Journal of Tongji Medical University = Tong ji yi ke da xue xue bao最新文献_第8页

Expression of multidrug-associated protein, P-glycoprotein, P53 and Bcl-2 proteins in bladder cancer and clinical implication. 膀胱癌中多药相关蛋白、P-糖蛋白、P53 和 Bcl-2 蛋白的表达及其临床意义。

Journal of Tongji Medical University = Tong ji yi ke da xue xue bao Pub Date : 2001-01-01 DOI: 10.1007/BF02888038

Z Chen, Y Zhang, X Zhang, G Du, W Yang, Z Hu, J Li, Y Zhang

{"title":"Expression of multidrug-associated protein, P-glycoprotein, P53 and Bcl-2 proteins in bladder cancer and clinical implication.","authors":"Z Chen, Y Zhang, X Zhang, G Du, W Yang, Z Hu, J Li, Y Zhang","doi":"10.1007/BF02888038","DOIUrl":"10.1007/BF02888038","url":null,"abstract":"The expression of multidrug resistant proteins in bladder cancer and clinical implication was studied. Expression of multidrug-associated protein (MRP), P-glycoprotein (P-gp), P53 and Bcl-2 proteins were detected by using immunohistochemical method in 40 specimens of bladder transitional cell carcinoma. The results showed that the positive rate of MRP, P-gp, P53 and Bcl-2 was 52.5%, 57.5%, 47.5% and 62.5% respectively. The positive rate of MRP, P-gp, P53 and Bcl-2 in the grade I, II and III of tumors was 46.3%, 38.5%, 38.5%, 23.1%; 52.9%, 39.8%, 47.1%, 76.4%; 60.0%, 80.0%, 60.0%, 90.0% respectively. The positive rate of MRP, P-gp, P53 and Bcl-2 in 24 primary tumor specimens was 37.5%, 41.7%, 33.3%, 45.8% and that in 16 cases in recurrent specimens receiving chemotherapy 75.0%, 81.3%, 68.8%, 87.5% respectively. It was suggested the positive rate of MRP, P-gp, P53 and Bcl-2 was increased with the advance of tumor grade. The positive rate of four proteins in all recurrent cases was significantly increased (P < 0.05). The expression of MRP, P-gp, P53 and Bcl-2 proteins might be the important factors for chemotherapy failure.","PeriodicalId":73995,"journal":{"name":"Journal of Tongji Medical University = Tong ji yi ke da xue xue bao","volume":"21 1","pages":"56-8"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52207878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic renal scintigraphy in diagnosis of upper urinary tract obstruction in transplanted kidney. 动态肾脏闪烁扫描在诊断移植肾上尿路梗阻中的应用

Journal of Tongji Medical University = Tong ji yi ke da xue xue bao Pub Date : 2001-01-01 DOI: 10.1007/BF02888084

Z Xianyu, H Wu, J Zhou, P Zhou, M Zhao

{"title":"Dynamic renal scintigraphy in diagnosis of upper urinary tract obstruction in transplanted kidney.","authors":"Z Xianyu, H Wu, J Zhou, P Zhou, M Zhao","doi":"10.1007/BF02888084","DOIUrl":"10.1007/BF02888084","url":null,"abstract":"Nuclide renal dynamic imaging was performed on 88 (110 times) transplanted kidney. Two kinds of renal scintigraphic characteristics were identified in recipients with supravesical obstruction of the graft. First, the regular type was characterized by radioactivity defect area in kidney parenchyma during early uptake period followed by ureteropelvic retention. Second, the tubular type was typified by cortical retention and attenuation in collecting system during the whole test period with a special sign of \"hollow kidney\". Non-obstructive dilated calyces showed similar signs as the regular type. Acute rejection reaction and tubule necrosis demonstrated obstructive time-activity curves. However, the radioactivity retention appeared in cortex. It was suggested that dilated calyces and obstructive renogram might not be reliable evidence for upper urinary tract obstruction. The signs of radioactivity attenuation in kidney parenchyma during early uptake period followed by ureteropelvic retention may be more valuable for the evaluation. As for tubular obstruction, specified \"hollow kidney\" was the characteristic sign which is helpful for the diagnosis.","PeriodicalId":73995,"journal":{"name":"Journal of Tongji Medical University = Tong ji yi ke da xue xue bao","volume":"21 2","pages":"156-8"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10037603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on the changes in microvessel density in hepatocellular carcinoma following transcatheter arterial chemoembolization. 肝细胞癌经导管动脉化疗栓塞后微血管密度变化的研究。

Journal of Tongji Medical University = Tong ji yi ke da xue xue bao Pub Date : 2001-01-01 DOI: 10.1007/BF02886568

J Yi, X Liao, Z Yang, X Li

引用次数: 4

Pulmonary sequestration: three dimensional dynamic contrast-enhanced MR angiography and MRI. 肺部嵌塞：三维动态对比增强磁共振血管造影和磁共振成像。

Journal of Tongji Medical University = Tong ji yi ke da xue xue bao Pub Date : 2001-01-01 DOI: 10.1007/BF02886576

H Xu, D Jiang, X Kong, Y Xiong, D Liu, X Liu, X Deng

{"title":"Pulmonary sequestration: three dimensional dynamic contrast-enhanced MR angiography and MRI.","authors":"H Xu, D Jiang, X Kong, Y Xiong, D Liu, X Liu, X Deng","doi":"10.1007/BF02886576","DOIUrl":"10.1007/BF02886576","url":null,"abstract":"In order to evaluate the diagnostic value of three-dimensional contrast-enhanced MR angiography and MRI for pulmonary sequestration, 5 patients with pulmonary sequestration underwent 3D fast imaging by steady state precession (FISP) with a contrast medium and breath holding following chest radiography, CT and MR scans. The reconstructed MR angiography was performed using maximum intensity projection (MIP) and multiplanar reconstruction (MPR) techniques. It was found that the chest radiography showed pulmonary sequestration as a persistent area of opacity in the posterior basal segment of the left lower lobe, which was close to mediastinum in 2 cases and close to diaphragma in 3 cases. CT revealed a soft issue mass beyond descending aorta and lobar emphysema around the pulmonary sequestration. And the supplying vessel was documented in 2 cases on enhanced CT. MRI demonstrated a hyperintensity mass with respect to normal lung parenchyma on T1WI and T2WI, and the origin of the supplying vessel in 3 cases. The reconstructed CE MRA using MIP or MRP techniques clearly showed the supplying vessel and its course, branches as well as draining vessels. It was concluded that 3D CE MRA of demonstrating the supplying and draining vessels to pulmonary sequestration, together with plain MRI, can provide a diagnosis and aid in surgical planning without the need for DSA.","PeriodicalId":73995,"journal":{"name":"Journal of Tongji Medical University = Tong ji yi ke da xue xue bao","volume":"21 4","pages":"345-8"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22206414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cloning and identification of a novel variant of human vascular endothelial growth factor. 人血管内皮生长因子新型变体的克隆与鉴定。

Journal of Tongji Medical University = Tong ji yi ke da xue xue bao Pub Date : 2001-01-01 DOI: 10.1007/BF02886426

J Guo, S Qu

引用次数: 0

Total cavopulmonary connection for complex cardiac anomalies with the functional single ventricle. 复杂心脏畸形与功能性单心室的全腔肺连接。

Journal of Tongji Medical University = Tong ji yi ke da xue xue bao Pub Date : 2001-01-01 DOI: 10.1007/BF02888082

X Jinag, Z Sun, K Zhang, P Fu

{"title":"Total cavopulmonary connection for complex cardiac anomalies with the functional single ventricle.","authors":"X Jinag, Z Sun, K Zhang, P Fu","doi":"10.1007/BF02888082","DOIUrl":"10.1007/BF02888082","url":null,"abstract":"From Aug. 1999 to Feb. 2001, 8 patients with complex congenital heart diseases, including 5 cases accompanied by hypoplastic left ventricle and 3 by hypoplastic right ventricle, were subjected to total cavopulmonary connection (TCPC). Eight cases underwent the operation under cardiopulmonary bypass and 7 of whom under no cardiac clamp. Seven cases received cavopulmonary anastomosis by flaring method and one case by end-side anastomosis. All the patients underwent the intracardiac tunnels to drain inferior vena cava and plus 4 mm fenestration except one. The results showed that 6 patients had postoperative oxygen saturation more than 90%, sinus rhythm, no anastomostic stoma obstruction, no flow regurgitation and CVP < 16 cmH2O. Two (25%) patients died postoperatively from high venous pressure of 18-20 cmH2O, finally from cardiac failure and anoxima. It was concluded that TCPC was an effective treatment for complex congenital cardiac diseases, especially with ventricular maldevelopment. Intracardiac tunnel plus 4 mm fenestration and flaring cavopulmonary anastomosis could prevent the postoperative complications. Larger anastomotic stoma, venous pressure less than 16 cmH2O and artery saturation more than 90% might indicate excellent TCPC procedures in our experience.","PeriodicalId":73995,"journal":{"name":"Journal of Tongji Medical University = Tong ji yi ke da xue xue bao","volume":"21 2","pages":"149-51"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9663509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Establishment of hepatocellular carcinoma model by allogenic transplantation ]. [通过异基因移植建立肝细胞癌模型 ]。

Journal of Tongji Medical University = Tong ji yi ke da xue xue bao Pub Date : 2001-01-01 DOI: 10.1007/BF02886435

J Qian, G Feng, J Trübenbach, P E Huppert, P L Pereira, C D Claussen

引用次数: 0

Effect of ligustrazine on hematopoiesis in bone marrow transplantation mice. 利格列嗪对骨髓移植小鼠造血功能的影响

Journal of Tongji Medical University = Tong ji yi ke da xue xue bao Pub Date : 2001-01-01 DOI: 10.1007/BF02886559

H Sun, M Fang, T Ren, Q Dai, W Liu, W Lu, H Xu

{"title":"Effect of ligustrazine on hematopoiesis in bone marrow transplantation mice.","authors":"H Sun, M Fang, T Ren, Q Dai, W Liu, W Lu, H Xu","doi":"10.1007/BF02886559","DOIUrl":"10.1007/BF02886559","url":null,"abstract":"The effect of Ligustrazine on the hematopoiesis after bone marrow transplantation (BMT) in allogenic BMT mice was investigated. After the typical mice model of allogenic BMT had been established, the mice were randomly divided into three groups: BMT group, Ligustrazine group and normal group. The BMT group was given normal saline (0.2 ml, twice a day) through gastric tube, while the Ligustrazine group was given Ligustrazine through gastric tube (0.2 ml, twice a day). At the 1st, 7th and 14th day after BMT, we observed the peripheral blood cells and bone marrow nuclear cells (BMNC), as well as the expression level of Heparan Sulfate (HS) and stromal cell derived factor-1 (SDF-1) on bone marrow sections by using immunohistochemistry (SABC-AP), the expression of CXCR4 on the BMNC. The results showed that on the 7th and 14th day, the peripheral blood white cells, platelets, BMNC and the expression levels of CXCR4, HS and SDF-1 were significantly higher in Ligustrazine group than in the BMT group (P < 0.05). It was concluded that Ligustrazine could promote hematopoiesis at the early stage of hematopoietic reconstitution after BMT.","PeriodicalId":73995,"journal":{"name":"Journal of Tongji Medical University = Tong ji yi ke da xue xue bao","volume":"21 4","pages":"289-91, 300"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22204941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical significance and assessment of cytokines in various stages of ulcerative colitis. 细胞因子在溃疡性结肠炎各阶段的临床意义及评价。

Journal of Tongji Medical University = Tong ji yi ke da xue xue bao Pub Date : 2001-01-01 DOI: 10.1007/BF02886564

K Zou, S Liu, X Xie, C Yi

引用次数: 1

Experimental study of serum substantia nigra neuron autoantibody and its effect in Parkinson disease patients. 帕金森病患者血清黑质神经元自身抗体及其作用的实验研究。

Journal of Tongji Medical University = Tong ji yi ke da xue xue bao Pub Date : 2001-01-01 DOI: 10.1007/BF02886556

J Chen, X Cao, Y Xu, S Sun

引用次数: 1