Journal of epilepsy research最新文献

{"title":"Involvement of N-Methyl-D-Aspartate Receptors in the Anticonvulsive Effects of Licofelone on Pentylenetetrazole-Induced Clonic Seizure in Mice.","authors":"Ramtin Gholizadeh, Zohreh Abdolmaleki, Taraneh Bahremand, Mehdi Ghasemi, Mehdi Gharghabi, Ahmad Reza Dehpour","doi":"10.14581/jer.21003","DOIUrl":"10.14581/jer.21003","url":null,"abstract":"<p><strong>Background and purpose: </strong>Licofelone is a dual 5-lipoxygenase/cyclooxygenase inhibitor, with well-documented anti-inflammatory and analgesic effects, which is used for treatment of osteoarthritis. Recent preclinical studies have also suggested neuroprotective and anti-oxidative properties of this drug in some neurological conditions such as seizure and epilepsy. We have recently demonstrated a role for nitric oxide (NO) signaling in the anti-epileptic activity of licofelone in two seizure models in rodents. Given the important role of N-methyl-D-aspartate receptors (NMDARs) activation in the NO production and its function in the nervous system, in the present study, we further investigated the involvement of NMDAR in the effects of licofelone (1, 3, 5, 10, and 20 mg/kg, intraperitoneal [i.p.]) in an <i>in vivo</i> model of seizure in mice.</p><p><strong>Methods: </strong>Clonic seizures were induced in male NMRI mice by intravenous administration of pentylenetetrazol (PTZ).</p><p><strong>Results: </strong>Acute administration of licofelone exerted anticonvulsant effects at 10 (<i>p</i><0.01) and 20 mg/kg (<i>p</i><0.001). A combined treatment with sub-effective doses of the selective NMDAR antagonist MK-801 (0.05 mg/kg, i.p.) and licofelone (5 mg/kg, i.p.) significantly (<i>p</i><0.001) exerted an anticonvulsant effect on the PTZ-induced clonic seizures in mice. Notably, pre-treatment with the NMDAR co-agonist D-serine (30 mg/kg, i.p.) partially hindered the anticonvulsant effects of licofelone (20 mg/kg).</p><p><strong>Conclusions: </strong>Our data suggest a possible role for the NMDAR in the anticonvulsant effects of licofelone on the clonic seizures induced by PTZ in mice.</p>","PeriodicalId":73741,"journal":{"name":"Journal of epilepsy research","volume":"11 1","pages":"14-21"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2d/57/jer-21003.PMC8357553.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39313492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survey on Antiepileptic Drug Therapy in Patients with Drug Resistant Epilepsy.","authors":"Jun-Sang Sunwoo,&nbsp;Hyunjin Jo,&nbsp;Kyung Wook Kang,&nbsp;Keun Tae Kim,&nbsp;Daeyoung Kim,&nbsp;Dong Wook Kim,&nbsp;Min-Jee Kim,&nbsp;Saeyoon Kim,&nbsp;Woojun Kim,&nbsp;Hye-Jin Moon,&nbsp;Ha Ree Park,&nbsp;Jung-Ick Byun,&nbsp;Jong-Geun Seo,&nbsp;Sung Chul Lim,&nbsp;Min Kyung Chu,&nbsp;Su-Hyun Han,&nbsp;Kyoung Jin Hwang,&nbsp;Dae-Won Seo","doi":"10.14581/jer.21010","DOIUrl":"https://doi.org/10.14581/jer.21010","url":null,"abstract":"<p><strong>Background and purpose: </strong>Individualized anti-epileptic drug (AED) selection in patient with epilepsy is crucial. However, there is no unified opinion in treating patients with drug resistant epilepsy (DRE). This survey aimed to make a consolidate consensus with epileptologists' perspectives of the treatment for Korean DRE patients by survey responses.</p><p><strong>Methods: </strong>The survey was conducted with Korean epilepsy experts who have experience prescribing AEDs via e-mail. Survey questionnaires consisted of six items regarding prescription patterns and practical questions in treating patients with DRE in Korea. The research period was from February 2021 to March 2021.</p><p><strong>Results: </strong>The survey response rate was 83.3% (90/108). Most (77.8%) of the responders are neurologists. The proportion of patients whose seizures were not controlled by the second AED was 26.9%. The proportion of patients who had taken five or more AEDs is 13.9%, and those who are currently taking five or more AEDs are 7.3%, of which 54.5% and 37.9% reported positive effects on additional AED, respectively. The majority (91.1%) of respondents answered that the mechanism of action was the top priority factor when adding AED. Regarding data priority, responders considered that expert opinion should have the top priority, followed by clinical experiences, reimbursement guidelines and clinical evidence. Responders gave 64.9 points (range from 0 to 100) about overall satisfaction on reimbursement system of Health Insurance Review and Assessment Service for AED.</p><p><strong>Conclusions: </strong>This study on AED therapy for DRE patients is the first nationwide trial in Korean epilepsy experts. In five drug failure, the top priorities on AED selection are mechanism of action and expert opinion. These findings might help to achieve consensus and recognize the insight on optimal therapy of AED in DRE.</p>","PeriodicalId":73741,"journal":{"name":"Journal of epilepsy research","volume":"11 1","pages":"72-82"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ee/d1/jer-21010.PMC8357558.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39325134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Convulsive Status Epilepticus in a Cohort of Patients from a Peruvian Academic Hospital.","authors":"Marcelo Bedoya-Sommerkamp,&nbsp;Victor Hugo Chau-Rodríguez,&nbsp;Jesús Medina-Ranilla,&nbsp;Alejandro Escalaya-Advíncula,&nbsp;Ray Ticse-Aguirre,&nbsp;Walter De La Cruz-Ramírez,&nbsp;Jorge G Burneo","doi":"10.14581/jer.21011","DOIUrl":"10.14581/jer.21011","url":null,"abstract":"<p><strong>Background and purpose: </strong>Status epilepticus is a neurologic emergency whose epidemiology, etiology and management are scarcely known in developing countries. Our objective was to describe the demographic and clinical features as well as the management of generalized convulsive status epilepticus (GCSE) in adult patients admitted to the emergency department of an academic hospital in Peru, between March 2019 and March 2020.</p><p><strong>Methods: </strong>Observational study of a prospective cohort in which patients were assessed by the emergency and neurology department on the first day of hospitalization, at discharge and at 30 days post-discharge in a follow-up visit. Relevant demographics and clinical data were collected. After being encoded and sorted, univariate statistical analysis was carried out.</p><p><strong>Results: </strong>Of the sample of 59 patients, 62.7% were males, 57.6% were unemployed, 89.8% did not finish high school, and 55.9% had intermittent GCSE with no seizure at arrival. The total calculated median times were: 60 minutes from GCSE onset to hospital arrival, 110 minutes from GCSE onset to 1st line therapy, and 7 minutes from hospital arrival to 1st line therapy. The most frequently used antiepileptic drugs were one dose of benzodiazepine (41.7%), phenytoin (76.9%), and additional doses of benzodiazepines (60%) for 1st, 2nd, and 3rd line therapies, respectively. The most frequent etiologies were antiepileptic drug suspension (27.1%), undetermined (25.4%) and acute stroke (11.8%). 62.71% had 0-2 modified Rankin score at discharge.</p><p><strong>Conclusions: </strong>In this cohort of patients, GCSE was mainly intermittent. Management times differed from the guidelines' recommendations.</p>","PeriodicalId":73741,"journal":{"name":"Journal of epilepsy research","volume":"11 1","pages":"83-92"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f3/42/jer-21011.PMC8357561.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39325135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Altered Mental State Associated with Nonhepatic Hyperammonemia Presented in an Elderly Female Patient: Probable Late-Onset Urea Cycle Disorder.","authors":"Jung-Ju Lee,&nbsp;Soohyun Cho,&nbsp;Byung Kun Kim,&nbsp;Ohyun Kwon,&nbsp;Jong-Moo Park,&nbsp;Woong-Woo Lee,&nbsp;Kyusik Kang","doi":"10.14581/jer.21013","DOIUrl":"https://doi.org/10.14581/jer.21013","url":null,"abstract":"<p><p>Altered mentality associated with hyperammonemia is usually diagnosed in patients with liver disease. Nonhepatic hyperammonemia may be present in critically ill patients or may be caused by high protein diets or certain drugs. Urea cycle disorders (UCDs) rarely present with altered mentality with hyperammonemia in adult patients. An 82-year-old female visited our hospital with complaints of abnormal behavior and confusion. Routine blood tests revealed elevated serum ammonia. Her mentality and serum ammonia level normalized after lactulose enema and she was discharged thereafter. However, she was later re-admitted because of recurrent altered mentality. Amino acid analysis revealed that serum levels of ornithine and glutamine increased significantly, whereas the levels of alanine and glutamic acid increased slightly, and the levels of arginine, lysine, and citrulline were normal, which were probably caused by reduced activity of the mitochondrial ornithine carrier-1. Although our patient was not diagnosed genetically, this case illustrates the under-recognized fact that UCD can occur in a senile age. Clinical suspicion of UCDs in patients with hyperammonemia is critical for early diagnosis and to prevent the significant neurologic sequelae.</p>","PeriodicalId":73741,"journal":{"name":"Journal of epilepsy research","volume":"11 1","pages":"96-99"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/49/26/jer-21013.PMC8357551.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39325137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pedunculopontine Nucleus--Rapid Eye Movement Sleep--Electroencephalogram--Desynchronization (PRED) Axis in the Evolution of Epilepsy: A Novel Concept.","authors":"Harinder Jaseja","doi":"10.14581/jer.21001","DOIUrl":"https://doi.org/10.14581/jer.21001","url":null,"abstract":"<p><p>Epilepsy is one of the commonest and oldest neurological diseases in the history of mankind, the exact pathophysiology of the evolution of which still remains elusive. The intimate and intriguing relation between epilepsy and sleep has been known for a long time. Rapid eye movement sleep (REMS) is well documented to exert potent antiepileptic action in human epilepsies and the underlying mechanism of which is largely based on its property to induce widespread electroencephalogram (EEG)-desynchronization. The pedunculopontine nucleus (PPN) owing to its property to enhance REMS has recently been under study for its potential role in intractable epilepsy (IE) and has been proposed as a novel deep brain stimulation target in IE. This brief paper unfolds the existing role of PPN, REMS, and EEG-desynchronization (PRED) in the evolution of epilepsy in an axial manner, the realization and comprehension of which is likely to open new avenues for further understanding of epileptogenesis, improved treatment of epilepsy and reducing the risk of IE.</p>","PeriodicalId":73741,"journal":{"name":"Journal of epilepsy research","volume":"11 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/28/c3/jer-21001.PMC8357554.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39313490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Lenalidomide on Pentylenetetrazole-Induced Clonic Seizure Threshold in Mice: A Role for N-Methyl-D-Aspartic Acid Receptor/Nitric Oxide Pathway.","authors":"Elaheh Asgari Dafe,&nbsp;Nastaran Rahimi,&nbsp;Nina Javadian,&nbsp;Pegah Dejban,&nbsp;Monika Komeili,&nbsp;Sepideh Modabberi,&nbsp;Mehdi Ghasemi,&nbsp;Ahmad Reza Dehpour","doi":"10.14581/jer.21002","DOIUrl":"https://doi.org/10.14581/jer.21002","url":null,"abstract":"<p><strong>Background and purpose: </strong>Accumulating evidence suggest that lenalidomide, a structural analog of thalidomide, has neuro-modulatory and neuroprotective properties. In the present study, we investigated effects of acute administration of lenalidomide on clonic seizure threshold in mice induced by pentylenetetrazole (PTZ) and possible role of N-methyl-D-aspartic acid receptor (NMDAR) and nitric oxide (NO) pathway.</p><p><strong>Methods: </strong>We have utilized a clonic model of seizure in NMRI mice induced by PTZ to evaluate the potential effect of lenalidomide on seizure threshold. Different doses of lenalidomide (5, 10, 20, and 50 mg/kg, intraperitoneal [i.p.]) were administered 1 hour before PTZ. To evaluate probable role of NMDAR/NO signaling, the non-selective NO synthase inhibitor L-<i>N</i> ^G-nitroarginine methyl ester (L-NAME; 10 mg/kg, i.p.), neuronal NOS (nNOS) inhibitor 7-nitroindazole (7-NI; 30 mg/kg, i.p.), selective inducible NOS inhibitor aminoguanidine (AG; 100 mg/kg, i.p.), selective NMDAR antagonist MK-801 (0.01 mg/kg, i.p.), and selective NMDAR agonist D-serine (30 mg/kg, i.p.) were injected 15 minutes before lenalidomide.</p><p><strong>Results: </strong>Lenalidomide at 10 and 20 mg/kg significantly elevated the PTZ-induced seizure thresholds. Interestingly, L-NAME (10 mg/kg, i.p), 7-NI (30 mg/kg, i.p), and AG (100 mg/kg, i.p) reversed the anticonvulsive effect of lenalidomide (10 mg/kg). Moreover, treatment with the NMDAR agonist D-serine (30 mg/kg, i.p.) did not alter the anticonvulsive properties of lenalidomide (10 mg/kg, i.p). However, the NMDAR antagonist MK-801 (0.01 mg/kg, i.p) significantly reversed the anticonvulsive effects of lenalidomide (10 mg/kg).</p><p><strong>Conclusions: </strong>Our study demonstrated a role for the NMDAR/NO pathway in the anticonvulsive effects of lenalidomide on the PTZ-induced clonic seizures in mice.</p>","PeriodicalId":73741,"journal":{"name":"Journal of epilepsy research","volume":"11 1","pages":"6-13"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b4/4c/jer-21002.PMC8357552.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39313491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Severe Dementia Case in End of Life Care with Psychiatric Symptoms Treated by Perampanel.","authors":"Asaki Kumamoto,&nbsp;Yuhei Chiba,&nbsp;Akira Suda,&nbsp;Akitoyo Hishimoto,&nbsp;Akihiko Kase","doi":"10.14581/jer.21012","DOIUrl":"https://doi.org/10.14581/jer.21012","url":null,"abstract":"<p><p>Epilepsy is known to comorbid with Alzheimer's disease. It can promote cognitive decline, and eventually worsen their prognosis and mortality. It is sometimes difficult to find a suitable drug because of the adverse effects. Perampanel has a unique mechanism of action that antagonizes α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid type glutamate receptor. Here, we report a case of severe dementia due to Alzheimer's disease with intractable epilepsy, which perampanel effected for controlling seizures with less adverse effects. The subject is an 89-year-old Japanese woman with severe dementia due to Alzheimer's disease and intractable myoclonic epilepsy. She also had psychiatric symptoms, such as circadian rhythm disorder and irritability. Valproic acid, lacosamide, or carbamazepine were prescribed, but none of them was effective. Shortly after perampanel started, however, myoclonus and these psychiatric symptoms improved. Moreover, it did not cause any obvious adverse effects, which made it possible to continue perampanel until the end of her life. Perampanel may be useful for controlling intractable epilepsy accompanied by Alzheimer's disease. It may also improve psychiatric symptoms with less adverse effect. Accumulation of studies is necessary to evaluate the effectiveness of perampanel on the epilepsy of Alzheimer's disease patients and further understand that mechanism.</p>","PeriodicalId":73741,"journal":{"name":"Journal of epilepsy research","volume":"11 1","pages":"93-95"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ab/13/jer-21012.PMC8357559.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39325136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacoresistant Abdominal Seizures in Symptomatic Localization-Related Epilepsy.","authors":"Vadakke Puthanveetil Tushar,&nbsp;Sachin Sureshbabu,&nbsp;Kunnath Gopalakrishnan Sruthi,&nbsp;Smilu Mohanlal","doi":"10.14581/jer.21015","DOIUrl":"https://doi.org/10.14581/jer.21015","url":null,"abstract":"<p><p>Abdominal epilepsy is an uncommon cause of recurrent abdominal pain with or without other complaints seen in children and adults which often goes unnoticed. Here we are presenting a case of abdominal epilepsy in a 7-year boy who had recurrent abdominal pain since many years. He had a history of ventriculoperitoneal shunting which was performed for obstructive hydrocephalus at 1 month and left hemiparesis. He was evaluated at multiple centers for abdominal complaints before being referred here. The video electroencephalogram done showed inter ictal and ictal abnormalities which correlated with magnetic resonance imaging and positron emission tomography abnormalities on the right side. He was started on antiepileptics with a partial response and continued to get events even with four antiepileptics but the frequency and severity reduced significantly. The present case report is to highlight the drug refractoriness of abdominal seizures in a patient with symptomatic focal epilepsy.</p>","PeriodicalId":73741,"journal":{"name":"Journal of epilepsy research","volume":"11 1","pages":"106-109"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/19/89/jer-21015.PMC8357550.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39325139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posterior Reversible Encephalopathy Syndrome Is the Common Cause of New-Onset Seizures in the Peripartum Period: A Tertiary Hospital-Based Study in South India.","authors":"Jagarlapudi Mk Murthy,&nbsp;Shyam K Jaiswal,&nbsp;Keshava Anand Gaade","doi":"10.14581/jer.21007","DOIUrl":"https://doi.org/10.14581/jer.21007","url":null,"abstract":"<p><strong>Background and purpose: </strong>To study the aetiolgic spectrum of new-onset seizures in the peripartum period in south India.</p><p><strong>Methods: </strong>This is a retrospective analysis of case records of women with new-onset seizures in the peripartum period admitted between 2005 and 2018 (13 years).</p><p><strong>Results: </strong>Of the 41 women (mean age, 26.20 years; range, 19-35 years) admitted, 20 patients (48.7%) had hypertensive disorders of pregnancy (HDP). Generalized tonic-clonic seizure (88%) was the common seizure type. The aetiologies of new-onset seizures were: 1) pregnancy-related aetiologies in 33 (80.5%) and 2) non-pregnancy-related aetiologies in eight (19.5%). Of the pregnancy-related aetiologies, posterior reversible encephalopathy syndrome (PRES) was the commonest cause in 24 patients (58.5%). Seizure cluster presentation was common in patients with PRES (<i>p</i>=0.0087). Of the eight women with non-pregnancy-related aetiologies, endemic central nervous system (CNS) infections accounted for three (7.3%; brain tuberculoma in one and neurocystocercosis in two) of the aetiology. All the women had Glasgow outcome scale-5 outcome.</p><p><strong>Conclusions: </strong>PRES was the common cause of new-onset seizures in peripartum period in this cohort. Endemic infections of CNS accounted for 7.3% of the total aetiological spectrum. This study suggests that the possibility of PRES should be considerd in woman with HDP and seizure cluster in peripartum period.</p>","PeriodicalId":73741,"journal":{"name":"Journal of epilepsy research","volume":"11 1","pages":"49-55"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d6/18/jer-21007.PMC8357549.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39313496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ictal Swearing as a Lateralizing Value for the Dominant Hemisphere in Temporal Lobe Epilepsy.","authors":"Woohee Ju,&nbsp;Jong-Su Kim,&nbsp;Yangmi Park,&nbsp;Dae Lim Koo,&nbsp;Hyunwoo Nam","doi":"10.14581/jer.21016","DOIUrl":"https://doi.org/10.14581/jer.21016","url":null,"abstract":"<p><p>Ictal swearing, as an epileptic manifestation, has rarely been reported. Despite its poor localization value and unclear mechanism, several previous studies have reported that it frequently originates from the temporal lobe and more often from the non-dominant hemisphere. Herein, we report a case of a 41-year-old right-handed man with a history of stereotypical manifestation of ictal swearing with a left (dominant) hemisphere origin, confirmed by video electroencephalography monitoring. Reasonable suspicion that repetitive swearing could be a manifestation of seizures is important for clinicians not to misdiagnose the disease.</p>","PeriodicalId":73741,"journal":{"name":"Journal of epilepsy research","volume":"11 1","pages":"110-111"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7c/24/jer-21016.PMC8357548.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39325140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}