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Journal of Tongji Medical University = Tong ji yi ke da xue xue bao最新文献

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Immunophenotyping of lymphocyte T and B in the peripheral blood of systemic lupus erythematosus. 系统性红斑狼疮患者外周血中 T 淋巴细胞和 B 淋巴细胞的免疫分型。
Journal of Tongji Medical University = Tong ji yi ke da xue xue bao Pub Date : 2001-01-01 DOI: 10.1007/BF02888069
S Hu, D Tao, P He
{"title":"Immunophenotyping of lymphocyte T and B in the peripheral blood of systemic lupus erythematosus.","authors":"S Hu, D Tao, P He","doi":"10.1007/BF02888069","DOIUrl":"10.1007/BF02888069","url":null,"abstract":"<p><p>The immunophenotyping expression levels of lymphocyte in the peripheral blood from 21 patients with active systemic lupus erythematosus (SLE) were analyzed by using the immunofluorescence labeling-flow cytometry technique to investigate the immunophenotyping expression of lymphocytes T and B in the peripheral blood of active SLE patients and its clinical value. It was showed that, compared with normal controls, the expression of CD3+, CD4+ and the ratio of CD4+/CD8+ in the peripheral blood of these patients were decreased (P < 0.01), while the expression of CD8+, CD20+ was significantly increased (P < 0.01). It was suggested that both T and B cells in patients with active SLE involved in immunoregulation, were activated. The abnormal expression of lymphocyte immunophenotyping could influence the immune reaction in SLE patients, which might be one of the important pathogenesis factors in SLE.</p>","PeriodicalId":73995,"journal":{"name":"Journal of Tongji Medical University = Tong ji yi ke da xue xue bao","volume":"21 2","pages":"108-9"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9663503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of jianpiyiqi prescription on the expression of heat shock proteins in acetic acid-induced chronic gastric ulcer rats. 健脾益气方对醋酸致慢性胃溃疡大鼠热休克蛋白表达的影响
Journal of Tongji Medical University = Tong ji yi ke da xue xue bao Pub Date : 2001-01-01 DOI: 10.1007/BF02888068
X Tao, G Li, S Luo
{"title":"Effect of jianpiyiqi prescription on the expression of heat shock proteins in acetic acid-induced chronic gastric ulcer rats.","authors":"X Tao, G Li, S Luo","doi":"10.1007/BF02888068","DOIUrl":"10.1007/BF02888068","url":null,"abstract":"<p><p>To investigate the effect of Jianpiyiqi prescription on the expression of heat shock proteins (HSPs) and the changes of HSPs in gastric-ulcerated rats, the rat model of chronic gastric ulcer was induced by acetic acid. The SABC immunohistochemical method was used to observe HSP70 of mucosa around the gastric ulcer. Imaging analysis was performed. Western dot blot was used to detect HSPs contents in the plasma and gastric mucosal homogenate in each group. The results showed that HSP70 contents of the mucosa around the gastric ulcer in the model group and ranitidine-treated group were increased as compared with control group (P < 0.01). Jianpiyiqi could increase the expression of HSP70 of the mucosa around the gastric ulcer further as compared with that in the model group and ranitidine-treated group (P < 0.01). The HSP70 contents in the serum and mucosa in the model group and ranitidine-treated group were increased as compared with control group (P < 0.01, P < 0.05 respectively). HSP70 of serum and mucosa in the Jianpiyiqi-treated group was higher than in the model group and ranitidine-treated group (P < 0.05, P < 0.01 respectively). It was concluded that HSP might play a role in the process of pathophysiology of gastric ulcer. Jianpiyiqi could enhance gastric ulcer-healing through the protective mechanism of HSPs.</p>","PeriodicalId":73995,"journal":{"name":"Journal of Tongji Medical University = Tong ji yi ke da xue xue bao","volume":"21 2","pages":"105-7"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9663975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Experimental research about effectiveness of transarterial chemoembolization (TACE) in an animal model of hepatocellular carcinoma]. [经动脉化疗栓塞术（TACE）在肝细胞癌动物模型中有效性的实验研究]。
Journal of Tongji Medical University = Tong ji yi ke da xue xue bao Pub Date : 2001-01-01 DOI: 10.1007/BF02888072
J Qian, G Feng, L Trübenbach, P L Pereira, P E Huppert, C D Claussen
{"title":"[Experimental research about effectiveness of transarterial chemoembolization (TACE) in an animal model of hepatocellular carcinoma].","authors":"J Qian, G Feng, L Trübenbach, P L Pereira, P E Huppert, C D Claussen","doi":"10.1007/BF02888072","DOIUrl":"10.1007/BF02888072","url":null,"abstract":"","PeriodicalId":73995,"journal":{"name":"Journal of Tongji Medical University = Tong ji yi ke da xue xue bao","volume":"21 2","pages":"115-8"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10020020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical study on the treatment of 325 cases of atrioventricular node reentrant tachycardia by radiofrequency catheter ablation. 通过射频导管消融治疗 325 例房室结返折性心动过速的临床研究。
Journal of Tongji Medical University = Tong ji yi ke da xue xue bao Pub Date : 2001-01-01 DOI: 10.1007/BF02888028
S Yu, Q Zeng, J Zhang, Z Chen, J Li, M Lei
{"title":"Clinical study on the treatment of 325 cases of atrioventricular node reentrant tachycardia by radiofrequency catheter ablation.","authors":"S Yu, Q Zeng, J Zhang, Z Chen, J Li, M Lei","doi":"10.1007/BF02888028","DOIUrl":"10.1007/BF02888028","url":null,"abstract":"<p><p>In order to improve the efficacy of modified inferior method or middle method of radiofrequency catheter ablation (RFCA) in the treatment of atrioventricular node reentrant tachycardia (AVNRT), the clinical data of 325 cases of AVNRT from March 1992 to Feb. 2000 being subjected to the treatment of RFCA were retrospectively analyzed. The results showed that the successful rate was increased and recurrence was decreased year by year. In the recent 4 years the effective rate was up to 100%. The complication of three grade of AVB occurred in 3% and recurrent rate in 9.1% before March 1996, but both of them were zero in the last 3 years. The time of RFCA procedure and X-ray exposure was significantly reduced. It was concluded that ablating more than 3 targets by modified inferior method or middle method with energy titrating and strict endpoint was the crux of obtaining satisfactory therapeutic effects and preventing recurrence.</p>","PeriodicalId":73995,"journal":{"name":"Journal of Tongji Medical University = Tong ji yi ke da xue xue bao","volume":"21 1","pages":"23-5"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52207501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of diazepam on the contents of amino acids and free radical during ischemia/reperfusion injury. 地西泮对缺血再灌注损伤过程中氨基酸和自由基含量的影响
Journal of Tongji Medical University = Tong ji yi ke da xue xue bao Pub Date : 2001-01-01 DOI: 10.1007/BF02888067
B Hu, Y Mei, G Wei, X Qiu, S Sun, E Tong
{"title":"Effect of diazepam on the contents of amino acids and free radical during ischemia/reperfusion injury.","authors":"B Hu, Y Mei, G Wei, X Qiu, S Sun, E Tong","doi":"10.1007/BF02888067","DOIUrl":"10.1007/BF02888067","url":null,"abstract":"<p><p>The protective effect and mechanism of diazepam on ischemia neurons during cerebral ischemia and reperfusion were studied. Sixty-three Wistar rats were divided randomly into nine groups: control group (n = 7), ischemia (is) groups including subgroups of is3 h, is3-h/rep1-h, is3-h/rep2-h, is3-h/rep3-h(n = 7 in each group), diazepam treated groups (10 mg/kg, i.p.), including subgroups of is3-h, is3-h/rep1-h, is3-h/rep2-h, is3-h/rep3-h (n = 7 in each group) with Zea longa's animal model of middle cerebral artery occlusion. The comparison between the ischemia group and diazepam-treated group showed that diazepam could obviously decrease the production of glutamate, asparate, MDA and increase the synthesis and release of GABA, SOD and GSH-PX. It was concluded that diazepam exerted its protective effects on neurons through complex mechanisms of regulating the synthesis and release of excitotary/inhibitory amino acids and free radicals.</p>","PeriodicalId":73995,"journal":{"name":"Journal of Tongji Medical University = Tong ji yi ke da xue xue bao","volume":"21 2","pages":"102-4"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9663505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Transmural ERP-dispersion from epi-, mid-and endomyocardium in healthy and hypertrophied dog myocardium]. [健康和肥厚狗心肌的上心肌、中心肌和内心肌的跨膜 ERP 弥散]。
Journal of Tongji Medical University = Tong ji yi ke da xue xue bao Pub Date : 2001-01-01 DOI: 10.1007/BF02888063
J Lü, Z Lu, F Voss, W Schöls
{"title":"[Transmural ERP-dispersion from epi-, mid-and endomyocardium in healthy and hypertrophied dog myocardium].","authors":"J Lü, Z Lu, F Voss, W Schöls","doi":"10.1007/BF02888063","DOIUrl":"10.1007/BF02888063","url":null,"abstract":"","PeriodicalId":73995,"journal":{"name":"Journal of Tongji Medical University = Tong ji yi ke da xue xue bao","volume":"21 2","pages":"89-92"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9663506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Apoptosis and Fas system are significantly involved in the process of liver cirrhosis converting into hepatocellular carcinoma. 在肝硬化转化为肝细胞癌的过程中，细胞凋亡和 Fas 系统发挥着重要作用。
Journal of Tongji Medical University = Tong ji yi ke da xue xue bao Pub Date : 2001-01-01 DOI: 10.1007/BF02888075
Z Peng, H Tang, Y Ling, G Han
{"title":"Apoptosis and Fas system are significantly involved in the process of liver cirrhosis converting into hepatocellular carcinoma.","authors":"Z Peng, H Tang, Y Ling, G Han","doi":"10.1007/BF02888075","DOIUrl":"10.1007/BF02888075","url":null,"abstract":"<p><p>To investigate the roles of apoptosis and the Fas system (Fas, Fas ligand, soluble Fas) in the process of liver cirrhosis (LC) converting into hepatocellular carcinoma (HCC), expression of Fas and Fas ligand (FasL) in 49 LC and 36 HCC samples was detected by immunohistochemical method. Apoptosis was detected by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL) method. Serum soluble Fas (sFas) levels in 28 cases of LC and 27 cases of HCC were measured by enzyme-linked immunosorbent assay (ELISA) method. Compared with LC, apoptotic indices (AI) in HCC tissues were significantly reduced (P < 0.001), expression of Fas was decreased (P < 0.05), and that of FasL was increased (P < 0.05). Serum sFas levels in HCC patients were significantly higher than those in normal controls. Down-regulation of Fas expression, up-regulation of FasL expression in hepatocytes and elevation of sFas level in serum might contribute to tumor escape from immune surveillance of the body. Apoptosis and the Fas system are significantly involved in the process of liver cirrhosis converting into hepatocellular carcinoma.</p>","PeriodicalId":73995,"journal":{"name":"Journal of Tongji Medical University = Tong ji yi ke da xue xue bao","volume":"21 2","pages":"126-9, 148"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9663972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on the role of interleukin-4 in experimental murine systemic candidiasis. 白细胞介素-4 在实验性小鼠系统性念珠菌病中的作用研究。
Journal of Tongji Medical University = Tong ji yi ke da xue xue bao Pub Date : 2001-01-01 DOI: 10.1007/BF02888088
Z Liu, D Liu, H Liu, C Huang, Y Wu, J Li
{"title":"Study on the role of interleukin-4 in experimental murine systemic candidiasis.","authors":"Z Liu, D Liu, H Liu, C Huang, Y Wu, J Li","doi":"10.1007/BF02888088","DOIUrl":"10.1007/BF02888088","url":null,"abstract":"<p><p>In order to investigate the role of interleukin-4 (IL-4) in experimental murine systemic Candidiasis, we created the intact and dexamethasone-induced immunosuppressed murine systemic Candidiasis models. In these models, two-site ELISA and RT-PCR were applied to determine the level of IL-4 protein and mRNA expression in spleens respectively, clone forming units (CFUs) of infected kidneys were determined with the plating dilution method, and mean survival time (MST) of the mice was recorded. The results showed that, when compared with the controls, protein level of IL-4 increased in both intact mice infected with lethal doses of yeast (day 3, P < 0.05; day 7, P < 0.001) and immunosuppressed mice infected with sublethal doses of yeast (day 3, P > 0.05; day 7, P < 0.05). Furthermore, the level of IL-4 was higher on day 7 than on day 3 after infection (P < 0.001 and P < 0.05 respectively in two groups). The tendency of IL-4 mRNA expression was similar with that of IL-4 protein. As for fungal loads in kidneys, CFUs were significantly higher on day 7 than on day 3 after infection (P < 0.001 in both groups). Mice in both groups succumbed to infection within several days. It was suggested that IL-4 might play a promoting role in the development of murine systemic Candidiasis.</p>","PeriodicalId":73995,"journal":{"name":"Journal of Tongji Medical University = Tong ji yi ke da xue xue bao","volume":"21 2","pages":"168-70"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10020018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on Fas/Fas-L expression in liver tissue and hepatocyte apoptosis in patients with hepatitis gravis. 关于重症肝炎患者肝组织中 Fas/Fas-L 表达和肝细胞凋亡的研究
Journal of Tongji Medical University = Tong ji yi ke da xue xue bao Pub Date : 2001-01-01 DOI: 10.1007/BF02888071
Q Xia, S Shi
{"title":"Study on Fas/Fas-L expression in liver tissue and hepatocyte apoptosis in patients with hepatitis gravis.","authors":"Q Xia, S Shi","doi":"10.1007/BF02888071","DOIUrl":"10.1007/BF02888071","url":null,"abstract":"<p><p>To explore the expression of Fas/Fas-L in liver tissue of hepatitis gravis patients and its implication in hepatocyte apoptosis, Fas/Fas-L expression and cell apoptosis was detected by the means of inmmunohistochemistry and terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL). It was found that in the 20 patients with clinical hepatitis gravis, Fas in hepatocytes showed strong expression and Fas-L also showed intensive expression in infiltrating lymphocytes and scattering hepatocytes. The apoptosis existed in all the samples, scattering in the areas of inflammatory, necrotic area and hepatic lobule. It was suggested that the overexpression of Fas/Fas-L could cause the death of hepatocytes and thus the occurrence of hepatitis gravis. The apoptosis caused by Fas might be one of the important pathogeneses of hepatitis gravis. Among the detected samples, apoptosis and necrosis coexisted, indicating that both two types of cellular death were closely associated with the pathogenesis of hepatitis gravis.</p>","PeriodicalId":73995,"journal":{"name":"Journal of Tongji Medical University = Tong ji yi ke da xue xue bao","volume":"21 2","pages":"112-4"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10020022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The clinic study on synchronous detection of HCV RNA in the plasma and PBMC of hepatitis C patients. 关于同步检测丙型肝炎患者血浆和 PBMC 中 HCV RNA 的临床研究。
Journal of Tongji Medical University = Tong ji yi ke da xue xue bao Pub Date : 2001-01-01 DOI: 10.1007/BF02888070
J Ye, W Liu, J Guo, L Zeng
{"title":"The clinic study on synchronous detection of HCV RNA in the plasma and PBMC of hepatitis C patients.","authors":"J Ye, W Liu, J Guo, L Zeng","doi":"10.1007/BF02888070","DOIUrl":"10.1007/BF02888070","url":null,"abstract":"<p><p>In order to increase the positive detection rate of HCV RNA in the patients with chronic hepatitis C (CHC), RT-PCR was used to synchronously detect HCV RNA in the plasma and peripheral blood mononuclear cells (PBMC) of 583 CHC patients with a continuously elevated level of ALT for more than one year. The results showed that the positive detection rate of HCV RNA in the plasma of the CHC patients was 19.2%, while 24.5% in PBMC. It was demonstrated that the positive detection rate for HCV RNA in PBMC was obviously higher than that detected in plasma. To synchronously detect HCV RNA in PBMC by using RT-PCR can increase the positive detection rate of HCV RNA in the CHC patients.</p>","PeriodicalId":73995,"journal":{"name":"Journal of Tongji Medical University = Tong ji yi ke da xue xue bao","volume":"21 2","pages":"110-1"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10037606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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