Karoline Rutter, Thomas Horvatits, Andreas Drolz, Kevin Roedl, Stephanie Siedler, Stefan Kluge, Valentin Fuhrmann
{"title":"[Acute liver failure].","authors":"Karoline Rutter, Thomas Horvatits, Andreas Drolz, Kevin Roedl, Stephanie Siedler, Stefan Kluge, Valentin Fuhrmann","doi":"10.1007/s00740-018-0243-0","DOIUrl":"https://doi.org/10.1007/s00740-018-0243-0","url":null,"abstract":"<p><p>Acute liver failure (ALF) is a rare condition with fatal outcome. Characteristic is rapid onset of liver damage without preexisting liver diseases, including hepatic encephalopathy and coagulopathy. Early and correct diagnosis is essential for further management of patients, since diagnosis impacts therapy choice. Survival of patients with ALF has improved dramatically due to advances in critical care medicine and the use of liver transplantation.</p>","PeriodicalId":75323,"journal":{"name":"Wiener klinisches Magazin : Beilage zur Wiener klinischen Wochenschrift","volume":"22 1","pages":"38-47"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00740-018-0243-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37833854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thorsten Annecke, Andreas Hohn, Boris Böll, Matthias Kochanek
{"title":"[Cancer patients in operative intensive care medicine].","authors":"Thorsten Annecke, Andreas Hohn, Boris Böll, Matthias Kochanek","doi":"10.1007/s00740-018-0218-1","DOIUrl":"https://doi.org/10.1007/s00740-018-0218-1","url":null,"abstract":"<p><p>Cancer is one of the leading causes of death worldwide. New targeted and individualized therapies and drugs provide a survival benefit for an increasing number of patients, but can also cause severe side effects. An increasing number of oncology patients are admitted to intensive care units (ICU) because of cancer-related complications or treatment-associated side effects. Postoperative care, respiratory distress and sepsis are the leading causes for admission. Tumor mass syndromes and tumor lysis may require urgent treatment. Traditional anticancer chemotherapy is associated with infections and immunosuppression. Newer agents are generally well-tolerated and side effects are mild or moderate, but overwhelming inflammation and autoimmunity can also occur. Cellular treatment, such as with chimeric antigen receptor modified T‑cells, monoclonal and bispecific antibodies targeting immune effectors and tumor cells are associated with cytokine release syndrome (CRS) with hypotension, skin reactions and fever. It is related to excessively high levels of inflammatory cytokines. Immune checkpoint inhibitors can lead to immune-related adverse events (IRAEs), such as colitis and endocrine disorders. Noninfectious respiratory complications, such as pneumonitis can also occur. Recent studies revealed that short-term and medium-term survival of cancer patients is better than previously expected. In this review article we summarize diagnostic and treatment strategies for common life-threatening complications and emergencies requiring ICU admission. Furthermore, strategies for rational admission policies are presented.</p>","PeriodicalId":75323,"journal":{"name":"Wiener klinisches Magazin : Beilage zur Wiener klinischen Wochenschrift","volume":"21 2","pages":"68-77"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00740-018-0218-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37833852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Thrombocytopenia in the intensive care unit].","authors":"Paul Knöbl","doi":"10.1007/s00740-016-0155-9","DOIUrl":"https://doi.org/10.1007/s00740-016-0155-9","url":null,"abstract":"<p><p>Thrombocytopenia is a frequent phenomenon in intensive care medicine. A variety of conditions can be responsible for low platelet counts. As platelets are part of the primary hemostatic system, bleeding is the most important complication of thrombocytopenia. Proper workup of the differential diagnosis to identify the cause of thrombocytopenia is essential because the various underlying disorders require different diagnostic and therapeutic management strategies. A low platelet count is a strong predictor of outcome in critically ill patients.This article summarizes the differential diagnosis and diagnostic workup of thrombocytopenia in the critically ill, describes the most important conditions, and gives an overview on therapeutic options and strategies.</p>","PeriodicalId":75323,"journal":{"name":"Wiener klinisches Magazin : Beilage zur Wiener klinischen Wochenschrift","volume":"20 1","pages":"6-14"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00740-016-0155-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37833851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hämato-onkologische Intensivpatienten: Gefordert: Spezifisches Wissen der Intensivmediziner und Zusammenarbeit mit Onkologen.","authors":"Peter Schellongowski, Thomas Staudinger","doi":"10.1007/s00740-012-0455-7","DOIUrl":"https://doi.org/10.1007/s00740-012-0455-7","url":null,"abstract":"","PeriodicalId":75323,"journal":{"name":"Wiener klinisches Magazin : Beilage zur Wiener klinischen Wochenschrift","volume":"15 2","pages":"24-27"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00740-012-0455-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37833850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Management in Ausnahmesituationen: Taktisches Vorgehen in biologischen Gefahrenlagen.","authors":"Franz Seidl","doi":"10.1007/s00740-011-0347-2","DOIUrl":"https://doi.org/10.1007/s00740-011-0347-2","url":null,"abstract":"","PeriodicalId":75323,"journal":{"name":"Wiener klinisches Magazin : Beilage zur Wiener klinischen Wochenschrift","volume":"14 2","pages":"40-45"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00740-011-0347-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37833849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}