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Principles and practice of clinical research (2015)最新文献

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The HABIT: Heparin and Aspirin on Birth in Inherited Thrombophilia, an International Multicenter Phase IIb Randomized Triple Blinded Clinical Trial HABIT：肝素和阿司匹林在遗传性血栓形成倾向症出生时的作用，一项国际多中心IIb期随机三盲临床试验
Principles and practice of clinical research (2015) Pub Date : 2022-12-20 DOI: 10.21801/ppcrj.2022.83.8
Alessandra Carvalho
{"title":"The HABIT: Heparin and Aspirin on Birth in Inherited Thrombophilia, an International Multicenter Phase IIb Randomized Triple Blinded Clinical Trial","authors":"Alessandra Carvalho","doi":"10.21801/ppcrj.2022.83.8","DOIUrl":"https://doi.org/10.21801/ppcrj.2022.83.8","url":null,"abstract":"","PeriodicalId":74496,"journal":{"name":"Principles and practice of clinical research (2015)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47940387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of an mHealth App as an add-on for Smoking Cessation in One year: A multicenter and randomized Trial (The MASCOT study) 一款移动健康应用在一年内作为戒烟辅助工具的有效性:一项多中心随机试验(MASCOT研究)
Principles and practice of clinical research (2015) Pub Date : 2022-12-20 DOI: 10.21801/ppcrj.2022.83.6
Tatiana Gomez Gomez
{"title":"Effectiveness of an mHealth App as an add-on for Smoking Cessation in One year: A multicenter and randomized Trial (The MASCOT study)","authors":"Tatiana Gomez Gomez","doi":"10.21801/ppcrj.2022.83.6","DOIUrl":"https://doi.org/10.21801/ppcrj.2022.83.6","url":null,"abstract":"","PeriodicalId":74496,"journal":{"name":"Principles and practice of clinical research (2015)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42805511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuromuscular Electrical Stimulation (NMES) as an Add-on Therapy for the Improvement of Dyspnea in Patients with Post-Covid Syndrome: a Protocol for a Phase II Randomized, Non-Pharmacological Intervention-Controlled, Double-Blind Study. 神经肌肉电刺激(NMES)作为改善新冠肺炎后综合征患者呼吸困难的附加疗法:一项随机、非药物干预对照、双盲研究方案
Principles and practice of clinical research (2015) Pub Date : 2022-12-20 DOI: 10.21801/ppcrj.2022.83.1
Anusree Anil Kumar
{"title":"Neuromuscular Electrical Stimulation (NMES) as an Add-on Therapy for the Improvement of Dyspnea in Patients with Post-Covid Syndrome: a Protocol for a Phase II Randomized, Non-Pharmacological Intervention-Controlled, Double-Blind Study.","authors":"Anusree Anil Kumar","doi":"10.21801/ppcrj.2022.83.1","DOIUrl":"https://doi.org/10.21801/ppcrj.2022.83.1","url":null,"abstract":"","PeriodicalId":74496,"journal":{"name":"Principles and practice of clinical research (2015)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41536297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Cannabidiol Versus Ibuprofen in the Relief of Menstrual Pain in Females Living with Primary Dysmenorrhea A phase II, Non-Inferiority trial 大麻二酚与布洛芬缓解女性原发性痛经疼痛的疗效:II期非劣效性试验
Principles and practice of clinical research (2015) Pub Date : 2022-12-20 DOI: 10.21801/ppcrj.2022.83.7
Haneesha Mohan
{"title":"Efficacy of Cannabidiol Versus Ibuprofen in the Relief of Menstrual Pain in Females Living with Primary Dysmenorrhea A phase II, Non-Inferiority trial","authors":"Haneesha Mohan","doi":"10.21801/ppcrj.2022.83.7","DOIUrl":"https://doi.org/10.21801/ppcrj.2022.83.7","url":null,"abstract":"Introduction: Pain is the cardinal symptom in women living with primary dysmenorrhea (PDM), resulting in a relentless negative effect on their quality of life. Women with PDM have higher levels of prostaglandin in their endometrial fluid, which correlates with the degree of pain. The standard of care treatment for pain associated with PDM starts with nonsteroidal anti-inflammatory drugs (NSAIDs) that block prostaglandin-triggering enzymes. Although NSAIDs are a feasible option, they are also associated with a significant risk of side effects. Around 20 to 25% of patients will experience pain refractory to NSAIDs and seek alternative therapies. Cannabidiol (CBD) is a well-tolerated potential therapy for several chronic diseases, including pain, and acts by blocking prostaglandin-triggering enzymes, similar to NSAIDs. The safety of CBD is well established, with the advantage of acting via central and peripheral mechanisms. To date, no previous trials assessing CBD alone for dysmenorrhea have been conducted. Objective: To evaluate the effect of CBD alone in reducing acute menstrual pain compared to ibuprofen, as assessed by the total pain relief (TOTPAR) scale. Design: Randomized (with random block sizes), triple-blinded, multicenter, parallel-group, non-inferiority clinical trial. Participants: PDM patients aged 18 to 40 years, with regular menstrual cycles (ranging from 21 to 35 days) and a visual analog scale (VAS) score of ≥ 5. Academic Editor: Felipe Fregni Peer-reviewers: Natalia Suarez; Giovani Farina; Magali Andrea Pestana; Luis Morales Ojeda. Copyright: © 2022 by the authors. Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).","PeriodicalId":74496,"journal":{"name":"Principles and practice of clinical research (2015)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48093128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and hemodynamic phenotype of BMPR2 variation carriers with pulmonary arterial hypertension: A systematic review and a call to action 肺动脉高压BMPR2变异携带者的临床和血流动力学表型:系统回顾和行动呼吁
Principles and practice of clinical research (2015) Pub Date : 2022-12-20 DOI: 10.21801/ppcrj.2022.83.9
David Rodríguez, Miguel A. Floran-Bautista, B. Illigens, Tiago Lemos Cerqueira, A. Ramírez-Rivera, C. Jerjes-Sánchez
{"title":"Clinical and hemodynamic phenotype of BMPR2 variation carriers with pulmonary arterial hypertension: A systematic review and a call to action","authors":"David Rodríguez, Miguel A. Floran-Bautista, B. Illigens, Tiago Lemos Cerqueira, A. Ramírez-Rivera, C. Jerjes-Sánchez","doi":"10.21801/ppcrj.2022.83.9","DOIUrl":"https://doi.org/10.21801/ppcrj.2022.83.9","url":null,"abstract":"","PeriodicalId":74496,"journal":{"name":"Principles and practice of clinical research (2015)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42825400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and safety of over-the-scope clips® com-pared to through-the-scope clips for initial bleeding control in non-variceal upper gastrointestinal bleeding: a multicenter randomized clinical trial 非静脉曲张性上消化道出血患者经内镜夹与经内镜夹治疗初期出血的疗效和安全性：一项多中心随机临床试验
Principles and practice of clinical research (2015) Pub Date : 2022-12-20 DOI: 10.21801/ppcrj.2022.83.3
F. Lopes
{"title":"Efficacy and safety of over-the-scope clips® com-pared to through-the-scope clips for initial bleeding control in non-variceal upper gastrointestinal bleeding: a multicenter randomized clinical trial","authors":"F. Lopes","doi":"10.21801/ppcrj.2022.83.3","DOIUrl":"https://doi.org/10.21801/ppcrj.2022.83.3","url":null,"abstract":":","PeriodicalId":74496,"journal":{"name":"Principles and practice of clinical research (2015)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48986672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protective Effect of Surgical Masks versus N95 Respirator in Prevention of SARS-CoV-2 Contami-nation in Healthcare Professionals: Systematic Re-view Protocol 医用口罩与N95口罩对医护人员预防SARS-CoV-2污染的防护效果:系统评价方案
Principles and practice of clinical research (2015) Pub Date : 2022-12-20 DOI: 10.21801/ppcrj.2022.83.4
R. L. Gonçalves
{"title":"Protective Effect of Surgical Masks versus N95 Respirator in Prevention of SARS-CoV-2 Contami-nation in Healthcare Professionals: Systematic Re-view Protocol","authors":"R. L. Gonçalves","doi":"10.21801/ppcrj.2022.83.4","DOIUrl":"https://doi.org/10.21801/ppcrj.2022.83.4","url":null,"abstract":": Introduction","PeriodicalId":74496,"journal":{"name":"Principles and practice of clinical research (2015)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44130533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The KDEP Trial: Protocol for a phase II, multicenter, open label, randomized controlled trial to evaluate the efficacy of ketogenic diet for symptomatic improvement of moderate to severe Major Depressive Disorder KDEP试验：一项II期、多中心、开放标签、随机对照试验的方案，旨在评估生酮饮食对中重度重度抑郁症症状改善的疗效
Principles and practice of clinical research (2015) Pub Date : 2022-12-20 DOI: 10.21801/ppcrj.2022.83.10
Gargi Kakani
{"title":"The KDEP Trial: Protocol for a phase II, multicenter, open label, randomized controlled trial to evaluate the efficacy of ketogenic diet for symptomatic improvement of moderate to severe Major Depressive Disorder","authors":"Gargi Kakani","doi":"10.21801/ppcrj.2022.83.10","DOIUrl":"https://doi.org/10.21801/ppcrj.2022.83.10","url":null,"abstract":"","PeriodicalId":74496,"journal":{"name":"Principles and practice of clinical research (2015)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43787877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Bench to Bedside - the translation of intracortical inhibition marker to clinical practice. 编辑:从实验室到床边——皮质内抑制标志物到临床实践的转化。
Principles and practice of clinical research (2015) Pub Date : 2022-12-02 DOI: 10.21801/ppcrj.2022.83.11
Danielle Carolina Pimenta, Daniel Lima, Eric Slawka, Kevin Pacheco-Barrios, Felipe Fregni
{"title":"Editorial: Bench to Bedside - the translation of intracortical inhibition marker to clinical practice.","authors":"Danielle Carolina Pimenta, Daniel Lima, Eric Slawka, Kevin Pacheco-Barrios, Felipe Fregni","doi":"10.21801/ppcrj.2022.83.11","DOIUrl":"https://doi.org/10.21801/ppcrj.2022.83.11","url":null,"abstract":"","PeriodicalId":74496,"journal":{"name":"Principles and practice of clinical research (2015)","volume":"8 3","pages":"92-97"},"PeriodicalIF":0.0,"publicationDate":"2022-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343941/pdf/nihms-1863078.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9823803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Telehealth usability evaluation by healthcare professionals in post-pandemic treatment of non-communicable diseases (hypertension and diabetes): Systematic Review Protocol 卫生保健专业人员在大流行后非传染性疾病(高血压和糖尿病)治疗中的远程保健可用性评价:系统审查议定书
Principles and practice of clinical research (2015) Pub Date : 2022-11-28 DOI: 10.21801/ppcrj.2022.82.6
R. L. Gonçalves, A. Pagano, Z. Reis, Seth Kwaku Afagbedzi, Michael Head, K. Brackstone, M. Marcolino, T. Lopes, S. A. Cordeiro, J. M. Nunes, James Batchelor, A. L. P. Ribeiro
{"title":"Telehealth usability evaluation by healthcare professionals in post-pandemic treatment of non-communicable diseases (hypertension and diabetes): Systematic Review Protocol","authors":"R. L. Gonçalves, A. Pagano, Z. Reis, Seth Kwaku Afagbedzi, Michael Head, K. Brackstone, M. Marcolino, T. Lopes, S. A. Cordeiro, J. M. Nunes, James Batchelor, A. L. P. Ribeiro","doi":"10.21801/ppcrj.2022.82.6","DOIUrl":"https://doi.org/10.21801/ppcrj.2022.82.6","url":null,"abstract":"","PeriodicalId":74496,"journal":{"name":"Principles and practice of clinical research (2015)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42350326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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