Recent trends in pharmaceutical sciences and research最新文献

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Effect of Tamoxifen on Ethanol Induced Gastric Ulcer in Rats 他莫昔芬对乙醇性大鼠胃溃疡的影响
Recent trends in pharmaceutical sciences and research Pub Date : 2021-04-05 DOI: 10.46610/RTPSCR.2021.V03I01.005
Malak M. Eljafari, Al-Asayed R. Al-Attar
{"title":"Effect of Tamoxifen on Ethanol Induced Gastric Ulcer in Rats","authors":"Malak M. Eljafari, Al-Asayed R. Al-Attar","doi":"10.46610/RTPSCR.2021.V03I01.005","DOIUrl":"https://doi.org/10.46610/RTPSCR.2021.V03I01.005","url":null,"abstract":"Background: Tamoxifen is selective estrogen receptor modulators, used in treatment of breast cancer, some literatures reported its impact on the process of peroxidation. Aim: The aim of this study was to evaluate the effect of tamoxifen on ethanol induced gastric ulcer in rats. Method: Gastric ulcers were induced in Wistar albino rats by oral administration of absolute alcohol (1 ml/200 g). Antiulcer activity of tamoxifen (0.5 and 10 mg/kg, p.o.) was observed and compared to standard drug (omeprazole 20mg/kg, p.o.), the ulcer index, ulcers numbers, lengths, gastric volume and total gastric acidity were evaluated. Histopathology is performed for confirmation. Results: Tamoxifen in 10mg/kg dose produced a highly significant (P<0.001) decrease in ulcer parameters studied compared to ulcer control. While 0.5 mg/kg of tamoxifen produced a less significant (P<0.01) effect on gastric volume when compared to the ulcer group. The anti-ulcer effects of the drug of interest is highly compared to omeprazole was very, surprisingly; the higher dose of tamoxifen produced even a much significant reduction in gastric volume and ulcers length compered to standard drug. Conclusion: Tamoxifen shows significant antiulcer activity against ethanol induced gastric ulcers, and this could possibly related to its antioxidant properties.","PeriodicalId":74649,"journal":{"name":"Recent trends in pharmaceutical sciences and research","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87902912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmaceutical Management for Subarachnoid Hemorrhage. 蛛网膜下腔出血的药物治疗。
Arnav Barpujari, Chhaya Patel, Rebecca Zelmonovich, Alec Clark, Devan Patel, Kevin Pierre, Kyle Scott, Brandon Lucke Wold
{"title":"Pharmaceutical Management for Subarachnoid Hemorrhage.","authors":"Arnav Barpujari, Chhaya Patel, Rebecca Zelmonovich, Alec Clark, Devan Patel, Kevin Pierre, Kyle Scott, Brandon Lucke Wold","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Aneurysmal subarachnoid hemorrhage can have deleterious consequences. Vasospasm, delayed cerebral ischemia, and re-hemorrhage can all cause delayed sequelae. Furthermore, severe headaches are common and require careful modulation of pain medications. Limited treatment options currently exist and are becoming more complex with the rising use of oral anticoagulants needing reversal. In this review, we highlight the current treatment options currently employed and address avenues of future discovery based on emerging preclinical data. Furthermore, we dive into the best treatment approach for managing headaches following subarachnoid hemorrhage. The review is designed to serve as a catalyst for further prospective investigation into this important topic.</p>","PeriodicalId":74649,"journal":{"name":"Recent trends in pharmaceutical sciences and research","volume":"3 2","pages":"16-30"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39785794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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