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Citrus flavones Luteolin and Apigenin: targets fundamental mechanisms in colon cancer 柑橘类黄酮木犀草素和芹菜素:结肠癌的基本机制
Onco therapeutics Pub Date : 2022-01-01 DOI: 10.1615/oncotherap.2022045072
G. Nagaraju
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引用次数: 0
Microenvironment-dependent endothelial cells glycosylation influence on angiogenesis and cancer spreading 微环境依赖性内皮细胞糖基化对血管生成和肿瘤扩散的影响
Onco therapeutics Pub Date : 2022-01-01 DOI: 10.1615/oncotherap.2022042541
C. Kieda, Kinga Wilkus, C. Szczylik
{"title":"Microenvironment-dependent endothelial cells glycosylation influence on angiogenesis and cancer spreading","authors":"C. Kieda, Kinga Wilkus, C. Szczylik","doi":"10.1615/oncotherap.2022042541","DOIUrl":"https://doi.org/10.1615/oncotherap.2022042541","url":null,"abstract":"","PeriodicalId":74340,"journal":{"name":"Onco therapeutics","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88590260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel and latest computational routes for design and development of anticancer drugs for colon cancer 为结肠癌抗癌药物的设计和开发提供新的和最新的计算途径
Onco therapeutics Pub Date : 2022-01-01 DOI: 10.1615/oncotherap.2022044866
R. Malla, K. Patnala, Mini Fernandez
{"title":"Novel and latest computational routes for design and development of anticancer drugs for colon cancer","authors":"R. Malla, K. Patnala, Mini Fernandez","doi":"10.1615/oncotherap.2022044866","DOIUrl":"https://doi.org/10.1615/oncotherap.2022044866","url":null,"abstract":"","PeriodicalId":74340,"journal":{"name":"Onco therapeutics","volume":"02 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86326749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Naringenin in the prevention of colon cancer – An updated review 柚皮素预防结肠癌的最新研究综述
Onco therapeutics Pub Date : 2022-01-01 DOI: 10.1615/oncotherap.2022044893
Sarojamma Vemula, Ramakrishna Vadde
{"title":"Naringenin in the prevention of colon cancer – An updated review","authors":"Sarojamma Vemula, Ramakrishna Vadde","doi":"10.1615/oncotherap.2022044893","DOIUrl":"https://doi.org/10.1615/oncotherap.2022044893","url":null,"abstract":"","PeriodicalId":74340,"journal":{"name":"Onco therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89080420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Phytochemicals for colorectal cancer therapy 植物化学物质用于结直肠癌治疗
Onco therapeutics Pub Date : 2022-01-01 DOI: 10.1615/oncotherap.2022044943
G. Nagaraju
{"title":"Phytochemicals for colorectal cancer therapy","authors":"G. Nagaraju","doi":"10.1615/oncotherap.2022044943","DOIUrl":"https://doi.org/10.1615/oncotherap.2022044943","url":null,"abstract":"","PeriodicalId":74340,"journal":{"name":"Onco therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72714107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preface: Phytochemicals for Colorectal Cancer Therapy 前言:结直肠癌治疗中的植物化学物质
Onco therapeutics Pub Date : 2022-01-01 DOI: 10.1615/oncotherap.v9.i2.10
Ganji Ganji
{"title":"Preface: Phytochemicals for Colorectal Cancer Therapy","authors":"Ganji Ganji","doi":"10.1615/oncotherap.v9.i2.10","DOIUrl":"https://doi.org/10.1615/oncotherap.v9.i2.10","url":null,"abstract":"","PeriodicalId":74340,"journal":{"name":"Onco therapeutics","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73590297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Matrix Metalloproteinases in Colorectal Cancer 基质金属蛋白酶在结直肠癌中的作用
Onco therapeutics Pub Date : 2022-01-01 DOI: 10.1615/oncotherap.2022045773
N. Merchant
{"title":"Matrix Metalloproteinases in Colorectal Cancer","authors":"N. Merchant","doi":"10.1615/oncotherap.2022045773","DOIUrl":"https://doi.org/10.1615/oncotherap.2022045773","url":null,"abstract":"","PeriodicalId":74340,"journal":{"name":"Onco therapeutics","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85181411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic Applications of Curcumin and Derivatives in Colorectal Cancer. 姜黄素及其衍生物在结直肠癌中的治疗应用。
Onco therapeutics Pub Date : 2022-01-01 DOI: 10.1615/OncoTherap.2022044575
Christoffer Lambring, Kelly Varga, Keriman Livingston, Nicholas Lorusso, Amil Dudhia, Riyaz Basha
{"title":"Therapeutic Applications of Curcumin and Derivatives in Colorectal Cancer.","authors":"Christoffer Lambring, Kelly Varga, Keriman Livingston, Nicholas Lorusso, Amil Dudhia, Riyaz Basha","doi":"10.1615/OncoTherap.2022044575","DOIUrl":"10.1615/OncoTherap.2022044575","url":null,"abstract":"<p><p>Curcumin (CUR), a natural phenolic compound, has been increasingly investigated in several malignancies due to its safe profile and ability to affect a wide range of oncogenic targets. With the ability to affect metastasis, apoptosis, and angiogenesis in colorectal cancer (CRC) and its tolerability at high doses, CUR is an attractive target for study. However, poor bioavailability and unfavorable pharmacokinetics and pharmacodynamics have hampered CUR's efficacy in clinical trials. Development of its derivatives and alternative delivery methods have shown the potential to overcome its inherent bioavailability issues. Recent analyses of various derivatives and nanoparticle encapsulation of CUR have demonstrated increased effectiveness in CRC studies. A major advantage of CUR has been its synergistic effects when used in combination with various chemotherapeutic agents. CUR offers a unique treatment option in terms of patient safety and its ability to be used in combination with current treatments for CRC. Further development of its derivatives and alternative delivery options offer potential new avenues of treatment that could outperform previous efforts to establish CUR as a CRC therapy.</p>","PeriodicalId":74340,"journal":{"name":"Onco therapeutics","volume":"9 1","pages":"51-62"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262216/pdf/nihms-1904401.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10042336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-Cancer Pectins and Their Role in Colorectal Cancer Treatment. 抗癌果胶及其在大肠癌治疗中的作用
Onco therapeutics Pub Date : 2022-01-01 DOI: 10.1615/oncotherap.2022045040
Andrea Cedillo Ornelas, Sam Ferguson, Maya DePlaza, Tkai Adekunle, R. Basha
{"title":"Anti-Cancer Pectins and Their Role in Colorectal Cancer Treatment.","authors":"Andrea Cedillo Ornelas, Sam Ferguson, Maya DePlaza, Tkai Adekunle, R. Basha","doi":"10.1615/oncotherap.2022045040","DOIUrl":"https://doi.org/10.1615/oncotherap.2022045040","url":null,"abstract":"A class of plant polysaccharides, pectin is known to display several medicinal properties including in cancer. There is some evidence that pectin from some fruits can reduce the severity of colorectal cancer (CRC) due to its antiproliferative, anti-inflammatory, antimetastatic and pro-apoptotic properties. Pectin fermentation in the colon induces antiproliferative activity via butyrate. Research also showed that pectin acts as a potent inducer of programmed cell death and cell-cycle arrest, thereby selectively targeting cancer cells. Pectin can limit oxidative stress to maintain cellular homeostasis while increasing reactive oxygen species damage to activate cancer cell death. Pectin regulates various signaling cascades, e.g., signal transduction and transcriptional activator and mitogen-activated protein kinase signaling, that contribute to its anticancer activity. By curbing inflammation-activated signaling and bolstering immune-protective mechanisms pectin can eradicate CRC. Due to its chemical structure, pectin can also inhibit galectin-3 and suppress tumor growth and metastasis. Prior reports also suggested that pectin is beneficial to use alongside the CRC standard care. Pectin can increase sensitivity to conventional CRC drugs, alleviate unwanted side effects and reduce drug resistance. Although some preclinical studies are promising, early clinical trials are showing some evidence for pectin's efficacy in tumor growth inhibition and preventing metastasis in some cancers; however, the clinical use of pectin in CRC therapy is not yet well established. Further studies are needed to confirm the efficacy of pectin treatment as a valid clinical therapy for CRC in humans.","PeriodicalId":74340,"journal":{"name":"Onco therapeutics","volume":"8 1","pages":"43-55"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87130397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nano-formulation for Curcumin and Resveratrol in the Colorectal Cancer Therapy 姜黄素和白藜芦醇纳米制剂在大肠癌治疗中的应用
Onco therapeutics Pub Date : 2022-01-01 DOI: 10.1615/oncotherap.2022044940
S. Aliya, Y. Huh
{"title":"Nano-formulation for Curcumin and Resveratrol in the Colorectal Cancer Therapy","authors":"S. Aliya, Y. Huh","doi":"10.1615/oncotherap.2022044940","DOIUrl":"https://doi.org/10.1615/oncotherap.2022044940","url":null,"abstract":"","PeriodicalId":74340,"journal":{"name":"Onco therapeutics","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87531982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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