Venereology (Basel, Switzerland)最新文献_第4页

Novel Treatment Approaches to Combat Trichomoniasis, a Neglected and Sexually Transmitted Infection Caused by Trichomonas vaginalis: Translational Perspectives 新的治疗方法对抗滴虫病，一种被忽视的性传播感染引起的阴道毛滴虫:翻译的观点

Venereology (Basel, Switzerland) Pub Date : 2022-01-29 DOI: 10.3390/venereology1010005

G. V. Rigo, L. Frank, Giulia Bongiorni Galego, André Luis Souza dos Santos, T. Tasca

{"title":"Novel Treatment Approaches to Combat Trichomoniasis, a Neglected and Sexually Transmitted Infection Caused by Trichomonas vaginalis: Translational Perspectives","authors":"G. V. Rigo, L. Frank, Giulia Bongiorni Galego, André Luis Souza dos Santos, T. Tasca","doi":"10.3390/venereology1010005","DOIUrl":"https://doi.org/10.3390/venereology1010005","url":null,"abstract":"The multistep translational science behind new drugs comprehends the entire process through laboratory, clinical, and community observations turned into health interventions. The development of new drug options from discovering targets and leading compounds in basic research for implementing therapeutic guidelines contributes to the emergence of health policies essential for infection control. This review updates the translational research in the scenario of the most common non-viral sexually transmitted infection (STI), trichomoniasis. Paradoxically to its high occurrence, it is considered neglected since notification is not mandatory. It turns into a stable disease with health complications, and receives little emphasis from public health programs to control STI. Although related to curable STIs, the current drugs, metronidazole and tinidazole, present therapeutic failures. The need for new options to treat trichomoniasis is established by basic research studies and patents revealing novel synthetic compounds and natural products presenting anti-Trichomonas vaginalis activities, mainly based on in vitro findings. Clinical trials are still focused on new routes of administration for conventional drugs. In addition, nanotechnology approaches are in their infancy, shedding light on potential possibilities for creating more effective, targeted, and safe delivery systems. Overall, the novel proposed approaches need, in addition to pharmaceutical development and efficacy assessments, to ensure that the quality requirements for their use as medicines are met. It is essential to overcome these issues to cross the “Death Valley” of drug discovery and to advance in the translational science criteria in the trichomoniasis drug development field.","PeriodicalId":75296,"journal":{"name":"Venereology (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44724316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Sexual Health and HIV/STI Risk in Gay Refugee Men in Nairobi, Kenya: A Qualitative Study 肯尼亚内罗毕男同性恋难民的性健康和艾滋病毒/性传播感染风险:一项定性研究

Venereology (Basel, Switzerland) Pub Date : 2021-12-10 DOI: 10.3390/venereology1010003

Lourence Misedah, M. Ross, Solomon Wambua, V. Schick

{"title":"Sexual Health and HIV/STI Risk in Gay Refugee Men in Nairobi, Kenya: A Qualitative Study","authors":"Lourence Misedah, M. Ross, Solomon Wambua, V. Schick","doi":"10.3390/venereology1010003","DOIUrl":"https://doi.org/10.3390/venereology1010003","url":null,"abstract":"Refugees are often without financial support and some resort to survival sex. Some of these men are gay or bisexual who fled their countries because of actual or fear of death and other persecution, exacerbated by the criminalization of consensual same-sex practices by life imprisonment or death in extreme cases. We conducted qualitative interviews with 12 gay and bisexual men within a larger sample in Nairobi, Kenya, who engaged in survival sex. Thematic analysis indicated eight main themes: Physical dangers, sexual assault, lack of rights and recourse to justice; Emotional difficulties of sex work; Seeing treatable STIs as “normal”, but others like Hepatitis B and C as abnormal, and HIV as the most feared; Recognition of penile symptoms but concerns about sexual health including anal symptoms, such as fistulas and bleeding; good knowledge about HIV but confusions over PEP and PrEP, self-testing, health access to NGO clinics and some hospital clinics but concerns about stigma and discrimination in public clinics generally; and as a result of concerns about public healthcare settings, use of pharmacies for treatment. The data indicate that male refugees from gay repression, as found for refugees from other repressions, face many of the same issues with local variations.","PeriodicalId":75296,"journal":{"name":"Venereology (Basel, Switzerland)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41483973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Persistence and Increase in Sexually Transmitted Diseases (STDs) to Pandemic Levels 性传播疾病（STDs）持续并增加到流行病水平

Venereology (Basel, Switzerland) Pub Date : 2021-11-09 DOI: 10.3390/venereology1010002

L. Santacroce, Marica Colella, I. Charitos

引用次数: 3

Publisher’s Note: Venereology—A New Open Access Journal for the Study and Treatment of Sexually Transmitted Diseases 出版者注:《性病学》——一种新的开放获取性传播疾病研究和治疗期刊

Venereology (Basel, Switzerland) Pub Date : 2021-09-28 DOI: 10.3390/venereology1010001

M. Noguera, Shu-Kun Lin

引用次数: 0