Journal of neurobiology and physiology最新文献

Evaluation of chondrocyte dedifferentiation mechanisms using confocal Raman microscopy 利用共焦拉曼显微镜评估软骨细胞再分化机制

Journal of neurobiology and physiology Pub Date : 2023-12-21 DOI: 10.46439/neurobiology.5.024

N’Dré Jean N’DRE, P. A. Lecor, Assoumou Aa, Blohoua Mjj

引用次数: 0

Systematic evaluation of the effects of exenatide and liraglutide on neurodegenerative diseases induced by type 2 diabetes mellitus 艾塞那肽与利拉鲁肽对2型糖尿病所致神经退行性疾病疗效的系统评价

Journal of neurobiology and physiology Pub Date : 2022-12-31 DOI: 10.46439/neurobiology.4.022

引用次数: 0

The surgical philosophy for the management of rathke cleft cyst: Finding the sweet spot rathke裂囊肿治疗的手术理念：寻找最佳治疗点

Journal of neurobiology and physiology Pub Date : 2022-12-31 DOI: 10.46439/neurobiology.4.019

引用次数: 0

Commentary on “Calcitonin-gene related peptide and neurologic injury: An emerging target for headache management” “降钙素基因相关肽与神经损伤：头痛治疗的新靶点”评论

Journal of neurobiology and physiology Pub Date : 2022-11-16 DOI: 10.46439/neurobiology.4.023

Phillip Johansen, B. Lucke-Wold

{"title":"Commentary on “Calcitonin-gene related peptide and neurologic injury: An emerging target for headache management”","authors":"Phillip Johansen, B. Lucke-Wold","doi":"10.46439/neurobiology.4.023","DOIUrl":"https://doi.org/10.46439/neurobiology.4.023","url":null,"abstract":"Mehkri et al. have presented a thorough review of calcitonin-gene related peptide (CGRP) and its relationship with headaches, both primary (e.g., migraine headaches) and secondary headaches (e.g., headaches secondary to subarachnoid hemorrhage (SAH) and traumatic brain injury (TBI)) [1]. They have provided an accurate depiction of the literature and the current knowledge regarding CGRP’s association with neurologic injury, as well as some of the physiologic mechanisms and therapeutic targets. This commentary aims to further discuss the veracity of this article and to add an alternative viewpoint in terms of neuromodulators influencing post-traumatic headaches (PTH). Regarding PTH, the authors accurately depict a current understanding that is grounded in literature – CGRP’s association with neurologic injury is incompletely understood. Whether it be intracellular signaling leading to a pseudo-inflammatory response or hyperstimulation of the brain, CGRP is known to exacerbate headache symptoms. However, CGRP’s interactions in the setting of secondary headaches, such as those induced by subarachnoid hemorrhage (SAH) or traumatic brain injury (TBI), are variable depending on the timeframe. CGRP is thought to be neuroprotective in the acute setting time, CGRP levels normalize despite low-to-normal levels, patients with hypersensitized thorough","PeriodicalId":73855,"journal":{"name":"Journal of neurobiology and physiology","volume":"4 1","pages":"20 - 22"},"PeriodicalIF":0.0,"publicationDate":"2022-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44645873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Endoplasmic reticulum stress and mitochondrial dysfunctions in metal-induced neurological pathology 内质网应激和线粒体功能障碍在金属诱导的神经病理

Journal of neurobiology and physiology Pub Date : 2022-08-10 DOI: 10.46439/neurobiology.4.020

Sophia Cai, Min Woo Kim, Pan Chen

{"title":"Endoplasmic reticulum stress and mitochondrial dysfunctions in metal-induced neurological pathology","authors":"Sophia Cai, Min Woo Kim, Pan Chen","doi":"10.46439/neurobiology.4.020","DOIUrl":"https://doi.org/10.46439/neurobiology.4.020","url":null,"abstract":"Although essential metal ions are required in the body, neurotoxicity occurs when exposed to a concentration of metal that the body cannot accommodate. In the case of non-essential metals which are important in industry, these elements have the property of causing neurotoxicity even at small concentrations. When such neurotoxicity progresses chronically, it can contribute to various neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease. Therefore, research on the relationships between neurotoxicity and metal metabolism are being actively conducted, and some recent research has suggested that the mechanisms of metal-induced neurotoxicity critically involve endoplasmic reticulum (ER) stress and mitochondrial dysfunction. Hence, this mini-review is to summarize some examples of such evidence and raise new questions in attempting to address metal-induced neurotoxicity with ER stress and mitochondria dysfunctions, two important topics for the effects of metals in neurodegenerative diseases. Taken together, to study the molecular programs of integrating ER stress with mitochondrial dysfunction should be an important area of future research for appreciating the mechanisms of as well as developing strategies and targets for metal-induced neurological diseases.","PeriodicalId":73855,"journal":{"name":"Journal of neurobiology and physiology","volume":"4 1","pages":"4 - 8"},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46002647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on "Calcitonin-gene related peptide and neurologic injury: An emerging target for headache management". 关于 "降钙素基因相关肽与神经损伤：头痛治疗的新目标

Journal of neurobiology and physiology Pub Date : 2022-01-01

Phillip Johansen, Brandon Lucke-Wold

引用次数: 0

Endoplasmic reticulum stress and mitochondrial dysfunctions in metal-induced neurological pathology. 内质网应激和线粒体功能障碍在金属诱导的神经病理。

Journal of neurobiology and physiology Pub Date : 2022-01-01

Sophia Cai, Min Woo Kim, Pan Chen

{"title":"Endoplasmic reticulum stress and mitochondrial dysfunctions in metal-induced neurological pathology.","authors":"Sophia Cai, Min Woo Kim, Pan Chen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Although essential metal ions are required in the body, neurotoxicity occurs when exposed to a concentration of metal that the body cannot accommodate. In the case of non-essential metals which are important in industry, these elements have the property of causing neurotoxicity even at small concentrations. When such neurotoxicity progresses chronically, it can contribute to various neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. Therefore, research on the relationships between neurotoxicity and metal metabolism are being actively conducted, and some recent research has suggested that the mechanisms of metal-induced neurotoxicity critically involve endoplasmic reticulum (ER) stress and mitochondrial dysfunction. Hence, this mini-review is to summarize some examples of such evidence and raise new questions in attempting to address metal-induced neurotoxicity with ER stress and mitochondria dysfunctions, two important topics for the effects of metals in neurodegenerative diseases. Taken together, to study the molecular programs of integrating ER stress with mitochondrial dysfunction should be an important area of future research for appreciating the mechanisms of as well as developing strategies and targets for metal-induced neurological diseases.</p>","PeriodicalId":73855,"journal":{"name":"Journal of neurobiology and physiology","volume":" ","pages":"4-8"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40715525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allosteric interactions among voltage-sensor modules of sodium channels probed by scorpion toxin modifiers. 蝎子毒素改进剂探测钠通道电压传感器模块间的变构相互作用。

Journal of neurobiology and physiology Pub Date : 2022-01-01 DOI: 10.46439/neurobiology.4.021

Michael Gurevitz, Boris S Zhorov, Ke Dong

引用次数: 1

Surgical outcomes of the thoracic ossification of ligamentum flavum: A high incidence of combined spinal stenosis 胸椎黄韧带骨化症的手术结果：合并椎管狭窄的高发率

Journal of neurobiology and physiology Pub Date : 2021-12-31 DOI: 10.46439/neurobiology.3.016

引用次数: 0

The role of fathers on HPA-axis development and activity across the lifespan: A brief review 父亲在hpa轴发育和整个生命周期活动中的作用:简要回顾

Journal of neurobiology and physiology Pub Date : 2021-12-31 DOI: 10.46439/neurobiology.3.017

Erin E. Wood, Michael M. Criss, Jennifer byrd-craven

{"title":"The role of fathers on HPA-axis development and activity across the lifespan: A brief review","authors":"Erin E. Wood, Michael M. Criss, Jennifer byrd-craven","doi":"10.46439/neurobiology.3.017","DOIUrl":"https://doi.org/10.46439/neurobiology.3.017","url":null,"abstract":"Copyright: © 2021 Wood EE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Humans are within the rare 5% of mammal species that have paternal investment [1]. The quantity and quality of paternal investment is facultative on environmental and social context [1-3]. Because paternal investment is facultative in nature, father presence is not necessarily critical for survival [4-6]. However, the presence and involvement of the father can provide sociocompetitive advantages, and indicate valuable information about the safety and predictability of the environment that can have many downstream effects on development and health [7,8]. The safety and predictability of the environment is particularly critical in early childhood during the calibration of the hypothalamic-pituitary-adrenal axis (HPA-axis) and can shape sensitivity to stressors as children age, as discussed below [9-13]. Because fathers are shown to provide unique context to environmental conditions that are important for shaping mental and physical health, more research is needed examining the role of fathers on child development outcomes to provide better accuracy in predicting developmental trajectories [7].","PeriodicalId":73855,"journal":{"name":"Journal of neurobiology and physiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43385725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0