American Journal of Alzheimer's Disease & Other Dementias®最新文献_第7页

Use of Angiotensin-Converting Enzyme Inhibitors, Angiotensin Receptor Blockers, and Risk of Dementia in Heart Failure. 使用血管紧张素转换酶抑制剂、血管紧张素受体阻滞剂与心力衰竭患者痴呆症的风险。

American Journal of Alzheimer's Disease & Other Dementias® Pub Date : 2016-08-01 Epub Date: 2015-12-24 DOI: 10.1177/1533317515618799

Abhishek S Chitnis, Rajender R Aparasu, Hua Chen, Mark E Kunik, Paul E Schulz, Michael L Johnson

{"title":"Use of Angiotensin-Converting Enzyme Inhibitors, Angiotensin Receptor Blockers, and Risk of Dementia in Heart Failure.","authors":"Abhishek S Chitnis, Rajender R Aparasu, Hua Chen, Mark E Kunik, Paul E Schulz, Michael L Johnson","doi":"10.1177/1533317515618799","DOIUrl":"10.1177/1533317515618799","url":null,"abstract":"Objective: To test the effect of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin-receptor blockers (ARBs) on reducing the risk of dementia in patients with heart failure (HF).Methods: This retrospective, longitudinal study used a cohort of HF patients identified from a local Medicare advantage prescription drug plan. Multivariable time-dependent Cox model and marginal structural model using inverse-probability-oftreatment weighting were used to estimate the risk of developing dementia. Adjusted dementia rate ratios were estimated among current and former ACEI/ARB users, as compared with nonusers.Results: Using the time-dependent Cox model, the adjusted dementia rate ratios (95% confidence-interval) among current and former users were 0.90(0.70-1.16) and 0.89 (0.71-1.10), respectively. Use of marginal structural model resulted in similar effect estimates for current and former users as compared with the nonusers.Conclusion: This study found no difference in risk of dementia among the current and former users of ACEI/ARB as compared with the nonusers in an already at-risk HF population.","PeriodicalId":7526,"journal":{"name":"American Journal of Alzheimer's Disease & Other Dementias®","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10852826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82764840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrogen Proton Magnetic Resonance Spectroscopy in Multidomain Amnestic Mild Cognitive Impairment and Vascular Cognitive Impairment Without Dementia. 多域失忆性轻度认知障碍和无痴呆症的血管性认知障碍的氢质子磁共振波谱研究

American Journal of Alzheimer's Disease & Other Dementias® Pub Date : 2016-08-01 Epub Date: 2016-03-14 DOI: 10.1177/1533317515628052

Shuang-Qing Chen, Qing Cai, Yu-Ying Shen, Chuan-Xiao Xu, Hua Zhou, Zhong Zhao

{"title":"Hydrogen Proton Magnetic Resonance Spectroscopy in Multidomain Amnestic Mild Cognitive Impairment and Vascular Cognitive Impairment Without Dementia.","authors":"Shuang-Qing Chen, Qing Cai, Yu-Ying Shen, Chuan-Xiao Xu, Hua Zhou, Zhong Zhao","doi":"10.1177/1533317515628052","DOIUrl":"10.1177/1533317515628052","url":null,"abstract":"To investigate the value of hydrogen proton magnet resonance spectroscopy ((1)H-MRS) in the differential diagnosis of multiple-domain amnestic mild cognitive impairment (M-aMCI) and vascular cognitive impairment with no dementia (VCIND); (1)H-MRS was performed in patients with M-aMCI and VCIND. The level was determined for N-acetylaspartate (NAA), glutamate (Glu), inositol (mI), choline (Cho), and creatine (Cr). Compared with the normal control group, the NAA-Cr ratio in all regions studied was significantly lower in the M-aMCI and VCIND groups. The Glu-Cr ratio in the posterior cingulate gyrus of the M-aMCI group was significantly lower than in the VCIND. The mI-Cr ratio in the frontal white matter of the VCIND was significantly higher than in the M-aMCI group. In the white matter adjacent to the lateral ventricles, the Cho-Cr ratio was significantly higher in the VCIND than the M-aMCI. Our results suggested (1)H-MRS is an effective method in the differential diagnosis of M-aMCI and VCIND.","PeriodicalId":7526,"journal":{"name":"American Journal of Alzheimer's Disease & Other Dementias®","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10852783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82980244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tong Luo Jiu Nao, a Chinese Medicine Formula, Reduces Inflammatory Stress in a Mouse Model of Alzheimer's Disease. 中药配方通络九窍能减轻阿尔茨海默病小鼠模型的炎症应激反应

American Journal of Alzheimer's Disease & Other Dementias® Pub Date : 2016-08-01 Epub Date: 2016-03-17 DOI: 10.1177/1533317515628051

Ai-She Gao, Huan Du, Qing Gao, Yi-Jing Wang, Xie-Yan Wang, Jian-Wei Liu, Bin Lu

{"title":"Tong Luo Jiu Nao, a Chinese Medicine Formula, Reduces Inflammatory Stress in a Mouse Model of Alzheimer's Disease.","authors":"Ai-She Gao, Huan Du, Qing Gao, Yi-Jing Wang, Xie-Yan Wang, Jian-Wei Liu, Bin Lu","doi":"10.1177/1533317515628051","DOIUrl":"10.1177/1533317515628051","url":null,"abstract":"Aim: The aim of this study is to extend the molecular mechanism of Tong Luo Jiu Nao (TLJN) for Alzheimer's disease (AD), which is a modern Chinese formula that has been used to treat AD.Methods: The senescence-accelerated mouse prone 8 strain (SAMP8) is one of the most appropriate models to study the mechanism that underlies AD. The levels of plasma amyloid β (Aβ) and the Aβ deposits were measured using enzyme-linked immunosorbent assay and immunohistochemistry. Immunoblotting was used to observe the effect of TLJN on inflammatory mediator expression in an senescence-accelerated mouse model of AD.Results: Our data showed that the TLJN-treated groups exhibited a reduction in plasma Aβ levels and reduced Aβ expression. Moreover, TLJN effectively attenuated Aβ-induced activation of extracellular signal-regulated kinase and c-Jun N-terminal kinases and blocked changes in inflammatory mediator expression.Conclusion: These data suggest that TLJN might have protective effects and could potentially act to attenuate inflammatory stress in the pathogenesis of AD.","PeriodicalId":7526,"journal":{"name":"American Journal of Alzheimer's Disease & Other Dementias®","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10852978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87806807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of Neuropsychological Tests to Screen for Dementia in Chinese Patients With Parkinson's Disease. 中国帕金森病患者痴呆症筛查神经心理学测试的验证。

American Journal of Alzheimer's Disease & Other Dementias® Pub Date : 2016-06-01 Epub Date: 2015-12-08 DOI: 10.1177/1533317515619478

Jin Qiao, Xiaoyan Wang, Wenhui Lu, Hongmei Cao, Xing Qin

{"title":"Validation of Neuropsychological Tests to Screen for Dementia in Chinese Patients With Parkinson's Disease.","authors":"Jin Qiao, Xiaoyan Wang, Wenhui Lu, Hongmei Cao, Xing Qin","doi":"10.1177/1533317515619478","DOIUrl":"10.1177/1533317515619478","url":null,"abstract":"To compare the accuracy of different neuropsychological tests and their combinations for deriving reliable cognitive indices for dementia diagnosis in Parkinson's disease (PD). One hundred forty consecutive patients with PD were recruited and administrated an extensive battery of neuropsychological tests. Discriminant analysis and receiver-operator characteristic curve were used to evaluate their correct classifications and validity. Patients with PD having dementia (PDD; 23.5%) performed significantly worse in all tests than patients without dementia. Age of onset, disease duration, Hoehn-Yahr grade, Unified Parkinson's Disease Rating Scale part III scores, and education were associated with dementia in patients with PD. Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment, and Block Design (BD) showed better specificity and sensitivity when used alone, and combined use of MMSE and BD further increased the validity. Our results indicated that the accuracy of MMSE was better in dementia diagnosis of Chinese patients with PD, and combined use of MMSE and BD could further increase the validity of dementia diagnosis.","PeriodicalId":7526,"journal":{"name":"American Journal of Alzheimer's Disease & Other Dementias®","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10852760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80686871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge and Attitudes in Alzheimer’s Disease in a Cohort of Older African Americans and Caucasians 老年非裔美国人和白种人阿尔茨海默病的知识和态度

American Journal of Alzheimer's Disease & Other Dementias® Pub Date : 2016-06-01 DOI: 10.1177/1533317515619037

J. Howell, M. Parker, Thomas L. Jarrett, David L. Roberts, C. Dorbin, William T. Hu, BS Oretunlewa Soyinka

引用次数: 10

Acetylcholinesterase Inhibitors for Delirium in Older Adults. 乙酰胆碱酯酶抑制剂治疗老年人谵妄。

American Journal of Alzheimer's Disease & Other Dementias® Pub Date : 2016-06-01 Epub Date: 2015-12-08 DOI: 10.1177/1533317515619034

Rajesh R Tampi, Deena J Tampi, Ambreen K Ghori

{"title":"Acetylcholinesterase Inhibitors for Delirium in Older Adults.","authors":"Rajesh R Tampi, Deena J Tampi, Ambreen K Ghori","doi":"10.1177/1533317515619034","DOIUrl":"10.1177/1533317515619034","url":null,"abstract":"Objectives: The aim of this systematic review is to identify published randomized controlled trials (RCTs) that evaluated the use of acetylcholinesterase inhibitors for delirium in older adults (≥60 years).Methods: A literature search was conducted of PubMed, MEDLINE, EMBASE, PsycINFO, and Cochrane collaboration databases for RCTs in any language that evaluated the use of acetylcholinesterase inhibitors for delirium in older adults (≥60 years). Also, bibliographic databases of the published articles were searched for additional studies.Results: A total of 7 RCTs that evaluated the use of acetylcholinesterase inhibitors for delirium in older adults (≥60 years) were identified. In 5 of the 7 studies, there was no benefit for the acetylcholinesterase inhibitor in either the prevention or the management of delirium. In one study, there was a trend toward benefit for the active drug group on the incidence of delirium and the length of hospital stay, but both outcomes did not attain statistical significance. One study found a longer duration of delirium and a longer length of hospital stay in the active drug group when compared to the placebo group. The acetylcholinesterase inhibitors were well tolerated in 4 of the 7 studies. In 1 study, the mortality rate was found to be almost 3 times higher in the group receiving haloperidol and rivastigmine when compared to the group receiving haloperidol and placebo.Conclusion: Current evidence does not suggest efficacy of acetylcholinesterase inhibitors for the prevention or management of delirium in older adults.","PeriodicalId":7526,"journal":{"name":"American Journal of Alzheimer's Disease & Other Dementias®","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10852606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86283302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapidly Versus Slowly Progressing Patients With Alzheimer's Disease: Differences in Baseline Cognition. 阿尔茨海默病患者的快速进展与缓慢进展：基线认知的差异。

American Journal of Alzheimer's Disease & Other Dementias® Pub Date : 2016-06-01 Epub Date: 2015-12-08 DOI: 10.1177/1533317515617720

Jennifer N Travis Seidl, Paul J Massman

引用次数: 0

Neuropsychological and Neuroanatomical Correlates of the Social Norms Questionnaire in Frontotemporal Dementia Versus Alzheimer's Disease. 额颞叶痴呆症与阿尔茨海默病社会规范问卷的神经心理学和神经解剖学相关性。

American Journal of Alzheimer's Disease & Other Dementias® Pub Date : 2016-06-01 Epub Date: 2015-12-08 DOI: 10.1177/1533317515617722

Hemali Panchal, Pongsatorn Paholpak, Grace Lee, Andrew Carr, Joseph P Barsuglia, Michelle Mather, Elvira Jimenez, Mario F Mendez

{"title":"Neuropsychological and Neuroanatomical Correlates of the Social Norms Questionnaire in Frontotemporal Dementia Versus Alzheimer's Disease.","authors":"Hemali Panchal, Pongsatorn Paholpak, Grace Lee, Andrew Carr, Joseph P Barsuglia, Michelle Mather, Elvira Jimenez, Mario F Mendez","doi":"10.1177/1533317515617722","DOIUrl":"10.1177/1533317515617722","url":null,"abstract":"Traditional neuropsychological batteries may not distinguish early behavioral variant frontotemporal dementia (bvFTD) from Alzheimer's disease (AD) without the inclusion of a social behavioral measure. We compared 33 participants, 15 bvFTD, and 18 matched patients with early-onset AD (eAD), on the Social Norms Questionnaire (SNQ), neuropsychological tests and 3-dimensional T1-weighted magnetic resonance imaging (MRI). The analyses included correlations of SNQ results (total score, overendorsement or \"overadhere\" errors, and violations or \"break\" errors) with neuropsychological results and tensor-based morphometry regions of interest. Patients with BvFTD had significantly lower SNQ total scores and higher overadhere errors than patients with eAD. On neuropsychological measures, the SNQ total scores correlated significantly with semantic knowledge and the overadhere subscores with executive dysfunction. On MRI analysis, the break subscores significantly correlated with lower volume of lateral anterior temporal lobes (aTL). The results also suggest that endorsement of social norm violations corresponds to the role of the right aTL in social semantic knowledge.","PeriodicalId":7526,"journal":{"name":"American Journal of Alzheimer's Disease & Other Dementias®","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10852706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76794677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deficits in Attention and Visual Processing but not Global Cognition Predict Simulated Driving Errors in Drivers Diagnosed With Mild Alzheimer's Disease. 注意力和视觉处理缺陷而非整体认知缺陷可预测被诊断患有轻度阿尔茨海默病的驾驶员的模拟驾驶错误。

American Journal of Alzheimer's Disease & Other Dementias® Pub Date : 2016-06-01 Epub Date: 2015-12-10 DOI: 10.1177/1533317515618898

Stephanie Yamin, Arne Stinchcombe, Sylvain Gagnon

{"title":"Deficits in Attention and Visual Processing but not Global Cognition Predict Simulated Driving Errors in Drivers Diagnosed With Mild Alzheimer's Disease.","authors":"Stephanie Yamin, Arne Stinchcombe, Sylvain Gagnon","doi":"10.1177/1533317515618898","DOIUrl":"10.1177/1533317515618898","url":null,"abstract":"This study sought to predict driving performance of drivers with Alzheimer's disease (AD) using measures of attention, visual processing, and global cognition. Simulated driving performance of individuals with mild AD (n = 20) was contrasted with performance of a group of healthy controls (n = 21). Performance on measures of global cognitive function and specific tests of attention and visual processing were examined in relation to simulated driving performance. Strong associations were observed between measures of attention, notably the Test of Everyday Attention (sustained attention; r = -.651, P = .002) and the Useful Field of View (r = .563, P = .010), and driving performance among drivers with mild AD. The Visual Object and Space Perception Test-object was significantly correlated with the occurrence of crashes (r = .652, P = .002). Tests of global cognition did not correlate with simulated driving outcomes. The results suggest that professionals exercise caution when extrapolating driving performance based on global cognitive indicators.","PeriodicalId":7526,"journal":{"name":"American Journal of Alzheimer's Disease & Other Dementias®","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10852565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81752088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multisensory Stimulation as an Intervention Strategy for Elderly Patients With Severe Dementia: A Pilot Randomized Controlled Trial. 将多感官刺激作为严重痴呆症老年患者的干预策略：一项试点随机对照试验。

American Journal of Alzheimer's Disease & Other Dementias® Pub Date : 2016-06-01 Epub Date: 2015-12-01 DOI: 10.1177/1533317515618801

Alba Sánchez, M Pilar Marante-Moar, Carmen Sarabia, Carmen de Labra, Trinidad Lorenzo, Ana Maseda, José Carlos Millán-Calenti

{"title":"Multisensory Stimulation as an Intervention Strategy for Elderly Patients With Severe Dementia: A Pilot Randomized Controlled Trial.","authors":"Alba Sánchez, M Pilar Marante-Moar, Carmen Sarabia, Carmen de Labra, Trinidad Lorenzo, Ana Maseda, José Carlos Millán-Calenti","doi":"10.1177/1533317515618801","DOIUrl":"10.1177/1533317515618801","url":null,"abstract":"The objective of this study was to compare the effect of multisensory stimulation environment (MSSE) and one-to-one activity sessions in the symptomatology of elderly individuals with severe dementia. Thirty-two participants were randomly assigned to the following 3 groups: MSSE, activity, and control group. The MSSE and activity groups participated in two 30-minute weekly sessions over 16 weeks. Pre-, mid-, and posttrial; 8-week follow-up behavior; mood; cognitive status; and dementia severity were registered. Patients in the MSSE group demonstrated a significant improvement in the Neuropsychiatric Inventory and Bedford Alzheimer Nursing Severity Scale scores compared with the activity group. Both MSSE and activity groups showed an improvement during the intervention in the Cohen-Mansfield Agitation Inventory aggressive behavior factor and total score, with no significant differences between groups. The MSSE may have better effects on neuropsychiatric symptoms and dementia severity in comparison with one-to-one activity sessions in patients with severe dementia.","PeriodicalId":7526,"journal":{"name":"American Journal of Alzheimer's Disease & Other Dementias®","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10852803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77298339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0