Journal of orthopaedics and sports medicine最新文献_第8页

Rotator Cuff Health, Pathology, and Repair in the Perspective of Hyperlipidemia. 高脂血症视角下的肩袖健康、病理和修复。

Journal of orthopaedics and sports medicine Pub Date : 2022-01-01 Epub Date: 2022-10-17 DOI: 10.26502/josm.511500063

Armand N Yazdani, Vikrant Rai, Devendra K Agrawal

{"title":"Rotator Cuff Health, Pathology, and Repair in the Perspective of Hyperlipidemia.","authors":"Armand N Yazdani, Vikrant Rai, Devendra K Agrawal","doi":"10.26502/josm.511500063","DOIUrl":"10.26502/josm.511500063","url":null,"abstract":"Rotator Cuff Injuries (RCI) are prevalent cause of shoulder pain affecting over 20% of the population in the USA. Surgical repair of the torn rotator cuff helps in relieving the pressure on the rotator cuff tendon and from symptoms, however tendon-to-bone healing after rotator cuff surgery still has a high failure rate. Hyperlipidemia has been strongly associated with RCI although the cellular and molecular mechanisms are largely unknown. The focus of this critical review is to further explore the role of hyperlipidemia in RCI and rotator cuff tissue repair to determine its implication as a risk factor for tears, repair, and retears. A literature review was conducted to elucidate the role of hyperlipidemia as an inflammatory mediator and catalyst for structural instability within the shoulder. The results from various studies were critically reviewed to summarize the relationship between hyperlipidemia and rotator cuff pathology. Hyperlipidemia induces LDL-particle entrapment within the dense regular collagen of rotator cuff tendons resulting in foam cell aggregation and macrophage recruitment. Subsequent inflammatory pathways including the JAK2/STAT3 pathway and NLRP3 inflammasome pathway led to persistent inflammation and Extracellular Matrix (ECM) degradation within the rotator cuff. While arthroscopic repair remains the most common treatment modality, nonsurgical treatment including statins, vitamin D, and targeting miRNA are also of therapeutic benefit. Hyperlipidemia interferes with arthroscopic repairs by inducing inflammation and stiffness within tendons and increases the risk of retears. Most notably, targeting underlying mechanisms influencing inflammation has large therapeutic value as a novel treatment strategy for the management of rotator cuff pathology.","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":"4 4","pages":"263-275"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40469039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mindfulness Training Improves Sport Performance via Inhibiting Uncertainty Induced Emotional Arousal and Anger 正念训练通过抑制不确定性引起的情绪唤醒和愤怒提高运动表现

Journal of orthopaedics and sports medicine Pub Date : 2022-01-01 DOI: 10.26502/josm.511500066

Simeng Gu, Yumeng Li, Yao Jiang, Jason H Huang, Fushun Wang

{"title":"Mindfulness Training Improves Sport Performance via Inhibiting Uncertainty Induced Emotional Arousal and Anger","authors":"Simeng Gu, Yumeng Li, Yao Jiang, Jason H Huang, Fushun Wang","doi":"10.26502/josm.511500066","DOIUrl":"https://doi.org/10.26502/josm.511500066","url":null,"abstract":"Mindfulness training has gained popularity in the scientific field, and has been proposed as an efficient psychotherapy for affective disorders. Mindfulness training requires the individual to pay attention to the good things that are happening “right now and here” and neglect the nervous uncertainty. Uncertainty (un-expectancy) plays a critical role in inducing stressful emotions during sport games, and mindfulness training is especially useful in calming the body peacefully for the athletes. In this paper, we will review experimental studies and propose theoretic speculations concerning uncertainty and emotional arousal during sport games. We first analyzed the effects of emotions on sports according to two dimensions (arousal and valence), next we analyzed the effects according to our previous three-primary-color emotional theory, which suggested that there are three prototypical emotions (Joy, Fear and Disgust). In addition, we proposed that anger might be the only basic emotion that can only be evoked by others’ behavior responses and directly affect sport performance. Furthermore, we proposed that emotional arousal activates the sympathetic and norepinephrine system, while mindfulness activates the para-sympathetic and dopamine system. Therefore, mindfulness will activate the neural systems that are totally different from or contrary the emotional arousal systems to induce peaceful mind. This review will contribute greatly to theoretical and empirical explorations of emotional regulations with mindfulness during sports.","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Epidemiology of Downhill Mountain Biking Injuries: 178 Injuries in 129 Patients 下坡山地自行车损伤的流行病学:129例178例损伤

Journal of orthopaedics and sports medicine Pub Date : 2022-01-01 DOI: 10.26502/josm.511500070

D. Saragaglia, Guillaume Favarel, J. Banihachemi, A. Chamseddine

引用次数: 0

Is Rituximab Therapy Associated with Achilles Tendinopathy? 利妥昔单抗治疗与跟腱病相关吗?

Journal of orthopaedics and sports medicine Pub Date : 2022-01-01 DOI: 10.26502/josm.511500056

Mallak Zatreh

引用次数: 0

Hybrid Ilizarov’s Method and Fibular Strut for Humeral Diaphyseal Nonunion: A Case Report after Multiple Failed Plating 混合Ilizarov法与腓骨支架治疗肱骨骨干不连:多次钢板失败1例报告

Journal of orthopaedics and sports medicine Pub Date : 2022-01-01 DOI: 10.26502/josm.511500058

S. Shakya, Roshan Lal Shrestha, Shikshya Prakash Shrestha, N. Shrestha, Umesh Bahadur Bogatee, Anil Shakya

引用次数: 0

Acute and Long-Term Variations in Variables Related to Redox, Inflammation and Hormonal Status in Male Football Players: A Systematic Review and Recommendations 男性足球运动员氧化还原、炎症和激素状态相关变量的急性和长期变化:系统回顾和建议

Journal of orthopaedics and sports medicine Pub Date : 2022-01-01 DOI: 10.26502/josm.511500062

E. Varamenti, Catherine E. Beattie, D. Tod, T. Bommasamudram, C. Savoia, S. Pullinger

{"title":"Acute and Long-Term Variations in Variables Related to Redox, Inflammation and Hormonal Status in Male Football Players: A Systematic Review and Recommendations","authors":"E. Varamenti, Catherine E. Beattie, D. Tod, T. Bommasamudram, C. Savoia, S. Pullinger","doi":"10.26502/josm.511500062","DOIUrl":"https://doi.org/10.26502/josm.511500062","url":null,"abstract":"Introduction: The present study aimed to review the acute and long-term variations in variables related to redox, inflammation and hormonal status in male footballers. Materials and methods: A PRISMA-compliant systematic review was conducted. The entire content of PubMed, Scopus and Science Direct were systematically searched until May 2022. Studies with outcomes including: (1) adult male football players, (2) a redox and/or an inflammatory and/or a hormonal marker after a training period, and (3) variables measured in blood/saliva. Results: Thirty-four studies met the inclusion criteria for the qualitative synthesis. Fourteen studies on redox status, 16 on inflammation/muscle damage and 20 on hormonal variations. Only 4 studies incorporated markers related to all 3 statuses, while 8 studies looked at a combination of 2. Studies around redox homeostasis found several markers to fluctuate with MDA, TBARS, protein carbonyls, GSSG, GPx, CAT, and uric acid increasing immediately after a game. Hormonal markers, such as testosterone in blood, revealed no significant change after training. Some found T to increase post-exercise, and some a decrease. Cortisol increased in both short- and long monitoring periods. Markers associated with inflammation and muscle damage found creatine kinase elevated immediately post-game and over extended periods. LDH, C-RP, and IL-6 were also higher post-match. Discussion: Exposure to short or long-term participation in football training and competitions could significantly affect footballers' redox, inflammation and hormonal status. However, greater consistency across studies is required to ascertain the implications of structured training regimens on measured variables. Selecting the most relevant protocol/ conditions and biochemical markers, including the collection time and the type of specimen, must be considered.","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Pre-clinical Standard Operating Procedure for Evaluating Orthobiologics in an In Vivo Rat Spinal Fusion Model. 在活体大鼠脊柱融合模型中评估骨生物制品的临床前标准操作程序。

Journal of orthopaedics and sports medicine Pub Date : 2022-01-01 Epub Date: 2022-09-05 DOI: 10.26502/josm.511500060

Andrew L Alejo, Scott McDermott, Yusuf Khalil, Hope C Ball, Gabrielle T Robinson, Ernesto Solorzano, Amanda M Alejo, Jacob Douglas, Trinity K Samson, Jesse W Young, Fayez F Safadi

{"title":"A Pre-clinical Standard Operating Procedure for Evaluating Orthobiologics in an In Vivo Rat Spinal Fusion Model.","authors":"Andrew L Alejo, Scott McDermott, Yusuf Khalil, Hope C Ball, Gabrielle T Robinson, Ernesto Solorzano, Amanda M Alejo, Jacob Douglas, Trinity K Samson, Jesse W Young, Fayez F Safadi","doi":"10.26502/josm.511500060","DOIUrl":"10.26502/josm.511500060","url":null,"abstract":"The rat animal model is a cost effective and reliable model used in spinal pre-clinical research. Complications from various surgical procedures in humans often arise that were based on these pre-clinical animal models. Therefore safe and efficacious pre-clinical animal models are needed to establish continuity into clinical trials. A Standard Operating Procedure (SOP) is a validated method that allows researchers to safely and carefully replicate previously successful surgical techniques. Thus, the aim of this study is to describe in detail the procedures involved in a common rat bilateral posterolateral intertransverse spinal fusion SOP used to test the efficacy and safety different orthobiologics using a collagen-soaked sponge as an orthobiologic carrier. Only two orthobiologics are currently FDA approved for spinal fusion surgery which include recombinant bone morphogenetic protein 2 (rhBMP-2), and I-FACTOR. While there are many additional orthobiologics currently being tested, one way to show their safety profile and gain FDA approval, is to use well established pre-clinical animal models. A preoperative, intraoperative, and postoperative surgical setup including specific anesthesia and euthanasia protocols are outlined. Furthermore, we describe different postoperative methods used to validate the spinal fusion SOP, which include μCT analysis, histopathology, biomechanical testing, and blood analysis. This SOP can help increase validity, transparency, efficacy, and reproducibly in future rat spinal fusion surgery procedures.","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":"4 3","pages":"224-240"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534599/pdf/nihms-1837082.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33509493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Out of the Trenches: A Review of Modern Rheumatology’s Relationship with War 走出战壕:现代风湿病学与战争的关系综述

Journal of orthopaedics and sports medicine Pub Date : 2022-01-01 DOI: 10.26502/josm.511500071

M. Alexander

引用次数: 0

Cortical Activation Reorganization of Cerebral Regions in Charcot– Marie–Tooth Patients: A Task-state Functional Magnetic Resonance Imaging Study 沙科-玛丽- tooth患者大脑区域皮层激活重组:一项任务状态功能磁共振成像研究

Journal of orthopaedics and sports medicine Pub Date : 2022-01-01 DOI: 10.26502/josm.511500064

Zhifeng Wang, C. Han, C. Yuan, Yiyuan Shen, X. Geng, Chen Wang, Chao Zhang, Jiazhang Huang, Xin Ma, Hanqiu Liu, Xu Wang

引用次数: 0

Epidemiology of Injuries in High School Football Players: A Prospective Cohort Study 高中足球运动员受伤的流行病学:一项前瞻性队列研究

Journal of orthopaedics and sports medicine Pub Date : 2022-01-01 DOI: 10.26502/josm.511500065

S. Pelet, Jérémy Bergeron, Mireille Marquis, Etienne L Belzile

引用次数: 0