RPS pharmacy and pharmacology reports最新文献_第2页

A review of the medicinal uses and biological activities of Piliostigma thonningii (Schum). Milne-Redh Piliostigma thonningii（Schum）的药用价值和生物活性综述。米尔恩-雷德

RPS pharmacy and pharmacology reports Pub Date : 2024-02-09 DOI: 10.1093/rpsppr/rqae004

I. Abubakar, I. Malami, Aliyu Muhamamd, Tijjani Salihu Shinkafi, Dayyabu Shehu, Patrick MaduabuchiAja

{"title":"A review of the medicinal uses and biological activities of Piliostigma thonningii (Schum). Milne-Redh","authors":"I. Abubakar, I. Malami, Aliyu Muhamamd, Tijjani Salihu Shinkafi, Dayyabu Shehu, Patrick MaduabuchiAja","doi":"10.1093/rpsppr/rqae004","DOIUrl":"https://doi.org/10.1093/rpsppr/rqae004","url":null,"abstract":"\u0000 \u0000 \u0000 Piliostigma thonningii is a medicinal plant commonly found in Eastern and Western Africa with a potential traditional usage to treat various diseases. Several studies have revealed interesting pharmacological activities of the plant and different phytochemicals were identified. This study critically reviewed the medicinal uses, phytochemistry, and bioactivity of P. thonningii.\u0000 \u0000 \u0000 \u0000 Relevant databases including ISI Web of Knowledge, Science Direct, Scopus, PubMed, and Google Scholar as well as databases for theses were searched for information using the keyword P. thonningii and its synonym.\u0000 \u0000 \u0000 \u0000 P. thonningii is majorly prepared in Africa as a decoction, infusion, maceration, and ointment and administered orally or topically to treat several diseases such as malaria, cancer, hepatitis, diabetes, and others. Pharmacological studies have demonstrated activities including antimalarial, antiviral, antimicrobial, anti-proliferative, and other medicinal properties. Compounds including piliostigmin, C-methyl flavonols, quercetin, and others were among the active components.\u0000 \u0000 \u0000 \u0000 The general use of P. thonnigii in various medicinal forms in Africa presents a great opportunity for the development of innovative research toward the production of natural products and nutraceuticals. Nevertheless, additional studies especially in vivo are necessary to further elucidate the mechanism mediating the bioactivities, especially in relation to the medicinal and nutritional uses.\u0000","PeriodicalId":74744,"journal":{"name":"RPS pharmacy and pharmacology reports","volume":"410 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139848074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Theranostic Tools against Lung and Breast Cancers: Through the Lens of Mature Gold Nanoparticles and Emerging Graphene 抗击肺癌和乳腺癌的新疗法工具：通过成熟金纳米粒子和新兴石墨烯的视角

RPS pharmacy and pharmacology reports Pub Date : 2024-01-25 DOI: 10.1093/rpsppr/rqae003

Savuntherii Baskaran, Qi Yan Siew, Michelle T T Tan, H. Loh

{"title":"Theranostic Tools against Lung and Breast Cancers: Through the Lens of Mature Gold Nanoparticles and Emerging Graphene","authors":"Savuntherii Baskaran, Qi Yan Siew, Michelle T T Tan, H. Loh","doi":"10.1093/rpsppr/rqae003","DOIUrl":"https://doi.org/10.1093/rpsppr/rqae003","url":null,"abstract":"\u0000 \u0000 \u0000 In recent years, theranostic applications have emerged as promising tools in the fight against lung and breast cancers. This review aims to provide an in-depth exploration of the proof-of-concept theranostic applications of two cutting-edge nanomaterials: gold nanoparticles (AuNPs) and graphene.\u0000 \u0000 \u0000 \u0000 Nanotechnology plays a revolutionary role in cancer theranostics. AuNPs’ properties include high surface plasmon resonances, advantageous surface-to-volume ratio, remarkable photothermal conversion rates, and distinctive optical characteristics. Whereas graphene boasts high surface areas, optical transparency, and remarkable versatility in surface functionalisation. While AuNPs have long been recognised for their theranostic potential, this review spotlights the burgeoning role of graphene as a compelling choice for advancing theranostic applications in oncology with several exemplar studies. In fact, most recent advancements have witnessed the integration of AuNP-graphene nanocomposites in theranostic approaches targeting lung and breast cancers. Yet, there are still many intricate challenges that researchers face in harnessing the full potential of these nanomaterials in theranostics, from synthesis to clinical translation.\u0000 \u0000 \u0000 \u0000 This review provides valuable insights into both established and emerging nanomaterials. AuNPs show significant potential for diverse cancer theranostic applications, and graphene is rapidly evolving as a next-generation theranostic platform. The hybrid AuNP-graphene nanocomposite stands out as a promising candidate in the evolving landscape of cancer therapy, offering exciting prospects for future research and development.\u0000","PeriodicalId":74744,"journal":{"name":"RPS pharmacy and pharmacology reports","volume":"55 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139598997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PREDICTION OF NEW LIKELY EMERGENT AMINO ACID POINT MUTATIONS FROM USA, UK, ITALY, FRANCE, BRAZIL AND INDIA SARS-CoV-2 VARIANTS: A POSSIBLE SOURCE FOR MORE RELIABLE COCKTAIL CORONAVIRUS VACCINE 美国、英国、意大利、法国、巴西和印度 SARS-CoV-2 变异株新的可能突发氨基酸点突变的预测：更可靠的鸡尾酒冠状病毒疫苗的可能来源

RPS pharmacy and pharmacology reports Pub Date : 2024-01-08 DOI: 10.1093/rpsppr/rqae002

Saganuwan Alhaji Saganuwan

{"title":"PREDICTION OF NEW LIKELY EMERGENT AMINO ACID POINT MUTATIONS FROM USA, UK, ITALY, FRANCE, BRAZIL AND INDIA SARS-CoV-2 VARIANTS: A POSSIBLE SOURCE FOR MORE RELIABLE COCKTAIL CORONAVIRUS VACCINE","authors":"Saganuwan Alhaji Saganuwan","doi":"10.1093/rpsppr/rqae002","DOIUrl":"https://doi.org/10.1093/rpsppr/rqae002","url":null,"abstract":"\u0000 \u0000 \u0000 The interaction between genome components of the vaccines, host cells and SARS-CoV-2 variants can cause mutation of amino acids at high random frequency. Hence the present study is aimed at using the codon bases –amino acids components of some available strains with a view to determing new likely emergent strains of SARS-CoV-2.\u0000 \u0000 \u0000 \u0000 Some genome sizes and lengths of SARS-CoV-2 variants were either searched from literatures calculated. Point mutation of a single amino acid was deduced from 2/3 of sets of codon bases responsible for expression of amino acids. One base pair of 0.0047nm Codon Base Table was used to deduce the likely missense amino acids at probability of one-twentieth.\u0000 \u0000 \u0000 \u0000 New generated codon bases gave rise to new emergent strains of varying number of amino acid pairs. Amino acids have reappeared and disappeared in some strains. Nine strains altogether have shown stop codon bases and the remaining strains have tendency to form stop codons. Adenine has highest frequency of the stop codon bases whereas cytosine is not among stop codon. A total of 906 new variants were deduced from 54 coronavirus strains which initially lacked stop codons. The newly predicted strains may become less pathogenic and serve as immunogen via glycosylation. Strains with higher number of codon bases undergo mutation faster than that may end up in stop codons.\u0000 \u0000 \u0000 \u0000 Hence the likely emergent strains could be less virulent, less pathogenic and many from glycans that could serve as source for manufacturing of more reliable coronavirus vaccines.\u0000","PeriodicalId":74744,"journal":{"name":"RPS pharmacy and pharmacology reports","volume":"17 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139445387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Controlling chloroform content to a safe level in a pharmaceutical oral solution of Chloral hydrate 将水合氯醛口服药物溶液中的氯仿含量控制在安全水平

RPS pharmacy and pharmacology reports Pub Date : 2023-12-20 DOI: 10.1093/rpsppr/rqad036

J. T. McQuillan, H. Hashim, N. Woodbridge, K. Swaminathan

{"title":"Controlling chloroform content to a safe level in a pharmaceutical oral solution of Chloral hydrate","authors":"J. T. McQuillan, H. Hashim, N. Woodbridge, K. Swaminathan","doi":"10.1093/rpsppr/rqad036","DOIUrl":"https://doi.org/10.1093/rpsppr/rqad036","url":null,"abstract":"\u0000 Chloral hydrate is a halogenated hydrocarbon with sedative and hypnotic properties and has been used for its medicinal properties for many years. Its solubility and permeability determine it as a Biopharmaceutical Classification System Class 1 compound, and as such is ideal to be pharmaceutically presented as an aqueous oral liquid presentation. Its primary route of degradation is by hydrolysis to form formic acid and chloroform, and hence licensed pharmaceutical presentations require validated methods to analyse for these degradants. The content of the toxic chloroform degradation product was determined via a head-space gas chromatograph with a flame ionisation detector, and its level was controlled to a safe pharmaceutically acceptable level. This can be achieved by solution pH optimisation in the oral solution, incorporating a buffering system to control the rate of this degradation mechanism.\u0000 Where other behavioural and pharmacological therapies have failed for the treatment of short-term severe insomnia, a Chloral hydrate 500mg/5mL Oral Solution presentation with optimised safety profile has been developed as a medication for prescription. Extensive analytical and formulation development work has arrived at a room temperature stable oral solution, with a multi-year expiry date.","PeriodicalId":74744,"journal":{"name":"RPS pharmacy and pharmacology reports","volume":"17 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138955923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Useful trick for improvement of nasal spray use 改进鼻腔喷雾使用的实用窍门

RPS pharmacy and pharmacology reports Pub Date : 2023-12-01 DOI: 10.1093/rpsppr/rqad040

H. Jahandideh, M. Roomiani, Maryam Arab, Mohammad Dehghani Firouzabadi

引用次数: 0

Ethnopharmacology and phytochemistry of medicinal plants against enterocyte bacteria-linked infections and diarrhea in some African countries: A Systematic review 一些非洲国家针对肠道细菌相关感染和腹泻的药用植物的民族药理学和植物化学：系统综述

RPS pharmacy and pharmacology reports Pub Date : 2023-11-28 DOI: 10.1093/rpsppr/rqad041

H. Onohuean, B. Igere

{"title":"Ethnopharmacology and phytochemistry of medicinal plants against enterocyte bacteria-linked infections and diarrhea in some African countries: A Systematic review","authors":"H. Onohuean, B. Igere","doi":"10.1093/rpsppr/rqad041","DOIUrl":"https://doi.org/10.1093/rpsppr/rqad041","url":null,"abstract":"There is a dearth of relevant bioactive translational progress and post-scientific evidence on ethnopharmacology and phytochemistry of plants with anti-diarrheal potential in Africa. This study synthesized scientific evidence on commonly used African folkloric medicinal plants in the management/control of diarrhoea and antibiotic-resistant enterocyte-infecting bacteria in some African countries. Published articles from different databases on folk medicinal plants used in the treatment/management of bacteria-linked enterocyte infections and diarrhoea were reviewed systematically. The ethnopharmacology and phytochemistry of 75 folkloric plant species belonging to 67 families and 58 genera, including Asteraceae (10.45%), Myrtaceae (7.46%), (Anacardiaceae, Celastraceae, Fabaceae, Hydnoraceae) (5.97%) are the most used anti-diarrheal folkloric plants in the region. The minimum inhibitory concentration (MIC) (0.018mg/mL-8.45mg/mL) or (39μg/mL – 2000μg/mL) and 14.35 g/kg-8317.64 mg/kgLD50 on enterocyte bacteria strains. A solo author reported MIC of the pure component 6.25 μg/mL. Tree (38%) and tuber (3%) were the highest and least life forms of the folkloric plants used. Leaves (41%) were the most frequently used for folk preparations, while Aerial, fruits, seeds and combination of shoots+leaves (1.45%) were the least used. Fourteen authors' studies revealed the phytochemical profile, while six further elucidated the bioactive components of the folkloric plants used to manage diarrhoea. Our findings revealed the antibacterial potency of folkloric plants against diarrhoea and multiple antibiotic-resistant organisms. It suggests a gap in the appropriate documentation, application of such medicinal/folkloric plants, and low post-research advancement of effectively-tested plant types or bioactive agents, calling for well-organized future research engagements.","PeriodicalId":74744,"journal":{"name":"RPS pharmacy and pharmacology reports","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139221018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Twin-screw melt granulation for high-dose paracetamol tablets 用于高剂量扑热息痛片剂的双螺杆熔融制粒技术

RPS pharmacy and pharmacology reports Pub Date : 2023-11-24 DOI: 10.1093/rpsppr/rqad039

Steven A. Ross, M. S. Mithu, Dennis Douroumis

引用次数: 0

Preliminary investigation of organ-protective effects of fullerenol in vivo in acute toxicity during doxorubicin therapy in healthy pigs 健康猪阿霉素急性毒性治疗中富勒烯醇体内器官保护作用的初步研究

RPS pharmacy and pharmacology reports Pub Date : 2023-11-13 DOI: 10.1093/rpsppr/rqad038

Rade Injac, Aleksandar Djordjevic, Borut Strukelj

{"title":"Preliminary investigation of organ-protective effects of fullerenol in vivo in acute toxicity during doxorubicin therapy in healthy pigs","authors":"Rade Injac, Aleksandar Djordjevic, Borut Strukelj","doi":"10.1093/rpsppr/rqad038","DOIUrl":"https://doi.org/10.1093/rpsppr/rqad038","url":null,"abstract":"Abstract Objectives The potential protective effect of fullerenol C60(OH)24, a strong antioxidant, was investigated at a single dose of 25 mg/kg, administered orally (per os; p.o.) and intraperitoneally (i.p.), in the liver, lung, kidney, heart, and spleen of healthy pigs, prior to doxorubicin-induced toxicity at a single i.p. dose of 10 mg/kg. Methods We used the F1 generation of an in vivo pig model (whose parents were Swedish Landrace and Large Yorkshire), to explore whether fullerenol, administered 6 h for p.o. and 30 min for i.p. prior to doxorubicin treatment, could protect organs against damage caused by oxidative stress. Key findings According to the macroscopic, hematological, biochemical, and physiological results, fullerenol exerted a potential protective effect on all investigated organs (heart, liver, lung, spleen, and kidney) in pigs after i.p. administration. However, the results from fullerenol p.o. administration were inconclusive, therefore warranting further investigation. Conclusions Fullerenol at a low dose of 25 mg/kg demonstrated satisfactory organ protection against doxorubicin-induced toxicity in healthy pigs after i.p. injection, However, additional follow-up studies in pig models of cancer and with longer doxorubicin and fullerenol treatment periods would be required to further delineate the optimal and clinically-relevant conditions for fullerenol administration.","PeriodicalId":74744,"journal":{"name":"RPS pharmacy and pharmacology reports","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136281919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Anti-inflammatory and antioxidant activities assessment of an aqueous extract of Ceiba pentandra (L.) Gaertn (Malvaceae) 五角草水提物抗炎、抗氧化活性的研究Gaertn(锦葵科)

RPS pharmacy and pharmacology reports Pub Date : 2023-11-13 DOI: 10.1093/rpsppr/rqad037

Gniènèfèrètien Nounaféri Awa Silue, Mohamed Bonewendé Belemlilga, Ayoman Thierry-Lenoir Djadji, Tata Kadiatou Traore, Gilchrist Abdoul Laurent Boly, Moumouni Koala, Noufou Ouedraogo, Aristide Traore, Gisèle Kouakou-Siransy

{"title":"Anti-inflammatory and antioxidant activities assessment of an aqueous extract of <i>Ceiba pentandra</i> (L.) Gaertn (Malvaceae)","authors":"Gniènèfèrètien Nounaféri Awa Silue, Mohamed Bonewendé Belemlilga, Ayoman Thierry-Lenoir Djadji, Tata Kadiatou Traore, Gilchrist Abdoul Laurent Boly, Moumouni Koala, Noufou Ouedraogo, Aristide Traore, Gisèle Kouakou-Siransy","doi":"10.1093/rpsppr/rqad037","DOIUrl":"https://doi.org/10.1093/rpsppr/rqad037","url":null,"abstract":"Abstract Objective In traditional folk medicine, Ceiba pentandra has been used for its anti-diabetic and anti-infective effects. The present study investigates the anti-inflammatory and antioxidant activities of the aqueous extract of the plant's leaves. Methods The anti-oedematous tests with carrageenan and Lipoxygenase inhibition assay were carried out concerning anti-inflammatory studies. DPPH free radical scavenging, Ferric-reducing antioxidant power, ABTS.+ free radical scavenging assay, and lipid peroxide determination were investigated for antioxidant activities. Key findings As a result, C. pentandra extract inhibited edema between 3 and 5 h in the order of 83.07 % and 94.09 % at 200 kg. b.w and lipoxygenase enzyme with a percentage of 87.11 ± 3.02 %. This study used the lipid peroxidation level as a marker. The results of the lipid peroxidation test show a percentage inhibition of 49.60 %, close to Trolox 48.11 %, and present a good antioxidant activity compare to the free radical scavenging assay. Conclusions The aqueous decoction of C. pentandra leaves has demonstrated anti-inflammatory solid activities as well as lipid peroxidation due to the presence of phytochemical groups of interest such as sterols, polyphenols, quinones, catechin tannins, flavonoids, and saponins.","PeriodicalId":74744,"journal":{"name":"RPS pharmacy and pharmacology reports","volume":"121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136351615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Local drug delivery systems for the inner ear 内耳局部给药系统

RPS pharmacy and pharmacology reports Pub Date : 2023-10-20 DOI: 10.1093/rpsppr/rqad029

Xuelian Dong, Huaqiong Li, Wei Zuo

{"title":"Local drug delivery systems for the inner ear","authors":"Xuelian Dong, Huaqiong Li, Wei Zuo","doi":"10.1093/rpsppr/rqad029","DOIUrl":"https://doi.org/10.1093/rpsppr/rqad029","url":null,"abstract":"Abstract Objectives Recent advancements in molecular biology have led to a better understanding of the mechanisms associated with sensorineural hearing loss and other inner ear diseases. These developments offer hope for new treatment approaches benefiting millions of patients. However, drug therapy for the cochlea presents significant challenges, necessitating the development of innovative technologies to ensure safe and effective delivery of therapeutic compounds. Among these emerging technologies, microfluidic-based delivery systems are gaining attention as a promising method for direct intracochlear administration. Ultimately, these systems have the potential to provide sustained release of regenerative compounds, thereby restoring hearing in patients suffering from various auditory conditions. Key findings This article provides a comprehensive review of recent progress in the field of intracochlear drug delivery systems. In addition, the review encompasses passive systems, such as osmotic pumps, as well as active microfluidic devices. Moreover, the article discusses the integration of these delivery systems with existing cochlear implants. The primary objective is to offer a concise overview of the current state of development for intracochlear drug delivery systems, which can be combined with emerging therapeutic compounds to effectively treat inner ear diseases. Conclusions The safe and effective treatment of auditory diseases requires the development of microscale delivery devices capable of extended operation and direct application to the inner ear. To achieve this, significant advancements in miniaturization and integration of multiple functions are necessary. These functions include drug storage, delivery, power management, and sensing, ultimately enabling closed-loop control and timed-sequence delivery devices for the treatment of these diseases.","PeriodicalId":74744,"journal":{"name":"RPS pharmacy and pharmacology reports","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135617575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0