Journal of clinical and investigative dermatology最新文献

Uncommon Petaloid Form of Seborrheic Dermatitis Seen in Fitzpatrick Skin Types V-VI. 菲茨帕特里克皮肤类型 V-VI 中常见的脂溢性皮炎花瓣状。

Journal of clinical and investigative dermatology Pub Date : 2023-07-01 Epub Date: 2023-07-27 DOI: 10.13188/2373-1044.1000086

TongFan Wu, Timothy C Frommeyer, Craig A Rohan, Jeffrey B Travers

{"title":"Uncommon Petaloid Form of Seborrheic Dermatitis Seen in Fitzpatrick Skin Types V-VI.","authors":"TongFan Wu, Timothy C Frommeyer, Craig A Rohan, Jeffrey B Travers","doi":"10.13188/2373-1044.1000086","DOIUrl":"10.13188/2373-1044.1000086","url":null,"abstract":"Background: Seborrheic dermatitis (SD) is an inflammatory disease that has a papulosquamous morphology in areas rich in sebaceous glands such as the scalp, face, and body folds. Petaloid SD is an uncommon presentation found in patients with dark skin (Fitzpatrick Skin type V-VI). This form of SD can appear as pink or hypopigmented polycyclic coalescing rings or scaly macules and patches in the typical areas SD appears, which can mimic other conditions including lupus erythematosus. There is significant disproportion in the representation of darker skin types in dermatological textbooks and scarce literature on petaloid SD. This case demonstrates the presentation of the petaloid SD in an African American patient to contribute to the limited literature on dermatological conditions within this population.Case report: A 25-year-old African American female with a history of mild hidradenitis suppurativa and asthma who presented with asymptomatic hypopigmented rashes throughout her face, scalp, and chest. She was diagnosed with the petaloid form SD and treated with ketoconazole shampoo once weekly, ketoconazole cream 1-2x daily, and hydrocortisone 2.5% ointment twice daily as needed. At six-week post-treatment follow-up, the patient's rashes significantly improved.Conclusions: The petaloid form of SD is commonly experienced in dark-skinned patients. While common treatments for SD are effective in this form of SD, special consideration of skin types, skincare habits, and haircare in the African American population should be explored. This case report demonstrates how this uncommon skin condition presents in patients of Fitzpatrick skin type V-VI and a successful treatment course.","PeriodicalId":73660,"journal":{"name":"Journal of clinical and investigative dermatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10798803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66211441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of A Natural Anti- Dandruff Technology in a Shampoo Formulation via In-vivo and In-vitro Methods 通过体内和体外方法评价洗发水配方中的天然防屑技术

Journal of clinical and investigative dermatology Pub Date : 2023-01-01 DOI: 10.13188/2373-1044.1000083

H. Ahmed

{"title":"Evaluation of A Natural Anti- Dandruff Technology in a Shampoo Formulation via In-vivo and In-vitro Methods","authors":"H. Ahmed","doi":"10.13188/2373-1044.1000083","DOIUrl":"https://doi.org/10.13188/2373-1044.1000083","url":null,"abstract":"Background: Natural anti dandruff efficacy is an area of interest as there is a consumer need for natural technologies in over-the-counter shampoo formulations. Aim: This research explored dipotassium glycyrrhizate (DPG) for anti dandruff benefit utilizing in vitro and in vivo methodologies, examining a shampoo formulation with 0.15% DPG. Patients/Method: The in vitro investigation focused on the evaluation of antimicrobial efficacy of DPG in a shampoo formulation by use of bacteriostatic efficacy testing as well as a short interval kill test against well known dandruff causing microorganism i.e. Malassezia . Clinically, 28 female and male subjects possessing visible dandruff were enrolled in a non-comparative study with 1 shampoo formulation containing 0.15% DPG. A trained investigator conducted visual technical assessments evaluating dandruff intensity at baseline and after product use over 2 weeks. A product performance self-assessment questionnaire was also completed for all subjects. The clinical was conducted under the supervision of a dermatologist. Results: Shampoo formulation with 0.15% DPG showed bacteriostatic efficacy against well known dandruff causing microorganisms i.e. Malassezia . The short interval kill test shows that a shampoo formulation with 0.15% DPG is more effective against Malassezia furfur (ATCC 14521) compared to the placebo, a non-anti dandruff shampoo. Clinically, a shampoo formulation with 0.15% DPG significantly reduced visible flakes/dandruff after 1, 7 and 14 days of use from baseline and the greatest improvement as compared to baseline was seen at week 2 (P < 0.001) with 90% improvement in reduction of visible flakes/dandruff. The self-assessment questionnaire results correlated to the visual technical assessment results.","PeriodicalId":73660,"journal":{"name":"Journal of clinical and investigative dermatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66210916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digital Dermoscopy, Reflectance Confocal Microscopy, and Pigmented Lesion Assay Gep for In-Vivo Monitoring of Multiple Halo Nevi on an Adult Patient 数字皮肤镜、反射共聚焦显微镜和色素病变测定Gep用于成人患者多发性晕痣的体内监测

Journal of clinical and investigative dermatology Pub Date : 2023-01-01 DOI: 10.13188/2373-1044.1000084

J. Ludzik

引用次数: 0

Mycosis Fungoides Presenting After Dupilumab Therapy: Case Report and Systematic Review 杜匹单抗治疗后出现蕈样真菌病:病例报告和系统评价

Journal of clinical and investigative dermatology Pub Date : 2023-01-01 DOI: 10.13188/2373-1044.1000085

D. Fivenson

引用次数: 0

Role of Malassezia furfur and M. globosa in Dandruff and Seborrheic Dermatitis 毛马拉色菌和球孢菌在头皮屑和脂溢性皮炎中的作用

Journal of clinical and investigative dermatology Pub Date : 2023-01-01 DOI: 10.13188/2373-1044.1000082

CD Silvanose, V. Jibin

引用次数: 0

Moisturizers Free of Paraben, Mineral Oil, Alcohol and Ingredients from Animal Origin (Pama) - A New Way Forward 不含对羟基苯甲酸酯、矿物油、酒精和动物源性成分(帕玛)的保湿霜——一种新的前进方式

Journal of clinical and investigative dermatology Pub Date : 2022-01-01 DOI: 10.13188/2373-1044.1000079

Myn Gala

引用次数: 0

Nursing-Specific Management on Toxic Epidermal Necrolysis (Ten) In Cml Patient: Case Report Cml患者中毒性表皮坏死松解的护理特异性处理(10例

Journal of clinical and investigative dermatology Pub Date : 2022-01-01 DOI: 10.13188/2373-1044.1000078

Aswathy Asokan AN

引用次数: 0

Insights into Lichen Planus Pigmentosus Inversus using Minimally Invasive Dermal Patch and Whole Transcriptome Analysis. 利用微创皮肤斑块和全转录组分析深入了解扁平苔藓色素沉着症。

Journal of clinical and investigative dermatology Pub Date : 2022-01-01 Epub Date: 2022-04-05 DOI: 10.13188/2373-1044.1000077

Jacob Dickman, Michael Howell, Robert Hoopes, Yipeng Wang, Tobin J Dickerson, Michael Bottomley, H Nicholas Shamma, Christine M Rapp, Matthew J Turner, Craig A Rohan, Jeffrey B Travers

{"title":"Insights into Lichen Planus Pigmentosus Inversus using Minimally Invasive Dermal Patch and Whole Transcriptome Analysis.","authors":"Jacob Dickman, Michael Howell, Robert Hoopes, Yipeng Wang, Tobin J Dickerson, Michael Bottomley, H Nicholas Shamma, Christine M Rapp, Matthew J Turner, Craig A Rohan, Jeffrey B Travers","doi":"10.13188/2373-1044.1000077","DOIUrl":"10.13188/2373-1044.1000077","url":null,"abstract":"Lichen Planus Pigmentosus inversus (LPPi) is a rare interface and lichenoid dermatitis (ILD) and supposed variant of lichen planus (LP) that presents as well-demarcated brown to grey macules in flexural and intertriginous areas. LPPi is deemed 'inversus' because its anatomical distribution in skin folds is opposite that seen in lichen planus pigmentosus (LPP) whose pigmented lesions arise on sun-exposed skin. Biopsy is required for the clinical diagnosis of all ILDs. Though multiple clinically-oriented studies have reported differences between LPP, LPPi, and LP, few molecular studies have been performed. In this case study, 3 patients, 2 with LPPi and one with LP, provided samples using minimally invasive whole transcriptome analysis using a dermal biomarker patch. This study confirms the involvement of interferon signaling and T-cell activation in LPPi and suggests an expression profile distinct from LP. Specific genes significantly upregulated in LPPi vs LP include an intergenic splice variant of the primary pigmentation determining receptor in humans and dysregulation of genes essential for ceramide synthesis and construction of the cornified envelope. This work expands upon our knowledge of the pathogenesis of LPPi vs LP, and supports the potential use of this technology in the diagnostic clinical setting to mitigate the need for invasive procedures.","PeriodicalId":73660,"journal":{"name":"Journal of clinical and investigative dermatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9397586/pdf/nihms-1789618.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10059977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Valuing the Inpatient Dermatology Consult Service at a Single Academic Institution 评估单一学术机构的住院皮肤科咨询服务

Journal of clinical and investigative dermatology Pub Date : 2022-01-01 DOI: 10.13188/2373-1044.1000080

F. Yang

引用次数: 0

Sequencing of within-Subject Primary and Metastatic Cutaneous Squamous Cell Carcinomas Reveals Novel Diagnostic and Therapeutic Targets for Metastatic Disease 体内原发性和转移性皮肤鳞状细胞癌的测序揭示了转移性疾病的新诊断和治疗靶点

Journal of clinical and investigative dermatology Pub Date : 2022-01-01 DOI: 10.13188/2373-1044.1000081

Shang I. Brian Jiang

引用次数: 0