The journal of supportive oncology最新文献

{"title":"Perceived social support as a predictor of disease-specific quality of life in head-and-neck cancer patients.","authors":"Frank J Penedo,&nbsp;Lara Traeger,&nbsp;Catherine Benedict,&nbsp;Giovana Thomas,&nbsp;Jason R Dahn,&nbsp;Madeline Hernandez Krause,&nbsp;W Jarrard Goodwin","doi":"10.1016/j.suponc.2011.09.002","DOIUrl":"https://doi.org/10.1016/j.suponc.2011.09.002","url":null,"abstract":"<p><strong>Background: </strong>Treatment for head-and-neck cancer (HNC) can lead to severe decrements in disease-specific quality of life (DSQOL) due to disfigurement and disability in speech, eating, and/or breathing. Psychosocial factors such as social support may explain individual variance in DSQOL outcomes.</p><p><strong>Objective: </strong>The researchers sought to evaluate changes in perceived availability of social support from pretreatment to posttreatment and to determine whether decreases in perceived social support predicted poorer posttreatment DSQOL among HNC patients, controlling for disease- and treatment-related factors.</p><p><strong>Methods: </strong>Participants (n = 32) were newly diagnosed with HNC and were awaiting surgery and/or radiation treatment. Measures included the ENRICHD Social Support instrument (ESSI) to assess perceived social support and the Functional Assessment of Cancer Therapy-Head & Neck (FACT-H&N) to assess DSQOL. Paired-samples t-tests and hierarchical regression analyses were conducted to determine relationships between pretreatment and posttreatment perceived social support and DSQOL.</p><p><strong>Results: </strong>Perceived social support decreased significantly from pre- to posttreatment (F[31] = -2.71, P < .01). After adjusting for relevant covariates and pretreatment DSQOL, change in perceived social support remained a significant predictor of posttreatment DSQOL (β = .47, P < .01).</p><p><strong>Limitations: </strong>This study included a relatively small sample of HNC patients, which limited power to evaluate mechanisms of observed relationships.</p><p><strong>Conclusions: </strong>Increased social isolation may be a risk factor for poorer physical recovery from, or adjustment to, treatment-related side effects. Social support may be an important target for psychosocial interventions for patients who face challenging treatment side effects.</p>","PeriodicalId":75116,"journal":{"name":"The journal of supportive oncology","volume":"10 3","pages":"119-23"},"PeriodicalIF":0.0,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.suponc.2011.09.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30258936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coping and psychological distress in young adults with advanced cancer.","authors":"Kelly M Trevino, Paul K Maciejewski, Karen Fasciano, Joseph Greer, Ann Partridge, Elizabeth L Kacel, Susan Block, Holly G Prigerson","doi":"10.1016/j.suponc.2011.08.005","DOIUrl":"10.1016/j.suponc.2011.08.005","url":null,"abstract":"<p><strong>Background: </strong>Little is known about how young adults (YAs) cope with cancer or about the relationship between coping and psychological distress in YAs with advanced cancer.</p><p><strong>Objectives: </strong>The goals of this study were to identify coping strategies used by YAs with advanced cancer and examine the relationship between these coping strategies and psychological distress.</p><p><strong>Methods: </strong>Using structured clinical interviews with 53 YAs (aged 20-40 years) with advanced cancer, researchers assessed coping methods, depression, anxiety, and grief. A principal components factor analysis identified underlying coping factors. Regression analyses examined the relationship between these coping factors and depression, anxiety, and grief.</p><p><strong>Results: </strong>Six coping factors emerged and were labeled as proactive, distancing, negative expression, support-seeking, respite-seeking, and acceptance coping. Acceptance and support-seeking coping styles were used most frequently. Coping by negative expression was positively associated with severity of grief after researchers controlled for depression, anxiety, and confounding variables. Support-seeking coping was positively associated with anxiety after researchers controlled for depression and grief.</p><p><strong>Limitations: </strong>This study was limited by a cross-sectional design, small sample size, and focus on YAs with advanced cancer.</p><p><strong>Conclusions: </strong>YAs with advanced cancer utilize a range of coping responses that are uniquely related to psychological distress.</p>","PeriodicalId":75116,"journal":{"name":"The journal of supportive oncology","volume":"10 3","pages":"124-30"},"PeriodicalIF":0.0,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340430/pdf/nihms326668.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30419798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting the future: no pain, we all gain?","authors":"Thomas B Strouse","doi":"10.1016/j.suponc.2011.10.002","DOIUrl":"https://doi.org/10.1016/j.suponc.2011.10.002","url":null,"abstract":"","PeriodicalId":75116,"journal":{"name":"The journal of supportive oncology","volume":"10 3","pages":"97-8"},"PeriodicalIF":0.0,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.suponc.2011.10.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30418559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementing a standardized pharmacist assessment and evaluating the role of a pharmacist in a multidisciplinary supportive oncology clinic.","authors":"Robert Mancini","doi":"10.1016/j.suponc.2011.09.005","DOIUrl":"https://doi.org/10.1016/j.suponc.2011.09.005","url":null,"abstract":"<p><p>Supportive care, or palliative care, in oncology patients has been a shifting paradigm in the last few years. Patients with advanced cancer experience significant symptom burden and psychosocial distress from the onset of their diagnosis and throughout treatment. The focus on cancer treatment often defers the integration of palliative care to a more \"reactive\" vs \"proactive\" approach, which can hinder symptom management. Many cancer centers are integrating palliative care programs in their practice; however, the scope of services and degree of intervention varies widely, especially with regard to the pharmacist's role. The purpose of this article is to describe the operational aspects of a multidisciplinary supportive oncology clinic at St. Luke's Mountain States Tumor Institute (MSTI). The MSTI supportive oncology clinic is a half-day clinic where complex patients are seen by a multidisciplinary team led by a nurse practitioner. The team also includes a nurse, a pharmacist, a dietitian, and a social worker. The pharmacist is responsible for medication reconciliation, which includes assessment for drug interactions, adverse effects, duplications in therapy, lack of efficacy, and untreated conditions. Within the first year of the supportive oncology clinic's operation, we saw a total of 75 patients. Use of a standardized pharmacy assessment helped to elucidate and address medication issues such as duplicate therapies (46.7% of patients), drug interactions (44%), side effects (74.7%), lack of efficacy (94.7%), and untreated conditions (73.3%). Pharmacists are uniquely trained in medication therapy management, and a thorough medication therapy review has been shown to assist other disciplines in their own assessments.</p>","PeriodicalId":75116,"journal":{"name":"The journal of supportive oncology","volume":"10 3","pages":"99-106"},"PeriodicalIF":0.0,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.suponc.2011.09.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30404002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usual and worst symptom severity and interference with function in breast cancer survivors.","authors":"Ann M Berger,&nbsp;Constance Visovsky,&nbsp;Melody Hertzog,&nbsp;Shandra Holtz,&nbsp;Fausto R Loberiza","doi":"10.1016/j.suponc.2011.11.001","DOIUrl":"https://doi.org/10.1016/j.suponc.2011.11.001","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer survivors receive routine medical follow-up but are screened less frequently to detect symptom severity and interference with function in daily life.</p><p><strong>Objectives: </strong>Among breast cancer survivors, we describe the usual and worst severity of 5 common symptoms and the extent to which these symptoms interfere with general activity and enjoyment of life, we determine the associations among symptoms and the interference items, and we explore associations of interference with function and the most prevalent symptoms.</p><p><strong>Methods: </strong>The cross-sectional, descriptive 1-page Breast Cancer Survivor Symptom Survey was mailed to breast cancer survivors identified in a clinical database (ONCOBASE). In total, 184/457 (40.3%) surveys were returned and 162 (35.4%) were used. Participants recorded usual and worst severity of 5 symptoms (fatigue, disturbed sleep, pain, distress, and numbness/tingling) and symptom interference with general activity and enjoyment of life during the past 7 days.</p><p><strong>Results: </strong>Participants reported usual symptom severity as mild and highest for sleep disturbance, followed by fatigue, distress, numbness/tingling, and pain. Participants recorded worst sleep disturbance and fatigue as moderately severe. Higher pain and fatigue were associated with all other symptoms, whereas disturbed sleep and distress were related to all except numbness/tingling. All symptoms interfered with general activity and enjoyment of life. Pain and numbness/tingling were associated with lower function and disturbed sleep, and made a unique contribution to fatigue.</p><p><strong>Limitations: </strong>Limitations of the study include relatively low response and use of a modification of an established scale.</p><p><strong>Conclusion: </strong>Symptoms often coexisted and contributed to interference with daily function. Pain was most consistently associated with interference with function and severity of other symptoms.</p>","PeriodicalId":75116,"journal":{"name":"The journal of supportive oncology","volume":"10 3","pages":"112-8"},"PeriodicalIF":0.0,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.suponc.2011.11.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30412940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The alternatives for chronic pain management in cancer survivors.","authors":"Laura G Audell,&nbsp;Howard L Rosner","doi":"10.1016/j.suponc.2011.10.001","DOIUrl":"https://doi.org/10.1016/j.suponc.2011.10.001","url":null,"abstract":"","PeriodicalId":75116,"journal":{"name":"The journal of supportive oncology","volume":"10 3","pages":"96"},"PeriodicalIF":0.0,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.suponc.2011.10.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30418557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palonosetron plus 1-day dexamethasone for the prevention of nausea and vomiting due to moderately emetogenic chemotherapy: effect of established risk factors on treatment outcome in a phase III trial.","authors":"Luigi Celio,&nbsp;Angela Denaro,&nbsp;Francesco Agustoni,&nbsp;Emilio Bajetta","doi":"10.1016/j.suponc.2011.06.007","DOIUrl":"https://doi.org/10.1016/j.suponc.2011.06.007","url":null,"abstract":"<p><strong>Background: </strong>The non-inferiority of palonosetron plus 1-day versus 3-day dexamethasone in preventing chemotherapy-induced nausea and vomiting (CINV) due to moderately emetogenic chemotherapy (MEC) has been previously demonstrated.</p><p><strong>Objective: </strong>The objectives of this prespecified post hoc analysis were to demonstrate the non-inferiority hypothesis in an adjusted model for known risk factors (age, gender, alcohol consumption, and type of MEC [anthracycline plus cyclophosphamide (AC)-based versus other MEC]) for CINV and to explore the impact on antiemetic outcome of these risk factors.</p><p><strong>Methods: </strong>Chemonaive patients (n = 324) with solid tumors were randomized to receive palonosetron 0.25 mg IV plus dexamethasone 8 mg IV on day 1 of chemotherapy or the same regimen followed by oral dexamethasone 8 mg on days 2 and 3. The primary end point was complete response (CR, no emesis and no rescue antiemetics) during the 5-day study period. A modified intention-to-treat approach was used for multivariable analysis.</p><p><strong>Results: </strong>Non-inferiority of the 1-day regimen was confirmed even after adjusting for risk factors (risk difference -4.4%, 95% CI -14.1% to 5.4%; P = .381). Only age less than 50 years (P = .044) independently predicted a poor outcome of antiemetic treatment. However, most of the younger patients were women (1-day regimen 81.8%, 3-day regimen 88.4%) who underwent AC-based chemotherapy (1-day regimen 61.1%, 3-day regimen 71.0%). There were no significant between-treatment differences in the CR rate according to risk factors.</p><p><strong>Conclusion: </strong>This analysis confirmed that the 1-day regimen provides a valid treatment option for prevention of CINV in delayed, non-AC-based MEC.</p>","PeriodicalId":75116,"journal":{"name":"The journal of supportive oncology","volume":"10 2","pages":"65-71"},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.suponc.2011.06.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30214517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neoplastic meningitis: challenging to diagnose, difficult to treat, important to palliate.","authors":"Alexis Demopoulos","doi":"10.1016/j.suponc.2011.08.003","DOIUrl":"https://doi.org/10.1016/j.suponc.2011.08.003","url":null,"abstract":"","PeriodicalId":75116,"journal":{"name":"The journal of supportive oncology","volume":"10 2","pages":"54"},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.suponc.2011.08.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30214522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of spirituality and religious coping in the quality of life of patients with advanced cancer receiving palliative radiation therapy.","authors":"Mounica Vallurupalli, Katharine Lauderdale, Michael J Balboni, Andrea C Phelps, Susan D Block, Andrea K Ng, Lisa A Kachnic, Tyler J Vanderweele, Tracy A Balboni","doi":"10.1016/j.suponc.2011.09.003","DOIUrl":"10.1016/j.suponc.2011.09.003","url":null,"abstract":"<p><strong>Objectives: </strong>National palliative care guidelines outline spiritual care as a domain of palliative care, yet patients' religiousness and/or spirituality (R/S) are underappreciated in the palliative oncology setting. Among patients with advanced cancer receiving palliative radiation therapy (RT), this study aims to characterize patient spirituality, religiousness, and religious coping; examine the relationships of these variables to quality of life (QOL); and assess patients' perceptions of spiritual care in the cancer care setting.</p><p><strong>Methods: </strong>This is a multisite, cross-sectional survey of 69 patients with advanced cancer (response rate = 73%) receiving palliative RT. Scripted interviews assessed patient spirituality, religiousness, religious coping, QOL (McGill QOL Questionnaire), and perceptions of the importance of attention to spiritual needs by health providers. Multivariable models assessed the relationships of patient spirituality and R/S coping to patient QOL, controlling for other significant predictors of QOL.</p><p><strong>Results: </strong>Most participants (84%) indicated reliance on R/S beliefs to cope with cancer. Patient spirituality and religious coping were associated with improved QOL in multivariable analyses (β = 10.57, P < .001 and β = 1.28, P = .01, respectively). Most patients considered attention to spiritual concerns an important part of cancer care by physicians (87%) and nurses (85%).</p><p><strong>Limitations: </strong>Limitations include a small sample size, a cross-sectional study design, and a limited proportion of nonwhite participants (15%) from one US region.</p><p><strong>Conclusion: </strong>Patients receiving palliative RT rely on R/S beliefs to cope with advanced cancer. Furthermore, spirituality and religious coping are contributors to better QOL. These findings highlight the importance of spiritual care in advanced cancer care.</p>","PeriodicalId":75116,"journal":{"name":"The journal of supportive oncology","volume":"10 2","pages":"81-7"},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391969/pdf/nihms383584.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30258939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neoplastic meningitis.","authors":"Alixis Van Horn,&nbsp;Marc C Chamberlain","doi":"10.1016/j.suponc.2011.06.002","DOIUrl":"https://doi.org/10.1016/j.suponc.2011.06.002","url":null,"abstract":"<p><p>Neoplastic meningitis occurs in approximately 5%-10% of all patients with cancer, and aggressive supportive measures are a critical component of comprehensive care. A literature review of the current diagnostic methods, randomized controlled trials, and available treatments was undertaken; and a comprehensive discussion of best-practice supportive care measures is provided. Although the prognosis for those diagnosed with neoplastic meningitis is poor, treatment and supportive care may allow stabilization of neurologic symptoms and afford protection from further neurologic deterioration, allowing patients to maximize their function and independence and adjust their expectations of treatment from cure to palliation.</p>","PeriodicalId":75116,"journal":{"name":"The journal of supportive oncology","volume":"10 2","pages":"45-53"},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.suponc.2011.06.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30214513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}