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The quest for vaccine-induced immune correlates of protection against tuberculosis. 寻求疫苗诱导的预防结核病的免疫相关物。
Vaccine insights Pub Date : 2022-07-01 Epub Date: 2022-07-29 DOI: 10.18609/vac/2022.027
Elisa Nemes, Andrew Fiore-Gartland, Cesar Boggiano, Margherita Coccia, Patricia D'Souza, Peter Gilbert, Ann Ginsberg, Ollivier Hyrien, Dominick Laddy, Karen Makar, M Juliana McElrath, Lakshmi Ramachandra, Alexander C Schmidt, Solmaz Shororbani, Justine Sunshine, Georgia Tomaras, Wen-Han Yu, Thomas J Scriba, Nicole Frahm
{"title":"The quest for vaccine-induced immune correlates of protection against tuberculosis.","authors":"Elisa Nemes, Andrew Fiore-Gartland, Cesar Boggiano, Margherita Coccia, Patricia D'Souza, Peter Gilbert, Ann Ginsberg, Ollivier Hyrien, Dominick Laddy, Karen Makar, M Juliana McElrath, Lakshmi Ramachandra, Alexander C Schmidt, Solmaz Shororbani, Justine Sunshine, Georgia Tomaras, Wen-Han Yu, Thomas J Scriba, Nicole Frahm","doi":"10.18609/vac/2022.027","DOIUrl":"10.18609/vac/2022.027","url":null,"abstract":"<p><p>Immunization strategies against tuberculosis (TB) that confer better protection than neonatal vaccination with the 101-year-old Bacille Calmette-Guerin (BCG) are urgently needed to control the epidemic, but clinical development is hampered by a lack of established immune correlates of protection (CoPs). Two phase 2b clinical trials offer the first opportunity to discover human CoPs against TB. Adolescent BCG re-vaccination showed partial protection against <i>Mycobacterium tuberculosis</i> (<i>Mtb)</i> infection, as measured by sustained IFNγ release assay (IGRA) conversion. Adult M72/AS01<sub>E</sub> vaccination showed partial protection against pulmonary TB. We describe two collaborative research programs to discover CoPs against TB and ensure rigorous, streamlined use of available samples, involving international immunology experts in TB and state-of-the-art technologies, sponsors and funders. Hypotheses covering immune responses thought to be important in protection against TB have been defined and prioritized. A statistical framework to integrate the data analysis strategy was developed. Exploratory analyses will be performed to generate novel hypotheses.</p>","PeriodicalId":75292,"journal":{"name":"Vaccine insights","volume":"1 3","pages":"165-181"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10190569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developing a microneedle patch for vaccine delivery 开发用于疫苗递送的微针贴片
Vaccine insights Pub Date : 2022-06-17 DOI: 10.18609/vac.2022.019
T. Duc Nguyen
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引用次数: 0
Closing the window of vulnerability: better vaccine adjuvants for neonates 关闭脆弱性窗口:更好的新生儿疫苗佐剂
Vaccine insights Pub Date : 2022-06-17 DOI: 10.18609/vac.2022.021
Kiva Brennan
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引用次数: 0
Advancing adjuvants: what’s new & what’s next in vaccine formulation? 推进佐剂:疫苗配方有什么新进展和下一步是什么?
Vaccine insights Pub Date : 2022-06-17 DOI: 10.18609/vac.2022.003
D. O'hagan
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引用次数: 0
Engineering the next generation of vaccine delivery technology 设计下一代疫苗输送技术
Vaccine insights Pub Date : 2022-06-17 DOI: 10.18609/vac.2022.007
A. Jaklenec, R. Langer
{"title":"Engineering the next generation of vaccine delivery technology","authors":"A. Jaklenec, R. Langer","doi":"10.18609/vac.2022.007","DOIUrl":"https://doi.org/10.18609/vac.2022.007","url":null,"abstract":"","PeriodicalId":75292,"journal":{"name":"Vaccine insights","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47945304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVID-19 vaccine supply chain management: a LMIC perspective COVID-19疫苗供应链管理:LMIC视角
Vaccine insights Pub Date : 2022-06-04 DOI: 10.18609/vac.2022.018
D. Zehrung
{"title":"COVID-19 vaccine supply chain management: a LMIC perspective","authors":"D. Zehrung","doi":"10.18609/vac.2022.018","DOIUrl":"https://doi.org/10.18609/vac.2022.018","url":null,"abstract":"","PeriodicalId":75292,"journal":{"name":"Vaccine insights","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47089341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Should we vaccinate against long-COVID? 我们应该接种抗长冠病毒疫苗吗?
Vaccine insights Pub Date : 2022-06-04 DOI: 10.18609/vac.2022.016
P. Hotez, C. Batista, Y. B. Amor, O. Ergonul, Peter Figueroa, M. Gursel, M. Hassanain, Gagandeep Kang, D. Kaslow, Jerome H. Kim, B. Lall, Heidi Larson, T. Sheahan, S. Shoham, A. Wilder-Smith, S. Sow, Prashant Yadav, M. Bottazzi
{"title":"Should we vaccinate against long-COVID?","authors":"P. Hotez, C. Batista, Y. B. Amor, O. Ergonul, Peter Figueroa, M. Gursel, M. Hassanain, Gagandeep Kang, D. Kaslow, Jerome H. Kim, B. Lall, Heidi Larson, T. Sheahan, S. Shoham, A. Wilder-Smith, S. Sow, Prashant Yadav, M. Bottazzi","doi":"10.18609/vac.2022.016","DOIUrl":"https://doi.org/10.18609/vac.2022.016","url":null,"abstract":"","PeriodicalId":75292,"journal":{"name":"Vaccine insights","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67542968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Guiding America through a pandemic 引导美国战胜流行病
Vaccine insights Pub Date : 2022-06-04 DOI: 10.18609/vac.2022.004
A. Fauci
{"title":"Guiding America through a pandemic","authors":"A. Fauci","doi":"10.18609/vac.2022.004","DOIUrl":"https://doi.org/10.18609/vac.2022.004","url":null,"abstract":"","PeriodicalId":75292,"journal":{"name":"Vaccine insights","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44299632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developing broadly protective strategies to protect against future pandemic threats 制定广泛的保护战略，以防范未来的流行病威胁
Vaccine insights Pub Date : 2022-06-04 DOI: 10.18609/vac.2022.010
Ralph Baric
{"title":"Developing broadly protective strategies to protect against future pandemic threats","authors":"Ralph Baric","doi":"10.18609/vac.2022.010","DOIUrl":"https://doi.org/10.18609/vac.2022.010","url":null,"abstract":"","PeriodicalId":75292,"journal":{"name":"Vaccine insights","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46242173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVID-19: how is the pandemic changing the vaccines space? 新冠肺炎：大流行如何改变疫苗空间？
Vaccine insights Pub Date : 2022-06-04 DOI: 10.18609/vac.2022.009
Nicholas A. C. Jackson
{"title":"COVID-19: how is the pandemic changing the vaccines space?","authors":"Nicholas A. C. Jackson","doi":"10.18609/vac.2022.009","DOIUrl":"https://doi.org/10.18609/vac.2022.009","url":null,"abstract":"","PeriodicalId":75292,"journal":{"name":"Vaccine insights","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44518987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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