Journal of endometriosis最新文献

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Inhibition of macrophage migration inhibitory factor reduces endometriotic implant size in mice with experimentally induced disease. 抑制巨噬细胞迁移抑制因子可减少实验性诱导疾病小鼠子宫内膜异位症植入物的大小。

Journal of endometriosis Pub Date : 2011-09-30

Warren B Nothnick, Arlene Colvin, Kai Fan Cheng, Yousef Al-Abed

引用次数: 0

Adolescent physical activity and endometriosis risk. 青少年体育活动与子宫内膜异位症风险

Journal of endometriosis Pub Date : 2009-07-01

Allison F Vitonis, Sonia S Maruti, Susan E Hankinson, Mark D Hornstein, Stacey A Missmer

{"title":"Adolescent physical activity and endometriosis risk.","authors":"Allison F Vitonis, Sonia S Maruti, Susan E Hankinson, Mark D Hornstein, Stacey A Missmer","doi":"","DOIUrl":"","url":null,"abstract":"Background: In the one study examining the relationship, adolescent physical activity was not associated with risk for endometriosis. Case-control studies have shown 40-80% reductions in risk for adult activity, while only an 11% reduction in endometriosis risk was observed in a recent prospective analysis.Methods: Using data collected from the Nurses' Health Study II, a prospective cohort study of premenopausal US nurses that began in 1989, we have attempted to clarify this relation. Data are updated every 2 yrs with follow-up for these analyses through to 2001. Women reported the average amount of time per week spent in moderate and strenuous recreational activity during three age periods: ages 12-13, ages 14-17, and ages 18-22. A metabolic equivalent (MET) score was assigned to each activity and these were summed to estimate total activity.Results: During 637,747 person-years of follow-up, 1,481 cases of laparoscopically confirmed endometriosis were reported among women with no past infertility. After adjusting for age, calendar time, birth weight, age at menarche, parity, oral contraceptive use, and body mass index (BMI), we observed a 16% increase in the risk for endometriosis comparing the greatest amount of activity (≥80 MET-h/wk) with the least (<20 MET-h/wk) during ages 12-13 (RR=1.16, 95% CI=0.98-1.37, p-value test for trend=0.02), and no associations for ages 14-17 or ages 18-22. In analyses of the individual activity types within each time period, only strenuous activity during ages 12-13 was associated with endometriosis.Conclusions: We did not find evidence of a beneficial association between adolescent physical activity and laparoscopically confirmed endometriosis, but in fact found a small increase in risk.","PeriodicalId":73732,"journal":{"name":"Journal of endometriosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984885/pdf/nihms569455.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32266111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MULTI-CENTRE STUDIES OF THE GLOBAL IMPACT OF ENDOMETRIOSIS AND THE PREDICTIVE VALUE OF ASSOCIATED SYMPTOMS. 对子宫内膜异位症的全球影响和相关症状的预测价值进行多中心研究。

Journal of endometriosis Pub Date : 2009-01-01

Kelechi E Nnoaham, Sivahami Sivananthan, Lone Hummelshoj, Crispin Jenkinson, Premila Webster, Stephen H Kennedy, Krina T Zondervan

{"title":"MULTI-CENTRE STUDIES OF THE GLOBAL IMPACT OF ENDOMETRIOSIS AND THE PREDICTIVE VALUE OF ASSOCIATED SYMPTOMS.","authors":"Kelechi E Nnoaham, Sivahami Sivananthan, Lone Hummelshoj, Crispin Jenkinson, Premila Webster, Stephen H Kennedy, Krina T Zondervan","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Endometriosis can be difficult to diagnose clinically and models that use symptoms to predict whether the disease is present or not are based on limited patient populations. Endometriosis also influences health-related quality of life, but little is known about its impact across the world. We therefore initiated two integrated multicentre studies to collect prospective, standardised, epidemiological data, to 1) examine the global impact of endometriosis and relative effect of risk-factors, and 2) develop a symptom-based diagnostic tool.Methods: The Global Study of Women's Health (GSWH) and the Women's Health Symptom Survey (WHSS) prospectively recruit 18-45 year old women having a laparoscopy across 23 and 19 centres, respectively, worldwide. Women with a previous surgical diagnosis of endometriosis are excluded. Multi-lingual patient questionnaires and a surgical questionnaire, incorporating validated instruments, are used to collect the data. The GSWH aims to recruit >2,000 women by December 2009; the WHSS to recruit 1,000 women in each of the two model-generating and validation stages.Results: A six-week pilot study in Oxford, UK, established the feasibility of the study protocols. Of 32 eligible women, 27 participated (response rate - 84.4%); 26% completed the questionnaire online. Endometriosis was found in 47.4%. Extrapolating the recruitment rates from the pilot study, the target sample sizes for the GWSH and WHSS were deemed feasible.Conclusions: Using standardised data collection, the GSWH and WHSS will provide insight into the global impact of endometriosis and develop a validated, symptom-based, diagnostic tool. They have the potential to provide the basis for future, longitudinal, follow-up studies and a collaborative Endometriosis Biobank implementing standardised collection of DNA and tissue samples.","PeriodicalId":73732,"journal":{"name":"Journal of endometriosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197400/pdf/emss-60307.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9740508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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