Neuronal signaling最新文献_第2页

Amyloid-β in Alzheimer's disease - front and centre after all? 淀粉样蛋白β是阿尔茨海默病的前沿和中心?

Neuronal signaling Pub Date : 2023-03-01 DOI: 10.1042/NS20220086

Caroline Weglinski, Alexander Jeans

{"title":"Amyloid-β in Alzheimer's disease - front and centre after all?","authors":"Caroline Weglinski, Alexander Jeans","doi":"10.1042/NS20220086","DOIUrl":"https://doi.org/10.1042/NS20220086","url":null,"abstract":"The amyloid hypothesis, which proposes that accumulation of the peptide amyloid-β at synapses is the key driver of Alzheimer's disease (AD) pathogenesis, has been the dominant idea in the field of Alzheimer's research for nearly 30 years. Recently, however, serious doubts about its validity have emerged, largely motivated by disappointing results from anti-amyloid therapeutics in clinical trials. As a result, much of the AD research effort has shifted to understanding the roles of a variety of other entities implicated in pathogenesis, such as microglia, astrocytes, apolipoprotein E and several others. All undoubtedly play an important role, but the nature of this has in many cases remained unclear, partly due to their pleiotropic functions. Here, we propose that all of these AD-related entities share at least one overlapping function, which is the local regulation of amyloid-β levels, and that this may be critical to their role in AD pathogenesis. We also review what is currently known of the actions of amyloid-β at the synapse in health and disease, and consider in particular how it might interact with the key AD-associated protein tau in the disease setting. There is much compelling evidence in support of the amyloid hypothesis; rather than detract from this, the implication of many disparate AD-associated cell types, molecules and processes in the regulation of amyloid-β levels may lend further support.","PeriodicalId":74287,"journal":{"name":"Neuronal signaling","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9134258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

In vivo imaging of axonal transport in peripheral nerves of rodent forelimbs. 啮齿动物前肢周围神经轴突运输的体内成像。

Neuronal signaling Pub Date : 2023-03-01 DOI: 10.1042/NS20220098

Qiuhan Lang, Giampietro Schiavo, James N Sleigh

{"title":"In vivo imaging of axonal transport in peripheral nerves of rodent forelimbs.","authors":"Qiuhan Lang, Giampietro Schiavo, James N Sleigh","doi":"10.1042/NS20220098","DOIUrl":"https://doi.org/10.1042/NS20220098","url":null,"abstract":"Axonal transport is the essential process by which neurons actively traffic a variety of cargoes between the cell soma and axon terminals. Accordingly, dysfunctional axonal transport is linked to many nervous system conditions. Therefore, being able to image and quantify this dynamic process in live neurons of animal disease models is beneficial for understanding neuropathology and testing new therapies at the preclinical level. As such, intravital approaches have been developed to assess cargo movement in the hindlimb sciatic nerves of live, anaesthetised mice. Here, we describe an adapted method for in vivo imaging of axonal transport in intact median and ulnar nerves of the rodent forelimb. Injection of a fluorescently labelled and non-toxic fragment of tetanus neurotoxin (HCT) into the mouse forepaw permits the identification of signalling endosomes in intact axons of median and ulnar nerves. Through immunofluorescent analysis of forelimb lumbrical muscles and median/ulnar nerves, we confirmed that HCT is taken up at motor nerve terminals and predominantly locates to motor axons. We then showed that the baseline trafficking of signalling endosomes is similar between the median/ulnar nerves and the sciatic nerve in adult wild-type mice. Importantly, this adapted method can be readily tailored for assessment of additional cargoes, such as mitochondria. By measuring transport in forelimb and hindlimb nerves, comparative anatomical and functional analyses can be performed in rodent disease models to aid our understanding of peripheral nerve disease pathogenesis and response to injury.","PeriodicalId":74287,"journal":{"name":"Neuronal signaling","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10739694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Celebrating 125 years of the synapse: from Sherrington to the present day. 庆祝125年的突触:从谢林顿到现在。

Neuronal signaling Pub Date : 2022-12-22 eCollection Date: 2022-12-01 DOI: 10.1042/NS20220015

S Clare Stanford

引用次数: 0

The role of thalamic group II mGlu receptors in health and disease. 丘脑II组mGlu受体在健康和疾病中的作用。

Neuronal signaling Pub Date : 2022-12-01 DOI: 10.1042/NS20210058

Caroline S Copeland, Thomas E Salt

引用次数: 1

Introducing a new themed collection on emerging technologies for research models of human neuronal disorders in vivo and in vitro. 介绍了一个新的主题集合，在体内和体外的人类神经疾病的研究模型的新兴技术。

Neuronal signaling Pub Date : 2022-09-30 eCollection Date: 2022-09-01 DOI: 10.1042/NS20220065

Thomas J Cunningham, Clare Stanford

{"title":"Introducing a new themed collection on emerging technologies for research models of human neuronal disorders in vivo and in vitro.","authors":"Thomas J Cunningham, Clare Stanford","doi":"10.1042/NS20220065","DOIUrl":"https://doi.org/10.1042/NS20220065","url":null,"abstract":"This themed collection of articles was prompted by a collaboration between Neuronal Signaling and the British Neuroscience Association. The Biochemical Society and Portland Press organised a symposium at the BNA Festival of Neuroscience in 2021, focused on the development and use of experimental models of human neuronal disorders. One aspect dealt with how new technologies are being (or could be) used both as a substitute for, or to complement, research that uses whole animal models. Another aspect discussed factors that need to be considered when appraising the validity of animal models of complex, multifactorial neuronal disorders. Given its relevance to the scope of Neuronal Signaling, the journal's Editorial Board developed a themed collection of content around this symposium entitled Emerging technologies for research models of human neuronal disorders in vivo and in vitro. We were delighted that speakers from the symposium and other experts working in this field agreed to submit reviews for the collection, which offers an invaluable resource both for researchers who are already experts in this field and those who need merely to learn about its scope and potential.","PeriodicalId":74287,"journal":{"name":"Neuronal signaling","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33510161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Array tomography: 15 years of synaptic analysis. 阵列断层扫描：突触分析 15 年。

Neuronal signaling Pub Date : 2022-09-23 eCollection Date: 2022-09-01 DOI: 10.1042/NS20220013

Anna Sanchez Avila, Christopher M Henstridge

引用次数: 0

Keeping synapses in shape: degradation pathways in the healthy and aging brain. 保持突触的形状：健康和衰老大脑中的降解途径。

Neuronal signaling Pub Date : 2022-06-15 eCollection Date: 2022-06-01 DOI: 10.1042/NS20210063

Marijn Kuijpers

引用次数: 0

The synapse: people, words and connections. 突触：人、语言和联系。

Neuronal signaling Pub Date : 2022-06-08 eCollection Date: 2022-06-01 DOI: 10.1042/NS20220017

E M Tansey

引用次数: 0

Neuroligins in neurodevelopmental conditions: how mouse models of de novo mutations can help us link synaptic function to social behavior. 神经发育条件下的神经素:新生突变的小鼠模型如何帮助我们将突触功能与社会行为联系起来

Neuronal signaling Pub Date : 2022-05-10 eCollection Date: 2022-06-01 DOI: 10.1042/NS20210030

Tobias T Pohl, Hanna Hörnberg

{"title":"Neuroligins in neurodevelopmental conditions: how mouse models of de novo mutations can help us link synaptic function to social behavior.","authors":"Tobias T Pohl, Hanna Hörnberg","doi":"10.1042/NS20210030","DOIUrl":"10.1042/NS20210030","url":null,"abstract":"Neurodevelopmental conditions (or neurodevelopmental disorders, NDDs) are highly heterogeneous with overlapping characteristics and shared genetic etiology. The large symptom variability and etiological heterogeneity have made it challenging to understand the biological mechanisms underpinning NDDs. To accommodate this individual variability, one approach is to move away from diagnostic criteria and focus on distinct dimensions with relevance to multiple NDDs. This domain approach is well suited to preclinical research, where genetically modified animal models can be used to link genetic variability to neurobiological mechanisms and behavioral traits. Genetic factors associated with NDDs can be grouped functionally into common biological pathways, with one prominent functional group being genes associated with the synapse. These include the neuroligins (Nlgns), a family of postsynaptic transmembrane proteins that are key modulators of synaptic function. Here, we review how research using Nlgn mouse models has provided insight into how synaptic proteins contribute to behavioral traits associated with NDDs. We focus on how mutations in different Nlgns affect social behaviors, as differences in social interaction and communication are a common feature of most NDDs. Importantly, mice carrying distinct mutations in Nlgns share some neurobiological and behavioral phenotypes with other synaptic gene mutations. Comparing the functional implications of mutations in multiple synaptic proteins is a first step towards identifying convergent neurobiological pathways in multiple brain regions and circuits.","PeriodicalId":74287,"journal":{"name":"Neuronal signaling","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45412173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting the M1 muscarinic acetylcholine receptor in Alzheimer's disease. 靶向M1毒蕈碱乙酰胆碱受体治疗阿尔茨海默病

Neuronal signaling Pub Date : 2022-04-21 eCollection Date: 2022-04-01 DOI: 10.1042/NS20210004

Louis Dwomoh, Gonzalo S Tejeda, Andrew B Tobin

引用次数: 0