Journal of environmental science and public health最新文献

{"title":"PFOS Impairs Mitochondrial Biogenesis and Dynamics and Reduces Oxygen Consumption in Human Trophoblasts.","authors":"Alissa Hofmann,&nbsp;Jay S Mishra,&nbsp;Pankaj Yadav,&nbsp;Sri Vidya Dangudubiyyam,&nbsp;Chellakkan S Blesson,&nbsp;Sathish Kumar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Perfluorooctane sulfonate (PFOS), a synthetic chemical used in various commercial applications and industrial settings, has led to contamination of drinking water and has been detected in the bloodstream of pregnant women with gestational complications. Recent investigations have indicated that PFOS disrupts placental function; however, the mechanism remains elusive. Given the significant abundance of mitochondria in the placenta, which play a pivotal role in fulfilling the heightened energy requirements of pregnancy, our research aimed to examine the repercussions of PFOS exposure on mitochondrial dynamics within placental trophoblasts. Specifically, human trophoblasts (HTR-8/SVneo) were exposed to environmentally relevant concentrations of PFOS ranging from 0.1 to 50 μM for 48 hours. Findings revealed that PFOS exposure elicited a concentration-dependent decrease in basal, maximal, and ATP-linked respiration. PFOS inhibited the activity of electron transport complexes I, II, and III, resulting in diminished ATP production. Furthermore, PFOS reduced mitochondrial DNA copy number, indicating less mitochondrial content. Concurrently, there was a downregulation in the expression of mitochondrial biogenesis-related genes, including <i>PGC-1α, NRF1,</i> and <i>NRF2</i>. Notably, PFOS perturbed mitochondrial dynamics by suppressing the expression of fission-related genes (<i>FIS1</i> and <i>DRP1</i>) and fusion-related genes (<i>MFN1</i> and <i>MFN2</i>). In summary, our findings suggest that PFOS exposure leads to a decline in mitochondrial content and compromises the bioenergetic capacity of trophoblasts by impairing cellular respiration. This reduction in mitochondrial biogenesis and alterations in fission/fusion dynamics induced by PFOS may contribute to mitochondrial dysfunction in trophoblasts. Consequently, strategies that preserve mitochondrial function in trophoblasts may mitigate PFOS-induced impairment of placental energy metabolism.</p>","PeriodicalId":73740,"journal":{"name":"Journal of environmental science and public health","volume":"7 4","pages":"164-175"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71429923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indigenous Use and Commercialization of Urtica dioica l. from Local Communities of Kieni West Sub County, Nyeri County, Kenya","authors":"Wairimu Kamicha, Rebecca N. Karanja, Grace W. Ngaruiya.","doi":"10.26502/jesph.96120183","DOIUrl":"https://doi.org/10.26502/jesph.96120183","url":null,"abstract":"","PeriodicalId":73740,"journal":{"name":"Journal of environmental science and public health","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perception of Covid-19 Vaccine and Vaccination","authors":"Raj Kamal Choudhary, Abilesh Kumar, O. Ali, Anjum Pervez, Munesh Meena","doi":"10.26502/jesph.96120190","DOIUrl":"https://doi.org/10.26502/jesph.96120190","url":null,"abstract":"The economy, education, business, tourism, health care and every section of the society is severely affected by Covid-19 virus. It challenged the public health system and affected the people physically and psychologically. The Covid-19 virus resulted in economic crisis of every nation and declared as pandemic by World Health Organisation. Though vaccines are developed rapidly, its acceptance among the people is comparatively low and slow. The present study is conducted to identify the vaccination status, analyse the health issues due to vaccination, source of awareness about vaccine and to measure the perception of people of vaccine. It is a quantitative study conducted primary data collected from 655 respondents in Tamil Nadu. The study found that moderate level of acceptance for vaccines and positive perception of vaccine. Vaccination level is lower among female, and in rural areas. It resulted in health issues in the form of fever and cured in a day by tablets. Though the social media plays a vital role in creating awareness it also creates undue hype and anxiety among the people. Regression analysis of the study revealed the changes in the perception of vaccine reliability and social media impact could result in positive perception among people about vaccine. Creating awareness on Covid-19 and the essentiality of vaccination only could prevent the world from the giant hands of Coronavirus. The reliable information in social media could impact a positive perception among the people on vaccine. Thereby, entire world can overcome the pandemic situation, and save the prestigious life of everyone in this beautiful world.","PeriodicalId":73740,"journal":{"name":"Journal of environmental science and public health","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of Co-evolution to Model the Effects of Global Warming","authors":"C E Neal-Sturgess","doi":"10.26502/jesph.96120196","DOIUrl":"https://doi.org/10.26502/jesph.96120196","url":null,"abstract":"In their paper Natural selection for least action [1] depict evolution as a Path Integral process conforming to the Principle of Least Action (PLA). From this concept, an equation of motion for environmental coevolution was derived. Co-evolution [2] is a widespread phenomenon, as any system of coupled differential equations will conform to Co-evolution. Following this idea and the link to Path Integrals and PLA it is possible to generalise Co-evolution to any system of coupled differential equations such as Global Warming; that is what is done here. Taking an approximate approach to the Lagrangians involved gives a new simple metric defined as a “Coefficient of Impact” which reflects the importance of global warming on the particular effect, empirical evidence is used to calibrate the model; the results give similar levels of importance to other published values with the exception of the duration of heat waves.","PeriodicalId":73740,"journal":{"name":"Journal of environmental science and public health","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135959316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Finite Element Analysis of ‘Hexa-Zygomatic’ Implants vs Conventional Quad Zygomatic Implants for The Rehabilitation of Bilateral Maxillectomy Defects","authors":"","doi":"10.26502/jesph.96120185","DOIUrl":"https://doi.org/10.26502/jesph.96120185","url":null,"abstract":"","PeriodicalId":73740,"journal":{"name":"Journal of environmental science and public health","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated Maternal Testosterone Levels Alter PFOA Elimination and Tissue Distribution in Pregnant Rats.","authors":"Pankaj Yadav,&nbsp;Jay S Mishra,&nbsp;Sathish Kumar","doi":"10.26502/jesph.96120193","DOIUrl":"https://doi.org/10.26502/jesph.96120193","url":null,"abstract":"<p><p>Perfluorooctanoic acid (PFOA) is an enduring synthetic chemical that harms human health. Recent studies indicate heightened bioaccumulation of PFOA, particularly in pregnant women experiencing preeclampsia. Since plasma testosterone levels are elevated in pregnant women with preeclampsia, we hypothesized that hyperandrogenic conditions during pregnancy may hinder PFOA elimination and contribute to their higher body burden. Pregnant Sprague-Dawley rats were s/c injected with vehicle or testosterone propionate from gestational day (GD) 15 to 20 to increase plasma testosterone levels by 2-fold, similar to levels in preeclampsia. On GD 16, [¹⁴C]-PFOA (9.4 pmol/kg) was given intravenously, and subsequently, ¹⁴C radioactivity was measured in maternal blood, urine, feces, and tissues. PFOA was primarily eliminated through urine; however, less PFOA was excreted in urine of pregnant rats with elevated testosterone levels than controls. Fecal excretion of PFOA was minimal and did not significantly differ between groups. The total elimination of PFOA (urine plus feces) was significantly reduced by 12% in pregnant rats with elevated testosterone levels. In controls, PFOA distribution was highest in placenta, followed by the kidneys, liver, brain, heart, lungs, and spleen. Pregnant rats with elevated testosterone levels displayed 12% higher concentrations of PFOA in these tissues than controls. Furthermore, the renal expression of <i>Oat2</i> and <i>Oat3</i> was significantly decreased, while <i>Oatp1</i> and <i>Oat-k</i> expression was significantly increased in pregnant rats with elevated testosterone levels than controls. In conclusion, elevated maternal testosterone levels decrease urinary elimination of PFOA, possibly through altered expression of renal transporters leading to increased tissue concentrations of PFOA in pregnant rats.</p>","PeriodicalId":73740,"journal":{"name":"Journal of environmental science and public health","volume":"7 3","pages":"131-139"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470210/pdf/nihms-1923912.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10152154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Could the Omicron Variant be the last Variant of Concern of the COVID-19 Pandemic? - Global Immunity is Key","authors":"Y. Muscat Baron","doi":"10.26502/jesph.96120180","DOIUrl":"https://doi.org/10.26502/jesph.96120180","url":null,"abstract":"","PeriodicalId":73740,"journal":{"name":"Journal of environmental science and public health","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community Knowledge, Attitude and Practice towards Tuberculosis in Nakfa Subzone: Cross-Sectional Study, 2021","authors":"Abiel Yehdego Kidanemariam, Betiel Yihdego Kidanemariam, Eyasu H. Tesfamariam, Mengisteab Embaye Gulbetu.","doi":"10.26502/jesph.96120186","DOIUrl":"https://doi.org/10.26502/jesph.96120186","url":null,"abstract":"","PeriodicalId":73740,"journal":{"name":"Journal of environmental science and public health","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Practices and Experiences of Type II Diabetic Patients on Self- Care Management at the Limbe and Buea Treatment Centers","authors":"Andigema Sharon Negsang, Tendongfor Nicholas, Jules C Nguedia Assob, Kah Emmanuel Nji, N. Omer","doi":"10.26502/jesph.96120192","DOIUrl":"https://doi.org/10.26502/jesph.96120192","url":null,"abstract":"","PeriodicalId":73740,"journal":{"name":"Journal of environmental science and public health","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographic Transition Model and Population Growth of India - Implications and Assessments","authors":"Sanju Purohit","doi":"10.26502/jesph.96120198","DOIUrl":"https://doi.org/10.26502/jesph.96120198","url":null,"abstract":"The demographic transition model (DTM) describes the progression of a country's population growth based on societal development. This paper examines the applicability of the DTM to India's unique demographic scenario and delves into the implications and assessments of India's population growth. The study includes vital analyses of the influence of urbanization, socioeconomic variables, and governmental policies on the demographic transition. It concludes with India's demographic change's potential social, economic, and environmental consequences.","PeriodicalId":73740,"journal":{"name":"Journal of environmental science and public health","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135505574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}