Journal of endometriosis and uterine disorders最新文献

{"title":"Concurrent rates of pathology confirmed adenomyosis and endometriosis","authors":"Sanjanaa Senthilkumar ,&nbsp;Longwen Chen ,&nbsp;Christopher Dodoo ,&nbsp;Megan Wasson","doi":"10.1016/j.jeud.2025.100149","DOIUrl":"10.1016/j.jeud.2025.100149","url":null,"abstract":"<div><h3>Objective</h3><div>Understand rates of pathology confirmed adenomyosis occurring in the setting of endometriosis and identify predictive factors for the diagnosis of adenomyosis.</div></div><div><h3>Methods</h3><div>Retrospective cross-sectional study of patients undergoing concurrent hysterectomy and excision of pathology confirmed endometriosis over a two-year period. Patients without pathology confirmed endometriosis were excluded. Six full-thickness uterine sections for histologic analysis was performed to thoroughly evaluate for adenomyosis.</div></div><div><h3>Results</h3><div>A total of 95 patients with pathology confirmed endometriosis were identified that also underwent hysterectomy during the study period. Adenomyosis was pathologically noted in 53 individuals (55.8%; CI: 45.2%, 66.0%).The primary indications for hysterectomy were pelvic pain (78.9%), heavy menstrual bleeding (37.9%), and endometriosis (24.2%). Significant factors included age [adenomyosis: 40.9 years (SD = 7.1) vs no adenomyosis: 38.1 years (7.4)] (<em>p</em> = 0.026), dyspareunia (52.9% vs 81.0%; <em>p</em> = 0.006) and prior dilation and curettage (D&amp;C) (24.5% vs 9.5%; <em>p</em> = 0.039). There were no statistically significant differences in parity, uterine weight, endometriosis stage, or history of cesarean section, laparotomy, or laparoscopy in those with or without adenomyosis. After adjusting for age, ethnicity, and imaging type, patients with prior D&amp;C were 4.6 times at risk of having adenomyosis (OR: 4.6; CI: 1.19, 23.5). However, patients with dyspareunia were less likely to have adenomyosis (OR: 0.21; CI: 0.06, 0.61).</div></div><div><h3>Conclusion</h3><div>In this population, 45.2% did not have coexisting adenomyosis. Despite overlapping symptomology between endometriosis and adenomyosis, unique clinical factors, such as prior D&amp;C and absence of dyspareunia, were found to be predictive of adenomyosis.</div></div>","PeriodicalId":73733,"journal":{"name":"Journal of endometriosis and uterine disorders","volume":"14 ","pages":"Article 100149"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145929323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High prevalence of irritable bowel syndrome in women with chronic pelvic pain and discerning features relevant to deep endometriosis","authors":"Simon G. Powell ,&nbsp;James N.R. Wyatt ,&nbsp;Ilyas Arshad ,&nbsp;Shakil Ahmed ,&nbsp;Christopher J. Hill ,&nbsp;Christopher Probert ,&nbsp;Dharani K. Hapanagama","doi":"10.1016/j.jeud.2025.100148","DOIUrl":"10.1016/j.jeud.2025.100148","url":null,"abstract":"<div><h3>Objective</h3><div>Endometriosis is a chronic inflammatory condition associated with chronic pelvic pain (CPP), dysmenorrhea and bowel-related symptoms. Significant overlap exists between endometriosis and other benign abdominal pathologies, including irritable bowel syndrome (IBS). We aimed to identify the prevalence of IBS-related symptoms in a group of women undergoing either diagnostic or therapeutic surgical interventions for CPP.</div></div><div><h3>Materials and methods</h3><div>This ethically approved (IRAS 294803) prospective case-control study was undertaken between 8th November 2021 and 22nd February 2023. Premenopausal women presenting to the Liverpool Women's Hospital for surgical investigation and management of CPP completed an electronic questionnaire containing questions pertinent to the Rome IV diagnostic criteria for IBS and the validated British Society for Gynaecological Endoscopy (BSGE) endometriosis and pelvic pain questionnaire. Patients were grouped according to surgical findings: control (no endometriosis) (n = 49), superficial endometriosis (SE) (<em>n</em> = 21), or deep endometriosis (DE) (<em>n</em> = 19).</div></div><div><h3>Results</h3><div>Sixty-six (74.2%) women included in this study had a concurrent diagnosis of IBS. The prevalence of IBS was significantly higher in patients without surgical evidence of endometriosis (83.7% vs. 62.5%, <em>p</em> = 0.02). When considering endometriosis subtypes, patients with DE were less likely to meet the diagnostic criteria for IBS than those with SE and no endometriosis (57.9% vs. 66.7% vs. 83.7%, <em>p</em> = 0.062).</div></div><div><h3>Conclusion</h3><div>Patients presenting with CPP, regardless of the underlying diagnosis of endometriosis, have a high prevalence of concomitant IBS. Clinicians should discuss bowel symptoms with all CPP patients and consider commencing concurrent IBS treatments as appropriate to improve patient symptoms.</div></div>","PeriodicalId":73733,"journal":{"name":"Journal of endometriosis and uterine disorders","volume":"14 ","pages":"Article 100148"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145929322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual Progestin System (DPS) via levonorgestrel-releasing intrauterine system (LNG-IUS) and etonogestrel subdermal implant (ESI) for severe, refractory endometriosis-associated pain: A retrospective case series report","authors":"Cecilia Hoi Man Ng ,&nbsp;Moamar Al-Jefout ,&nbsp;Ian Stewart Fraser","doi":"10.1016/j.jeud.2025.100150","DOIUrl":"10.1016/j.jeud.2025.100150","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the clinical effectiveness of a dual progestogen-delivery system (DPS) using a levonorgestrel-releasing intrauterine system (LNG-IUS) combined with an etonogestrel subdermal implant (ESI) in women with severe, refractory endometriosis-associated pelvic pain.</div></div><div><h3>Design</h3><div>A retrospective analysis of 105 patients treated with simultaneous LNG-IUS and ESI for durations ranging from 24 to 102 months.</div></div><div><h3>Setting</h3><div>Tertiary referral centers and university-affiliated hospitals.</div></div><div><h3>Patients</h3><div>Women with surgically confirmed endometriosis and persistent pelvic pain unresponsive to standard care (medical and/or surgical management).</div></div><div><h3>Main Outcome Measures</h3><div>Pain relief (measured by VAS), continuation rates, treatment duration, and reported adverse events.</div></div><div><h3>Results</h3><div>The mean treatment duration was 28.1 months. Significant pain reduction was reported in 85% of patients, with VAS scores decreasing from a baseline mean of 9/10 to 3/10 (SD ± 1.04) by 3 months, and to minimal or no pain by 6 months. Most patients (n = 90/105, 85%) sustained symptom relief throughout therapy. Mild adverse effects were reported in 50% of patients, though primarily mild and non-disruptive.</div></div><div><h3>Conclusion</h3><div>The DPS represents a promising, alternative, long-term therapeutic option for managing severe, refractory endometriosis-related pain, offering both uterine and systemic suppression of endometriotic activity.</div></div>","PeriodicalId":73733,"journal":{"name":"Journal of endometriosis and uterine disorders","volume":"14 ","pages":"Article 100150"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146024332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variation in endometriosis aetiology, potential impact on lesion heterogeneity and the consequences for research and treatment","authors":"Isaac Kyei-Barffour ,&nbsp;Grant W. Montgomery ,&nbsp;Brett D. McKinnon","doi":"10.1016/j.jeud.2026.100152","DOIUrl":"10.1016/j.jeud.2026.100152","url":null,"abstract":"<div><div>Endometriosis is the extra-uterine development of endometrial-like tissue that affects 1 in 7 women of reproductive age. Endometriosis is associated with intense pain and suffering, sub-fertility, and reduction in the overall quality of life. It is significantly heterogeneous with variation in symptom presentation, lesion appearance and disease progression. Delayed diagnosis (7–12 years between disease onset and diagnosis) is a major problem for both clinical management and research. Laparoscopy remains the gold standard for diagnosis and treatment. Non-invasive methods are limited, and the natural progress of the disease is not understood. Current theories of pathogenesis can explain some form of lesions, but none can describe the entire spectrum. Here, we discuss a more subtle and nuanced version of endometriosis pathophysiology that incorporates multiple aetiologies. We explore the possibility that various aetiologies could explain different routes of lesion initiation where the underlying genetic architecture is the background that creates susceptibility to different routes. We propose this could contribute to lesion heterogeneity and finally outline approaches to investigate these possibilities using molecular profiling and high-fidelity <em>in vitro</em> models. A better understanding of both the complexity of disease aetiology and the subsequent presentation will lead to advances in understanding endometriosis heterogeneity, assist early detection, and improve treatments outcomes.</div></div>","PeriodicalId":73733,"journal":{"name":"Journal of endometriosis and uterine disorders","volume":"14 ","pages":"Article 100152"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146024333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies for self-management of endometriosis symptoms: An observational study","authors":"Claudia Benvenuti ,&nbsp;Antonella Martino ,&nbsp;Domitille Dereu ,&nbsp;Stanislas Mathivon ,&nbsp;Estelle Jobson ,&nbsp;Benno Rehberg","doi":"10.1016/j.jeud.2025.100145","DOIUrl":"10.1016/j.jeud.2025.100145","url":null,"abstract":"<div><h3>Background</h3><div>Endometriosis affects 10–15% of women of childbearing age, impacting their quality of life. Treatment options are limited, mainly relying on hormonal treatment and surgery. Symptoms are often incapacitating, but typical analgesics provide limited relief. Thus, many patients use self-management strategies such as dietary changes, lifestyle modifications, alternative medicine and non-medical pharmacological approaches. Understanding their use, effectiveness and tolerance in patients living with endometriosis could improve overall management.</div></div><div><h3>Methods</h3><div>A survey was distributed to women treated at the Endometriosis Centre of the University Hospitals of Geneva and on social media platforms from March 2020 to March 2024. Participants were only included if they had a confirmed diagnosis of endometriosis and completed questionnaires on their self-management strategies in the previous six months, along with their effectiveness and tolerance.</div></div><div><h3>Results</h3><div>Data from 146 valid survey responses were analysed. Self-management strategies were used by 95% of the participants. The most reported strategies included applying heat, rest and dietary changes. Participants perceived several strategies as more effective than treatments prescribed by healthcare providers (analgesics and hormones). Applying heat, dietary changes and osteopathy were perceived as the most effective, leading also to lower use of analgesics. For many strategies, even those with lower perceived effectiveness, more than 90% of participants using them would recommend them to friends and family.</div></div><div><h3>Conclusion</h3><div>Our study found that patients with endometriosis broadly rely on self-management strategies. Further assessment and integration of these strategies could improve management of endometriosis within the biopsychosocial model of chronic pain, emphasizing patient empowerment.</div></div>","PeriodicalId":73733,"journal":{"name":"Journal of endometriosis and uterine disorders","volume":"13 ","pages":"Article 100145"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging findings differentiating uterine cavity polypoidal masses","authors":"Aditi Raj,&nbsp;Neha Bagri,&nbsp;Aanchal Bhayana,&nbsp;Ritu Misra","doi":"10.1016/j.jeud.2025.100146","DOIUrl":"10.1016/j.jeud.2025.100146","url":null,"abstract":"<div><div>Uterine leiomyomas uncommonly manifest as submucous pedunculated masses, a few of which are adenomyomas. These must be differentiated from endometrial polyps (EPs) due to their different malignant potential, prognosis and management. We aim to differentiate between these uterine cavity polypoidal masses by illustrating the imaging features on ultrasound (US), Doppler and magnetic resonance imaging (MRI). On US, uterine leiomyomas appear hypoechoic with an overlying layer of echogenic endometrium, distorting the endometrial-myometrial junction with multiple feeding vessels. However, the endometrial polyp appears isoechoic with preservation of the endometrial-myometrial interface and a well-defined single vascular pedicle within the stalk. The presence of cysts with haemorrhage on MRI is a crucial feature of prolapsing adenomyoma. This differentiation is essential for the prompt management of the patients. Imaging helps detect and differentiate uterine submucous pedunculated leiomyomas from adenomyomas and polyps and thus, plays a crucial role in the patient’s therapeutic approach.</div></div>","PeriodicalId":73733,"journal":{"name":"Journal of endometriosis and uterine disorders","volume":"13 ","pages":"Article 100146"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145790100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Müllerian duct anomalies: A retrospective case series focussing on outcomes in patients with a uterine septum","authors":"Eline Dhont ,&nbsp;Laura D’hoore ,&nbsp;Laurence Van de Loo ,&nbsp;Kristien Roelens ,&nbsp;Tjalina Hamerlynck","doi":"10.1016/j.jeud.2025.100147","DOIUrl":"10.1016/j.jeud.2025.100147","url":null,"abstract":"<div><h3>Objective</h3><div>The impact of the various (sub)classes of Müllerian anomalies on reproductive and obstetric outcomes remains unclear. Accurate diagnosis of these anomalies is also challenging due to the use of different diagnostic methods and classification systems. Furthermore, the benefits of hysteroscopic septum resection are still debated. This study aimed to describe reproductive and obstetric outcomes in patients with Müllerian anomalies, specifically uterine septa, with a focus on outcomes before and after hysteroscopic septum resection.</div></div><div><h3>Material and methods</h3><div>Patients aged ≤45 years with a Müllerian anomaly diagnosed or treated at Ghent University Hospital between 2000–2020 were retrospectively included. Anomalies were classified using the ESHRE/ESGE system.</div></div><div><h3>Results</h3><div>134 patients were included, of which 50.0% reported subfertility. The most frequent diagnosis was a partial uterine septum (n = 56, 41.8%). Seventy patients underwent hysteroscopic septum resection. The proportion of patients with live births was 60.0% higher after septum resection (95% CI 45.0–71.0 %, p &lt; .001), whereas the proportion of patients with pregnancy loss &lt;12 weeks was 40.0% (95%CI 17.2–57.1 %, p = .001) lower after septum resection. A subgroup analysis among patients who had been pregnant both before and after septum resection confirmed these results. In those patients (n = 31), obstetric complications were reported in 70.0% of ongoing pregnancies before and 37.8% after surgery.</div></div><div><h3>Discussion</h3><div>Our findings confirm the higher risk of adverse reproductive outcomes in patients with uterine septa. Hysteroscopic septum resection was associated with more live births and fewer early pregnancy losses. No severe complications were observed.</div></div>","PeriodicalId":73733,"journal":{"name":"Journal of endometriosis and uterine disorders","volume":"13 ","pages":"Article 100147"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145839450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of a smartphone app to shorten the diagnostic delay in endometriosis: a prospective observational pilot study","authors":"Mark E. Schoep ,&nbsp;Annemiek W. Nap ,&nbsp;Lisa Esam ,&nbsp;Channah Kesseler ,&nbsp;Didi D.M. Braat ,&nbsp;Theodoor E. Nieboer","doi":"10.1016/j.jeud.2025.100138","DOIUrl":"10.1016/j.jeud.2025.100138","url":null,"abstract":"<div><h3>Background</h3><div>Endometriosis is a chronic condition in which endometrium-like tissue is found in extrauterine locations. It is associated with long diagnostic delay and this may result in a longer period of pain or higher stage at diagnosis. A smartphone app could help to speed up the diagnostic process.</div></div><div><h3>Objective</h3><div>The objective of this study is to explore whether an app can differentiate pain patterns in patients with endometriosis and controls.</div></div><div><h3>Materials and methods</h3><div>Patients with proven endometriosis and participants without a diagnosis of endometriosis kept a digital pain diary with twice-daily entries using the Q1.6 app. The app is a medically registered smartphone application that uses adaptive questioning to collect real-time pain scores for general pain as well as dysuria, dyschezia, and dyspareunia.</div></div><div><h3>Results</h3><div>Twenty-six patients and 105 controls were included. The mean use of the app was 58 days. The number of painful days was higher in participants with endometriosis (23.5 vs 13.3; <em>P</em> &lt; 0.01). Mean pain scores were higher in patients with endometriosis for dysuria (3.3 vs 1.5; <em>P</em> &lt; 0.01), dyschezia (5.3 vs 2.5; <em>P</em> &lt; 0.01), and dyspareunia (4.3 vs 1.8; <em>P</em> &lt; 0.01). A combination of dysuria, dyschezia and/or dyspareunia was more frequently found in patients with endometriosis.</div></div><div><h3>Conclusions</h3><div>This smartphone app seems to be able to differentiate between pain patterns in patients with endometriosis and controls. Future prospective validation in patients with suspected endometriosis will have to prove the real value of the app in shortening the duration of the diagnostic process.</div></div>","PeriodicalId":73733,"journal":{"name":"Journal of endometriosis and uterine disorders","volume":"13 ","pages":"Article 100138"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145579830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MED12 somatic mutation promotes human uterine leiomyoma’s growth by trigging canonical Wnt4/beta-catenin and TGF-B signaling through the EMT pathway","authors":"Vivek Pandey ,&nbsp;Yashvant Patel ,&nbsp;Sonal Tiwari ,&nbsp;Anjali Rani ,&nbsp;Sangeeta Rai ,&nbsp;Sakshi Agarwal ,&nbsp;Anima Tripathi ,&nbsp;Pawan K. Dubey","doi":"10.1016/j.jeud.2025.100137","DOIUrl":"10.1016/j.jeud.2025.100137","url":null,"abstract":"<div><div>Somatic mutation in mediator complex subunit 12 (MED12) plays a significant role in the transformation of normal myometrium to uterine leiomyomas (UFs); however, the molecular mechanism of UF caused by genetic aberrations in the MED12 gene remains unclear. We established a patient-derived primary culture of tissue sample and confirmed MED12 mutations in UF tissue and primary culture by Sanger sequencing and RT-PCR. Further, to investigate the functional relationship between MED12-wild and MED12-mut, Wnt4/β-catenin signaling with TGF-β pathways was investigated. We found a single nucleotide substitution in exon-2 of MED12 (c.131G&gt;A), consequently leading to a change in amino acid from Glycine to Aspartate, which has a pathogenic and lethal impact. We have shown that this somatic mutation (131G&gt;A) aggressively activates Wnt4/β-catenin and TGF-β signaling to promote growth, proliferation, and ECM deposition by targeting the EMT pathway in MED12-Mut compared to MED12-WT UL cells. Analysis of Vimentin, MMP-2/9, and α-SMA protein expression levels in the same set of ULs revealed significantly higher expression in MED12-mut compared to MED12-wild type of tissue. We conclude that mutation in the MED12 gene in ULs triggers two mutually exclusive pathways, one with over-expression of ECM protein, and another with epithelial-mesenchymal transition (EMT) pathway in the genesis of ULs.</div></div>","PeriodicalId":73733,"journal":{"name":"Journal of endometriosis and uterine disorders","volume":"13 ","pages":"Article 100137"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145374409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement project examples for enhanced patient care in endometriosis","authors":"Paola Vigano' ,&nbsp;Sun-Wei Guo","doi":"10.1016/j.jeud.2026.100151","DOIUrl":"10.1016/j.jeud.2026.100151","url":null,"abstract":"","PeriodicalId":73733,"journal":{"name":"Journal of endometriosis and uterine disorders","volume":"13 ","pages":"Article 100151"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145976175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}