Journal of infectious disease and therapy最新文献_第10页

Central Venous Oxygen Saturation above 75% on Day Three of Septic Shock is Associated with Tripled Mortality 败血症休克第三天中心静脉血氧饱和度高于75%与死亡率三倍相关

Journal of infectious disease and therapy Pub Date : 2017-10-12 DOI: 10.4172/2332-0877.1000338

Timo Sturm, Jan Dertinger, M. Hagmann, M. Thiel, Verena Schneider-Lindner

{"title":"Central Venous Oxygen Saturation above 75% on Day Three of Septic Shock is Associated with Tripled Mortality","authors":"Timo Sturm, Jan Dertinger, M. Hagmann, M. Thiel, Verena Schneider-Lindner","doi":"10.4172/2332-0877.1000338","DOIUrl":"https://doi.org/10.4172/2332-0877.1000338","url":null,"abstract":"Background: Central venous oxygen saturation (ScvO2) is commonly used to identify global oxygen uptakedelivery mismatches. A level above 70% was the declared goal in early resuscitation of septic shock for over a decade. Recent evidence leads to doubts and levels higher than 80% may represent harmful conditions. This study ´s aim was to identify favourable ScvO2 levels in treatment of septic shock. \u0000Methods: Electronic data of patients suffering from septic shock who have been admitted to the surgical intensive care unit of a university hospital were analysed surveying a period of six years with focus on the association of ScvO2 levels with in-hospital mortality. \u0000Results: Data from 238 individuals were included. No difference was found comparing initially measured values of ScvO2 of survivors to non-survivors. Patients whose levels of ScvO2 never exceeded 70% (n=28) had a higher mortality rate (73.2% vs. 54.3%, p<0.05). On day three patients with values above 75% (n=32) had higher mortality rates (59.4% vs. 38.5%, p<0.05). A mortality rate of 100% was detected if ScvO2 levels exceeded 84% (n=6). \u0000Conclusions: ScvO2 develops from a therapy guiding parameter to a prognostic marker. Reaching levels of at least 70% within the first 72 h of disease is favourable in regard to prognosis. Exceeding 75% after day two is associated with higher mortality. These findings require further confirmation. At this point it can be assumed that a varying, time-dependent ScvO2 approach might be required for clinical decision-making.","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":"2017 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2017-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2332-0877.1000338","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46698239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Malaria on the People of Anambra State Nigeria and their Response to the Disease 疟疾对尼日利亚阿南布拉州人民的影响及其对这一疾病的反应

Journal of infectious disease and therapy Pub Date : 2017-10-10 DOI: 10.4172/2332-0877.1000324

Paul C. Emeka

引用次数: 2

Vancomycin Induced Neutropenia Associated with Fever: A Case Report 万古霉素诱导中性粒细胞减少伴发热1例报告

Journal of infectious disease and therapy Pub Date : 2017-10-10 DOI: 10.4172/2332-0877.1000336

Adila Shaukat, M. Maslamani, Sumaira Rafiqui

引用次数: 1

The impact of opt-out hiv testing among hospitalized patients on number of cases detected and linkage to care: a systematic review 住院患者选择退出艾滋病毒检测对发现病例数的影响及其与护理的联系:一项系统评价

Journal of infectious disease and therapy Pub Date : 2017-10-06 DOI: 10.4172/2332-0877-C1-033

Isabelle Dominique Tomacruz Carlo Miguel Berba Lance Isidor Catedral, Regina Berba

引用次数: 1

Experience with Aerosolized Imipenem in Patients with Cystic Fibrosis and Achromobacter xylosoxidans 雾化亚胺培南治疗囊性纤维化和木糖氧化无色杆菌的经验

Journal of infectious disease and therapy Pub Date : 2017-09-25 DOI: 10.4172/2332-0877.1000335

M. C. Marcos, E. Espinosa, T. Pérez, L. D. Cáceres, A. Meca, C. Serrano, R. Moreno

引用次数: 3

Combined Effect of Platelets and Anidulafungin against Aspergillus fumigatus Infections 血小板与抗烟曲霉素联合抗烟曲霉感染的研究

Journal of infectious disease and therapy Pub Date : 2017-09-22 DOI: 10.4172/2332-0877.1000334

Schiefermeier Mach N, Bellmann R, Frealle E, Perkhofer S

{"title":"Combined Effect of Platelets and Anidulafungin against Aspergillus fumigatus Infections","authors":"Schiefermeier Mach N, Bellmann R, Frealle E, Perkhofer S","doi":"10.4172/2332-0877.1000334","DOIUrl":"https://doi.org/10.4172/2332-0877.1000334","url":null,"abstract":"Invasive aspergillosis (IA) is one of the major causes of morbidity and mortality in severely immunocompromised patients. Despite the existence of antifungal treatment IA mortality rate remains extremely high and may reach up to 80%. Previous studies have suggested important role of platelets in antifungal host defence. In vitro data show that platelets are able to attenuate germination, hyphal elongation and viability of Aspergillus fumigatus. Interaction of platelets with Aspergillus fumigatus induces differential expressions of fungal genes associated with stress response regulation, cellular transport and metabolism. \u0000A new class of antifungals, echinocandins (caspofungin, micafungin and anidulafungin), have entered the market. Anidulafungin displays strong antifungal activity against Candida and Aspergillus species and has very few side effects due to its specific inhibiting effect on the fungal cell wall synthesis. Anidulafungin is currently licensed for the treatment of adult patients with invasive candidiasis. Clinical significance of anidulafungin for IA treatment has to be further evaluated. \u0000Recently published studies have shown that efficiency of antifungal substances can be enhanced when combined with platelets. In this review we discuss the literature on the potential combined effect of platelets and anidulafungin against Aspergillus fumigatus infections.","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":"2017 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2332-0877.1000334","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47298019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A Historical Overview of the Classification, Evolution, and Dispersion of Leishmania Parasites and Sandflies in Morocco 摩洛哥利什曼原虫寄生虫和沙蝇的分类、进化和分布的历史综述

Journal of infectious disease and therapy Pub Date : 2017-09-06 DOI: 10.4172/2332-0877.1000332

A. Tabbabi, Sajida Sboui, K. Bekhti

引用次数: 1

Nosocomial Infection of Pantoea Spp in Neonatal Unit About 11 Cases 新生儿病房Pantoea Spp医院感染11例报告

Journal of infectious disease and therapy Pub Date : 2017-08-30 DOI: 10.11648/j.ijidt.20170204.12

M. Chemsi, Youssef Benechchehab, M. Lehlimi, K. Zerouali, A. Habzi, S. Benomar

引用次数: 1

Effect of Antifungal Drugs against Candida Isolates from Diabetic Women with Vaginitis 抗真菌药物对糖尿病合并阴道炎妇女念珠菌分离株的影响

Journal of infectious disease and therapy Pub Date : 2017-08-17 DOI: 10.4172/2332-0877.1000331

R. Rajalakshmi, D. Sangeetha, Udhaya

引用次数: 3

Complete Remission of Primary Cutaneous Cryptococcosis in an Immunosuppressed Patient after Fluconazole Treatment 氟康唑治疗后免疫抑制患者原发性皮肤隐球菌病完全缓解

Journal of infectious disease and therapy Pub Date : 2017-07-26 DOI: 10.4172/2332-0877.1000326

G. Landucci, P. Farinelli, E. Zavattaro, R. Giorgione, L. C. Gironi, F. Veronese, S. Astolfi, R. Tiberio, R. Boldorini, E. Colombo, P. Savoia

{"title":"Complete Remission of Primary Cutaneous Cryptococcosis in an Immunosuppressed Patient after Fluconazole Treatment","authors":"G. Landucci, P. Farinelli, E. Zavattaro, R. Giorgione, L. C. Gironi, F. Veronese, S. Astolfi, R. Tiberio, R. Boldorini, E. Colombo, P. Savoia","doi":"10.4172/2332-0877.1000326","DOIUrl":"https://doi.org/10.4172/2332-0877.1000326","url":null,"abstract":"Cryptococcus neoformans is opportunistic encapsulated yeast that represents the most frequent cryptococcal species found in humans. It can cause three types of infections: pulmonary cryptococcosis, cryptococcal meningitis and cutaneous cryptococcosis. Cutaneous cryptococcosis may represent the dissemination of a systemic infection (especially from nervous or pulmonary primary site of infection) or may be the only localization, due to a direct inoculation into the skin, because of a traumatic injury. Primary cutaneous cryptococcosis (PCC) is rare and mainly affects elderly patients, from rural areas, with history of cutaneous injuries and activities predisposing wounds or exposure to bird droppings. Immunosuppression may be a predisponing factor. The most utilized treatment is fluconazole, but often, especially for ulcers or deep wounds; surgery is required for complete tissues repair. Herein, we present a case of PCC in an immunosuppressed patient, with destroying ulcers involving deep tissues, completely resolved after fluconazole treatment, without surgical intervention.","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":" ","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2332-0877.1000326","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47099583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0