><strong>Methods: </strong>We performed a cross-sectional study with biobanked blood samples from 327 postmenopausal women with no evidence of clinical disease. Genotyping for rs1205 C > T SNP of the <i>CRP</i> gene was done by real-time polymerase chain reaction with allelic discrimination assays.</p><p><strong>Results: </strong>Mean age was 55.6 ± 5.6 years. Mean body mass index (BMI) was 27.3 ± 4.7. Participants were divided according to hs-CRP levels: ≥3 mg/l (low-grade chronic inflammation) or < 3 mg/l. The frequency of allele C at rs1205 was 74.2% in the hs-CRP ≥ 3 mg/l group vs. 59% in the hs-CRP < 3 mg/l. In a multivariable model, higher prevalence of hs-CRP ≥ 3 mg/l was associated with CC genotype (PR 1.53; 95%CI 1.07-2.18; <i>p</i> = 0.018) and waist circumference ≥ 88 cm (PR 2.45; 95%CI 1.66-3.60; <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong><i>CRP</i> rs1205 CC homozygotes may be at higher risk of a low-grade chronic inflammatory status compared to individuals carrying the T allele.</p>","PeriodicalId":75330,"journal":{"name":"Women's midlife health","volume":"6 ","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2020-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40695-020-00051-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38024037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mid-life predictors of late-life depressive symptoms; determining risk factors spanning two decades in the Women's Heathy Ageing Project.","authors":"Katherine E Campbell,&nbsp;Alexandra Gorelik,&nbsp;Cassandra E Szoeke,&nbsp;Lorraine Dennerstein","doi":"10.1186/s40695-020-00050-3","DOIUrl":"https://doi.org/10.1186/s40695-020-00050-3","url":null,"abstract":"<p><strong>Background: </strong>Data available from longitudinal studies of adequate duration to explore midlife risk factors for late life higher depressive symptom scores in women is lacking. This study examines midlife (mean ages 50 years and 60 years) predictors of late life (mean age 70 years) depressive symptom scores to enrich our understanding of the role of changing risk factors across the lifespan.</p><p><strong>Methods: </strong>This investigation was an assessment of the long-term impact of lifestyle and health variables on depressive symptoms. Data were drawn from an epidemiological prospective study of women's healthy ageing spanning two decades. Variables included assessment of mood, demographics, physical health, smoking status, attitudes towards ageing and menopause, alcohol consumption and employment. Analysis was conducted to determine the set of strongest predictors assessed in 1992 (mean age 50 years) and in 2002 (mean age 60 years) in relation to higher CESD-SF scores measured in 2012 (mean aged 70 years (<i>n</i> = 249)). A cross-sectional analysis determining concurrent associations at mean age 70 years was also conducted.</p><p><strong>Results: </strong>An increase in positive mood at 50 and 60 years was associated with a 0.3 (95% CI 0.1-0.5) and 0.4 (95%CI 0.1-0.8) point reduction in CESD score at 70 years respectively. An increase in Hassles score at age 50 was associated with a 0.18-point increase in CESD (95% CI 0.01-0.05) 20 years later. However, no relationship was observed between Hassles score at 60 and CESD 10 years later. Analysis of concurrent risk factors demonstrated that bothersome symptom frequency and higher anxiety were associated with higher depressive symptom scores when women were 70 years.</p><p><strong>Conclusion: </strong>Low levels of positive mood were consistently associated with depressive symptoms scores 10 and 20 years later, suggesting clinical interventions aimed at improving positive affect may be particularly useful across the midlife.</p>","PeriodicalId":75330,"journal":{"name":"Women's midlife health","volume":"6 ","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2020-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40695-020-00050-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37726505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaginal, sexual and urinary symptoms following hysterectomy: a multi-centre randomized controlled trial.","authors":"Chanil Ekanayake,&nbsp;Arunasalam Pathmeswaran,&nbsp;Rasika Herath,&nbsp;Prasantha Wijesinghe","doi":"10.1186/s40695-020-0049-2","DOIUrl":"https://doi.org/10.1186/s40695-020-0049-2","url":null,"abstract":"<p><strong>Background: </strong>Hysterectomy is the most common major gynaecological procedure. The aim of this study was to study vaginal, sexual and urinary symptoms following total abdominal hysterectomy (TAH), non-descent vaginal hysterectomy (NDVH) and total laparoscopic hysterectomy (TLH) in a low resource setting.</p><p><strong>Methods: </strong>A multi-centre randomized controlled trial (RCT) was conducted in two public sector hospitals in Sri Lanka. Participants were patients requiring hysterectomy for non-malignant uterine causes. Exclusion criteria were uterus> 14 weeks, previous pelvic surgery, medical illnesses which contraindicated laparoscopic surgery, and those requiring incontinence surgery or pelvic floor surgery.Vaginal, sexual function and urinary symptoms were assessed by the validated translations of ICIQ-VS and ICIQ-FLUTS questionnaires. Post-operative improvement (pre-operative - post-operative) was assessed.</p><p><strong>Results: </strong>There was an improvement (median (IQ1-IQ3) in vaginal symptoms [TAH 6(2-8) vs 4(0-8), <i>p</i> < 0.001; NDVH 6(4-8.5) vs 5(0-8), p < 0.001; TLH 4(2-10.5) vs 4(0-10), p < 0.001], urinary flow symptoms [TAH 2(1-4) vs 1 (0-3), p < 0.001; NDVH 3 (2-5) vs 2 (0.5-4), p < 0.001; TLH 1(1-4) vs 1(0-3), <i>p</i> < 0.05], urinary voiding symptoms [TAH 0(0-0) vs 0(0-0), <i>p</i> = 0.20; NDVH 0(0-1) vs 0(0-0.8), <i>p</i> < 0.05; TLH 0(0-0) vs 0(0-0), p < 0.05] and urinary incontinence symptoms [TAH 0(0-2) vs 0(0-2), <i>p</i> = 0.06; NDVH 0(0-3) vs 0(0-3), <i>p</i> < 0.001; TLH 0(0-3) vs 0(0-2), <i>p</i> < 0.05] at 1-year (TAH <i>n</i> = 47, NDVH <i>n</i> = 45, TLH n = 47). There was an improvement in sexual symptoms only in the TLH group [TAH 0(0-11.5) vs 0(0-14), <i>p</i> = 0.08); NDVH 0(0-0) vs 0(0-0), <i>p</i> = 0.46; TLH 0(0-0) vs 0(0-4), p < 0.05].There was no significant difference among the three different routes in terms of vaginal symptoms score [TAH 2 (0-2), NDVH 0 (0-2), TLH 0 (0-2), <i>p</i> = 0.33], sexual symptoms [TAH 0 (0-0), NDVH 0 (0-0), TLH 0 (0-0), <i>p</i> = 0.52], urinary flow symptoms [TAH 0 (0-1), NDVH 0 (0-1), TLH 0 (0-2), <i>p</i> = 0.56], urinary voiding symptoms [TAH 0 (0-0), NDVH 0 (0-0), TLH 0 (0-0), <i>p</i> = 0.64] and urinary incontinence symptoms [TAH 0 (0-0), NDVH 0 (0-1), TLH 0 (0-1), <i>p</i> = 0.35] at 1-year.</p><p><strong>Conclusions: </strong>There was a post-operative improvement in vaginal symptoms and urinary symptoms in all three groups. There was no significant difference in pelvic organ symptoms between the three routes; TAH, NDVH and TLH.</p><p><strong>Trial registration: </strong>Sri Lanka clinical trials registry, SLCTR/2016/020 and the International Clinical Trials Registry Platform, U1111-1194-8422, on 26 July 2016. Available from: http://slctr.lk/trials/515.</p>","PeriodicalId":75330,"journal":{"name":"Women's midlife health","volume":"6 ","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2020-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40695-020-0049-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37728964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A proper reference metabolic equivalent value to assess physical activity intensity in Japanese female nurses","authors":"Yuki Ideno, Kunihiko Hayashi, J. S. Lee, Y. Miyazaki, Shosuke Suzuki","doi":"10.1186/s40695-019-0048-3","DOIUrl":"https://doi.org/10.1186/s40695-019-0048-3","url":null,"abstract":"","PeriodicalId":75330,"journal":{"name":"Women's midlife health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40695-019-0048-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48382271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Types of pain and their psychosocial impact in women with rheumatoid arthritis","authors":"M. Chancay, Shirin Nouri Guendsechadze, I. Blanco","doi":"10.1186/s40695-019-0047-4","DOIUrl":"https://doi.org/10.1186/s40695-019-0047-4","url":null,"abstract":"","PeriodicalId":75330,"journal":{"name":"Women's midlife health","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40695-019-0047-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43548245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abdominal pain during the menopause transition and early postmenopause: observations from the Seattle Midlife Women’s Health Study","authors":"N. Callan, E. Mitchell, M. Heitkemper, N. Woods","doi":"10.1186/s40695-019-0046-5","DOIUrl":"https://doi.org/10.1186/s40695-019-0046-5","url":null,"abstract":"","PeriodicalId":75330,"journal":{"name":"Women's midlife health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40695-019-0046-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46750429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Undesirable stressful life events, impact, and correlates during midlife: observations from the Seattle midlife women's health study.","authors":"Annette Joan Thomas,&nbsp;Ellen Sullivan Mitchell,&nbsp;Nancy Fugate Woods","doi":"10.1186/s40695-018-0045-y","DOIUrl":"10.1186/s40695-018-0045-y","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the undesirable stressful life events midlife women experience, including: 1) which life events midlife women reported most frequently; 2) which life events women rated as most undesirable; and 3) whether age, years of education, income, employment, race/ethnicity, marital status, being a parent, and the menopausal transition stage were associated with the impact scores of the life event categories.</p><p><strong>Background: </strong>In addition to the menopausal transition, midlife is a time of increased responsibilities for women related to multiple roles such as taking care of children, caring for elderly parents, managing households, and working outside the home. These multiple roles put midlife women at risk for increased stress with little time for themselves in order to relieve stress.</p><p><strong>Methods: </strong>The sample used in this study is part of a larger longitudinal study, The Seattle Midlife Women's Health Study. Women (<i>N</i> = 380 for Occasion 1) completed the 77-item Life Events Scale on four occasions during the course of the SMWHS: Occasion 1 (1990), Occasion 2 (1992), Occasion 3 (1997), and Occasion 4 (2000). In addition to descriptive analyses of frequency of life events and the undesirable impact of life events, demographic correlates (age, education, income, employment, being a parent as well as marital status, race/ethnicity, and menopausal transition stages) were examined in relation to the stressful life event scores.</p><p><strong>Results: </strong>Highest scores of undesirable life events were for categories of both Financial and Family/Friends over 3 of the 4 occasions. Health and Crime/Legal scores were among the highest for 2 occasions. Impact of the undesirable stressful life events was greatest for categories of Family/Friends; Personal/Social; Work; and, Health. Age, income, marital status, being a parent, and menopausal transition stage were each associated with specific categories of the stressful event impact scores.</p><p><strong>Conclusion: </strong>Most commonly reported undesirable life events were not those women described as having the greatest impact. Impact of life event stress reflected women's social roles and connections as seen in the categories with the highest impact scores: Family/Close Friends, Personal/Social, and Work. Menopausal transition stages were related only to undesirable health events.</p>","PeriodicalId":75330,"journal":{"name":"Women's midlife health","volume":"5 ","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2019-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40695-018-0045-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36967232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1. A Brief History of the Midlife Crisis","authors":"","doi":"10.1515/9781400888474-002","DOIUrl":"https://doi.org/10.1515/9781400888474-002","url":null,"abstract":"","PeriodicalId":75330,"journal":{"name":"Women's midlife health","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78307645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontmatter","authors":"","doi":"10.1515/9781400888474-fm","DOIUrl":"https://doi.org/10.1515/9781400888474-fm","url":null,"abstract":"","PeriodicalId":75330,"journal":{"name":"Women's midlife health","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83176001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"6. Living in the Present","authors":"","doi":"10.1515/9781400888474-007","DOIUrl":"https://doi.org/10.1515/9781400888474-007","url":null,"abstract":"","PeriodicalId":75330,"journal":{"name":"Women's midlife health","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83180422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}