The journal of allergy and clinical immunology. Global最新文献

{"title":"The triple radiologic asthma phenotype is associated with worse disease control","authors":"Rory Chan MBChB, PhD ,&nbsp;Chary Duraikannu FRCR ,&nbsp;Mohamed Jaushal Thouseef FRCR ,&nbsp;Brian Lipworth MD","doi":"10.1016/j.jacig.2024.100341","DOIUrl":"10.1016/j.jacig.2024.100341","url":null,"abstract":"<div><h3>Background</h3><div>Efforts have been made to combine radiographic biomarkers such as bronchiectasis or bronchial wall thickness (BWT) for the purpose of identifying asthma subphenotypes and their clinical implications.</div></div><div><h3>Objective</h3><div>Our aim was to assess whether a composite triple radiologic phenotype measured by high-resolution computed tomography comprising BWT, mucus plug score (MPS), and mediastinal lymph node (MLN) size might provide a better insight into subphenotypes in persistent asthma.</div></div><div><h3>Methods</h3><div>A total of 112 patients with moderate-to-severe asthma were included in this retrospective observational study. A binary method was used to classify patients according to median values for the following: a pooled mediastinal lymph node size of 3.6 mm or more; a BWT as a pooled wall area of at least 50% of the total airway area; and a mucus plug score of 1 or higher, with a mucus plug considered positive if complete bronchial obstruction was imaged more than 2 cm from a pleural surface.</div></div><div><h3>Results</h3><div>Patients with the triple imaging phenotype exhibited significantly worse Asthma Control Questionnaire scores, with their scores exceeding minimal clinical important difference, a higher prevalence of concomitant chronic rhinosinusitis with nasal polyps, and a greater total IgE level.</div></div><div><h3>Conclusion</h3><div>We have demonstrated an association between poorer symptom control and the triple radiologic asthma phenotype.</div></div>","PeriodicalId":75041,"journal":{"name":"The journal of allergy and clinical immunology. Global","volume":"3 4","pages":"Article 100341"},"PeriodicalIF":0.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142427957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report of secondary T-cell deficiency following the AstraZeneca COVID-19 vaccine","authors":"Amin Esmailian BSC (Hons), MD ,&nbsp;Sara Laura Barnes MBBS (Hons), MBA, FRACP, ADJAOP ,&nbsp;Marsus Pumar BBiomedSc (Hons), BMBS, MPhil","doi":"10.1016/j.jacig.2024.100339","DOIUrl":"10.1016/j.jacig.2024.100339","url":null,"abstract":"<div><div>We present a case of secondary T-cell deficiency particularly affecting CD4 T cells, along with the emergence of chronic spontaneous urticaria in a patient following COVID-19 vaccination. The condition was partially managed with omalizumab after initial first-line therapy proved ineffective.</div></div>","PeriodicalId":75041,"journal":{"name":"The journal of allergy and clinical immunology. Global","volume":"3 4","pages":"Article 100339"},"PeriodicalIF":0.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772829324001358/pdfft?md5=18984cb165c25986a8596a564a6b8786&pid=1-s2.0-S2772829324001358-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142314326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of cardiovascular events in a population-based Danish cohort with atopic dermatitis","authors":"Alexander Egeberg MD, PhD ,&nbsp;Andreas Wollenberg MD ,&nbsp;Thomas Bieber MD, PhD ,&nbsp;Adina R. Lemeshow PhD ,&nbsp;Shefali Vyas MD","doi":"10.1016/j.jacig.2024.100338","DOIUrl":"10.1016/j.jacig.2024.100338","url":null,"abstract":"<div><h3>Background</h3><div>The risk of cardiovascular disease in atopic dermatitis (AD) is not well established.</div></div><div><h3>Objectives</h3><div>Our aims were to evaluate the incidence rate (IR) of venous thromboembolism (VTE) in patients with AD in a population-based cohort study and to assess atherosclerotic cardiovascular disease (ASCVD) risk factors and incidence of malignancies, major adverse cardiovascular events (MACE), and VTE in patients with AD and rheumatoid arthritis (RA) in a nested cohort analysis.</div></div><div><h3>Methods</h3><div>Data from individuals age 12 years or older (nested cohort age ≥ 18 years) from January 1, 2000, to December 31, 2018, were extracted from the Danish National Patient Registry. Patients with AD were age- and sex-matched with 10 healthy controls. ASCVD risk factors included age 65 years or older and history of smoking, coronary artery disease, stroke, deep vein thrombosis (DVT), pulmonary embolism (PE), and malignancy.</div></div><div><h3>Results</h3><div>The population-based cohort comprised 190,751 patients (17,341 patients with AD and 173,410 healthy controls). The IRs per 100 patient-years were comparable between the AD cohort and healthy controls for VTE (0.14 [95% CI = 0.12-0.16] vs 0.11 [95% CI = 0.11-0.12]), DVT (0.08 [95% CI = 0.06-0.09] vs 0.06 [95% CI = 0.06-0.07]), and PE (0.06 [95% CI = 0.05-0.08] vs 0.05 [95% CI = 0.05-0.05]). The IR for VTE was higher in the AD cohort age 65 years or older (0.71 [95% CI = 0.56-0.90]) than in the age-matched controls (0.50 [95% CI = 0.46-0.54]). ASCVD risk factors were more frequent in the patients with RA than in the patients with AD. The IRs for malignancies and MACE were higher with specific ASCVD risk factors.</div></div><div><h3>Conclusions</h3><div>The IRs of cardiovascular events were comparable between the AD cohort and general population. The risk of VTE, malignancy, or MACE was higher with specific ASCVD risk factors, underscoring the need for patient monitoring.</div></div>","PeriodicalId":75041,"journal":{"name":"The journal of allergy and clinical immunology. Global","volume":"3 4","pages":"Article 100338"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142326999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carboxymethylcellulose: A hidden culprit in immediate hypersensitivity reactions after triamcinolone injections","authors":"Aiwei Yan MD ,&nbsp;Edward Fernandez MD ,&nbsp;Matthew Steven Krantz MD ,&nbsp;Basil M. Kahwash MD ,&nbsp;Elizabeth J. Phillips MD ,&nbsp;Cosby A. Stone Jr. MD, MPH","doi":"10.1016/j.jacig.2024.100337","DOIUrl":"10.1016/j.jacig.2024.100337","url":null,"abstract":"<div><div>We aim to bring awareness of allergies to excipients such as carboxymethylcellulose as “hidden dangers” that can be easily missed in diagnosis, leading to severe effects on patient health, and falsely limit the drug treatments that a patient can receive.</div></div>","PeriodicalId":75041,"journal":{"name":"The journal of allergy and clinical immunology. Global","volume":"3 4","pages":"Article 100337"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772829324001334/pdfft?md5=23fef908c2b03bf14f54458265c5a4f2&pid=1-s2.0-S2772829324001334-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 vaccine uptake among young adults and influence of asthma","authors":"Hineptch Daungsupawong PhD ,&nbsp;Viroj Wiwanitkitb MD","doi":"10.1016/j.jacig.2024.100331","DOIUrl":"10.1016/j.jacig.2024.100331","url":null,"abstract":"","PeriodicalId":75041,"journal":{"name":"The journal of allergy and clinical immunology. Global","volume":"3 4","pages":"Article 100331"},"PeriodicalIF":0.0,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772829324001279/pdfft?md5=2b100bbed9cd6477c993c1a627bd3d9e&pid=1-s2.0-S2772829324001279-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142162366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the scientific reliability of ChatGPT as a source of information on asthma","authors":"Simon Høj BSc ,&nbsp;Simon Francis Thomsen MD, PhD, DMSci ,&nbsp;Charlotte Suppli Ulrik MD, PhD, DMSci ,&nbsp;Hanieh Meteran MD ,&nbsp;Torben Sigsgaard MD, PhD ,&nbsp;Howraman Meteran MD, PhD","doi":"10.1016/j.jacig.2024.100330","DOIUrl":"10.1016/j.jacig.2024.100330","url":null,"abstract":"<div><h3>Background</h3><p>This study assessed the reliability of ChatGPT as a source of information on asthma, given the increasing use of artificial intelligence–driven models for medical information. Prior concerns about misinformation on atopic diseases in various digital platforms underline the importance of this evaluation.</p></div><div><h3>Objective</h3><p>We aimed to evaluate the scientific reliability of ChatGPT as a source of information on asthma.</p></div><div><h3>Methods</h3><p>The study involved analyzing ChatGPT’s responses to 26 asthma-related questions, each followed by a follow-up question. These encompassed definition/risk factors, diagnosis, treatment, lifestyle factors, and specific clinical inquiries. Medical professionals specialized in allergic and respiratory diseases independently assessed the responses using a 1-to-5 accuracy scale.</p></div><div><h3>Results</h3><p>Approximately 81% of the responses scored 4 or higher, suggesting a generally high accuracy level. However, 5 responses scored &gt;3, indicating minor potentially harmful inaccuracies. The overall median score was 4. Fleiss multirater kappa value showed moderate agreement among raters.</p></div><div><h3>Conclusion</h3><p>ChatGPT generally provides reliable asthma-related information, but its limitations, such as lack of depth in certain responses and inability to cite sources or update in real time, were noted. It shows promise as an educational tool, but it should not be a substitute for professional medical advice. Future studies should explore its applicability for different user demographics and compare it with newer artificial intelligence models.</p></div>","PeriodicalId":75041,"journal":{"name":"The journal of allergy and clinical immunology. Global","volume":"3 4","pages":"Article 100330"},"PeriodicalIF":0.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772829324001267/pdfft?md5=31dff3c3eab39fc9f40519b2c8ca51eb&pid=1-s2.0-S2772829324001267-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acidic oral environment’s potential contribution to palladium-induced systemic contact dermatitis: Case report","authors":"Takeya Adachi MD, PhD ,&nbsp;Katsunori Masaki MD, PhD ,&nbsp;Kazuyo Sujino MD ,&nbsp;Utako Okata-Karigane MD ,&nbsp;Taro Murakami MD ,&nbsp;Chiaki Takahashi MD ,&nbsp;Shiori Nakayama DMD ,&nbsp;Saki Tomiyasu MD ,&nbsp;Masato Asaoka MD ,&nbsp;Hiroki Kabata MD, PhD ,&nbsp;Jun Miyata MD, PhD ,&nbsp;Hayato Takahashi MD, PhD ,&nbsp;Koichi Fukunaga MD, PhD","doi":"10.1016/j.jacig.2024.100333","DOIUrl":"10.1016/j.jacig.2024.100333","url":null,"abstract":"<div><p>Acidic oral environments may trigger systemic contact dermatitis via ionization of metals, including palladium. A patch test revealed a late delayed positive response to palladium, emphasizing the need for nuanced diagnostic approaches for allergy management.</p></div>","PeriodicalId":75041,"journal":{"name":"The journal of allergy and clinical immunology. Global","volume":"3 4","pages":"Article 100333"},"PeriodicalIF":0.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772829324001292/pdfft?md5=8428938c544271cbd1457b9b34bb0eaa&pid=1-s2.0-S2772829324001292-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The first case of erythritol-induced anaphylaxis in Europe diagnosed with skin tests and basophil activation tests","authors":"Marco Dubini MD ,&nbsp;Patrizia Pignatti PhD ,&nbsp;Federica Rivolta MD ,&nbsp;Antonella Gurrado BSc ,&nbsp;Paolo Marraccini MD","doi":"10.1016/j.jacig.2024.100335","DOIUrl":"10.1016/j.jacig.2024.100335","url":null,"abstract":"<div><p>The use of erythritol as a food sweetener has spread significantly from Japan throughout the world. We describe a case of severe anaphylaxis due to immediate-type allergy to erythritol that was diagnosed with <em>in vitro</em> basophil activation tests and <em>in vivo</em> skin tests.</p></div>","PeriodicalId":75041,"journal":{"name":"The journal of allergy and clinical immunology. Global","volume":"3 4","pages":"Article 100335"},"PeriodicalIF":0.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772829324001310/pdfft?md5=ed7e3be22d234629a978b27fed6d9c70&pid=1-s2.0-S2772829324001310-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BAFF-associated granulomatous lung disease in a patient with GATA2 deficiency","authors":"Motoko Yasutomi-Sakai MD, PhD ,&nbsp;Taihei Hayashi MD, PhD ,&nbsp;Koji Suzuki MD, PhD ,&nbsp;Hayaki Akeda MD ,&nbsp;Yumekichi Maeda MD, PhD ,&nbsp;Akitoshi Okada MD ,&nbsp;Toshihiro Takeda MD ,&nbsp;Yasuhiro Watanabe MD ,&nbsp;Yoshiaki Imamura MD, PhD ,&nbsp;Yusei Ohshima MD, PhD","doi":"10.1016/j.jacig.2024.100336","DOIUrl":"10.1016/j.jacig.2024.100336","url":null,"abstract":"<div><p>A patient with GATA2 deficiency developed corticosteroid-responsive sterile granulomatous lung disease despite monocytopenia. The presence of B-lymphopenia, autoimmunity, an elevated level of serum B-cell–activating factor, and pulmonary plasma cell infiltration, which together suggested an underlying mechanism similar to that of combined variable immunodeficiency lung disease.</p></div>","PeriodicalId":75041,"journal":{"name":"The journal of allergy and clinical immunology. Global","volume":"3 4","pages":"Article 100336"},"PeriodicalIF":0.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772829324001322/pdfft?md5=9faac18996a29cf60cb46ce01563dc80&pid=1-s2.0-S2772829324001322-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic literature review of asthma biologic self-administration enhanced by a patient perspective","authors":"Simona Boccaletti MSc ,&nbsp;Rafael Alfonso-Cristancho PhD ,&nbsp;Waseem Ahmed MBA ,&nbsp;Lehanne Sergison ,&nbsp;Adaeze Eze MSc ,&nbsp;Prashant Auti MS (Pharm) ,&nbsp;Cathelijne Alleman MSc ,&nbsp;Lohit Badgujar PhD ,&nbsp;Nicholas Halfpenny MSc ,&nbsp;Dorothea Heldt MSc","doi":"10.1016/j.jacig.2024.100334","DOIUrl":"10.1016/j.jacig.2024.100334","url":null,"abstract":"<div><h3>Background</h3><div>Several biologics for the treatment of severe asthma are available as self-administration devices.</div></div><div><h3>Objective</h3><div>We performed a systematic literature review to understand the use, benefits, and challenges of these self-administration devices.</div></div><div><h3>Methods</h3><div>Electronic databases and conference proceedings were searched using terms for asthma, biologic treatment, and at-home/self-administration (GSK study 213094). Publications were scanned for relevance using prespecified Population, Intervention, Comparison, Outcomes, Study Design (PICOS) criteria. Data on efficacy, safety, patient experience, and economic outcomes were extracted; study quality was assessed. A firsthand patient perspective was obtained.</div></div><div><h3>Results</h3><div>Thirty-five of 504 records met the inclusion criteria. Across four phase 3 studies, ≥95% of biologic self-administrations were successful on the basis of predefined criteria. At-home self-administration was preferred over in-clinic administration by 43-96% of patients across 5 studies. Most patients (≥89%) in two phase 3 studies reported completing self-administration easily without repeated reference to instructions; high proportions of patients (≥98%) were confident in their ability to self-administer their biologic, and ≥96% rated it as extremely, very or moderately easy to self-administer. Across 16 studies reporting efficacy data, there was evidence of reduced blood eosinophil counts and improved asthma control with biologic self-administration, with improved health-related quality of life shown across 6 studies. Economic outcomes data were limited. From a patient perspective, autonomy is the major benefit of self-administration.</div></div><div><h3>Conclusion</h3><div>Although more evidence is needed, this systematic literature review provides consistent evidence of high injection success rates and, supported by a patient perspective, preference for self-administration of biologics among patients with severe asthma.</div></div>","PeriodicalId":75041,"journal":{"name":"The journal of allergy and clinical immunology. Global","volume":"3 4","pages":"Article 100334"},"PeriodicalIF":0.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772829324001309/pdfft?md5=d952829a934e948b9e28bfd850c74b84&pid=1-s2.0-S2772829324001309-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}