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Amyotrophic Lateral Sclerosis: From Mechanisms to Current, Emerging, and Alternative Therapeutics. 肌萎缩侧索硬化症：从机制到当前、新兴和替代疗法。

Med discoveries Pub Date : 2023-01-01 Epub Date: 2023-08-09

Ivelina P Kioutchoukova, Devon Foster, Rajvi N Thakkar, Hayley N Kurz, Brandon Lucke-Wold

{"title":"Amyotrophic Lateral Sclerosis: From Mechanisms to Current, Emerging, and Alternative Therapeutics.","authors":"Ivelina P Kioutchoukova, Devon Foster, Rajvi N Thakkar, Hayley N Kurz, Brandon Lucke-Wold","doi":"","DOIUrl":"","url":null,"abstract":"Amyotrophic Lateral Sclerosis (ALS) is a severe neurodegenerative disease affecting the motor neurons. Although the etiology remains unknown, mutations in superoxide dismutase 1 have been observed in patients with familial ALS, resulting in increased calcium in the cells and leading to cell death. Additionally, studies in patients with the C9orf72 repeat expansion have shown lower age of onset, cognitive and behavioral impairments, and reduced survival. Accumulation of TDP-43 in the cytoplasm of neurons and glial cells caused by the loss of UBQLN2 has been shown to lead to mitotoxicity and proteasomal overload. Early diagnosis of ALS is necessary for the optimization of care between a patient's neurologist and interdisciplinary team members to ensure the best outcomes possible. Proper management between physical therapy, occupation therapy, and pharmaceutical medications can improve ALS symptoms, achieving the highest quality of life possible for the patient. The current therapeutic medication recommended for ALS is Riluzole, but new therapies are emerging. This paper analyzes mechanisms of injury and progression of ALS along while analyzing current, emerging, and alternative therapeutics targeting ALS.","PeriodicalId":74134,"journal":{"name":"Med discoveries","volume":"2 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41124831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing Analytics of EEG Signals. 推进脑电信号分析。

Med discoveries Pub Date : 2023-01-01 Epub Date: 2023-04-12

Fnu Ruchika, Durga Neupane, Siddharth Shah, Maliya Delawan, Brandon Lucke-Wold

{"title":"Advancing Analytics of EEG Signals.","authors":"Fnu Ruchika, Durga Neupane, Siddharth Shah, Maliya Delawan, Brandon Lucke-Wold","doi":"","DOIUrl":"","url":null,"abstract":"Electro Encephalo Graphy (EEG) is a non-invasive diagnostic tool that is widely used in the field of neurosurgery. The EEG measures the electrical activity of the brain, which provides essential information about brain function and can help diagnose various neurological conditions. In neurosurgery, EEG monitors the brain during surgery to ensure that the patient's brain function remains stable and minimize the risk of neurological complications. EEG is also used in the preoperative evaluation of patients who are being considered for brain surgery. This information is critical in helping the neurosurgeon determine the best surgical approach and to minimize the risk of damaging critical brain structures. Additionally, EEG can be used to monitor the brain's recovery after surgery, which can help predict the patient's prognosis and inform the treatment plan.In recent years, the use of EEG has become increasingly sophisticated and has allowed for more precise and detailed monitoring of brain function during surgery. For example, high-resolution EEG techniques can be used to provide real-time information about the activity of specific brain regions. Additionally, developing wearable and portable devices in the future will allow continuous monitoring of brain function, providing real-time data on a patient's condition. In conclusion, EEG is a critical tool in the field of neurosurgery and has dramatically improved the ability of neurosurgeons to diagnose, treat, and monitor patients with neurological conditions. With continued advances in EEG technology, its use in neurosurgery will likely continue to grow and play an increasingly important role in improving patient outcomes.","PeriodicalId":74134,"journal":{"name":"Med discoveries","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9538364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment of Melanoma Metastasis: Surgical, Chemotherapy, and Innovation. 黑色素瘤转移的治疗：手术、化疗和创新。

Med discoveries Pub Date : 2023-01-01 Epub Date: 2023-04-14

Chelsea Rosen, Taeya Mayes, Claire Overholt, Brandon Lucke-Wold

{"title":"Treatment of Melanoma Metastasis: Surgical, Chemotherapy, and Innovation.","authors":"Chelsea Rosen, Taeya Mayes, Claire Overholt, Brandon Lucke-Wold","doi":"","DOIUrl":"","url":null,"abstract":"Melanoma is a form of skin cancer with an increased ability to metastasis to organs such as the brain and other visceral organs, contributing to its aggressiveness and seriousness. Melanoma's prevalence around the globe rapidly continues to rise. Melanoma development is a complex process often depicted as a step-wise process with the potential to end in metastatic disease. Recent studies suggest that the process could be non-linear. Melanoma has many risk factors including genetics, UV exposure, or exposure to carcinogens. Current treatments for metastatic melanoma include surgery, chemotherapy, and immune checkpoint inhibitors (ICIs); however, each of these treatments comes with limitations, toxicities, and relatively poor outcomes. There are various guidelines set by the American Joint Committee on Cancer guiding surgical treatment options based on the site of metastasis. Surgical treatments cannot fully treat widespread metastatic melanoma but can contribute to better patient outcomes overall. Many chemotherapy options are ineffective against melanoma or come with extreme toxicities; however, alkylating agents, platinum analogs, and microtubular toxins have shown some effectiveness against metastatic melanoma. ICIs are a relatively new treatment option and offer a promising option for patients; however, ICIs are subject to tumor resistance mechanisms and are not effective for every metastatic melanoma patient. Due to the limitations of conventional treatments, there is a need for newer and more effective treatment options for metastatic melanoma. This review aims to highlight the current surgical, chemotherapy, and ICI treatments for metastatic melanoma, as well as current clinical and preclinical investigations to discover revolutionary options for patients.","PeriodicalId":74134,"journal":{"name":"Med discoveries","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9538366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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