JU open plus最新文献

{"title":"Office-Based Transperineal Laser Ablation for Benign Prostatic Hyperplasia Under Local Anesthesia: 2-Year Results from a Dose Range Confirmatory Trial","authors":"Fernando J. Bianco, E. Luna, A. Lopez-Prieto, Pedro González, E. Gheiler, Ariel M. Kaufman, L. Avila, Giuseppe Maiolino","doi":"10.1097/ju9.0000000000000105","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000105","url":null,"abstract":"\u0000 \u0000 To evaluate the safety and tolerability profile of transperineal laser ablation (TPLA) for patients with benign prostatic hyperplasia in an office setting under sedative-free anesthesia, including the functional outcome results at 24 months.\u0000 \u0000 \u0000 \u0000 This is a prospective, single-center, dose range confirmatory trial involving 20 male patients. TPLA was performed by urologists in an office setting, using nonsedative local anesthesia. Self-administered nitrous oxide/oxygen dissociating gas was optional. Tolerability was assessed using a visual analog scale. Safety was evaluated by recording Grade 3 or worse adverse events within 30 days after the procedure. International Prostate Symptom Score, Sexual Health Inventory for Men, ejaculation function, and uroflowmetry parameters were assessed at 6, 12, and 24 months.\u0000 \u0000 \u0000 \u0000 All 20 procedures were performed as intended without request of cessation from any patient, who tolerated them very well, recording a median pain score of 2 (range 1-4). It is important to note that there was a rapid escalation of dose, and the last 18 consecutive patients were initiated at the maximal energy dose of 7 watts. No hospital transfers were recorded, and no urgent hospital admissions within 30 days post-procedure occurred. There was 1 Grade 3 complication registered during the 24-month study interval. We observed a statistically significant and sustained reduction in the median International Prostate Symptom Score at 6 months (6, 3-8), 12 months (3, 5-2), and 24 months (3, 2-4) when compared with baseline values (14, 12-17). Uroflowmetry parameters showed a similar trend. The median Sexual Health Inventory for Men values did not change significantly, and only approximately 10% of patients reported absence of anterograde ejaculation at 12 and 24 months.\u0000 \u0000 \u0000 \u0000 TPLA for benign prostatic hyperplasia is a safe and well-tolerated office-based procedure, with durable benefits on functional outcomes over 2 years of follow-up. Further studies are required to confirm these results.\u0000 \u0000 \u0000 \u0000 NCT04760483.\u0000","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":"84 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139966586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment: Office-Based Transperineal Laser Ablation for Benign Prostatic Hyperplasia Under Local Anaesthesia: 2-Year Results from a Dose Range Confirmatory Trial","authors":"Mario I. Fernández, Alberto Bustamante","doi":"10.1097/ju9.0000000000000115","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000115","url":null,"abstract":"","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":"50 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139965620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment: Case Report: Sacral Neuromodulation with Suspected Neuromuscular Blockade Secondary to a Butyrylcholinesterase (BCHE) Variant","authors":"J. Kikuchi","doi":"10.1097/ju9.0000000000000085","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000085","url":null,"abstract":"","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":" 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138620237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Sacral Neuromodulation with Suspected Neuromuscular Blockade Secondary to Butyrylcholinesterase Variant","authors":"Nadia Megahed, Prapti Singh, Yaseen Maleki, Rachel A. High, Julie Stewart","doi":"10.1097/ju9.0000000000000083","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000083","url":null,"abstract":"","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":"98 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138623163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment: Postoperative Oral Care Pathways Are Not Required at the Time of Buccal Mucosa Harvest","authors":"Ryan Terlecki, Ethan Matz, Connor Policastro","doi":"10.1097/ju9.0000000000000086","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000086","url":null,"abstract":"","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":"620 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139024572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Editorial Comment: Pelvic Floor Dysfunction: A Common Cause of Chronic Orchialgia","authors":"Amy Zheng, Susan M. MacDonald","doi":"10.1097/ju9.0000000000000091","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000091","url":null,"abstract":"","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":"770 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139018704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JU Open Plus: Updates on the American Urological Association Family of Journals","authors":"John W. Davis","doi":"10.1097/ju9.0000000000000099","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000099","url":null,"abstract":"","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":"33 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139026102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment: Microbiomes in Post-DRE Urine Samples Are Linked to Prostate Cancer Risk","authors":"Michael A. Liss","doi":"10.1097/ju9.0000000000000084","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000084","url":null,"abstract":"","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":" 690","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138610754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiomes in Post–Digital Rectal Exam Urine Samples are Linked to Prostate Cancer Risk","authors":"E. D. Crawford, R. Martin, Caleb D. Phillips, Whitney N. Stanton, A. van Bokhoven, M. S. Lucia, Paul Arangua, Francisco G. La Rosa, Zachary Grasmick, Ryan Terlecki, Margaret F. Meagher, Daisaku Hirano, J. C. Nickel, P. Werahera","doi":"10.1097/ju9.0000000000000082","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000082","url":null,"abstract":"\u0000 \u0000 \u0000 Bacterial species including Cutibacterium acnes (C. acnes) have been associated with different inflammatory and neoplastic conditions in prostate cancer (PCa) tissue samples, but their clinical impact is unknown. Using next-generation sequencing (NGS)–based clinical reports, we investigated the differential abundance and incidence of microbiomes in post–digital rectal exam (DRE) urine samples from patients with PCa and a matched control group at low risk of PCa.\u0000 \u0000 \u0000 \u0000 A total of 200 post-DRE urine samples were analyzed, 100 from patients with histopathologically confirmed PCa and 100 from men at very low risk of PCa with PSA <1.5 ng/mL as controls. Bacterial and fungal communities were characterized by NGS of 16S and internal transcribed spacer (ITS) loci, respectively, with species' relative abundances provided on physicians' clinical reports. The differential abundance and incidence of species between cancer and control groups were evaluated.\u0000 \u0000 \u0000 \u0000 Microbes were reported in 39% and 56% of PCa and control group samples, respectively. C. acnes had a significantly higher relative abundance in patients with PCa vs controls (P < .05), and C. acnes incidence rates were also nominally higher in patients with PCa as compared with controls (12.82% and 7.27%, respectively). By contrast, Finegoldia magna (F. magna) had a significantly higher relative abundance (P < .05) and incidence rate (P < .05) in controls as compared with patients with PCa.\u0000 \u0000 \u0000 \u0000 \u0000 C. acnes was among the most prevalent bacterial species in PCa urine samples. F. magna identified in the low-risk group is responsible for production of equol, a soy metabolite associated with lowering risk of PCa, suggesting a role in prostate cancer chemoprevention.\u0000","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":" 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138619754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uropathogenic Dysbiosis Pattern is Associated With Urethral Fibrosis","authors":"Michael Witthaus, Saager Chawla, Dhruvi Puri, Kyoko Sakamoto, Jill Buckley, Aaron Miller, Mahadevan Rajasekaran","doi":"10.1097/ju9.0000000000000089","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000089","url":null,"abstract":"Cellular mechanisms of stricture progression after repeated transurethral interventions are unclear. We hypothesize that urethral injury and mechanical stretch cause tears on the urethral epithelial cell lining leading to leaking epithelium and urine extravasation. Urinary bacteria traverse the epithelial lining and may promote fibrogenesis through inflammation due to microbial activity. Our objective was to perform a case-control study of the urobiome from patients with urethral stricture disease or healthy controls using 16S rRNA and shotgun metagenomic sequencing profiling to elucidate the clinical relevance of the urobiome in urinary stricture progression.\u0000 \u0000 \u0000 \u0000 First catch urine samples from patients and healthy volunteers were collected and pelleted urine was used for DNA extraction, followed by high throughput 16S rRNA and shotgun metagenomic sequencing. Sequencing data were used to determine microbial taxa and functions associated with urethral stricture disease.\u0000 \u0000 \u0000 \u0000 Sequencing results revealed that the lower urinary tract urobiome was significantly different between urethral stricture disease cases and healthy controls. In particular, taxonomic and metabolic profiles point toward anaerobic biofilm formation by antibiotic-resistant species of Klebsiella, which is a known uropathogen. Importantly, no patients in the study exhibited signs or symptoms of clinical infection.\u0000 \u0000 \u0000 \u0000 Our findings suggest a role for biofilm formation by uropathogens such as Klebsiella spp. in developing an inflammatory environment and consequent fibrosis progression. Future studies will elucidate specific mechanisms of Klebsiella-induced fibrosis. Our data suggest that targeting specific bacteria or biofilm formation may be beneficial for urethral stricture disease detection and prevention of progression.","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":"125 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138608918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}