Modern trends in pharmacopsychiatry最新文献_第2页

Pharmacological and Nonpharmacological Interventions to Arrest Neuroprogression in Psychiatric Disorders. 阻止精神疾病神经进展的药物和非药物干预。

Modern trends in pharmacopsychiatry Pub Date : 2017-01-01 Epub Date: 2017-07-24 DOI: 10.1159/000470814

Fotini Boufidou, Angelos Halaris

{"title":"Pharmacological and Nonpharmacological Interventions to Arrest Neuroprogression in Psychiatric Disorders.","authors":"Fotini Boufidou, Angelos Halaris","doi":"10.1159/000470814","DOIUrl":"https://doi.org/10.1159/000470814","url":null,"abstract":"The concept of neuroprogression describes the progressive course of the disorder and stresses the progressive, recurrent, and chronic course of the disease entity under consideration. It subsumes clinical manifestations of the disease process and may also entail morphological, biochemical, neurochemical, immunological, physiological, and genetic aspects that contribute to the progressive course of the disease in question. In an attempt to identify the appropriate agent or method that could arrest neuroprogression in psychiatric patients, we conducted an evaluation of the use of anti-inflammatory drugs under the perspective of current pharmacological and neurophysiological data. This evaluation included the use of nonsteroidal anti-inflammatory drugs (NSAIDs) as adjunctive treatment to conventional pharmacotherapy as well as the use of natural products exerting anti-inflammatory properties (i.e., ω-3 fatty acids) given as adjunctive or monotherapeutic treatments in less severe cases. The therapeutic significance of nonpharmacological methods, such as psychotherapy, physical exercise, and body-mind therapies, was also considered and will be discussed in this chapter. In conclusion, the role of psychotropic and select anti-inflammatory drugs in arresting neuroprogression is a very promising new frontier in psychiatric research and clinical practice. Modulators of a specific prostanoid synthase or receptor across the cyclooxygenase (COX)-2 downstream pathway along with new multitarget NSAIDs are expected to be tested by the pharmaceutical industry as potential agents to antagonize neuroprogression. Meanwhile, salicylates and selective COX-2 inhibitors could still be used in carefully selected subgroups of patients. Psychotherapy and nonpharmacological, stress-relieving methods should be considered as adjunctive tools to aid in arresting neuroprogression.","PeriodicalId":74212,"journal":{"name":"Modern trends in pharmacopsychiatry","volume":" ","pages":"162-176"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000470814","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35193699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Major Depression as a Neuroprogressive Prelude to Dementia: What Is the Evidence? 重度抑郁症是痴呆的神经进行性前奏:证据是什么?

Modern trends in pharmacopsychiatry Pub Date : 2017-01-01 Epub Date: 2017-07-24 DOI: 10.1159/000470807

Brian E Leonard

{"title":"Major Depression as a Neuroprogressive Prelude to Dementia: What Is the Evidence?","authors":"Brian E Leonard","doi":"10.1159/000470807","DOIUrl":"https://doi.org/10.1159/000470807","url":null,"abstract":"Epidemiological studies implicate chronic depression as a predisposing factor for dementia in later life. However, the link is incompletely understood and controversial. The aim of this review is to consider some of the biological factors that contribute to neuroprogressive brain dysfunction in late life as a consequence of prolonged, low-grade inflammation in the course of depressive episodes. As chronic inflammation is known to precipitate increased apoptosis of neurons and astrocytes, this could be a contributing factor to brain dysfunction. In addition, certain proinflammatory cytokines activate the neurotoxic derivatives of the tryptophan-kynurenine pathway. This results in the synthesis of the NMDA glutamate agonist, quinolinic acid, and kynurenine metabolites which initiate oxidative stress and insulin receptor resistance. As a consequence of these changes, combined with a structural and functional defect in brain mitochondria, glucose transport into the brain is affected. Due to the ensuing reduction in the metabolic energy needed to sustain brain function, brain cells die prematurely. These changes could provide a link between chronic inflammation and dementia, at least in some patients with recurrent and chronic depression. This outcome may be particularly true in poor responders and treatment-resistant depression.","PeriodicalId":74212,"journal":{"name":"Modern trends in pharmacopsychiatry","volume":" ","pages":"56-66"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000470807","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35194415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Cytokines in Neuropathic Pain and Associated Depression. 细胞因子在神经性疼痛和相关抑郁中的作用。

Modern trends in pharmacopsychiatry Pub Date : 2015-01-01 Epub Date: 2015-09-18 DOI: 10.1159/000435932

Justin G Lees, Brett Fivelman, Samuel S Duffy, Preet G S Makker, Chamini J Perera, Gila Moalem-Taylor

{"title":"Cytokines in Neuropathic Pain and Associated Depression.","authors":"Justin G Lees, Brett Fivelman, Samuel S Duffy, Preet G S Makker, Chamini J Perera, Gila Moalem-Taylor","doi":"10.1159/000435932","DOIUrl":"https://doi.org/10.1159/000435932","url":null,"abstract":"Neuropathic pain occurs as a result of lesion or disease affecting the somatosensory nervous system and is present in a diverse set of peripheral and central pathologies such as nerve trauma, diabetic neuropathy, post-herpetic neuralgia, chemotherapy-induced peripheral neuropathy, spinal cord injury and multiple sclerosis. Debilitating symptoms including allodynia, hyperalgesia and spontaneous pain have a substantial negative impact on patients' quality of life. The currently available therapeutic treatments are generally ineffective and characterised by poor response rates. Accumulating evidence suggests that neuroinflammation and cytokine signalling play a critical role in neuropathic pain. Numerous experimental studies have demonstrated that certain pro-inflammatory cytokines are elevated in neuropathic pain conditions, and administration of these cytokines can elicit pain hypersensitivity in the absence of injury or disease. This phenomenon is also apparent in the 'sickness response', which encompasses a broad inflammatory response to disease and injury and involves a series of physiological and behavioural changes including pain hypersensitivity. Interestingly, the 'sickness response' is also similar in nature to some of the defining characteristics of the depressed state of affective disorder. In this review, we explore links that may relate the co-existence of depression in neuropathic pain patients with the activity of cytokines and discuss the role of several key pro-inflammatory and anti-inflammatory cytokines in neuropathic pain. ","PeriodicalId":74212,"journal":{"name":"Modern trends in pharmacopsychiatry","volume":"30 ","pages":"51-66"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000435932","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34130062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Emotional and Cognitive Influences on Pain Experience. 情绪和认知对疼痛体验的影响。

Modern trends in pharmacopsychiatry Pub Date : 2015-01-01 Epub Date: 2015-09-18 DOI: 10.1159/000435938

Madelon L Peters

{"title":"Emotional and Cognitive Influences on Pain Experience.","authors":"Madelon L Peters","doi":"10.1159/000435938","DOIUrl":"https://doi.org/10.1159/000435938","url":null,"abstract":"Multiple emotional and cognitive factors impact on the experience of pain. This chapter will review some of the most important emotional and cognitive determinants of the pain experience as found in experimental and clinical studies with human participants. Emotional factors that may increase pain perception are anxiety, depression and anger. Positive emotions usually decrease perceived pain. The cognitive factors attention, expectancy and appraisal can either increase or decrease pain experiences depending on their specific focus and content. Many brain regions are involved in nociceptive processing and bringing pain into awareness. There are profound interconnections between areas processing sensory, emotional and cognitive information. Descending pathways from cortical areas to the midbrain and spinal levels can facilitate or inhibit spinal nociceptive information and thereby afferent nociceptive input to the brain. The underlying mechanisms of the various emotional and cognitive modulatory influences may partly overlap, but also have some unique aspects. What becomes clear is that pain is not merely a reflection of the nociceptive input, but should be considered as a complex experience shaped by psychological factors that may be unique for each individual. ","PeriodicalId":74212,"journal":{"name":"Modern trends in pharmacopsychiatry","volume":"30 ","pages":"138-52"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000435938","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34230801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 46

Neuroinflammatory Mechanisms Linking Pain and Depression. 疼痛和抑郁之间的神经炎症机制。

Modern trends in pharmacopsychiatry Pub Date : 2015-01-01 Epub Date: 2015-09-18 DOI: 10.1159/000435931

Nikita N Burke, David P Finn, Michelle Roche

引用次数: 49

Animal Models for the Study of Comorbid Pain and Psychiatric Disorders. 共病疼痛和精神疾病研究的动物模型。

Modern trends in pharmacopsychiatry Pub Date : 2015-01-01 Epub Date: 2015-09-18 DOI: 10.1159/000435929

Hugo Leite-Almeida, Filipa Pinto-Ribeiro, Armando Almeida

{"title":"Animal Models for the Study of Comorbid Pain and Psychiatric Disorders.","authors":"Hugo Leite-Almeida, Filipa Pinto-Ribeiro, Armando Almeida","doi":"10.1159/000435929","DOIUrl":"https://doi.org/10.1159/000435929","url":null,"abstract":"Animal models of chronic pain have provided valuable information on the mechanisms of initiation and maintenance of the disease. Much of the research effort has targeted sensory abnormalities like hyperalgesia and allodynia. However, in the past 15 years a significant number of research groups have focused their attention on comorbid anxiety, depression and cognitive impairments that frequently emerge in chronic pain conditions. A myriad of paradigms have since then been introduced in the field to tackle multiple dimensions of rodents' behavior. Concerning emotional behavior, these include the elevated plus (and zero) maze and dark/light box for anxiety, the forced swimming and tail suspension tests for depression, and the spontaneous burrowing behavior for general well-being. Regarding the cognitive dimension, several water mazes (spatial-reference memory), attentional set-shifting test (attention and reversal learning), novel object recognition (memory), 5-choice serial reaction time task (sustained attention) and variable delay-to-signal task (impulsivity) are among the most commonly employed paradigms. The construct of some of these paradigms in the context of chronic pain will be reviewed in this chapter, with special emphasis on mood and cognitive alterations that are associated with the development of neuropathic and arthritic pain. ","PeriodicalId":74212,"journal":{"name":"Modern trends in pharmacopsychiatry","volume":"30 ","pages":"1-21"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000435929","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34129518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Genetic and Epigenetic Mechanisms Linking Pain and Psychiatric Disorders. 疼痛与精神疾病相关的遗传和表观遗传机制。

Modern trends in pharmacopsychiatry Pub Date : 2015-01-01 Epub Date: 2015-09-18 DOI: 10.1159/000435937

Artur H Swiergiel, Grzegorz R Juszczak, Adrian M Stankiewicz

引用次数: 6

Pain, Depression and Inflammation: Are Interconnected Causative Factors Involved? 疼痛、抑郁和炎症:是否有相互关联的致病因素?

Modern trends in pharmacopsychiatry Pub Date : 2015-01-01 Epub Date: 2015-09-18 DOI: 10.1159/000435930

Brian E Leonard

引用次数: 23

Supraspinal Transient Receptor Potential Subfamily V Member 1 (TRPV1) in Pain and Psychiatric Disorders. 疼痛和精神疾病中的棘上瞬时受体电位亚家族V成员1 (TRPV1)。

Modern trends in pharmacopsychiatry Pub Date : 2015-01-01 Epub Date: 2015-09-18 DOI: 10.1159/000435934

Manish K Madasu, Michelle Roche, David P Finn

引用次数: 25

Visceral Pain and Psychiatric Disorders. 内脏疼痛和精神疾病。

Modern trends in pharmacopsychiatry Pub Date : 2015-01-01 Epub Date: 2015-09-18 DOI: 10.1159/000435936

Valeria D Felice, Rachel D Moloney, John F Cryan, Timothy G Dinan, Siobhain M O'Mahony

{"title":"Visceral Pain and Psychiatric Disorders.","authors":"Valeria D Felice, Rachel D Moloney, John F Cryan, Timothy G Dinan, Siobhain M O'Mahony","doi":"10.1159/000435936","DOIUrl":"https://doi.org/10.1159/000435936","url":null,"abstract":"The high comorbidity existing between visceral pain and psychiatric disorders such as depression and anxiety is well documented and it is gaining increasing interest among scientists. When visceral pain and psychiatric disorders are comorbid, they present a more debilitating condition than each disorder alone, impacting significantly on the quality of life of these patients. Despite several groups having shown that an overlapping pathophysiology exists between visceral pain and stress-related disorders the link between them is not clear yet. Moreover, it still remains to be elucidated if psychiatric conditions predispose the individual to develop visceral hypersensitivity or vice versa. The brain-gut-microbiome axis is the bidirectional communication between the CNS and the gastrointestinal tract. Alterations at different levels of this axis have been implicated in both visceral hypersensitivity and psychiatric disorders. Here we give an overview of what it is known about comorbid visceral pain and psychiatric disorders and provide evidence of potential overlapping pathophysiological mechanisms involved. Preclinical models of comorbid visceral pain and stress-related disorders are also discussed. ","PeriodicalId":74212,"journal":{"name":"Modern trends in pharmacopsychiatry","volume":"30 ","pages":"103-19"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000435936","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34059892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17