Adverse drug reactions and toxicological reviews最新文献_第2页

An evaluation of selected herbal reference texts and comparison to published reports of adverse herbal events. 对选定的草药参考文献进行评价，并与已发表的草药不良事件报告进行比较。

Adverse drug reactions and toxicological reviews Pub Date : 2002-01-01 DOI: 10.1007/BF03256189

Christine A Haller, Ilene B Anderson, Susan Y Kim, Paul D Blanc

{"title":"An evaluation of selected herbal reference texts and comparison to published reports of adverse herbal events.","authors":"Christine A Haller, Ilene B Anderson, Susan Y Kim, Paul D Blanc","doi":"10.1007/BF03256189","DOIUrl":"https://doi.org/10.1007/BF03256189","url":null,"abstract":"Objective: There has been a recent proliferation of medical reference texts intended to guide practitioners whose patients use herbal therapies. We systematically assessed six herbal reference texts to evaluate the information they contain on herbal toxicity.Methods: We selected six major herbal references published from 1996 to 2000 to evaluate the adequacy of their toxicological information in light of published adverse events. To identify herbs most relevant to toxicology, we reviewed herbal-related calls to our regional California Poison Control System, San Francisco division (CPCS-SF) in 1998 and identified the 12 herbs (defined as botanical dietary supplements) most frequently involved in these CPCS-SF referrals. We searched Medline (1966 to 2000) to identify published reports of adverse effects potentially related to these same 12 herbs. We scored each herbal reference text on the basis of information inclusiveness for the target 12 herbs, with a maximal overall score of 3.Results: The herbs, identified on the basis of CPCS-SF call frequency were: St John's wort, ma huang, echinacea, guarana, ginkgo, ginseng, valerian, tea tree oil, goldenseal, arnica, yohimbe and kava kava. The overall herbal reference scores ranged from 2.2 to 0.4 (median 1.1). The Natural Medicines Comprehensive Database received the highest overall score and was the most complete and useful reference source. All of the references, however, lacked sufficient information on management of herbal medicine overdose, and several had incorrect overdose management guidelines that could negatively impact patient care.Conclusion: Current herbal reference texts do not contain sufficient information for the assessment and management of adverse health effects of botanical therapies.","PeriodicalId":7401,"journal":{"name":"Adverse drug reactions and toxicological reviews","volume":"21 3","pages":"143-50"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03256189","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22022831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

The life of Andrew Boorde, c1490-1549. 安德鲁·伯德的一生(1490-1549)

Adverse drug reactions and toxicological reviews Pub Date : 2002-01-01 DOI: 10.1007/BF03256200

Patricia E S Fletcher

{"title":"The life of Andrew Boorde, c1490-1549.","authors":"Patricia E S Fletcher","doi":"10.1007/BF03256200","DOIUrl":"https://doi.org/10.1007/BF03256200","url":null,"abstract":"Physician, traveller, writer and spy, Andrew Boorde was born c1490 and became a Carthusian monk after abandoning his medical studies at Oxford. Temperamentally unsuited to the life of a religious, after 20 years at the London Charterhouse he obtained a dispensation to travel to Europe to continue his medical studies. Returning to England he began to practise medicine, treating members of the nobility and, through a meeting with Thomas Cromwell which was to influence the rest of his life, he attended the King, Henry VIII. In 1534, after a second, more extensive, tour of Europe in which he visited many medical schools and universities seeking yet more medical knowledge, he returned to the London Charterhouse which was undergoing a brutal dissolution at the hands of Thomas Cromwell. Boorde reluctantly signed the Oath of Supremacy, an act which was to haunt him for the rest of his life. He was then used by Cromwell to travel abroad again but this time as a spy to gather intelligence for the King while continuing to study medicine. Boorde finally took his MD at the University of Montpellier and was incorporated in the same degree a year later at Oxford. He then gave expression to all he had learnt by writing his legacy, four books which were published in 1547. 'A Compendyous Regyment or a Dyetary of Health' was one of the earliest treatises on the cultivation of health composed in England and stressed the importance of sanitation together with a detailed examination of diet. The 'Brevyary of Health' listed diseases alphabetically together with remedies and treatment, blending sound medical advice with religion and superstition: its companion volume was 'The Principles of Astronomy'. But Boorde's 'Fyrst Boke of the Introduction of Knowledge' was his tour-de-force; it was a comprehensive encyclopaedia of all the European countries he had visited, illustrated by woodcuts. By 1547 Boorde was settled in England, probably Master of the Hospital of St Giles-in-the-Fields in London but by 1549 he was living the life of a recluse in Winchester. Tortured by guilt at his perceived lack of religious integrity and persecuted by his enemies he died in the Fleet prison amid rumors that he had poisoned himself.","PeriodicalId":7401,"journal":{"name":"Adverse drug reactions and toxicological reviews","volume":"21 4","pages":"243-52"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03256200","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22172886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Leper Hospital of St Mary Magdalene at Baldock, Hertfordshire 位于赫特福德郡巴尔多克的圣玛丽抹大拉麻风医院

Adverse drug reactions and toxicological reviews Pub Date : 2002-01-01 DOI: 10.1007/BF03256185

J. Griffin

引用次数: 0

Adverse Drug Reaction Update 药物不良反应更新

Adverse drug reactions and toxicological reviews Pub Date : 2002-01-01 DOI: 10.1007/BF03256186

引用次数: 0

Toxicity of the Chinese herb mu tong (Aristolochia manshuriensis). What history tells us. 中药木通(马兜铃)的毒性。历史告诉我们的。

Adverse drug reactions and toxicological reviews Pub Date : 2002-01-01 DOI: 10.1007/BF03256194

You-Ping Zhu

引用次数: 40

Citalopram-induced severe hyponatraemia with coma and seizure. Case report with literature and spontaneous reports review. 西酞普兰引起的严重低钠血症伴昏迷和癫痫发作。病例报告，文献和自发报告复习。

Adverse drug reactions and toxicological reviews Pub Date : 2002-01-01 DOI: 10.1007/BF03256195

Alexander Fisher, Michael Davis, James Croft-Baker, Patrick Purcell, Allan McLean

{"title":"Citalopram-induced severe hyponatraemia with coma and seizure. Case report with literature and spontaneous reports review.","authors":"Alexander Fisher, Michael Davis, James Croft-Baker, Patrick Purcell, Allan McLean","doi":"10.1007/BF03256195","DOIUrl":"https://doi.org/10.1007/BF03256195","url":null,"abstract":"Numerous case reports of hyponatraemia followed increasing use of selective serotonin re-uptake inhibitors (SSRIs) but this adverse effect was only rarely observed in relation to citalopram. We report a case of severe hyponatraemia associated with deep coma, seizure, atrial fibrillation and muscle damage in a 92-year-old woman after only two doses of citalopram, and review 14 cases previously published in the literature and 28 cases spontaneously reported to Australian Drug Reaction Advisory Committee (ADRAC). The data presented suggest that citalopram, as well as SSRIs may cause hyponatraemia secondary to syndrome of inappropriate secretion of antidiuretic hormone (SIADH). The majority of symptomatic cases occurred in elderly patients (79% were older than 70 years) and in women (74%). Polymedication and concomitant use of another psychotropic drug or thiazide diuretic may precipitate and/or augment the development of hyponatraemia/SIADH. In 84% of cases, the hyponatraemia associated with citalopram was detected during the first month of treatment. High level of suspicion, close and careful monitoring of serum sodium concentration particularly in elderly patients and especially in the first month of therapy with citalopram may reduce the incidence of this serious and likely not rare adverse effect.","PeriodicalId":7401,"journal":{"name":"Adverse drug reactions and toxicological reviews","volume":"21 4","pages":"179-87"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03256195","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22173519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

Investigation of the potential of clozapine to cause torsade de pointes. 氯氮平致髋部扭转的可能性研究。

Adverse drug reactions and toxicological reviews Pub Date : 2002-01-01 DOI: 10.1007/BF03256196

Barbara Warner, Peter Hoffmann

{"title":"Investigation of the potential of clozapine to cause torsade de pointes.","authors":"Barbara Warner, Peter Hoffmann","doi":"10.1007/BF03256196","DOIUrl":"https://doi.org/10.1007/BF03256196","url":null,"abstract":"Antipsychotics are frequently associated with QTc interval prolongation, a proposed marker for vulnerability to fatal ventricular arrhythmias, e.g. torsade de pointes (TdP). Little has been published on this topic in relation to clozapine. The objectives of this review were to: (i) calculate the frequency of QTc interval prolongation, T-wave abnormalities, TdP, ventricular tachycardia/fibrillation and sudden unexplained death in patients treated with clozapine and thioridazine from clinical trial and post-marketing reports; (ii) to compare these data with published findings for haloperidol, risperidone, olanzapine, sertindole and ziprasidone; and (iii) to correlate these clinical data with results from preclinical tests presently considered to be of predictive value for a compound's potential to cause QTc interval prolongation and TdP. A review of the global Novartis databases for clozapine and thioridazine and a Medline/Internet search for information on these cardiac events and for preclinical effects on the human ether-a-go-go related gene channels, action potential duration, and QT interval changes produced by the selected antipsychotics were performed. The clozapine database (2.8 million patient-years spanning 27 years) demonstrated that at therapeutic doses all but three reports of QTc interval prolongation and both of TdP were confounded by relevant co-medication/comorbidity. The literature review revealed that all antipsychotics considered except clozapine induced TdP and/or QTc interval prolongation at therapeutic doses. Preclinical in vitro tests appear to overestimate the risk of clozapine, haloperidol and risperidone to prolong QTc interval in patients and underestimate such a risk for sertindole and ziprasidone. Extrapolation of in vitro results to clinical events requires qualified interpretation.","PeriodicalId":7401,"journal":{"name":"Adverse drug reactions and toxicological reviews","volume":"21 4","pages":"189-203"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03256196","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22173520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 41

The Anti-Depressant Fact Book 抗抑郁药物说明书

Adverse drug reactions and toxicological reviews Pub Date : 2002-01-01 DOI: 10.1007/BF03256187

引用次数: 1

Carbamazepine-provoked hepatotoxicity and possible aetiopathological role of glutathione in the events. Retrospective review of old data and call for new investigation. 卡马西平引起的肝毒性和谷胱甘肽在事件中的可能的病理作用。回顾性审查旧数据并呼吁进行新的调查。

Adverse drug reactions and toxicological reviews Pub Date : 2002-01-01 DOI: 10.1007/BF03256188

Miklós Péter Kalapos

{"title":"Carbamazepine-provoked hepatotoxicity and possible aetiopathological role of glutathione in the events. Retrospective review of old data and call for new investigation.","authors":"Miklós Péter Kalapos","doi":"10.1007/BF03256188","DOIUrl":"https://doi.org/10.1007/BF03256188","url":null,"abstract":"The antiepileptic drug (AED) carbamazepine is widely used in the treatment of different kinds of seizures as well as affective and behavioural disorders. This paper presents an epidemiological study of carbamazepine-induced hepatic injuries and death, and describes the possible mechanisms of its toxicity. A retrospective analysis of clinical data revealed that the likelihood of hepatic death was comparatively higher in children, particularly when they were receiving medication with multiple AEDs, whereas reversible hepatic injuries were more likely to be seen in elderly patients. As suggested in this paper, the development of carbamazepine hepatotoxicity is rare, and unpredictable with the present state of knowledge, but it is somehow related to disturbance of glutathione metabolism, although data in this regard are imperfect. There appear to be two types of carbamazepine-initiated idiosyncratic liver injury, hypersensitivity and toxin-induced. It is feasible that both are due to the accumulation of toxic metabolite(s), and arene oxides may probably be considered as damaging derivatives of carbamazepine metabolism. Despite the lack of clear-cut underlying clinical and experimental findings in those patients in whom an inherited weakness of drug eliminating capacity is present, those conditions that may deteriorate glutathione balance, may increase the possibility of the emergence of toxic events during carbamazepine therapy. Finally, some recommendations for carbamazepine therapy are presented.","PeriodicalId":7401,"journal":{"name":"Adverse drug reactions and toxicological reviews","volume":"21 3","pages":"123-41"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03256188","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22022830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 56

Lamotrigine-induced neutropenia following two attempts to increase dosage above 50 mg/day with recovery between episodes. 拉莫三嗪诱导的中性粒细胞减少，两次尝试增加剂量超过50mg /天，两次发作之间恢复。

Adverse drug reactions and toxicological reviews Pub Date : 2002-01-01 DOI: 10.1007/BF03256191

Olivier Lambert, Gwenaëlle Veyrac, Christophe Armand, Sandra Bourlon, Michel Bourin, Pascale Jolliet

引用次数: 11