Journal of immunological sciences最新文献_第6页

Simulation Exercises To Strengthen Polio Outbreak Preparedness in The Horn of Africa: Experiences and Lessons Learnt. 加强非洲之角预防脊髓灰质炎爆发的模拟演习：经验教训。

Journal of immunological sciences Pub Date : 2021-04-05 DOI: 10.29245/2578-3009/2021/S2.1107

Samuel Okiror, Chidiadi Nwogu, Obianuju Igweonu, Rustam Hydarov, Djiboui Karim, Farkhard Imambakiev, John Ogange, Annet Kisakye, Joseph Okeibunor, Hemant Shukla

{"title":"Simulation Exercises To Strengthen Polio Outbreak Preparedness in The Horn of Africa: Experiences and Lessons Learnt.","authors":"Samuel Okiror, Chidiadi Nwogu, Obianuju Igweonu, Rustam Hydarov, Djiboui Karim, Farkhard Imambakiev, John Ogange, Annet Kisakye, Joseph Okeibunor, Hemant Shukla","doi":"10.29245/2578-3009/2021/S2.1107","DOIUrl":"10.29245/2578-3009/2021/S2.1107","url":null,"abstract":"Background: Poliovirus importations and related outbreaks occurred in the Horn of Africa (HoA) following an initial outbreak, which started in Somalia, spread into Kenya within ten days and later into Ethiopia and gradually to other countries in the region. National preparedness plans for responding to poliovirus introduction were insufficient in many countries of the Region. We describe a series of polio outbreak simulation exercises that were implemented to formally test polio outbreak preparedness plans in the HoA countries, as a step to interrupting further transmission.Methods: The Polio Outbreak Simulation Exercises (POSEs) were designed and implemented. The results were evaluated and recommendations made. The roles of outbreak simulation exercises in maintaining regional polio-free status were assessed. In addition, we performed a comprehensive review of the national plans of all for seven countries in the HoA Region.Results: Seven simulation exercises, delivered between 2016 and 2017 revealed that participating countries were generally prepared for poliovirus introduction, but the level of preparedness needed improvement. The areas in particular need of strengthening were national preparedness plans, initial response, plans for securing vaccine supply, and communications.Conclusions: Polio outbreak simulation exercises can be valuable tools to help maintain polio-free status and should be extended to other high-risk countries and subnational areas in the HoA Region and elsewhere. There is also need to standardize the process and methods for conducting POSE for comparability.","PeriodicalId":73785,"journal":{"name":"Journal of immunological sciences","volume":"Spec Issue 2","pages":"1107"},"PeriodicalIF":0.0,"publicationDate":"2021-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38953118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overview of Polio Outbreak Response in Kenya, 2013 to 2015. 2013年至2015年肯尼亚脊灰疫情应对概述。

Journal of immunological sciences Pub Date : 2021-04-02 DOI: 10.29245/2578-3009/2021/S2.1103

Chidiadi Nwogu, Johnny Musyoka, Carolyne Gathenji, Rosemary Nzunza, Iheoma Onuekwusi, Joseph Okeibunor, Pascal Mkanda, Hemant Shukla, Shaikh Humayun Kabir, Sam O Okiror

{"title":"Overview of Polio Outbreak Response in Kenya, 2013 to 2015.","authors":"Chidiadi Nwogu, Johnny Musyoka, Carolyne Gathenji, Rosemary Nzunza, Iheoma Onuekwusi, Joseph Okeibunor, Pascal Mkanda, Hemant Shukla, Shaikh Humayun Kabir, Sam O Okiror","doi":"10.29245/2578-3009/2021/S2.1103","DOIUrl":"10.29245/2578-3009/2021/S2.1103","url":null,"abstract":"Background: Globally, tremendous improvement has been made in Polio eradication since its inception in 1988. For the third time in a decade, Kenya has experienced a Polio outbreak along the border with Somalia. The affected areas were in Garissa County, replete with previous occurrences in 2006 and 2012. This article, give an account of series of events and activities that were used to stop the transmission within 13 weeks, an interval between the first and the last case of the 2013 outbreak.Methods: In an attempt to stop further transmission and time bound closure of the outbreak, many activities were brought to fore: the known traditional methods, innovative approaches, improved finances and surge capacity. These assisted in case detection, implementation, and coordination of activities. The external outbreak assessments and the six-monthly technical advisory group recommendations were also employed.Result: There were increased case detections of >=2/100,000, stool adequacy >=80%, due to enhanced surveillance, timely feedbacks from laboratory investigation and diagnosis. Sustained coverage in supplemental immunisation of > 90%, ensured that immune profile of >=3 polio vaccine doses was quickly attained to protect the targeted population, prevent further polio infection and eventual reduction of cases coming up with paralysis.Conclusion: Overall, the outbreak was stopped within the 120 days of the first case using 14 rounds of supplemental immunisation activities.","PeriodicalId":73785,"journal":{"name":"Journal of immunological sciences","volume":"Spec Issue 2","pages":"1103"},"PeriodicalIF":0.0,"publicationDate":"2021-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38886725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Dementia Human Leukocyte Antigen (HLA) Profile with Human Herpes Viruses 3 and 7: An in silico Investigation. 痴呆症人类白细胞抗原（HLA）谱与人类疱疹病毒3和7的关联：一项计算机研究

Journal of immunological sciences Pub Date : 2021-01-01 DOI: 10.29245/2578-3009/2021/3.1218

Lisa M James, Spyros A Charonis, Apostolos P Georgopoulos

{"title":"Association of Dementia Human Leukocyte Antigen (HLA) Profile with Human Herpes Viruses 3 and 7: An in silico Investigation.","authors":"Lisa M James, Spyros A Charonis, Apostolos P Georgopoulos","doi":"10.29245/2578-3009/2021/3.1218","DOIUrl":"10.29245/2578-3009/2021/3.1218","url":null,"abstract":"Human leukocyte antigen (HLA), the most highly polymorphic region of the human genome, is increasingly recognized as an important genetic contributor to dementia risk and resilience. HLA is involved in protection against foreign antigens including human herpes viruses (HHV), which have been widely implicated in dementia. Here we used an in silico approach1 to determine binding affinities of glycoproteins from 9 human herpes virus (HHV) strains to 113 HLA alleles, and to examine the association of a previously identified HLA-dementia risk profile2 to those affinities. We found a highly significant correlation between high binding affinities of HLA alleles to HHV 3 and 7 and the dementia risk scores of those alleles, such that the higher the estimated binding affinity, the lower the dementia risk score. These findings suggest that protection conferred by HLA alleles may be related to their ability to bind and eliminate HHV3 and HHV7 and point to the possibility that protection against these viruses may reduce dementia incidence.","PeriodicalId":73785,"journal":{"name":"Journal of immunological sciences","volume":"130 1","pages":"7-14"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86367284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytokine Storm and its Implication in Coronavirus disease 2019 (COVID-19) 细胞因子风暴及其在2019冠状病毒病中的意义

Journal of immunological sciences Pub Date : 2020-09-01 DOI: 10.29245/2578-3009/2020/2.1190

C. Datta, A. Bhattacharjee

{"title":"Cytokine Storm and its Implication in Coronavirus disease 2019 (COVID-19)","authors":"C. Datta, A. Bhattacharjee","doi":"10.29245/2578-3009/2020/2.1190","DOIUrl":"https://doi.org/10.29245/2578-3009/2020/2.1190","url":null,"abstract":"Corona virus disease 2019 (COVID-19), is a viral disease caused by novel corona virus known as severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). The disease was declared as a pandemic by the World Health Organisation (WHO) on March 11, 2020. Initial studies have shown the molecular resemblances in the receptor binding domains of SARS-CoV and SARS-CoV-2 which bind angiotensin converting enzyme 2 (ACE 2) receptors and helps the virus to enter into the host cells to cause infection. Illness caused by COVID19 ranges from mild common cold to life threatening acute respiratory distress syndrome (ARDS), multi-organ dysfunction and shock. The key step in converting mild disease to severe is immune dysfunction and cytokine dysregulation resulting in “cytokine storm syndrome”. Clinical investigations in patients with COVID-19 have shown that a strong upregulation of cytokine and interferon production is common feature in SARS-CoV2-induced pneumonia, with an associated cytokine storm syndrome. Consequently, spotting of existing approved therapies with proper safety profiles to treat hyperinflammation is very essential in order to reduce COVID-19 associated mortality. Till date, no specific therapeutic drugs or vaccines are available to treat COVID-19. In this review, we intended to describe how cytokine storm is associated with the severity of COVID-19 disease and also tried to find out the best possible way to manage the hyperinflammatory response due to cytokine storm during COVID-19 infection using several interleukin receptor antagonists, inhibitors, intravenous immunoglobulins, cytokine adsorption device and repurposing of pre-existing antiviral and some antimalarial drugs etc. Cytokine Storm and its Implication in Coronavirus disease 2019 (COVID-19)","PeriodicalId":73785,"journal":{"name":"Journal of immunological sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83939218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

SARS-CoV-2 Subversion of the Antiviral Interferon Alpha-Response of Lung Macrophages? SARS-CoV-2颠覆肺巨噬细胞抗病毒干扰素α反应?

Journal of immunological sciences Pub Date : 2020-09-01 DOI: 10.29245/2578-3009/2020/2.1189

M. Kloc, R. Ghobrial, J. Kubiak

{"title":"SARS-CoV-2 Subversion of the Antiviral Interferon Alpha-Response of Lung Macrophages?","authors":"M. Kloc, R. Ghobrial, J. Kubiak","doi":"10.29245/2578-3009/2020/2.1189","DOIUrl":"https://doi.org/10.29245/2578-3009/2020/2.1189","url":null,"abstract":"The interferons (IFNs) are the main antiviral immune factors. Currently, various IFNs therapies are used for the treatment of human immunodeficiency virus (HIV), hepatitis B (HBV), and hepatitis C (HCV), cancer, and autoimmune diseases. Recently, it has been suggested that IFN-α therapy should be used to lessen the respiratory symptoms in the SARS-CoV-2 virusinfected (COVID-19) patients. The SARS-CoV-2 enters the cells by binding to the Angiotensinconverting enzyme 2 (ACE2), which by recognizing the spike S1 protein of the virus, acts as a virus receptor. Because the expression of ACE2 is induced by IFN-α, the SARS-CoV-2 virus may exploit the anti-viral response by subverting the IFN functions to further its own propagation and infectability. We discuss here how the SARS-CoV-2 may also subvert the immune response of the lung macrophages, which also express ACE2, to exacerbate the severity of the COVID-19 respiratory symptoms. SARS-CoV-2 Subversion of the Antiviral Interferon Alpha-Response of Lung Macrophages? Malgorzata Kloc1,2,3*, Rafik M. Ghobrial1,2, Jacek Z Kubiak4,5* 1The Houston Methodist Research Institute, Houston, Texas 77030, USA 2The Houston Methodist Hospital, Department of Surgery, Houston, Texas, USA 3The University of Texas, M.D. Anderson Cancer Center, Department of Genetics, Houston Texas, USA 4Laboratory of Regenerative Medicine and Cell Biology, Military Institute of Hygiene and Epidemiology (WIHE), Warsaw, Poland 5UnivRennes, UMR 6290, CNRS, Institute of Genetics and Development of Rennes, Cell Cycle Group, Faculty of Medicine, Rennes, France","PeriodicalId":73785,"journal":{"name":"Journal of immunological sciences","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75299021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Diagnostic and Prognostic value of Immunohistochemistry in Destructive Paediatric Maxillary Pathologies 免疫组织化学对小儿上颌破坏性病变的诊断及预后价值

Journal of immunological sciences Pub Date : 2020-09-01 DOI: 10.29245/2578-3009/2020/3.1192

P. Jeyaraj

引用次数: 0

Bispecific Antibodies as an Alternative to Antibody Cocktails for SARS-CoV-2: A Mini- Review 双特异性抗体替代鸡尾酒抗体治疗SARS-CoV-2的研究综述

Journal of immunological sciences Pub Date : 2020-06-16 DOI: 10.29245/2578-3009/2022/2.1237

Gavin Yuen, S. Bhanot, Jeremy Steen, Minahil Syed, A. Mardon

{"title":"Bispecific Antibodies as an Alternative to Antibody Cocktails for SARS-CoV-2: A Mini- Review","authors":"Gavin Yuen, S. Bhanot, Jeremy Steen, Minahil Syed, A. Mardon","doi":"10.29245/2578-3009/2022/2.1237","DOIUrl":"https://doi.org/10.29245/2578-3009/2022/2.1237","url":null,"abstract":"Vaccination is a powerful inducer of immunity against SARS-CoV-2 and its recent variants. However, it is important to expand the defensive repertoire against this virus as vaccination is not always efficacious or accessible to everyone. Protein therapeutics in the form of monoclonal antibodies have been used to neutralize the Spike protein, but their efficacy has been limited with rapidly evolving mutations. Cocktail antibodies have been used to combat antigenic escape through diversifying antigen recognition and the overall neutralization capacity. However, the production of cocktail antibodies can be costly and requires a high dosage to achieve the desired therapeutic effect. Alternatively, bispecific antibodies have been used, which contain two recognition specificities within the same molecule. This effectively reduces the cost of production and dosage required to achieve a target therapeutic effect. Bispecific antibodies were reported to bind SARS-CoV-2 antigen with nanomolar affinities. The neutralization potentials (IC50 values) within the same studies were generally more efficacious than their cocktail antibody counterparts. Some studies showed that bispecific antibodies could also confer additional neutralization effector functions, such as recruiting the complement system. Although the recognition of variants was diverse, to our knowledge, there is no data to suggest that bispecific antibodies have a broader recognition of variant strains than cocktail antibodies. Future studies should aim to explore the clinical benefits of bispecific antibodies for SARS-CoV-2 and the emerging variant strains to better understand its benefits in treatment.","PeriodicalId":73785,"journal":{"name":"Journal of immunological sciences","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86765088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary: An Allele-Specific Functional SNP Associated with Two Systemic Autoimmune Diseases Modulates IRF5 Expression by Long-Range Chromatin Loop Formation 评论：与两种系统性自身免疫疾病相关的一个等位基因特异性功能 SNP 通过长程染色质环形成调节 IRF5 的表达

Journal of immunological sciences Pub Date : 2020-03-01 DOI: 10.29245/2578-3009/2020/1.1182

Hlaing Nwe Thynn, Xiao-Feng Chen, Shanshan Dong, Yan Guo, Tie-Lin Yang

引用次数: 0

Immunosuppressive drugs in organ transplantation to prevent allograft rejection: Mode of action and side effects 器官移植免疫抑制药物预防同种异体移植排斥反应:作用方式和副作用

Journal of immunological sciences Pub Date : 2019-11-01 DOI: 10.29245/2578-3009/2019/4.1178

Elisa Claeys, K. Vermeire

引用次数: 30

Immunometabolic Links Underlying the Infectobesity with Persistent Viral Infections 免疫代谢与持续性病毒感染之间的联系

Journal of immunological sciences Pub Date : 2019-08-01 DOI: 10.29245/2578-3009/2019/4.1176

Yongming Sang

{"title":"Immunometabolic Links Underlying the Infectobesity with Persistent Viral Infections","authors":"Yongming Sang","doi":"10.29245/2578-3009/2019/4.1176","DOIUrl":"https://doi.org/10.29245/2578-3009/2019/4.1176","url":null,"abstract":"Obesity and its related comorbidities are prevailing globally. Multiple factors are etiological to cause obesity and relevant metabolic disorders. In this regard, some pathogenic infections including those by viruses have also been associated with obesity (termed especiallky as infectobesity). In this mini-review, I examined recent publications about primary or cofactorial role of viral infections to exacerbate the local and systemic immunometabolic cues that underlie most cofactorial obesity. Major immuno-metabolic pathways involved, including that mediated by interferon (IFN) signaling and peroxisome proliferator activated receptor-γ (PPAR-γ), are discussed. at an inter-systemic level. While excess intake of energy-dense food (such as high-fat diet, HFD) forms a substantial physical factor for adipogenesis, active molecules derived from diet-microbiota interaction in gut, such as short- or long-chain fatty acid (LFA) in HFD, dramatically alter immune and metabolic homeostasis locally and systemically that entails obesity — a globally prevalent disease at the interface of immunity and metabolism involving multiple organs in digestive, endocrine and nervous systems. Major immunological links underlying obesity including local and systemic inflammation, altered cytokine and hormonal regulation, activated immune cells (macrophages, T cells etc.) as briefly listed by each major organ in obesogenesis. From an immunological view, some infections, particularly chronic viral infections as focused here, are associated and even form a reciprocal causality with obesity through their pathogenic intervention with host immune and metabolic systems at various stages of obesity development. Abbreviations: FA, fatty acid; IFN, interferon;","PeriodicalId":73785,"journal":{"name":"Journal of immunological sciences","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79408067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0