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Strengthening regulatory oversight & boosting clinical trial capacity in Africa 加强监管，提高非洲临床试验能力
Vaccine insights Pub Date : 2022-08-01 DOI: 10.18609/vac.2022.024
B. Akanmori
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引用次数: 0
EATRIS: providing the right tools, at the right time, for vaccine development in a pandemic EATRIS：在正确的时间为大流行中的疫苗开发提供正确的工具
Vaccine insights Pub Date : 2022-08-01 DOI: 10.18609/vac.2022.022
David Morrow, Lucia Gabriele, Antonio L. Andreu, Florence Bietrix, A. Ussi, J. Langermans
{"title":"EATRIS: providing the right tools, at the right time, for vaccine development in a pandemic","authors":"David Morrow, Lucia Gabriele, Antonio L. Andreu, Florence Bietrix, A. Ussi, J. Langermans","doi":"10.18609/vac.2022.022","DOIUrl":"https://doi.org/10.18609/vac.2022.022","url":null,"abstract":"As society continues to take its first cautious steps out of the COVID-19 pandemic, researchers, including vaccine developers, continue to reflect on the challenges that they faced and overcame together during the last 2 years and the improvements necessary for better pandemic preparedness in future. Now more than ever, the world is recognizing the importance of vaccines, and the European Research Infrastructure for Translational Medicine (EATRIS) and its infrastructure partners across Europe and beyond have strived to accelerate promising candidates through the R&D pipeline, by offering innovative services to vaccine developers in academic and industry settings. traditional boundaries to access-ing key technologies in a fast and efficient our","PeriodicalId":75292,"journal":{"name":"Vaccine insights","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49138080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The quest for vaccine-induced immune correlates of protection against tuberculosis. 寻求疫苗诱导的预防结核病的免疫相关物。
Vaccine insights Pub Date : 2022-07-01 Epub Date: 2022-07-29 DOI: 10.18609/vac/2022.027
Elisa Nemes, Andrew Fiore-Gartland, Cesar Boggiano, Margherita Coccia, Patricia D'Souza, Peter Gilbert, Ann Ginsberg, Ollivier Hyrien, Dominick Laddy, Karen Makar, M Juliana McElrath, Lakshmi Ramachandra, Alexander C Schmidt, Solmaz Shororbani, Justine Sunshine, Georgia Tomaras, Wen-Han Yu, Thomas J Scriba, Nicole Frahm
{"title":"The quest for vaccine-induced immune correlates of protection against tuberculosis.","authors":"Elisa Nemes, Andrew Fiore-Gartland, Cesar Boggiano, Margherita Coccia, Patricia D'Souza, Peter Gilbert, Ann Ginsberg, Ollivier Hyrien, Dominick Laddy, Karen Makar, M Juliana McElrath, Lakshmi Ramachandra, Alexander C Schmidt, Solmaz Shororbani, Justine Sunshine, Georgia Tomaras, Wen-Han Yu, Thomas J Scriba, Nicole Frahm","doi":"10.18609/vac/2022.027","DOIUrl":"10.18609/vac/2022.027","url":null,"abstract":"<p><p>Immunization strategies against tuberculosis (TB) that confer better protection than neonatal vaccination with the 101-year-old Bacille Calmette-Guerin (BCG) are urgently needed to control the epidemic, but clinical development is hampered by a lack of established immune correlates of protection (CoPs). Two phase 2b clinical trials offer the first opportunity to discover human CoPs against TB. Adolescent BCG re-vaccination showed partial protection against <i>Mycobacterium tuberculosis</i> (<i>Mtb)</i> infection, as measured by sustained IFNγ release assay (IGRA) conversion. Adult M72/AS01<sub>E</sub> vaccination showed partial protection against pulmonary TB. We describe two collaborative research programs to discover CoPs against TB and ensure rigorous, streamlined use of available samples, involving international immunology experts in TB and state-of-the-art technologies, sponsors and funders. Hypotheses covering immune responses thought to be important in protection against TB have been defined and prioritized. A statistical framework to integrate the data analysis strategy was developed. Exploratory analyses will be performed to generate novel hypotheses.</p>","PeriodicalId":75292,"journal":{"name":"Vaccine insights","volume":"1 3","pages":"165-181"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10190569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developing a microneedle patch for vaccine delivery 开发用于疫苗递送的微针贴片
Vaccine insights Pub Date : 2022-06-17 DOI: 10.18609/vac.2022.019
T. Duc Nguyen
{"title":"Developing a microneedle patch for vaccine delivery","authors":"T. Duc Nguyen","doi":"10.18609/vac.2022.019","DOIUrl":"https://doi.org/10.18609/vac.2022.019","url":null,"abstract":"","PeriodicalId":75292,"journal":{"name":"Vaccine insights","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45434642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Closing the window of vulnerability: better vaccine adjuvants for neonates 关闭脆弱性窗口:更好的新生儿疫苗佐剂
Vaccine insights Pub Date : 2022-06-17 DOI: 10.18609/vac.2022.021
Kiva Brennan
{"title":"Closing the window of vulnerability: better vaccine adjuvants for neonates","authors":"Kiva Brennan","doi":"10.18609/vac.2022.021","DOIUrl":"https://doi.org/10.18609/vac.2022.021","url":null,"abstract":"","PeriodicalId":75292,"journal":{"name":"Vaccine insights","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48566089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing adjuvants: what’s new & what’s next in vaccine formulation? 推进佐剂:疫苗配方有什么新进展和下一步是什么?
Vaccine insights Pub Date : 2022-06-17 DOI: 10.18609/vac.2022.003
D. O'hagan
{"title":"Advancing adjuvants: what’s new & what’s next in vaccine formulation?","authors":"D. O'hagan","doi":"10.18609/vac.2022.003","DOIUrl":"https://doi.org/10.18609/vac.2022.003","url":null,"abstract":"","PeriodicalId":75292,"journal":{"name":"Vaccine insights","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48223080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering the next generation of vaccine delivery technology 设计下一代疫苗输送技术
Vaccine insights Pub Date : 2022-06-17 DOI: 10.18609/vac.2022.007
A. Jaklenec, R. Langer
{"title":"Engineering the next generation of vaccine delivery technology","authors":"A. Jaklenec, R. Langer","doi":"10.18609/vac.2022.007","DOIUrl":"https://doi.org/10.18609/vac.2022.007","url":null,"abstract":"","PeriodicalId":75292,"journal":{"name":"Vaccine insights","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47945304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVID-19 vaccine supply chain management: a LMIC perspective COVID-19疫苗供应链管理:LMIC视角
Vaccine insights Pub Date : 2022-06-04 DOI: 10.18609/vac.2022.018
D. Zehrung
{"title":"COVID-19 vaccine supply chain management: a LMIC perspective","authors":"D. Zehrung","doi":"10.18609/vac.2022.018","DOIUrl":"https://doi.org/10.18609/vac.2022.018","url":null,"abstract":"","PeriodicalId":75292,"journal":{"name":"Vaccine insights","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47089341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Should we vaccinate against long-COVID? 我们应该接种抗长冠病毒疫苗吗?
Vaccine insights Pub Date : 2022-06-04 DOI: 10.18609/vac.2022.016
P. Hotez, C. Batista, Y. B. Amor, O. Ergonul, Peter Figueroa, M. Gursel, M. Hassanain, Gagandeep Kang, D. Kaslow, Jerome H. Kim, B. Lall, Heidi Larson, T. Sheahan, S. Shoham, A. Wilder-Smith, S. Sow, Prashant Yadav, M. Bottazzi
{"title":"Should we vaccinate against long-COVID?","authors":"P. Hotez, C. Batista, Y. B. Amor, O. Ergonul, Peter Figueroa, M. Gursel, M. Hassanain, Gagandeep Kang, D. Kaslow, Jerome H. Kim, B. Lall, Heidi Larson, T. Sheahan, S. Shoham, A. Wilder-Smith, S. Sow, Prashant Yadav, M. Bottazzi","doi":"10.18609/vac.2022.016","DOIUrl":"https://doi.org/10.18609/vac.2022.016","url":null,"abstract":"","PeriodicalId":75292,"journal":{"name":"Vaccine insights","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67542968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Guiding America through a pandemic 引导美国战胜流行病
Vaccine insights Pub Date : 2022-06-04 DOI: 10.18609/vac.2022.004
A. Fauci
{"title":"Guiding America through a pandemic","authors":"A. Fauci","doi":"10.18609/vac.2022.004","DOIUrl":"https://doi.org/10.18609/vac.2022.004","url":null,"abstract":"","PeriodicalId":75292,"journal":{"name":"Vaccine insights","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44299632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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