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NEJM evidence最新文献

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Cluster-Randomized Trials - Insights from Cardiovascular Prevention. 集群随机试验-心血管预防的见解。
IF 11.6
NEJM evidence Pub Date : 2026-09-01 Epub Date: 2026-08-25 DOI: 10.1056/EVIDctw2600148
Ravi Vazirani, Borja Ibanez, Deepak L Bhatt, Valentín Fuster
{"title":"Cluster-Randomized Trials - Insights from Cardiovascular Prevention.","authors":"Ravi Vazirani, Borja Ibanez, Deepak L Bhatt, Valentín Fuster","doi":"10.1056/EVIDctw2600148","DOIUrl":"https://doi.org/10.1056/EVIDctw2600148","url":null,"abstract":"<p><p>AbstractCluster-randomized trials are increasingly relevant to the evaluation of preventive and treatment strategies for chronic disease, especially when interventions are delivered through groups, practices, communities, or health systems rather than individuals. Using cardiovascular prevention as an illustrative example, we review key design, conduct, and analytic issues that determine when cluster randomization is appropriate and how such trials should be designed, analyzed, and interpreted. Particular attention is given to the choice of the unit of randomization, protection of internal validity, implications for statistical efficiency, and alignment of outcomes and analyses with the level and mechanism of intervention delivery. A clear understanding of these principles should strengthen the design, interpretation, and policy relevance of cluster-randomized trials.</p>","PeriodicalId":74256,"journal":{"name":"NEJM evidence","volume":"5 9","pages":"EVIDctw2600148"},"PeriodicalIF":11.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LAMs Leading Shepherds - MRD-Guided Consolidation in Intermediate-Risk AML. 拉姆斯领导的牧羊人- mrd引导巩固中风险AML。
IF 11.6
NEJM evidence Pub Date : 2026-09-01 Epub Date: 2026-08-25 DOI: 10.1056/EVIDe2600250
Daniel T Peters, Brittany Knick Ragon
{"title":"LAMs Leading Shepherds - MRD-Guided Consolidation in Intermediate-Risk AML.","authors":"Daniel T Peters, Brittany Knick Ragon","doi":"10.1056/EVIDe2600250","DOIUrl":"https://doi.org/10.1056/EVIDe2600250","url":null,"abstract":"","PeriodicalId":74256,"journal":{"name":"NEJM evidence","volume":"5 9","pages":"EVIDe2600250"},"PeriodicalIF":11.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A 6-Month-Old Infant with Episodes of Unresponsiveness. 6个月大婴儿无反应性发作。
IF 11.6
NEJM evidence Pub Date : 2026-09-01 Epub Date: 2026-08-25 DOI: 10.1056/EVIDmr2500143
Khalifah A Aldawsari, Jane Nydam, Kathryn C Chatfield
{"title":"A 6-Month-Old Infant with Episodes of Unresponsiveness.","authors":"Khalifah A Aldawsari, Jane Nydam, Kathryn C Chatfield","doi":"10.1056/EVIDmr2500143","DOIUrl":"10.1056/EVIDmr2500143","url":null,"abstract":"<p><p>AbstractMorning Report is a time-honored tradition where physicians-in-training present cases to their colleagues and clinical experts to collaboratively examine an interesting patient presentation. The Morning Report section seeks to carry on this tradition by presenting a patient's chief concern and story, inviting the reader to develop a differential diagnosis and discover the diagnosis alongside the authors of the case. This report examines the story of a 6-month-old male infant brought in for evaluation of episodes of unresponsiveness and bluish discoloration of the lips. Using questions, physical examination, and testing, an illness script for the presentation emerges. As the clinical course progresses, the differential is refined until a diagnosis is made.</p>","PeriodicalId":74256,"journal":{"name":"NEJM evidence","volume":"5 9","pages":"EVIDmr2500143"},"PeriodicalIF":11.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metformin in Pregnancy - A Role beyond Gestational Diabetes Prevention? 二甲双胍对妊娠期糖尿病的预防作用？
IF 11.6
NEJM evidence Pub Date : 2026-09-01 Epub Date: 2026-08-25 DOI: 10.1056/EVIDe2600254
Bea Gardner, Claire L Meek
{"title":"Metformin in Pregnancy - A Role beyond Gestational Diabetes Prevention?","authors":"Bea Gardner, Claire L Meek","doi":"10.1056/EVIDe2600254","DOIUrl":"https://doi.org/10.1056/EVIDe2600254","url":null,"abstract":"","PeriodicalId":74256,"journal":{"name":"NEJM evidence","volume":"5 9","pages":"EVIDe2600254"},"PeriodicalIF":11.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimizing Induction Therapy for High-Risk Nasopharyngeal Carcinoma. 高危鼻咽癌诱导治疗的优化
IF 11.6
NEJM evidence Pub Date : 2026-09-01 Epub Date: 2026-08-25 DOI: 10.1056/EVIDe2600244
Jong Chul Park
{"title":"Optimizing Induction Therapy for High-Risk Nasopharyngeal Carcinoma.","authors":"Jong Chul Park","doi":"10.1056/EVIDe2600244","DOIUrl":"https://doi.org/10.1056/EVIDe2600244","url":null,"abstract":"","PeriodicalId":74256,"journal":{"name":"NEJM evidence","volume":"5 9","pages":"EVIDe2600244"},"PeriodicalIF":11.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cyfendus for Postexposure Prophylaxis after Inhalation Anthrax Exposures in Wyoming. Cyfendus用于怀俄明州吸入性炭疽暴露后的暴露后预防。
IF 11.6
NEJM evidence Pub Date : 2026-08-01 Epub Date: 2026-07-16 DOI: 10.1056/EVIDpha2600122
Courtney Tillman, Brittney N Waranius, Clayton Van Houten, Alexia Harrist, Dawn Blackburn, Caitlin M Cossaboom, Alex Hoffmaster, Caroline A Schrodt, William A Bower, Anne E Boyer, John R Barr, Maribel Gallegos-Candela, Patricia A Yu, Yon Yu, Emily Curren
{"title":"Cyfendus for Postexposure Prophylaxis after Inhalation Anthrax Exposures in Wyoming.","authors":"Courtney Tillman, Brittney N Waranius, Clayton Van Houten, Alexia Harrist, Dawn Blackburn, Caitlin M Cossaboom, Alex Hoffmaster, Caroline A Schrodt, William A Bower, Anne E Boyer, John R Barr, Maribel Gallegos-Candela, Patricia A Yu, Yon Yu, Emily Curren","doi":"10.1056/EVIDpha2600122","DOIUrl":"10.1056/EVIDpha2600122","url":null,"abstract":"<p><p>AbstractAnthrax is a zoonotic disease caused by the bacterium <i>Bacillus anthracis</i> that can lead to severe illness and death. Although human infections are rare in the United States, outbreaks are common in U.S. livestock. In August 2024, an anthrax outbreak among cattle in Wyoming resulted in multiple human exposures. This report describes the use of postexposure prophylaxis among 13 individuals identified with potential exposure.</p>","PeriodicalId":74256,"journal":{"name":"NEJM evidence","volume":" ","pages":"EVIDpha2600122"},"PeriodicalIF":11.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148474643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Measles Hospitalizations in Utah, 2025-2026. 2025-2026年犹他州麻疹住院情况。
IF 11.6
NEJM evidence Pub Date : 2026-08-01 Epub Date: 2026-07-14 DOI: 10.1056/EVIDpha2600141
Anna Jones, Amelia Salmanson, Angela Weil, Danielle Timothy, Leisha D Nolen
{"title":"Measles Hospitalizations in Utah, 2025-2026.","authors":"Anna Jones, Amelia Salmanson, Angela Weil, Danielle Timothy, Leisha D Nolen","doi":"10.1056/EVIDpha2600141","DOIUrl":"10.1056/EVIDpha2600141","url":null,"abstract":"<p><p>AbstractThe ongoing 2025-2026 outbreak of measles in Utah is the state's largest in 40 years. To characterize the epidemiology and clinical features of hospitalized patients, we conducted a chart review of patients admitted to Utah hospitals between June 20, 2025, and April 14, 2026. Of the 602 measles cases reported during that period, we identified 49 patients (8%) who were hospitalized. Most hospitalized patients (44, 90%) were unvaccinated. The most common reasons for hospitalization were dehydration and hypoxemia. These findings highlight the preventable health care burden associated with measles in Utah.</p>","PeriodicalId":74256,"journal":{"name":"NEJM evidence","volume":" ","pages":"EVIDpha2600141"},"PeriodicalIF":11.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13446724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148450871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A 36-Year-Old Woman with Left-Sided Weakness and Difficulty Speaking. 36岁女性，左侧虚弱，说话困难。
IF 11.6
NEJM evidence Pub Date : 2026-08-01 Epub Date: 2026-07-28 DOI: 10.1056/EVIDmr2400335
Marina Martínez Sánchez, Eugenia Garcia-Amor, Laura Dorado Bouix, Juan Pablo Fernandez Romero, Berta Torruella Trias, Gladys Junca Puig, Gizem Kasa, Mònica Millan Torne
{"title":"A 36-Year-Old Woman with Left-Sided Weakness and Difficulty Speaking.","authors":"Marina Martínez Sánchez, Eugenia Garcia-Amor, Laura Dorado Bouix, Juan Pablo Fernandez Romero, Berta Torruella Trias, Gladys Junca Puig, Gizem Kasa, Mònica Millan Torne","doi":"10.1056/EVIDmr2400335","DOIUrl":"https://doi.org/10.1056/EVIDmr2400335","url":null,"abstract":"<p><p>AbstractMorning Report is a time-honored tradition where physicians-in-training present cases to their colleagues and clinical experts to collaboratively examine an interesting patient presentation. The Morning Report section seeks to carry on this tradition by presenting a patient's chief concern and story, inviting the reader to develop a differential diagnosis and discover the diagnosis alongside the authors of the case. This report examines the story of a 36-year-old woman who presented with sudden onset of difficulty speaking and left-sided weakness. Additional symptoms included generalized polyarthralgia, weight loss, and severe headaches during the preceding 4 months. Using questions, physical examination, and testing, an illness script for the presentation emerges. As the clinical course progresses, the differential is refined until a diagnosis is made.</p>","PeriodicalId":74256,"journal":{"name":"NEJM evidence","volume":"5 8","pages":"EVIDmr2400335"},"PeriodicalIF":11.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148610872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
All-Trans Retinoic Acid for Immune Thrombocytopenia - Sustained Response? 全反式维甲酸治疗免疫性血小板减少症-持续反应？
IF 11.6
NEJM evidence Pub Date : 2026-08-01 Epub Date: 2026-07-28 DOI: 10.1056/EVIDe2600196
Michael Peng, Heyu Ni
{"title":"All-Trans Retinoic Acid for Immune Thrombocytopenia - Sustained Response?","authors":"Michael Peng, Heyu Ni","doi":"10.1056/EVIDe2600196","DOIUrl":"https://doi.org/10.1056/EVIDe2600196","url":null,"abstract":"","PeriodicalId":74256,"journal":{"name":"NEJM evidence","volume":"5 8","pages":"EVIDe2600196"},"PeriodicalIF":11.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148610878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emergence of Babesiosis in Nova Scotia, Canada. 加拿大新斯科舍省巴贝斯虫病的出现。
IF 11.6
NEJM evidence Pub Date : 2026-08-01 Epub Date: 2026-07-28 DOI: 10.1056/EVIDpha2600131
Steven J Drews, Carmen L Charlton, Molly A Trecker, Mark Bigham, Evan M Bloch, Leisa Bruneau, Heather Coatsworth, Valerie Conrod, Cynthia Cranney, Mindy Goldman, Todd F Hatchette, Dilini Kumaran, Kathryn E McIsaac, Momar Ndao, Lori Osmond, Glenn Patriquin, Sandra Ramirez-Arcos, Laura Todd, Jennifer Cram, Sheila F O'Brien, Chantale Pambrun
{"title":"Emergence of Babesiosis in Nova Scotia, Canada.","authors":"Steven J Drews, Carmen L Charlton, Molly A Trecker, Mark Bigham, Evan M Bloch, Leisa Bruneau, Heather Coatsworth, Valerie Conrod, Cynthia Cranney, Mindy Goldman, Todd F Hatchette, Dilini Kumaran, Kathryn E McIsaac, Momar Ndao, Lori Osmond, Glenn Patriquin, Sandra Ramirez-Arcos, Laura Todd, Jennifer Cram, Sheila F O'Brien, Chantale Pambrun","doi":"10.1056/EVIDpha2600131","DOIUrl":"10.1056/EVIDpha2600131","url":null,"abstract":"<p><p>AbstractAs part of a multi-year surveillance program of tick-borne diseases, we describe babesia surveillance of blood donors using nucleic acid tests conducted in 2025 and summarize cases of babesiosis reported by public health officials in Nova Scotia, Canada, from 2023 through 2025. Among 10,976 blood donor specimens, one specimen, collected from a blood donor in Nova Scotia Health's Western Zone, was positive, although this result was unable to be confirmed. Since babesiosis became reportable in Nova Scotia on May 23, 2023, eleven clinical cases have been documented, including eight in individuals who resided in the Western Zone and had no recent history of travel.</p>","PeriodicalId":74256,"journal":{"name":"NEJM evidence","volume":"5 8","pages":"EVIDpha2600131"},"PeriodicalIF":11.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148610868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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