Adverse drug reactions and toxicological reviews最新文献

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Methaemoglobinaemia. Methaemoglobinaemia。
J P Griffin
{"title":"Methaemoglobinaemia.","authors":"J P Griffin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7401,"journal":{"name":"Adverse drug reactions and toxicological reviews","volume":"16 1","pages":"45-63"},"PeriodicalIF":0.0,"publicationDate":"1997-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20138019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paracetamol. 扑热息痛。
P F D'Arcy
{"title":"Paracetamol.","authors":"P F D'Arcy","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7401,"journal":{"name":"Adverse drug reactions and toxicological reviews","volume":"16 1","pages":"9-14"},"PeriodicalIF":0.0,"publicationDate":"1997-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20138017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of alcohol on the heart. 酒精对心脏的影响。
V B Patel, H J Why, P J Richardson, V R Preedy
{"title":"The effects of alcohol on the heart.","authors":"V B Patel,&nbsp;H J Why,&nbsp;P J Richardson,&nbsp;V R Preedy","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We have discussed in this review many features and possible mechanisms responsible for the development of alcoholic cardiomyopathy. The evidence suggests that defects in myofibrillar protein turnover occur in both acute and chronic alcohol studies. Possible mechanisms to explain poor contractile function include alterations in cellular calcium, magnesium or phosphate homeostasis. The toxic effects of acetaldehyde or the formation of fatty acid ethyl esters may cause impairment of mitochondrial oxidative phosphorylation. Alternatively, reduced amounts of heat shock proteins may result in poor assembly and protection of proteins. In acute ethanol toxicity ischaemia may occur, possibly due to increased xanthine oxidase activity or beta-adrenergic stimulation. Chronic alcohol consumption can also lead to the development of hypertension via magnesium loss and consequent alterations in peripheral vascular calcium regulation. However, these are only a few facets of a complex relationship between alcohol and the cardiovascular system.</p>","PeriodicalId":7401,"journal":{"name":"Adverse drug reactions and toxicological reviews","volume":"16 1","pages":"15-43"},"PeriodicalIF":0.0,"publicationDate":"1997-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20138018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two UK Government proposals bearing on drug safety. 两项英国政府关于药品安全的提案。
J P Griffin
{"title":"Two UK Government proposals bearing on drug safety.","authors":"J P Griffin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7401,"journal":{"name":"Adverse drug reactions and toxicological reviews","volume":"16 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"1997-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20138016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug interactions with medicinal plastics. 药物与医用塑料的相互作用。
P F D'Arcy
{"title":"Drug interactions with medicinal plastics.","authors":"P F D'Arcy","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7401,"journal":{"name":"Adverse drug reactions and toxicological reviews","volume":"15 4","pages":"207-19"},"PeriodicalIF":0.0,"publicationDate":"1996-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20062044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug interactions with agents used in the treatment of epilepsy. 药物与治疗癫痫药物的相互作用。
J P Griffin
{"title":"Drug interactions with agents used in the treatment of epilepsy.","authors":"J P Griffin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7401,"journal":{"name":"Adverse drug reactions and toxicological reviews","volume":"15 4","pages":"221-46"},"PeriodicalIF":0.0,"publicationDate":"1996-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20062045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The tarantula--poison spider or a case of mistaken identity? 狼蛛——是毒蜘蛛还是认错人?
{"title":"The tarantula--poison spider or a case of mistaken identity?","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7401,"journal":{"name":"Adverse drug reactions and toxicological reviews","volume":"15 4","pages":"199-202"},"PeriodicalIF":0.0,"publicationDate":"1996-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20061461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An overview of the adverse reactions to adrenal corticosteroids. 肾上腺皮质类固醇的不良反应概述。
A G Frauman
{"title":"An overview of the adverse reactions to adrenal corticosteroids.","authors":"A G Frauman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Glucocorticoids are amongst the most potent immunosuppressant drugs available and are widely used in many inflammatory and autoimmune conditions such as asthma and systemic lupus erythematosus. These agents are, however, associated with potentially substantial systemic side effects including electrolyte disturbances, cardiovascular effects, diabetes mellitus and loss of bone density and osteoporosis with concomitant vertebral fracture. The clinical utility of these agents should be tempered by the use of a minimum effective dose and, where possible, by the administration of alternate daily or pulse steroids which may have some impact on reducing the prevalence of these adverse effects. Moreover, recent evidence suggests that calcium and vitamin D co-administration may offset the chronic effects of glucocorticoids in inducing bone loss. A greater understanding of the molecular and cellular basis of glucocorticoid action, particularly as it relates to bone loss, is necessary to optimize efficacy and safety and to utilize therapies which may minimize the long-term effects of glucocorticoids. Furthermore, there is a need to develop newer glucocorticoids which have lesser effects on bone and other sites of adverse events, whilst retaining their immunosuppressive and anti-inflammatory action.</p>","PeriodicalId":7401,"journal":{"name":"Adverse drug reactions and toxicological reviews","volume":"15 4","pages":"203-6"},"PeriodicalIF":0.0,"publicationDate":"1996-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20061462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug interactions with medicinal plastics. 药物与医用塑料的相互作用。
Adverse drug reactions and toxicological reviews Pub Date : 1996-11-01 DOI: 10.1016/B978-044482406-6/50019-8
D'arcy Pf
{"title":"Drug interactions with medicinal plastics.","authors":"D'arcy Pf","doi":"10.1016/B978-044482406-6/50019-8","DOIUrl":"https://doi.org/10.1016/B978-044482406-6/50019-8","url":null,"abstract":"","PeriodicalId":7401,"journal":{"name":"Adverse drug reactions and toxicological reviews","volume":"26 1","pages":"207-219"},"PeriodicalIF":0.0,"publicationDate":"1996-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72673794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
An update of the safety topics post ICH3. ICH3后安全主题的更新。
D Tweats, D Scales
{"title":"An update of the safety topics post ICH3.","authors":"D Tweats,&nbsp;D Scales","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7401,"journal":{"name":"Adverse drug reactions and toxicological reviews","volume":"15 3","pages":"173-80"},"PeriodicalIF":0.0,"publicationDate":"1996-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19895347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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