Journal of orthopaedics and sports medicine最新文献_第8页

Rotator Cuff Health, Pathology, and Repair in the Perspective of Hyperlipidemia. 高脂血症视角下的肩袖健康、病理和修复。

Journal of orthopaedics and sports medicine Pub Date : 2022-01-01 Epub Date: 2022-10-17 DOI: 10.26502/josm.511500063

Armand N Yazdani, Vikrant Rai, Devendra K Agrawal

{"title":"Rotator Cuff Health, Pathology, and Repair in the Perspective of Hyperlipidemia.","authors":"Armand N Yazdani, Vikrant Rai, Devendra K Agrawal","doi":"10.26502/josm.511500063","DOIUrl":"10.26502/josm.511500063","url":null,"abstract":"Rotator Cuff Injuries (RCI) are prevalent cause of shoulder pain affecting over 20% of the population in the USA. Surgical repair of the torn rotator cuff helps in relieving the pressure on the rotator cuff tendon and from symptoms, however tendon-to-bone healing after rotator cuff surgery still has a high failure rate. Hyperlipidemia has been strongly associated with RCI although the cellular and molecular mechanisms are largely unknown. The focus of this critical review is to further explore the role of hyperlipidemia in RCI and rotator cuff tissue repair to determine its implication as a risk factor for tears, repair, and retears. A literature review was conducted to elucidate the role of hyperlipidemia as an inflammatory mediator and catalyst for structural instability within the shoulder. The results from various studies were critically reviewed to summarize the relationship between hyperlipidemia and rotator cuff pathology. Hyperlipidemia induces LDL-particle entrapment within the dense regular collagen of rotator cuff tendons resulting in foam cell aggregation and macrophage recruitment. Subsequent inflammatory pathways including the JAK2/STAT3 pathway and NLRP3 inflammasome pathway led to persistent inflammation and Extracellular Matrix (ECM) degradation within the rotator cuff. While arthroscopic repair remains the most common treatment modality, nonsurgical treatment including statins, vitamin D, and targeting miRNA are also of therapeutic benefit. Hyperlipidemia interferes with arthroscopic repairs by inducing inflammation and stiffness within tendons and increases the risk of retears. Most notably, targeting underlying mechanisms influencing inflammation has large therapeutic value as a novel treatment strategy for the management of rotator cuff pathology.","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40469039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute and Long-Term Variations in Variables Related to Redox, Inflammation and Hormonal Status in Male Football Players: A Systematic Review and Recommendations 男性足球运动员氧化还原、炎症和激素状态相关变量的急性和长期变化:系统回顾和建议

Journal of orthopaedics and sports medicine Pub Date : 2022-01-01 DOI: 10.26502/josm.511500062

E. Varamenti, Catherine E. Beattie, D. Tod, T. Bommasamudram, C. Savoia, S. Pullinger

{"title":"Acute and Long-Term Variations in Variables Related to Redox, Inflammation and Hormonal Status in Male Football Players: A Systematic Review and Recommendations","authors":"E. Varamenti, Catherine E. Beattie, D. Tod, T. Bommasamudram, C. Savoia, S. Pullinger","doi":"10.26502/josm.511500062","DOIUrl":"https://doi.org/10.26502/josm.511500062","url":null,"abstract":"Introduction: The present study aimed to review the acute and long-term variations in variables related to redox, inflammation and hormonal status in male footballers. Materials and methods: A PRISMA-compliant systematic review was conducted. The entire content of PubMed, Scopus and Science Direct were systematically searched until May 2022. Studies with outcomes including: (1) adult male football players, (2) a redox and/or an inflammatory and/or a hormonal marker after a training period, and (3) variables measured in blood/saliva. Results: Thirty-four studies met the inclusion criteria for the qualitative synthesis. Fourteen studies on redox status, 16 on inflammation/muscle damage and 20 on hormonal variations. Only 4 studies incorporated markers related to all 3 statuses, while 8 studies looked at a combination of 2. Studies around redox homeostasis found several markers to fluctuate with MDA, TBARS, protein carbonyls, GSSG, GPx, CAT, and uric acid increasing immediately after a game. Hormonal markers, such as testosterone in blood, revealed no significant change after training. Some found T to increase post-exercise, and some a decrease. Cortisol increased in both short- and long monitoring periods. Markers associated with inflammation and muscle damage found creatine kinase elevated immediately post-game and over extended periods. LDH, C-RP, and IL-6 were also higher post-match. Discussion: Exposure to short or long-term participation in football training and competitions could significantly affect footballers' redox, inflammation and hormonal status. However, greater consistency across studies is required to ascertain the implications of structured training regimens on measured variables. Selecting the most relevant protocol/ conditions and biochemical markers, including the collection time and the type of specimen, must be considered.","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Pre-clinical Standard Operating Procedure for Evaluating Orthobiologics in an In Vivo Rat Spinal Fusion Model. 在活体大鼠脊柱融合模型中评估骨生物制品的临床前标准操作程序。

Journal of orthopaedics and sports medicine Pub Date : 2022-01-01 Epub Date: 2022-09-05 DOI: 10.26502/josm.511500060

Andrew L Alejo, Scott McDermott, Yusuf Khalil, Hope C Ball, Gabrielle T Robinson, Ernesto Solorzano, Amanda M Alejo, Jacob Douglas, Trinity K Samson, Jesse W Young, Fayez F Safadi

{"title":"A Pre-clinical Standard Operating Procedure for Evaluating Orthobiologics in an In Vivo Rat Spinal Fusion Model.","authors":"Andrew L Alejo, Scott McDermott, Yusuf Khalil, Hope C Ball, Gabrielle T Robinson, Ernesto Solorzano, Amanda M Alejo, Jacob Douglas, Trinity K Samson, Jesse W Young, Fayez F Safadi","doi":"10.26502/josm.511500060","DOIUrl":"10.26502/josm.511500060","url":null,"abstract":"The rat animal model is a cost effective and reliable model used in spinal pre-clinical research. Complications from various surgical procedures in humans often arise that were based on these pre-clinical animal models. Therefore safe and efficacious pre-clinical animal models are needed to establish continuity into clinical trials. A Standard Operating Procedure (SOP) is a validated method that allows researchers to safely and carefully replicate previously successful surgical techniques. Thus, the aim of this study is to describe in detail the procedures involved in a common rat bilateral posterolateral intertransverse spinal fusion SOP used to test the efficacy and safety different orthobiologics using a collagen-soaked sponge as an orthobiologic carrier. Only two orthobiologics are currently FDA approved for spinal fusion surgery which include recombinant bone morphogenetic protein 2 (rhBMP-2), and I-FACTOR. While there are many additional orthobiologics currently being tested, one way to show their safety profile and gain FDA approval, is to use well established pre-clinical animal models. A preoperative, intraoperative, and postoperative surgical setup including specific anesthesia and euthanasia protocols are outlined. Furthermore, we describe different postoperative methods used to validate the spinal fusion SOP, which include μCT analysis, histopathology, biomechanical testing, and blood analysis. This SOP can help increase validity, transparency, efficacy, and reproducibly in future rat spinal fusion surgery procedures.","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534599/pdf/nihms-1837082.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33509493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Out of the Trenches: A Review of Modern Rheumatology’s Relationship with War 走出战壕:现代风湿病学与战争的关系综述

Journal of orthopaedics and sports medicine Pub Date : 2022-01-01 DOI: 10.26502/josm.511500071

M. Alexander

引用次数: 0

Cortical Activation Reorganization of Cerebral Regions in Charcot– Marie–Tooth Patients: A Task-state Functional Magnetic Resonance Imaging Study 沙科-玛丽- tooth患者大脑区域皮层激活重组:一项任务状态功能磁共振成像研究

Journal of orthopaedics and sports medicine Pub Date : 2022-01-01 DOI: 10.26502/josm.511500064

Zhifeng Wang, C. Han, C. Yuan, Yiyuan Shen, X. Geng, Chen Wang, Chao Zhang, Jiazhang Huang, Xin Ma, Hanqiu Liu, Xu Wang

引用次数: 0

Epidemiology of Injuries in High School Football Players: A Prospective Cohort Study 高中足球运动员受伤的流行病学:一项前瞻性队列研究

Journal of orthopaedics and sports medicine Pub Date : 2022-01-01 DOI: 10.26502/josm.511500065

S. Pelet, Jérémy Bergeron, Mireille Marquis, Etienne L Belzile

引用次数: 0

Cyclops Lesion of Non-Operated Knees — A Case Report 未手术膝关节独眼病变1例

Journal of orthopaedics and sports medicine Pub Date : 2022-01-01 DOI: 10.26502/josm.511500055

Atef Ibrahim Awad, Ibrahim el sebaei, K. Ayed

引用次数: 0

Effectiveness of Core Stabilization Exercise along with Conventional Physiotherapy on Pain, Proprioception and Disability in Patients with Chronic Low Back Pain: A Randomized Control Trial Protocol 核心稳定运动联合常规物理治疗对慢性腰痛患者疼痛、本体感觉和残疾的疗效:一项随机对照试验方案

Journal of orthopaedics and sports medicine Pub Date : 2022-01-01 DOI: 10.26502/josm.511500057

Md. Waliul Islam, Md Tanzir-Uz-Zaman, Md. Golam Kibria, Md. Mostafijur Rahman, Md Jubair Hassan, Saddam Hossain, Md. Kutub Uddin, Mohammad Ainur Nishad Rhajib, Md Zakir Hossain, Abdullah Ibn Abul Fazal, Mohammad Anwar Hossain

引用次数: 0

Clinical and Imaging Evaluation of Rotator Cuff in Male Elite Water polo Players - A Cross-Sectional Study 男性优秀水球运动员肩袖的临床和影像学评价-一项横断面研究

Journal of orthopaedics and sports medicine Pub Date : 2022-01-01 DOI: 10.26502/josm.511500059

R. A., C. L., Ronga M

引用次数: 0

Training the Industrial Athlete: Targeted Exercises to Reduce Occupational Injury Risks 训练工业运动员:有针对性的练习，以减少职业伤害的风险

Journal of orthopaedics and sports medicine Pub Date : 2021-01-01 DOI: 10.26502/josm.511500051

Michael L. Callihan, Megan Leonard

引用次数: 1