Wasim Baqir, William K. Gray, Alistair Blair, Shona Haining, Fraser Birrell
{"title":"Osteoporosis group consultations are as effective as usual care: Results from a non-inferiority randomized trial","authors":"Wasim Baqir, William K. Gray, Alistair Blair, Shona Haining, Fraser Birrell","doi":"10.1002/lim2.3","DOIUrl":"https://doi.org/10.1002/lim2.3","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Group consultations led by doctors or nurses are widely used in diabetes and hypertension and are promising in inflammatory arthritis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To show effectiveness in other musculoskeletal conditions with other professionals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Hypothesis</h3>\u0000 \u0000 <p>Group consultations as effective as one-to-one consultations for treating patients at risk of osteoporotic fracture, defined by 10-year fracture risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Randomized controlled non-inferiority trial, with parallel groups randomized by patient</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>Three primary care practices, Northumberland, United Kingdom</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients</h3>\u0000 \u0000 <p>A total of 158 patients consenting to the study from 1052 patients ≥50 years invited from the highest 10-year fracture risk group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Interventions</h3>\u0000 \u0000 <p>Pharmacist-led clinic appointment either in one of four 90-min group consultations (n = 75) or comparator usual care consultation (n = 83).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Measurements</h3>\u0000 \u0000 <p>Primary outcome measure – mean possession ratio of bisphosphonates over 12 months (doses requested/all possible doses). Secondary outcomes included treatment persistence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Ten-year fracture risk for major osteoporotic/hip fracture was 26%/14% for group and 23%/10% for usual care, respectively. Mean possession ratio was 0.62 (interquartile range [IQR] = 0.23-0.92) for group and 0.54 (IQR = 0.15-0.92) for usual care (confirmed as non-inferior).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Limitations</h3>\u0000 \u0000 <p>Single pharmacist delivered the intervention/comparator, although piloting showed nurses or doctors equally competent; small number of practices.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 ","PeriodicalId":74076,"journal":{"name":"Lifestyle medicine (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/lim2.3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72192537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thomas R. Wood BM, BCh, PhD, Guðmundur F. Jóhannsson MD
{"title":"Metabolic health and lifestyle medicine should be a cornerstone of future pandemic preparedness","authors":"Thomas R. Wood BM, BCh, PhD, Guðmundur F. Jóhannsson MD","doi":"10.1002/lim2.2","DOIUrl":"10.1002/lim2.2","url":null,"abstract":"<p>The recent impact of SARS-CoV-2 and coronavirus disease 2019 (COVID-19) has shown major differences in infrastructure and approach across healthcare systems worldwide. One thing we can already be certain of is that governments and policy makers worldwide will place a greater focus on pandemic preparedness in the future. However, as well as ensuring that robust pipelines for rapid test, highly effective treatment or vaccine, and personal protective equipment (PPE) production are in place, we must address underlying resilience and susceptibility of our populations to infectious disease. Although the true spread and case fatality rate of SARS-CoV-2 may not be known for several months or even years, what is becoming increasingly clear is the significant degree to which underlying conditions associated with suboptimal metabolic health appear to be associated with poor outcomes in those with COVID-19. Considering the nature of these underlying conditions, such as obesity and hypertension, lifestyle-based approaches are likely to be one of our best tools in order to address ongoing and future disease burden during pandemics.</p>","PeriodicalId":74076,"journal":{"name":"Lifestyle medicine (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/lim2.2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44347854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Inaugural Lifestyle Medicine Editorial","authors":"Fraser Birrell","doi":"10.1002/lim2.1","DOIUrl":"10.1002/lim2.1","url":null,"abstract":"<p>When first drafting this inaugural editorial in November 2019, events were already starting to unfold on the other side of the world, which would lead to the current pandemic, transform all of our lives and cause a still-mounting death toll. We now know that the first case of what is now named COVID-19 was traced back to 17 November 2019 in Wuhan, Hubei province, China and that at least 266 people were infected last year,<span><sup>1</sup></span> despite initial reports suggesting the very end of December for case zero. However, this version of events was inconsistent with a case identified retrospectively from a retained swab in France taken 27 December 2019 (BBC, 2020)<span><sup>2</sup></span>, although this report is awaiting confirmation from the French Government. Sequencing supports a current scientific consensus that the SARS-CoV2 coronavirus is of natural origin, with 96% homology with a bat coronavirus (RaTG13) and all six key residues from the pangolin spike receptor-binding domain.<span><sup>3</sup></span> We know the SARS virus had further outbreaks after the initial outbreak on at least four occasions at three labs in China, Taiwan, and Singapore.<span><sup>4</sup></span> However, in May 2020 speculation continues about whether patterns of mobile phone activity in October 2019 indicate a “hazardous event” between 6 and 11 October causing a shutdown of the Wuhan Institute of Virology.<span><sup>5</sup></span></p><p>There have been a variety of commentators, with academic leadership from the <i>New England Journal</i>,<span><sup>6</sup></span> <i>JAMA</i>,<span><sup>7</sup></span> and <i>Lancet</i>,<span><sup>8</sup></span> with Richard Horton critical about the unheeded timely warnings about testing and personal protective equipment (PPE) requirements. Changes in UK advice on staff use of PPE in hospital outpatients in May, plus patients and other visitors and public transport users using face coverings from June have brought guidance in line with the practice of those of us informed by both the ecological evidence from countries who have coped well with the pandemic and the precautionary principle. Trish Greenhalgh has been highly influential on Twitter and in print on the revision of this guidance (Greenhalgh et al, 2020).<span><sup>9</sup></span> However, some of the most useful literature has been open access and online. For example, Tomas Pueyo is a Silicon Valley online educator, who rose to international prominence with a razor-sharp, insightful, comparative international analysis on the causes and consequences of failing to arrest spread of such an infectious and relatively deadly pathogen<span><sup>10</sup></span> and the subsequent impact of relaxing control measures.<span><sup>11</sup></span> As I write the first revision, these articles have been viewed 40 million and 10 million times, respectively, with a total of 60 million by the time of publication. The reasons why this was so powerful include it being a fresh persp","PeriodicalId":74076,"journal":{"name":"Lifestyle medicine (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/lim2.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47517070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lifestyle Approaches Targeting Obesity to Reduce Cancer Risk, Progression, and Recurrence","authors":"D. Bruno, N. Berger","doi":"10.1201/9781315201108-33","DOIUrl":"https://doi.org/10.1201/9781315201108-33","url":null,"abstract":"","PeriodicalId":74076,"journal":{"name":"Lifestyle medicine (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43310344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevention, Screening, and Treatment of Sexually Transmitted Infections","authors":"K. Carlson","doi":"10.1201/9781315201108-57","DOIUrl":"https://doi.org/10.1201/9781315201108-57","url":null,"abstract":"","PeriodicalId":74076,"journal":{"name":"Lifestyle medicine (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43270219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Medication Dosing and Adherence in Secondary Prevention","authors":"O. Bilen, N. Wenger","doi":"10.1201/9781315201108-60","DOIUrl":"https://doi.org/10.1201/9781315201108-60","url":null,"abstract":"","PeriodicalId":74076,"journal":{"name":"Lifestyle medicine (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42107717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Community as a Catalyst for Healthier Behaviors","authors":"J. Ellery, P. Ellery","doi":"10.1201/9781315201108-107","DOIUrl":"https://doi.org/10.1201/9781315201108-107","url":null,"abstract":"","PeriodicalId":74076,"journal":{"name":"Lifestyle medicine (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49303228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Implementing Nutritional Lifestyle Treatment Programs in Type 2 Diabetes","authors":"G. Guthrie","doi":"10.1201/9781315201108-31","DOIUrl":"https://doi.org/10.1201/9781315201108-31","url":null,"abstract":"","PeriodicalId":74076,"journal":{"name":"Lifestyle medicine (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49605451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}