Journal of endometriosis and uterine disorders最新文献

{"title":"Complementary therapies for endometriosis associated pain: An extensive survey","authors":"Laëtitia Mercier Des Rochettes ,&nbsp;Giacomo Serboli ,&nbsp;Leonardo Nelva Stellio ,&nbsp;Elisabetta Manzoni ,&nbsp;Aubert Agostini","doi":"10.1016/j.jeud.2025.100126","DOIUrl":"10.1016/j.jeud.2025.100126","url":null,"abstract":"<div><h3>Objective</h3><div>Our primary objective is to evaluate the use of complementary therapies among women with endometriosis to manage chronic pelvic pain. As a secondary objective, the study aims to assess satisfaction levels with these therapies and respondents' perceptions of their impact on the disease.</div></div><div><h3>Material and methods</h3><div>Patients were recruited at Centre Hospitalier des Escartons de Briançon, with help from EndoFrance Association and social media. Women with a history of endometriosis and chronic pain were invited to complete an anonymous online form via Google Forms.</div></div><div><h3>Results</h3><div>Between March and July 2022, 24.337 patients were invited to complete a questionnaire, with 778 responses, resulting in a 3.2% response rate. The average age of respondents was 35 years. Among those, 671 patients (86%) were using non-pharmacological therapies for endometriosis-related pain. The most common treatments included osteopathy (56%), anti-inflammatory diet (56%), sophrology (46%), yoga (46%), and physiotherapy (42%), with many using multiple treatments. Satisfaction levels ranged from 69% to 27%, with osteopathy and yoga being the most appreciated. Furthermore, 58% of patients reported reducing their conventional analgesic intake. Despite the widespread use of complementary therapies and 83% of patients discussing them with healthcare providers, 43% of respondents expressed distrust in their doctors regarding these therapies.</div></div><div><h3>Conclusion</h3><div>Complementary medicine is commonly utilized by women with endometriosis to alleviate pain, potentially decreasing reliance on conventional medications. As such, it represents a valuable alternative and supplementary option for pain management. Consequently, it should be considered as part of the treatment plan for all women with endometriosis.</div></div>","PeriodicalId":73733,"journal":{"name":"Journal of endometriosis and uterine disorders","volume":"12 ","pages":"Article 100126"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"I wish I had known: A preliminary study of the journey of people with early onset endometriosis in U.S","authors":"Karenina M. Paredes ,&nbsp;Nicole O. Afuape ,&nbsp;Perla A. Vargas","doi":"10.1016/j.jeud.2025.100125","DOIUrl":"10.1016/j.jeud.2025.100125","url":null,"abstract":"<div><h3>Objective</h3><div>Endometriosis is a complex, estrogen-dependent chronic condition characterized by the growth of endometrial-like tissue outside of the uterus. Lack of Health Care Practitioners (HCPs) knowledge seems to be a key driving factor of diagnostic delays and misdiagnosis. The study's primary aim was to explore the first-hand experience of people assigned female at birth (PAFAB) with early-onset endometriosis using semi-structured online interviews.</div></div><div><h3>Materials and methods</h3><div>We interviewed English-speaking PAFAB recruited from virtual endometriosis support groups with a physician diagnosis of endometriosis before age 25. Twenty-four PAFAB who inquired about the study were interviewed. The interviews were conducted via Zoom conferencing, audio-recorded, transcribed, and analyzed using a thematic approach.</div></div><div><h3>Results</h3><div>Most participants were Caucasian (88.1%) ages 19–44 years (M = 31.13 – IQR 24.5–36.5). Mean age of symptoms onset was 13.6 years, and mean age at diagnosis was 26.2. PAFAB with early-onset endometriosis struggle with the lack of reliable information and lack of support and empathy needed to cope with the disease. Their young age at the time of symptoms onset and the cultural taboos about PAFAB’s sexual health negatively impacted their clinical experience.</div></div><div><h3>Conclusion</h3><div>The challenges that PAFAB with early-onset endometriosis face hinder their ability to advocate for themselves, leading to helplessness and poor quality of life. Timely diagnosis and treatment and supportive environments that accommodate public health policies would favor endometriosis patients’ quality of life.</div></div>","PeriodicalId":73733,"journal":{"name":"Journal of endometriosis and uterine disorders","volume":"11 ","pages":"Article 100125"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144330036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial disparities in non-hysterectomy surgeries for endometriosis","authors":"Tarangi Sutaria ,&nbsp;Katherine Freedy ,&nbsp;Lisa Flowers ,&nbsp;Marie Shockley ,&nbsp;Danielle M. Blemur ,&nbsp;Whitney A. Barnes ,&nbsp;Mark Lachiewicz","doi":"10.1016/j.jeud.2025.100124","DOIUrl":"10.1016/j.jeud.2025.100124","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the self-reported prevalence of hysterectomy and non-hysterectomy surgeries for endometriosis by race/ethnicity.</div></div><div><h3>Methods</h3><div>This cross-sectional study used data from the National Survey of Family Growth (NSFG) 2017–2019 cycle. This study included persons ages 15–49 years who identify as female and who reported receiving a diagnosis of endometriosis from a healthcare professional. The main study outcomes were self-reported receipt of hysterectomy and non-hysterectomy surgeries for endometriosis. The main exposure was race/ethnicity. Multivariable logistic regression estimated adjusted prevalence odds ratios and 95% confidence intervals of hysterectomy and non-hysterectomy endometriosis surgery. Differences in social determinants of health (SDH) among women who did and did not receive non-hysterectomy endometriosis surgery were tested using chi-square analysis.</div></div><div><h3>Results</h3><div>Of 6,141 survey participants, 314 (5.11%) answered yes to ever being diagnosed with endometriosis. While there were no significant differences in the odds of having a hysterectomy for endometriosis when stratifying by race/ethnicity, Black women had a significantly lower odds of non-hysterectomy endometriosis surgery compared to White women. The analysis of SDH revealed a higher prevalence of poverty among women who did not receive non-hysterectomy endometriosis surgeries. However, including poverty in the multivariable logistic regression model did not alter racial disparity findings.</div></div><div><h3>Conclusion</h3><div>White women have over four times higher odds of receiving non-hysterectomy endometriosis surgery compared to Black women in a fully adjusted model, which cannot be explained by a secondary analysis of SDH. Further examination of factors that may influence decisions on surgery for endometriosis will create a better understanding of disparities in endometriosis care.</div></div>","PeriodicalId":73733,"journal":{"name":"Journal of endometriosis and uterine disorders","volume":"11 ","pages":"Article 100124"},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to bridge the gap between evidence-based and clinical management of endometriosis","authors":"Philippe R. Koninckx ,&nbsp;Anastasia Ussia ,&nbsp;Charles Miller ,&nbsp;Sun-Wei Guo ,&nbsp;Emmanuel Lesaffre ,&nbsp;Arnaud Wattiez ,&nbsp;Leila Adamyan","doi":"10.1016/j.jeud.2025.100123","DOIUrl":"10.1016/j.jeud.2025.100123","url":null,"abstract":"<div><div>Evidence-based medicine (EBM) rightly intends to use the best available evidence for clinical decisions. The pyramid of evidence reflects the absence of allocation, user, or judgment bias, with on top double-blind, randomised, controlled trials (RCTs) or their meta-analyses having sufficient statistical power. Unfortunately, perfect trials are rare, and the quality of evidence has to be graded. Although important for drug development, the clinical impact of EBM has remained limited in areas such as surgery and endometriosis. The results are limited to the group investigated, and rare events, surgery complications or multimorbidity often require prohibitive large numbers. There is a mismatch between multifactorial clinical and surgical decisions and mono-factorial RCTs. The pitfalls of frequentist statistical inference and cognitive biases are often ignored, and observational medicine, clinical experience and surgical skills are poorly integrated.</div><div>The EBM guidelines could be updated and expanded with data from collective clinical experience, including rare events, Black Swans, and surgical skills. Clinicians should document their sequential decisions regarding diagnosis, therapy, and surgery, including what should not be done. The agreement between clinicians will be reflected in the range of probabilities, which can then be used to update EBM data. These updated EBM guidelines cover all decisions the clinician has to make, many without trial evidence. These guidelines might vary according to local situations and should be updated when new data become available from trials, documented collective experience, including surgical skills, or models derived from the analysis of observational data.</div></div>","PeriodicalId":73733,"journal":{"name":"Journal of endometriosis and uterine disorders","volume":"11 ","pages":"Article 100123"},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical practices in the diagnosis and management of endometriosis among obstetrician-gynecologists in the Philippines: A cross-sectional study","authors":"Bernadette Ann S. Alcazaren ,&nbsp;Maria Jesusa B. Banal-Silao ,&nbsp;Glaiza S. de Guzman","doi":"10.1016/j.jeud.2025.100122","DOIUrl":"10.1016/j.jeud.2025.100122","url":null,"abstract":"<div><h3>Objective</h3><div>To determine the practices and experiences of Filipino obstetrician-gynecologists in diagnosing and managing endometriosis.</div></div><div><h3>Materials and methods</h3><div>A cross-sectional, online survey was administered to fellows and diplomates of the Philippine Obstetrical and Gynecological Society.</div></div><div><h3>Results</h3><div>A total of 355 respondents participated in the study. Half (50.4%) were between 30 and 40 years old. Majority of the respondents were fellows of the society (76.9%), with less than five years of clinical practice (32.4%), non-reproductive medicine specialists (88.5%), from the National Capital Region (49.0%). The diagnosis of endometriosis was made based on clinical history (98.9%), pelvic examination (94.9%), and ultrasound (94.1%). The most common presenting symptoms were dysmenorrhea (99.7%), dyspareunia (84.8%), and infertility (82.3%). Dienogest was the most prescribed first-line medical treatment (42.8%) and post-operative medication (72.1%). Post-operative medications were given to delay recurrence of endometriosis-associated pain (86.2%) and to delay recurrence of endometriotic lesions (85.3%). More than one-third of post-operative patients were lost to follow-up. Lifestyle modification was the most common non-surgical intervention advised to patients.</div></div><div><h3>Conclusion</h3><div>Aligning medical practices with patient-centered guidelines is crucial for early diagnosis and prompt management of endometriosis. Emphasis must be given on individualizing treatment in collaboration with the patient. Raising awareness of both patient and health-care providers on the various treatment strategies, especially fertility preservation, are essential. Improving patient education and support is vital to address poor follow-up. Advocating for an Endometriosis Clinic in every hospital is a vital step towards providing a multi-disciplinary and holistic approach to the care of individuals with endometriosis.</div></div>","PeriodicalId":73733,"journal":{"name":"Journal of endometriosis and uterine disorders","volume":"11 ","pages":"Article 100122"},"PeriodicalIF":0.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient preferences for non-invasive diagnostic biospecimens among women with chronic pelvic pain: A cross-sectional survey","authors":"James Wyatt ,&nbsp;Simon G. Powell ,&nbsp;Ilyas Arshad ,&nbsp;Christopher J. Hill ,&nbsp;Alison Maclean ,&nbsp;Chris Probert ,&nbsp;Shakil Ahmed ,&nbsp;Dharani K. Hapangama","doi":"10.1016/j.jeud.2025.100121","DOIUrl":"10.1016/j.jeud.2025.100121","url":null,"abstract":"<div><h3>Background</h3><div>Chronic pelvic pain (CPP) frequently prompts visits to gynaecology services, commonly resulting in invasive laparoscopic examinations. Various non-invasive sampling methods are the subject of research, but patient preferences remain largely unexplored. This study aims to delineate the acceptability of different non-invasive biosamples and explore the reasoning behind preferences.</div></div><div><h3>Methods</h3><div>A questionnaire was developed to investigate acceptability and preferences regarding the provision and testing of five different biological samples: urine, blood, saliva, vaginal tampons, and faeces. Premenopausal women with CPP and suspected or confirmed endometriosis were recruited between October 2022 and January 2023. Participants were classified into three groups based on laparoscopic findings: superficial or ovarian endometriosis, deep bowel-involving endometriosis, and no endometriosis. Responses were statistically compared between groups.</div></div><div><h3>Results</h3><div>Eighty-seven participants completed the survey. Urine testing was the preferred biosample with 86 (98.8%) respondents ranking it as their first, second or third most preferred sample type. Blood and saliva samples ranked second and third, respectively with 82 (94.3%) and 61 (70.1%) respondents ranking this test third or higher. Tampon (28, (32.2%)) and faeces (4 (4.6%)) tests were ranked lowest and were described as \"uncomfortable\" or \"embarrassing\" by 48 (55.1%) and 68 (78.1%) respondents, respectively. There were minimal differences in responses between those with and without endometriosis.</div></div><div><h3>Conclusion</h3><div>Among this cohort, urine testing provided the most acceptable non-invasive sample type, followed by blood and saliva tests. However, respondents indicated that any non-invasive test would be largely acceptable to determine the need for more invasive diagnostic tests.</div></div>","PeriodicalId":73733,"journal":{"name":"Journal of endometriosis and uterine disorders","volume":"11 ","pages":"Article 100121"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144134785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of intraoperative ultrasound to aid in diagnosis and management of unusual “endometrioma\"","authors":"Ran Nagar ,&nbsp;Saar Aharoni ,&nbsp;Mathew Leonardi","doi":"10.1016/j.jeud.2025.100116","DOIUrl":"10.1016/j.jeud.2025.100116","url":null,"abstract":"<div><div>Ovarian endometriomas, have a distinct sonographic appearance. However, various ovarian and non-ovarian pathologies, can mimic their appearance, leading to diagnostic challenges. A 41-year-old woman with a regular menstrual cycle presented with severe dysmenorrhea, deep dyspareunia, cyclic dyschezia, bloating, and catamenial rectal bleeding. Over time, her symptoms worsened. Transvaginal ultrasound identified adenomyosis, superficial endometriosis in the bladder peritoneum and rectouterine pouch, and a deep endometriotic nodule in the rectouterine pouch, with no bowel or ovarian involvement Laparoscopic total hysterectomy, bilateral salpingectomy, and excision of endometriosis were planned. Intraoperative ultrasound revealed a new 14 × 12 × 12 mm unilocular cystic lesion with a “ground glass” appearance near the uterus, distinct from the ovary. Laparoscopy-guided intraoperative transvaginal ultrasound was repeated. Using Reverse Trendelenburg positioning, the lesion was identified as a normal segment of the small bowel. Surgery proceeded without complications. In this case, a targeted ultrasound examination under general anesthesia revealed a cystic pelvic lesion not previously identified. Although the lesion’s “ground glass” appearance suggested an endometrioma, its separation from the ovary and absence on earlier imaging prompted a broader differential diagnosis This case exemplifies the diagnostic complexity and clinical variability of endometriosis—or when something mimics endometriosis but is not. The necessity of side-by-side use of transvaginal ultrasound and laparoscopy emphasizes the limitations of imaging modalities alone, particularly when sonographic findings are unusual, and the importance of integrating multiple diagnostic techniques, including surgery. In future instances, when an endometrioma-appearing structure does not have classic features, bowel can be considered as an alternative structure being visualized.</div></div>","PeriodicalId":73733,"journal":{"name":"Journal of endometriosis and uterine disorders","volume":"10 ","pages":"Article 100116"},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143881944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness of fertility preservation strategy in patients with endometriosis: The Xverse (formerly Twitterverse) model","authors":"Claudia Ferraro ,&nbsp;Marco Reschini ,&nbsp;Roberta Bellinghieri ,&nbsp;Laura Sichenze ,&nbsp;Giada Polenghi ,&nbsp;Bianca Magni ,&nbsp;Alexander Fiore ,&nbsp;Gianfranco Fornelli ,&nbsp;Letizia Li Piani ,&nbsp;Noemi Salmeri ,&nbsp;Maíra Casalechi","doi":"10.1016/j.jeud.2025.100115","DOIUrl":"10.1016/j.jeud.2025.100115","url":null,"abstract":"<div><h3>Objective</h3><div>Women with endometriosis are potential candidates for fertility preservation (FP) and oocyte freezing. However, awareness of FP remains limited, and many women are unaware of this option. This study aimed to explore the level of awareness of FP in women with endometriosis by assessing the content on X (formerly Twitter) in order to evaluate the reach and impact of the shared information and to identify key contributors actively engaged in FP discussion.</div></div><div><h3>Methods</h3><div>This was a digital surveillance study analyzing X posts between January 1^st, 2020 and September 30^th, 2024. Queries in the X words advance research tool were created to find messages that included “endometriosis” in combination with “oocytes” OR “eggs” OR “fertility preservation” OR “fertilitypreservation” Posts were categorized by content and user types. Descriptive statistics were used for analysis.</div></div><div><h3>Results</h3><div>A total of n = 202 tweets were initially captured and n = 107 tweets from n = 82 accounts were reviewed. Accounts discussing FP were mostly from healthcare professionals (22.0%) and private healthcare centers or companies (22.0%). Patients’ accounts made up 14.6%. The most common content category was informative posts directed to patients (41.5%).</div></div><div><h3>Conclusions</h3><div>Discussions on FP in endometriosis on X were mostly supported by healthcare professionals and private healthcare centers/companies. Also, advocacy groups showed limited activity on X social platform. Although a significant proportion of posts were directed at patients, their active involvement remained limited. Our findings highlight the need to enhance the quality of FP information available in X in order to raise awareness among affected women.</div></div>","PeriodicalId":73733,"journal":{"name":"Journal of endometriosis and uterine disorders","volume":"11 ","pages":"Article 100115"},"PeriodicalIF":0.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143883200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of peritoneal macrophage depletion on endometriotic lesion development in a mouse model","authors":"Christina Anna Stratopoulou ,&nbsp;Luciana Cacciottola ,&nbsp;Nimisha Gawde ,&nbsp;Anaftali Joao Ngombo ,&nbsp;Davide Brusa ,&nbsp;Jacques Donnez ,&nbsp;Hugh S. Taylor ,&nbsp;Marie-Madeleine Dolmans","doi":"10.1016/j.jeud.2025.100113","DOIUrl":"10.1016/j.jeud.2025.100113","url":null,"abstract":"<div><h3>Objective</h3><div>Despite a prevalence as high as 10% in reproductive-age women, the pathogenesis of endometriosis has not yet been fully elucidated, with available treatments remaining limited and often ineffective. Aberrant macrophage accumulation has been reported in endometriosis and may be crucial to better understanding and treating the disease. This study aimed to investigate the outcomes of macrophage depletion in a mouse model of endometriosis.</div></div><div><h3>Materials and methods</h3><div>Endometriosis was induced by allografting uterine fragments onto the peritoneum of C57BL/6 mice and intraperitoneal macrophage depletion was mediated by injecting clodronate-containing liposomes. The mice were then euthanized, and peritoneal fluid was collected for quantification of immune cells by flow cytometry. Endometriotic lesions were retrieved to assess levels of fibrosis, proliferation, apoptosis, and activation of the angiogenic mechanism.</div></div><div><h3>Results</h3><div>Flow cytometry demonstrated a clear decrease in macrophage accumulation in treated mice compared to placebo controls, accompanied by an increase in T-cell rates. Endometriotic lesions from treated mice were smaller and exhibited lower rates of Ki67-positive proliferating cells and higher rates of TUNEL-positive apoptotic cells. Masson’s trichrome staining showed comparable rates of fibrosis between the two groups. Vascular endothelial growth factor immunostaining was weaker in mice injected with clodronate within both epithelial and stromal compartments.</div></div><div><h3>Conclusion</h3><div>Peritoneal macrophage depletion had a strong inhibitory effect against endometriosis development, resulting in smaller lesions, reduced proliferation and angiogenesis, and enhanced cell death. Our study points to a fundamental role for macrophages in endometriosis development, opening up new horizons for research into novel therapeutic options.</div></div>","PeriodicalId":73733,"journal":{"name":"Journal of endometriosis and uterine disorders","volume":"10 ","pages":"Article 100113"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143807793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue removal system versus bipolar resection for hysteroscopic polypectomy: Long-term results","authors":"Basiel Weyers ,&nbsp;Margot Van Geyte ,&nbsp;Alejandra De Frenne ,&nbsp;Steven Weyers ,&nbsp;Huib van Vliet ,&nbsp;Steffi van Wessel ,&nbsp;Tjalina Hamerlynck","doi":"10.1016/j.jeud.2025.100114","DOIUrl":"10.1016/j.jeud.2025.100114","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to compare long-term outcomes, including recurrence of abnormal uterine bleeding and polyp recurrence, following hysteroscopic polypectomy using either a mechanical tissue removal system or bipolar resection.</div></div><div><h3>Material and methods</h3><div>This is a multicentre follow-up study of a randomised controlled trial comparing a tissue removal system with bipolar resection for hysteroscopic polypectomy. The study was conducted at Ghent University Hospital (Belgium) and Catharina Hospital Eindhoven (The Netherlands). The trial was approved by the ethical committees of both centres and registered at Clinicaltrials.gov (<span><span>NCT05337046</span><svg><path></path></svg></span>, April 2022). Thirty-eight patients (49.4%) were willing to participate in this follow-up study, with 19 patients in each group. The primary endpoint was abnormal uterine bleeding recurrence after the procedure. Secondary endpoints included polyp recurrence, symptom relief, patient-reported satisfaction, and need for additional treatments.</div></div><div><h3>Results</h3><div>Mean follow-up time was over nine years in both groups. The recurrence rate of abnormal uterine bleeding was 25% in the tissue removal system group and 40% in the bipolar resection group (<em>p</em> = .65), with a mean time to recurrence of 8.6 years (95% CI, 6.5–10.7 years) in the tissue removal system group and 8.1 years (95% CI, 5.8–10.5 years) in the bipolar resection group (<em>p</em> = .57). Furthermore, there was no significant difference in time to polyp recurrence (<em>p</em> = .93) or symptom relief between the two groups (<em>p</em> = .62).</div></div><div><h3>Conclusion</h3><div>This long-term follow-up study found no significant difference in the recurrence of abnormal uterine bleeding between a tissue removal system and bipolar resection for hysteroscopic polypectomy.</div></div>","PeriodicalId":73733,"journal":{"name":"Journal of endometriosis and uterine disorders","volume":"10 ","pages":"Article 100114"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}