Journal of spine research and surgery最新文献

{"title":"The Decline of Lumbar Artificial Disc Replacement.","authors":"Tony Eskandar, Zubair Ahmed, Jeremy Pan, Devendra K Agrawal","doi":"10.26502/fjsrs0078","DOIUrl":"https://doi.org/10.26502/fjsrs0078","url":null,"abstract":"<p><p>Lower back pain associated with degenerative disc disease is a common occurrence, with many surgical treatments targeting the degenerated disc to relieve symptoms. Current surgical options for degenerative disc disease primarily consist of a discectomy followed by either spinal fusion or artificial disc replacement, with the former being increasingly more common in the lumbar region despite the risk of adjacent segment disease. Though artificial disc replacement aims to provide an increase in range of motion and decreases risk of adjacent segment disease, surgeons are increasingly opting for spinal fusion in the lumbar region. This review investigates underlying factors that may be contributing to this trend by assessing lumbar artificial disc replacement selection criteria, clinical outcomes, surgical technique, complications, revision burden, and overall cost. While these factors had some role in the physician's decision, ultimately the narrow selection criteria and lack of cost reimbursement by insurance has primarily led to the decline in lumbar artificial disc replacement.</p>","PeriodicalId":73951,"journal":{"name":"Journal of spine research and surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11392031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142302707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modification of the Diabetes Prevention Program Lifestyle Intervention in Persons with Spinal Cord Injury: Efficacy for Reducing Major Cardiometabolic Risks, Increased Fitness, and Improved Health-Related Quality of Life.","authors":"Gregory E Bigford, Doug A Lehmann, Luisa F Betancourt, Jennifer L Maher, Armando J Mendez, Mark S Nash","doi":"10.26502/fjsrs0070","DOIUrl":"10.26502/fjsrs0070","url":null,"abstract":"<p><p>Individuals with chronic spinal cord injury (SCI) face elevated risks of cardiometabolic diseases, including cardiovascular disease and type 2 diabetes, due to factors like physical inactivity, neurogenic obesity, and disrupted glucose and insulin regulation. We conducted a prospective intervention cohort study involving 20 individuals with SCI (aged 28-60) with neurologic injuries at levels C4-T10 and ASIA scale grades A-D, lasting over a year. Our study assessed the impact of a therapeutic lifestyle intervention (TLI) based on the Diabetes Prevention Program (DPP) and its maintenance phase. The TLI comprised circuit resistance training, a Mediterranean-style calorie-restricted diet, and tailored behavioral support. Key outcomes measured included cardiometabolic risks (plasma analytes and disease biomarkers), anthropometrics (body mass, BMI, tissue composition), global metabolism, fitness (aerobic capacity, peak strength), and health-related quality of life (SF36). Results demonstrated a significant reduction in body mass and BMI by 7.5%, a 7% decrease in total fat mass, and substantial improvements in glucose regulation and insulin sensitivity. Lipid profiles improved, with reduced total cholesterol, triglycerides, and LDL-C, and increased HDL-C. Resting energy expenditure and fat oxidation increased by 27.4% and 58.5%, respectively. Aerobic capacity and dynamic strength also improved significantly. The Physical and Mental Composite Scores of the SF36 improved by 22.8% and 30.5%, respectively. Following the maintenance phase, several positive outcomes persisted, indicating a reduction in risk for cardiovascular disease and comorbid disorders. Our findings support the effectiveness of TLI in reducing cardiometabolic risks, enhancing fitness, and improving health-related quality of life in individuals with chronic SCI.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov, ID: NCT02853149 Registered August 2, 2016.</p>","PeriodicalId":73951,"journal":{"name":"Journal of spine research and surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11414834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142302706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Outcomes of the Spinal Cord Injury Assessing Tolerability and Use of Combine Rehabilitation and NeuroAID (SATURN STUDY)","authors":"Ramesh Kumar, O. Htwe, A.’qilah Baharudin, Shaharuddin Abdul Rhani","doi":"10.26502/fjsrs0053","DOIUrl":"https://doi.org/10.26502/fjsrs0053","url":null,"abstract":"Background: Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of individuals each year. Recent advances in research have given us greater understanding of the molecular and cellular events in SCI.The latest frontier in research involves neuroprotection, repair and regeneration. This paper aims to evaluate the effects of the initial 6-month treatment with MLC601/MLC901 on long term outcomes at 12 months,18 months and 24 months. Methods: The study was an open label, prospective, cohort trial of MLC601/MLC901 (NeuroAiD) in subjects with moderate to severe SCI. Patients age was 18 to 65 years old, and the SCI occurs within 3 days and 4 weeks. Each received MLC601/MLC901 for 6 months in addition to standard care and rehabilitation. Key endpoints were safety, American Spinal Injury Association (ASIA) Impairment Scale (AIS) grade and AIS motor scores at month 6 (M6). The protocol and the primary results of the 6 th month period were previously published. The primary result showed safety and potential role of MLC601/MLC901 in moderate to severe spinal cord Injury. Outcomes of the long-term follow up was assessed up to 24 months. Results: Long term follow-up after 6-month treatment showed durability of improvement in total motor, sensory and SCIM score .The improvement was maintained until 12, 18 and 24 months. Conclusion: The long-term outcomes further provided evidence in the safety and potential role of MLC601/MLC901 in SCI. This findings should help plan a study design for a randomized controlled trial.","PeriodicalId":73951,"journal":{"name":"Journal of spine research and surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of PEEK vs 3D printed titanium cage for ACDF- Is there any difference in subsidence?","authors":"Dr. Harshadkumar A. Patel, MD,, Francine Zeng, MD, Dr. Hardeep Singh, MD, Dr. Scott S. Mallozzi, MD, Mark Cote, P.T, Dr. Isaac L. Moss, MD","doi":"10.26502/fjsrs0061","DOIUrl":"https://doi.org/10.26502/fjsrs0061","url":null,"abstract":"Objectives: To compare the subsidence between PEEK vs new 3D printed titanium cage(3DTC) for ACDF surgery. Design: Retrospective cohort study","PeriodicalId":73951,"journal":{"name":"Journal of spine research and surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral Nerve Regeneration: Opportunities and Challenges.","authors":"Rajiv Supra,&nbsp;Devendra K Agrawal","doi":"10.26502/fjsrs0052","DOIUrl":"https://doi.org/10.26502/fjsrs0052","url":null,"abstract":"<p><p>Peripheral nerve injury has detrimental effects on the quality of life for patients and is a worldwide issue with high rates of morbidity. Research on the molecular mechanisms of nerve injury, microsurgical techniques, and advances in stem cell research have led to substantial progress in the field of translational neurophysiology. Current research on peripheral nerve regeneration aims to accelerate peripheral nerve development through pluripotent stem cells and potential use of smart exosomes, pharmacological agents, and bioengineering of nerve conduits. In this article critically reviewed and summarized various methods used for peripheral nerve regeneration and highlight the opportunities and challenges that come along with these strategies.</p>","PeriodicalId":73951,"journal":{"name":"Journal of spine research and surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9983644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9080821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Traumatic Spinal Cord Injury in Rajshahi: A prospective study in Rajshahi Medical College Hospital","authors":"Md. Raihan Habib, Dr. A.F.M Momtazul Haque, Dr. Md. Shamsul Huda, Saraban Tohura, Bahauddin Bayzid, S. Kamal, M. Islam, Md. Rejwan Gani Mazumder, Gazi Md. Najmul Alam, Mst. Sharmin Rima","doi":"10.26502/fjsrs0056","DOIUrl":"https://doi.org/10.26502/fjsrs0056","url":null,"abstract":"Background: Traumatic spinal cord injury (SCI) is a devastating condition that can lead to significant physical, psychological, and social consequences for affected individuals and their families. SCI is a major public health problem worldwide, with an estimated incidence of 10-83 cases per million population per year, depending on the region and study population. Objective: This study was to determine the epidemiology of traumatic spinal cord injury (SCI) in Rajshahi, Bangladesh. Methods: This was a prospective study conducted at the Rajshahi Medical College Hospital from January 2018 to December 2021. The total sample size was 218. Data on demographic characteristics, cause and level of injury, associated injuries, and neurological status were collected and analyzed. Results: The majority of patients (69.3%) were male and the mean age was 39.8 years. The most common cause of SCI was road traffic accidents (47.7%), followed by falls (25.7%) and violence (15.6%). The cervical spine was the most common level of injury (50.9%), followed by the thoracic spine (37.2%) and lumbar spine (11.9%). Associated injuries were present in 43.1% of patients. The most common neurological status at admission was complete injury (47.7%). The mortality rate was 9.6%. Conclusion: Traumatic SCI is a significant public health problem in Rajshahi, with road traffic accidents being the leading cause. The cervical spine was the most commonly affected level, and associated injuries were present in a significant proportion of patients. The mortality rate was also considerable. These findings highlight the need for the development of effective prevention strategies, improved trauma care, and rehabilitation services for individuals with SCI in the region.","PeriodicalId":73951,"journal":{"name":"Journal of spine research and surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Peculiar Concurrent Presentation of Spinal Tuberculosis In A Diagnosed Case of Neurofibromatosis Type 1 – An Atypical Case Report","authors":"Vishnu Vikraman Nair, Vishal G. Kundnani, Mukul Jain, Sunil Chodavadiya, Jenil R. Patel","doi":"10.26502/fjsrs0057","DOIUrl":"https://doi.org/10.26502/fjsrs0057","url":null,"abstract":"Spinal tuberculosis is a prevalent ailment observed in the Asian demographic, which can result in neurodeficit if not addressed during the initial phases. Neurofibromatosis is a hereditary disorder that results in the manifestation of dystrophic bony characteristics accompanied by the development of multiple spinal tumors. This study presents a unique case of a young female who had previously been diagnosed with Neurofibromatosis. Additionally, she exhibited symptoms of tubercular spondylodiscitis, resulting in kyphotic deformity and paraparesis. The present case report discusses the challenges encountered during the preoperative and intra-operative management of a patient presenting with the co-occurrence of neurofibromatosis and tuberculosis of the spine. Despite the advancements in imaging modalities, such as magnetic resonance imaging, and surgical techniques, the prompt diagnosis and management of spinal tuberculosis with Neurofibramatosis remains complex and demanding. The objective of this review is to examine the diagnosis, preoperative planning, and treatment of spinal tuberculosis in a patient of Neurofibromatosis type 1, utilizing studies that possess adequate literature, lucidly presented outcomes, and defensible conclusions.","PeriodicalId":73951,"journal":{"name":"Journal of spine research and surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lumbar Disc Nucleus Replacement for Refractory Back Pain: A Case Report","authors":"Jeff D. Golan, Michael G. Hess, Francisco Javier Duarte, Loren R. Francis, Maren Lange","doi":"10.26502/fjsrs0060","DOIUrl":"https://doi.org/10.26502/fjsrs0060","url":null,"abstract":"Back pain is one of the most common sources of pain and disability in the world. The value of surgically treating discogenic low back pain (dLBP) is controversial and currently limited to fusion or total disc replacement. The clinical case presented is a 25-year-old man with 5 years of spontaneous onset low back pain refractory to medical care. The patient was enrolled in a Phase 1 clinical trial designed to test the safety profile of a novel nucleus replacement device. He underwent a left-sided anterior retroperitoneal approach, nuclectomy and implantation of the PerQdisc. At the 2-year follow up period his pain scores had improved significantly. Dynamic radiographs demonstrated 23.4 degrees of segmental motion with no suggestion of inflammation on MRI. This case demonstrates successful diagnosis of dLBP and surgical treatment using a novel motion-sparing and form-fitting nucleus replacement device, in the context of a clinical trial. While the diagnostic criteria used in this case report may be a useful guide to identify other patients with dLBP, the surgical treatment offered should be interpreted with caution until appropriate clinical trials are presented.","PeriodicalId":73951,"journal":{"name":"Journal of spine research and surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanobiology of MicroRNAs in Intervertebral Disk Degeneration.","authors":"Rajiv Supra,&nbsp;Devendra K Agrawal","doi":"10.26502/fjsrs0051","DOIUrl":"https://doi.org/10.26502/fjsrs0051","url":null,"abstract":"<p><p>Intervertebral disk degeneration (IDD) is an intricate pathological process contributing to one of the major causes of low back pain. The degradation of the extracellular matrix (ECM), inflammation, and apoptosis have all been investigated as critical factors involved in the pathology of degenerative disk disease. Additionally, the presence of aberrant microRNAs (miRNAs), conserved molecules that regulate the amount protein post-transcriptionally, may play a crucial role in the pathogenesis of IDD. Research regarding the dysfunction of miRNAs in IDD has been well researched over the past five years. Here, we provide a critical overview of the current knowledge of miRNAs, emphasizing the processes involved in the degenerative disk pathology.</p>","PeriodicalId":73951,"journal":{"name":"Journal of spine research and surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10707542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a chiropractic three-dimensional surface on vagal nerve activity and distress: An experimental study","authors":"Hadas Tavil, Ariel D. Levine, Ronen Tuchfeld, B. Sekeles, Ronen Mendi, Y. Gidron","doi":"10.26502/fjsrs0062","DOIUrl":"https://doi.org/10.26502/fjsrs0062","url":null,"abstract":"Background: Research in the past 30 years has shown the importance of the vagal nerve in predicting reduced risk and possible therapeutic effects on fatal diseases (e.g., heart disease, cancer) and chronic pain. Vagal nerve activity is indexed by heart-rate variability (HRV). Objective: This study compared the effects of a unique chiropractic 3D surface on HRV, distress, and discomfort with two control conditions. Methods: Thirty-s i x participants were recruited (mean age 51.6 years; 52.8% women), who were randomly assigned to rest for 10 minutes either in supine position on a standard mattress (control 1), rest in prone position on a standard mattress (control 2), or to rest in prone position on a chiropractic surface (experimental group). We measured HRV, blood pressure, heart rate (HR), distress, and discomfort, before, immediately after the 10min rest, and 5min later. Results: For participants in control 1, SDNN and PNN50 increased significantly from 1st to 3rd measures only. For participants in control 2, HRV did not change significantly. In the experimental condition, SDNN, RMSSD, and PNN50 increased significantly from 1st to 2nd measure, and SDNN increased significantly from 1st to 3rd measure. Increases in PNN50 were more prominent in the experimental group than in both controls combined . Conclusions: This study showed that a chiropractic surface significantly increased multiple HRV parameters, more than two control conditions. Suppose the results are reproducible in clinical situations involving the vagal nerve (e.g., diabetes); such a chiropractic surface may be a novel treatment for chronic health conditions associated with reduced HRV.","PeriodicalId":73951,"journal":{"name":"Journal of spine research and surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}