The European journal of cardiovascular medicine最新文献

{"title":"Effects of Aerobic Fitness and Adiposity on Coagulation Biomarkers in Men vs. Women with Elevated Blood Pressure.","authors":"Kathleen L Wilson, Lianne Tomfohr, Kate Edwards, Cindy Knott, Suzi Hong, Laura Redwine, Karen Calfas, Cheryl L Rock, Roland von Känel, Paul J Mills","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A hypercoagulable state is a potential mechanism linking elevated blood pressure (BP), adiposity and a sedentary lifestyle to development of coronary heart disease (CHD). We examined relationships among aerobic fitness and adiposity in 76 sedentary subjects with elevated BP. Blood levels of plasminogen activator inhibitor-1 (PAI-1), D-dimer, von Willebrand factor (vWF) and thrombomodulin were assessed as biomarkers of coagulation. In individuals with elevated BP, percent body fat and fitness were associated with biomarkers indicative of a hypercoagulable state, even after demographic and metabolic factors were considered. D-dimer was positively associated with percent body fat (beta=0.37, p=0.003). PAI-1 was higher in men than in women (beta=-0.31, p=0.015) and associated with lower VO2peak (beta=-0.35, p=0.024). Thrombomodulin was positively associated with VO2peak (beta=0.56, p< 0.01). vWF was not significantly associated with fitness or adiposity. Our results emphasise that both percent body fat and physical fitness are important in the maintenance of haemostatic balance.</p>","PeriodicalId":75000,"journal":{"name":"The European journal of cardiovascular medicine","volume":"2 2","pages":"122-128"},"PeriodicalIF":0.0,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480183/pdf/nihms-410972.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31010245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal Antihypertensive Combination Treatments","authors":"M. Volpe, G. Tocci, S. A. Omar","doi":"10.5083/EJCM.20424884.76","DOIUrl":"https://doi.org/10.5083/EJCM.20424884.76","url":null,"abstract":"","PeriodicalId":75000,"journal":{"name":"The European journal of cardiovascular medicine","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70861494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Hybrid and Norwood Strategies in Hypoplastic Left Heart Syndrome","authors":"H. Kato, O. Honjo, C. Caldarone, G. Arsdell","doi":"10.5083/EJCM.20424884.70","DOIUrl":"https://doi.org/10.5083/EJCM.20424884.70","url":null,"abstract":"The Norwood-based strategy for single ventricle palliation has improved with technical innovations and refinements over the last decades; such as regional cerebral perfusion during aortic arch reconstruction [1], placement of a right ventricle-to-pulmonary artery (RV-PA) shunt rather than a systemic-to-pulmonary shunt [2, 3], and the concept of aggressive afterload reduction to maximise oxygen delivery following Norwood procedure [4, 5].","PeriodicalId":75000,"journal":{"name":"The European journal of cardiovascular medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70861637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-eluting Balloons in Coronary Artery Disease: Past, Present and Future","authors":"A. Belkacemi, P. Stella, M. Voskuil, K. Onsea, Chunlai Shao, P. Doevendans, Pierfrancesco Agoston","doi":"10.5083/EJCM.20424884.69","DOIUrl":"https://doi.org/10.5083/EJCM.20424884.69","url":null,"abstract":"The use of drug eluting stents (DES) majorly reduced in-stent restenosis though preventing not only recoil of the vessel wall and late negative remodelling, but also significantly inhibiting neo-intimal hyperplasia formation. However, concerns about in-stent thrombosis, and the dependency on prolonged dual antiplatelet therapy, and continued restenosis in complex lesion subsets, led to a search for alternative treatment devices that will tackle restenosis rates without the drawbacks associated with DES.2-5 1. University Medical Center Utrecht, department of Interventional Cardiology","PeriodicalId":75000,"journal":{"name":"The European journal of cardiovascular medicine","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70861518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How To Prevent Foot Ulcers In Diabetic Patients","authors":"G. Morshed","doi":"10.5083/EJCM.20424884.75","DOIUrl":"https://doi.org/10.5083/EJCM.20424884.75","url":null,"abstract":"Among diabetics, 15% are at risk of developing foot ulcers(1). Annual incidence ranges between 1% to 4.1%(2) and prevalence is between 4% to 10%(3-4). Diabetic foot problems are one of the commonest causes of admission to hospital for diabetic sufferers, and diabetics are affected more than non diabetics(5). Foot ulcers affect the physical and emotional state of diabetic persons and can lead to financial losses(6-9).","PeriodicalId":75000,"journal":{"name":"The European journal of cardiovascular medicine","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70861861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echocardiographic Partition Values and Prevalence of Left Ventricular Hypertrophy in Hypertensive Jamaicans","authors":"Chiranjivi Potu, Edwin Tulloch-Reid, Dainia S. Baugh, Olusegun. A Ismail, E. Madu","doi":"10.5083/EJCM.20424884.73","DOIUrl":"https://doi.org/10.5083/EJCM.20424884.73","url":null,"abstract":"Background: Left ventricular hypertrophy (LVH) detected by either electrocardiography or echocardiography has been shown to be an extremely strong predictor of morbidity and mortality in patients with essential hypertension and in members of the general population. Alternative to LVH, left ventricular geometrical patterns offer incremental prognostic value beyond that provided by the other cardiovascular risk factors including left ventricular mass (LVM). Combination of LVM and relative wall thickness (RWT) can be used to identify different left ventricular geometrical patterns. Various indexation methods normalised for LVM have been shown to offer prognostic significance. There was no prior study on the prevalence of LVH and geometric patterns in hypertensive patients in Jamaica using multiple partition values. Our study was designed to estimate the prevalence of LVH and geometrical patterns in a hypertensive Caribbean population in Jamaica using 10 different published cut-off values. Methods: Clinical and echocardiographic data were collected from 525 consecutive hypertensive patients attending the cardiology clinic of the Heart Institute of the Caribbean over a period of 24 months who met the inclusion criteria for the study. LVM was calculated using different methods of indexation for body size and different partition values (PV) to identify LVH as described below: LVM/ BSA (g/m 2 ) PVs for men/women 116/104, 125/110, 125/125, 131/100; LVM/height (g/m) PVs 143/102, 126/105; LVM/height 2.0 PV 77.5/58.0; LVM/height 2.13 PV 68/61 and LVM/height 2.7 (g/m 2.7 ) PVs 51/51 and 49.2/46.7. RWT was calculated using the formula 2 X Posterior Wall Thickness (PWT)/ Left Ventricular Internal Diameter in diastole (LVIDd). Left ventricular geometrical patterns were categorised utilising the RWT and LVM. The impact of selected indexation methods and PVs on the prevalence of LVH and geometrical patterns were analysed. Results: Complete data was obtained in 501(95.5%) of the 525 subjects (40.5% men & 59.5% women). The prevalence of LVH ranged between 19.3–38.5%. The highest prevalence of LVH was found when the LVM was indexed to the height with a partition value of 126 g/ht in men and 105 g/ht in women and height raised to the power of 2.7 with a partition value of 49.2 g/ht 2.7 in men and 46.7 g/ht 2.7 in women. Abnormal LV geometry ranged between 71.4-77.8%. Concentric remodelling was the most common type of abnormal geometry (38.5-52.1%) while the eccentric hypertrophy was the least common type (3.99-10.3%) found for all indexation methods and partition values. Concentric hypertrophy (15.3-28.9%) was the second most common type of abnormal geometry found in our patients.","PeriodicalId":75000,"journal":{"name":"The European journal of cardiovascular medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70861810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management Options in Atrial Fibrillation – The Role of Vernakalant","authors":"S. Hohnloser, S. A. Omar","doi":"10.5083/EJCM.20424884.61","DOIUrl":"https://doi.org/10.5083/EJCM.20424884.61","url":null,"abstract":"AF is characterised by uncoordinated electrical activation of the atria, apparent as the absence of coordinated P waves on the ECG. This rapid supraventricular activity then leads to an irregularly irregular and usually rapid ventricular response rate.[1] The pathophysiology of AF is complex and likely to be multifactorial. Its existence is reliant on the structural and electrical remodelling of the left atrium, which provides the substrate that sustains the arrhythmia. Often, AF is initiated by a trigger originating from the root of the pulmonary veins. [2, 3]","PeriodicalId":75000,"journal":{"name":"The European journal of cardiovascular medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70861618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of risk factors and cardiovascular disease in diabetes care - 2011","authors":"J. Cederholm, P. Nilsson","doi":"10.5083/EJCM.20424884.43","DOIUrl":"https://doi.org/10.5083/EJCM.20424884.43","url":null,"abstract":"Evidence exists today from observational studies that hyperglycemia is an important risk factor for cardiovascular diseases, with a risk increase per 1 %-unit increase in HbA1c of 27% in type 1 diabetes (1) and 11-16% in type 2 diabetes (2, 3), independently of clinical characteristics and other traditional risk factors. A risk reduction by glucose-lowering has most obviously been demonstrated in patients with type 1 diabetes, often younger or middle-aged with less traditional risk factors than patients with type 2 diabetes.","PeriodicalId":75000,"journal":{"name":"The European journal of cardiovascular medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5083/EJCM.20424884.43","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70861017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epicardial Ventricular Tachycardia Ablation: Clinical Practice and Recent Developments","authors":"M. Efremidis, G. Kollias, Athens Greece","doi":"10.5083/EJCM.20424884.48","DOIUrl":"https://doi.org/10.5083/EJCM.20424884.48","url":null,"abstract":"It is ambiguous whether one should use this approach only after an endocardial VT ablation failure or when the ECG of clinical VT suggests an epicardial origin. Consequently, multiple published ECG criteria may be used to predict epicardial VT origin. A maximal deflection index (MDI, the longest precordial lead onset-peak time divided by total QRS duration) of 0.55 or more is reported to identify idiopathic epicardial VT with high sensitivity and specificity (4).","PeriodicalId":75000,"journal":{"name":"The European journal of cardiovascular medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5083/EJCM.20424884.48","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70861323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal Complications Following Heart Surgery: An Updated Review","authors":"D. Karangelis, K. Oikonomou, T. Koufakis, G. Tagarakis","doi":"10.5083/EJCM.20424884.32","DOIUrl":"https://doi.org/10.5083/EJCM.20424884.32","url":null,"abstract":"Gastrointestinal (GI) complications occurring after cardiac surgery are considered as “second line” complications due to their scarcity. Cardiac surgeons, ICU staff and nursing personnel are usually aware and suspicious of cardiac-related mishappenings after heart surgery; however they often tend to underestimate potentially lethal manifestations involving the gastrointestinal track, or organs of the abdomen and subsequent complications because of their relative infrequency and the fact that they lack a “visible connection” to the primary target organ of the operation.","PeriodicalId":75000,"journal":{"name":"The European journal of cardiovascular medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5083/EJCM.20424884.32","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70860577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}