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Induction of MYCN-amplified neuroblastoma differentiation through NMYC suppression using PPAR-γ antagonist. PPAR-γ拮抗剂抑制NMYC诱导mycn扩增的神经母细胞瘤分化
IF 2.4
Molecular biology (Los Angeles, Calif.) Pub Date : 2023-11-01 Epub Date: 2023-06-28 DOI: 10.3164/jcbn.23-28
Yukako Nakao-Ise, Takumi Narita, Shingo Miyamoto, Motoki Watanabe, Takuji Tanaka, Yoshihiro Sowa, Yosuke Iizumi, Mitsuharu Masuda, Gen Fujii, Yasuko Hirai, Toshimasa Nakao, Hideki Takakura, Michihiro Mutoh
{"title":"Induction of <i>MYCN</i>-amplified neuroblastoma differentiation through NMYC suppression using PPAR-γ antagonist.","authors":"Yukako Nakao-Ise, Takumi Narita, Shingo Miyamoto, Motoki Watanabe, Takuji Tanaka, Yoshihiro Sowa, Yosuke Iizumi, Mitsuharu Masuda, Gen Fujii, Yasuko Hirai, Toshimasa Nakao, Hideki Takakura, Michihiro Mutoh","doi":"10.3164/jcbn.23-28","DOIUrl":"10.3164/jcbn.23-28","url":null,"abstract":"<p><p>Neuroblastomas are the most common extracranial solid tumors in children and have a unique feature of neuronal differentiation. Peroxisome proliferator-activated receptor (PPAR)-γ is reported to have neuroprotective effects in addition to having antitumor effects in various cancers. Thus, we aimed to clarify the role of PPAR-γ agonist and antagonist in malignant neuroblastomas, which also possess neuronal features. In <i>MYCN</i>-amplified neuroblastoma CHP212 cells, treatment with the PPAR-γ antagonist GW9662 induced growth inhibition in a dose-dependent manner. In addition, the PPAR-γ antagonist treatment changed cell morphology with increasing expression of the neuronal differentiation marker tubulin beta 3 (TUBB3) and induced G1 phase arrest and apoptosis in <i>MYCN</i>-amplified neuroblastoma. Notably, the PPAR-γ antagonist treatment significantly decreased expression of NMYC, B-cell lymphoma 2 (BCL2) and bromodomain-containing protein 4 (BRD4). It is implied that BRD4, NMYC, BCL2 suppression by the PPAR-γ antagonist resulted in cell growth inhibition, differentiation, and apoptosis induction. In our <i>in vivo</i> study, the PPAR-γ antagonist treatment induced CHP212 cells differentiation and resultant tumor growth inhibition. Our results provide a deeper understanding of the mechanisms of tumor cell differentiation and suggest that PPAR-γ antagonist is a new therapeutic and prevention option for neuroblastomas.</p>","PeriodicalId":74216,"journal":{"name":"Molecular biology (Los Angeles, Calif.)","volume":"57 1","pages":"191-197"},"PeriodicalIF":2.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69361537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytochrome bd as Antioxidant Redox Enzyme 细胞色素bd作为抗氧化氧化还原酶
Molecular biology (Los Angeles, Calif.) Pub Date : 2023-09-06 DOI: 10.1134/s0026893323060031
V. Borisov, M. R. Nastasi, E. Forte
{"title":"Cytochrome bd as Antioxidant Redox Enzyme","authors":"V. Borisov, M. R. Nastasi, E. Forte","doi":"10.1134/s0026893323060031","DOIUrl":"https://doi.org/10.1134/s0026893323060031","url":null,"abstract":"","PeriodicalId":74216,"journal":{"name":"Molecular biology (Los Angeles, Calif.)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49026201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DNA Phenotyping of Remains from Elite Burials of the Khazar Period of Southern Russia 俄罗斯南部哈扎尔时期精英墓葬遗骸的DNA表型分析
Molecular biology (Los Angeles, Calif.) Pub Date : 2023-08-01 DOI: 10.1134/S0026893323040040
D. Fesenko, O. Y. Aramova, E. Vdovchenkov, I. Ivanovsky, O. E. Fesenko, S. A. Polyakov, T. Faleeva, M. Filippova, V. S. Florinskaya, I. Kornienko
{"title":"DNA Phenotyping of Remains from Elite Burials of the Khazar Period of Southern Russia","authors":"D. Fesenko, O. Y. Aramova, E. Vdovchenkov, I. Ivanovsky, O. E. Fesenko, S. A. Polyakov, T. Faleeva, M. Filippova, V. S. Florinskaya, I. Kornienko","doi":"10.1134/S0026893323040040","DOIUrl":"https://doi.org/10.1134/S0026893323040040","url":null,"abstract":"","PeriodicalId":74216,"journal":{"name":"Molecular biology (Los Angeles, Calif.)","volume":"57 1","pages":"593 - 603"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45547359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MicroRNA Biogenesis in Cell Senescence Induced by Chronic Endoplasmic Reticulum Stress 慢性内质网应激诱导细胞衰老的MicroRNA生物发生
Molecular biology (Los Angeles, Calif.) Pub Date : 2023-08-01 DOI: 10.1134/S0026893323040192
D. Zaichenko, A. A. Mikryukova, I. R. Astafeva, S. G. Malakho, A. Kubatiev, A. Moskovtsev
{"title":"MicroRNA Biogenesis in Cell Senescence Induced by Chronic Endoplasmic Reticulum Stress","authors":"D. Zaichenko, A. A. Mikryukova, I. R. Astafeva, S. G. Malakho, A. Kubatiev, A. Moskovtsev","doi":"10.1134/S0026893323040192","DOIUrl":"https://doi.org/10.1134/S0026893323040192","url":null,"abstract":"","PeriodicalId":74216,"journal":{"name":"Molecular biology (Los Angeles, Calif.)","volume":"57 1","pages":"670 - 683"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64064291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methylation of Regulatory Regions of DNA Repair Genes in Carotid Atherosclerosis 颈动脉粥样硬化中DNA修复基因调控区的甲基化
Molecular biology (Los Angeles, Calif.) Pub Date : 2023-08-01 DOI: 10.1134/S0026893323040027
N. Babushkina, A. Zarubin, I. Koroleva, D. Gomboeva, E. Bragina, I. A. Goncharova, M. Golubenko, R. R. Salakhov, A. Sleptcov, M. Kuznetsov, B. Kozlov, E. Muslimova, S. Afanasiev, A. Kucher, M. Nazarenko
{"title":"Methylation of Regulatory Regions of DNA Repair Genes in Carotid Atherosclerosis","authors":"N. Babushkina, A. Zarubin, I. Koroleva, D. Gomboeva, E. Bragina, I. A. Goncharova, M. Golubenko, R. R. Salakhov, A. Sleptcov, M. Kuznetsov, B. Kozlov, E. Muslimova, S. Afanasiev, A. Kucher, M. Nazarenko","doi":"10.1134/S0026893323040027","DOIUrl":"https://doi.org/10.1134/S0026893323040027","url":null,"abstract":"","PeriodicalId":74216,"journal":{"name":"Molecular biology (Los Angeles, Calif.)","volume":"57 1","pages":"637 - 652"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43101830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assembly and Disassembly of the Nuclear Pore Complex: A View from the Structural Side 核孔复合物的组装与拆卸:从结构角度看
Molecular biology (Los Angeles, Calif.) Pub Date : 2023-08-01 DOI: 10.1134/S0026893323040131
A. Orlova, S. Georgieva, D. Kopytova
{"title":"Assembly and Disassembly of the Nuclear Pore Complex: A View from the Structural Side","authors":"A. Orlova, S. Georgieva, D. Kopytova","doi":"10.1134/S0026893323040131","DOIUrl":"https://doi.org/10.1134/S0026893323040131","url":null,"abstract":"","PeriodicalId":74216,"journal":{"name":"Molecular biology (Los Angeles, Calif.)","volume":"57 1","pages":"572 - 583"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42993905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AdipoRon Effect on Expression of Lipid Metabolism Genes in Cultured Human Primary Macrophages AdipoRon对人原代巨噬细胞脂质代谢基因表达的影响
Molecular biology (Los Angeles, Calif.) Pub Date : 2023-08-01 DOI: 10.1134/S0026893323040143
I. Pobozheva, K. Dracheva, S. Pchelina, V. Miroshnikova, Genomics Transcriptomics
{"title":"AdipoRon Effect on Expression of Lipid Metabolism Genes in Cultured Human Primary Macrophages","authors":"I. Pobozheva, K. Dracheva, S. Pchelina, V. Miroshnikova, Genomics Transcriptomics","doi":"10.1134/S0026893323040143","DOIUrl":"https://doi.org/10.1134/S0026893323040143","url":null,"abstract":"","PeriodicalId":74216,"journal":{"name":"Molecular biology (Los Angeles, Calif.)","volume":"57 1","pages":"616 - 623"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44795550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interaction of DNA Methyltransferase Dnmt3a with Phosphorus Analogs of S-Adenosylmethionine and S-Adenosylhomocysteine DNA甲基转移酶Dnmt3a与s -腺苷蛋氨酸和s -腺苷同型半胱氨酸的磷类似物的相互作用
Molecular biology (Los Angeles, Calif.) Pub Date : 2023-08-01 DOI: 10.1134/S0026893323040064
V. L. Filonov, M. Khomutov, A. V. Sergeev, A. Khandazhinskaya, S. Kochetkov, E. Gromova, A. Khomutov
{"title":"Interaction of DNA Methyltransferase Dnmt3a with Phosphorus Analogs of S-Adenosylmethionine and S-Adenosylhomocysteine","authors":"V. L. Filonov, M. Khomutov, A. V. Sergeev, A. Khandazhinskaya, S. Kochetkov, E. Gromova, A. Khomutov","doi":"10.1134/S0026893323040064","DOIUrl":"https://doi.org/10.1134/S0026893323040064","url":null,"abstract":"","PeriodicalId":74216,"journal":{"name":"Molecular biology (Los Angeles, Calif.)","volume":"57 1","pages":"747-754"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48753019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Universal Panel of Insertion/Deletion Polymorphisms and Biochip-Based Kit ChipID106 for Genetic Personal Identification 通用插入/缺失多态性小组和基于生物芯片的基因个人识别试剂盒ChipID106
Molecular biology (Los Angeles, Calif.) Pub Date : 2023-08-01 DOI: 10.1134/S0026893323040052
D. Fesenko, I. Ivanovsky, P. Ivanov, E. Y. Zemskova, S. A. Polyakov, O. E. Fesenko, M. Filippova, A. Zasedatelev
{"title":"Universal Panel of Insertion/Deletion Polymorphisms and Biochip-Based Kit ChipID106 for Genetic Personal Identification","authors":"D. Fesenko, I. Ivanovsky, P. Ivanov, E. Y. Zemskova, S. A. Polyakov, O. E. Fesenko, M. Filippova, A. Zasedatelev","doi":"10.1134/S0026893323040052","DOIUrl":"https://doi.org/10.1134/S0026893323040052","url":null,"abstract":"","PeriodicalId":74216,"journal":{"name":"Molecular biology (Los Angeles, Calif.)","volume":"57 1","pages":"624 - 636"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45867770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatial Reconstruction of TRPC Mechanoreceptors of the Ctenophore Mnemiopsis leidyi A. Agassiz, 1865 Ctenophore Mnemiopsis leidyi A.Agassiz的TRPC机械感受器的空间重建，1865
Molecular biology (Los Angeles, Calif.) Pub Date : 2023-08-01 DOI: 10.1134/S0026893323040106
A. Kuznetsov, D. N. Vtyurina
{"title":"Spatial Reconstruction of TRPC Mechanoreceptors of the Ctenophore Mnemiopsis leidyi A. Agassiz, 1865","authors":"A. Kuznetsov, D. N. Vtyurina","doi":"10.1134/S0026893323040106","DOIUrl":"https://doi.org/10.1134/S0026893323040106","url":null,"abstract":"","PeriodicalId":74216,"journal":{"name":"Molecular biology (Los Angeles, Calif.)","volume":"57 1","pages":"755-763"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47197229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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