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Journal of cellular and molecular immunology最新文献

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Identification and validation of N7-methylguanosine-associated gene NCBP1 as prognostic and Prognostic immune-associated biomarkers in breast cancer patients 将 N7-甲基鸟苷相关基因 NCBP1 鉴定和验证为乳腺癌患者的预后和预后免疫相关生物标记物
Journal of cellular and molecular immunology Pub Date : 2024-02-21 DOI: 10.46439/immunol.3.023
Yusi Yang, Lin Zheng, Jianrong Li, Baiqi Wen
{"title":"Identification and validation of N7-methylguanosine-associated gene NCBP1 as prognostic and Prognostic immune-associated biomarkers in breast cancer patients","authors":"Yusi Yang, Lin Zheng, Jianrong Li, Baiqi Wen","doi":"10.46439/immunol.3.023","DOIUrl":"https://doi.org/10.46439/immunol.3.023","url":null,"abstract":"","PeriodicalId":73643,"journal":{"name":"Journal of cellular and molecular immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140444913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multiple RNA-binding proteins associated with long interspersed element-1 encoded ORF1p are targeted by the autoimmune response in systemic lupus erythematosus 系统性红斑狼疮患者的自身免疫反应靶向了与长穿插元件-1编码的 ORF1p 相关的多种 RNA 结合蛋白
Journal of cellular and molecular immunology Pub Date : 2023-10-27 DOI: 10.46439/immunol.2.022
Kennedy C Ukadike, Alyssa N. Colyer, Bhargavi Duvvuri, Anders A. Bengtsson, Martin S Taylor, J. LaCava, C. Lood, Tomas Mustelin
{"title":"Multiple RNA-binding proteins associated with long interspersed element-1 encoded ORF1p are targeted by the autoimmune response in systemic lupus erythematosus","authors":"Kennedy C Ukadike, Alyssa N. Colyer, Bhargavi Duvvuri, Anders A. Bengtsson, Martin S Taylor, J. LaCava, C. Lood, Tomas Mustelin","doi":"10.46439/immunol.2.022","DOIUrl":"https://doi.org/10.46439/immunol.2.022","url":null,"abstract":"Systemic lupus erythematosus (SLE) is a relatively common autoimmune disease characterized by the presence of autoantibodies against nucleic acids and proteins that associate with them, such as the ORF1p protein encoded by the long interspersed element-1 (LINE-1 or L1). Because well-known lupus autoantigens like RO60 associate with ORF1p in macromolecular assemblies, together with many other RNA-binding proteins, we tested whether these other proteins are also recognized by IgG autoantibodies in SLE patients. By ELISAs and immunoblots, we detected autoantibodies in the serum of SLE patients recognizing proteins encoded by LARP7, MOV10, ZCCHC3, MEPCE, YARS2, RPL18A, RPL27A, and H2BC17 (p<0.05), but not CORO1B, DDX6, PABPC1, and PABPC4, and were mostly absent or low in healthy controls. The titers of antibodies against RO60, LARP7, MOV10, and MEPCE were higher (p<0.05) in those patients who also had anti-ORF1p autoantibodies. These antibodies also correlated with dsDNA antibodies, the presence of arthritis, and higher levels of type I interferons. A cluster analysis revealed that all these autoantibodies collectively identified patients with more active disease. We conclude that patients with SLE have elevated IgG autoantibodies not only against the L1-encoded ORF1p, but also against 8 other proteins that co-localize with ORF1p in RNA-rich granules. These autoantibodies are higher in patients who have autoantibodies to ORF1p and together correlate with elevated type I interferon levels. Our findings are compatible with the notion that ORF1p-containing ribonucleoprotein granules are a target of the autoimmunity in SLE.","PeriodicalId":73643,"journal":{"name":"Journal of cellular and molecular immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of MRI in detecting and characterizing brain metastases from breast cancer MRI在乳腺癌脑转移的检测和表征中的作用
Journal of cellular and molecular immunology Pub Date : 2023-10-03 DOI: 10.46439/immunol.2.019
Sana Mohammadi, Sadegh Ghaderi
{"title":"The role of MRI in detecting and characterizing brain metastases from breast cancer","authors":"Sana Mohammadi, Sadegh Ghaderi","doi":"10.46439/immunol.2.019","DOIUrl":"https://doi.org/10.46439/immunol.2.019","url":null,"abstract":"","PeriodicalId":73643,"journal":{"name":"Journal of cellular and molecular immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135696463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FXYD3-IL-17 positive feedback loop promotes psoriasis exacerbation FXYD3-IL-17正反馈回路促进银屑病恶化
Journal of cellular and molecular immunology Pub Date : 2023-08-23 DOI: 10.46439/immunol.2.016
Meng Xia, Qingqing Wang
{"title":"FXYD3-IL-17 positive feedback loop promotes psoriasis exacerbation","authors":"Meng Xia, Qingqing Wang","doi":"10.46439/immunol.2.016","DOIUrl":"https://doi.org/10.46439/immunol.2.016","url":null,"abstract":"","PeriodicalId":73643,"journal":{"name":"Journal of cellular and molecular immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81223647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring Immune Cell Profiles and NLRP3 Gene Expression as Potential Diagnostic Markers in COVID-19 Patients: A Commentary 探索免疫细胞谱和NLRP3基因表达作为COVID-19患者潜在的诊断标志物:综述
Journal of cellular and molecular immunology Pub Date : 2023-08-23 DOI: 10.46439/immunol.2.017
Maedeh Radandish, N. Esmaeil, A. Andalib
{"title":"Exploring Immune Cell Profiles and NLRP3 Gene Expression as Potential Diagnostic Markers in COVID-19 Patients: A Commentary","authors":"Maedeh Radandish, N. Esmaeil, A. Andalib","doi":"10.46439/immunol.2.017","DOIUrl":"https://doi.org/10.46439/immunol.2.017","url":null,"abstract":"","PeriodicalId":73643,"journal":{"name":"Journal of cellular and molecular immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84177351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Commentary on Aplasia cutis congenita in monozygotic twins: What should we do further? 单卵双生儿先天性皮肤发育不全评述:下一步我们应该做些什么?
Journal of cellular and molecular immunology Pub Date : 2023-08-23 DOI: 10.46439/immunol.2.018
Hui-Jun Lai, Ping-Ping Ma, Mei‐Yan Lai, Hong-Wei Guo
{"title":"Commentary on Aplasia cutis congenita in monozygotic twins: What should we do further?","authors":"Hui-Jun Lai, Ping-Ping Ma, Mei‐Yan Lai, Hong-Wei Guo","doi":"10.46439/immunol.2.018","DOIUrl":"https://doi.org/10.46439/immunol.2.018","url":null,"abstract":"","PeriodicalId":73643,"journal":{"name":"Journal of cellular and molecular immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87025785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coal workers’ serum immunoglobulins provide hints for pneumoconiosis 煤矿工人血清免疫球蛋白可提示尘肺病
Journal of cellular and molecular immunology Pub Date : 2023-06-05 DOI: 10.46439/immunol.2.015
Zhao-guo Li, J. Pang, Peiran Yang, Jing Wang, H. Dai
{"title":"Coal workers’ serum immunoglobulins provide hints for pneumoconiosis","authors":"Zhao-guo Li, J. Pang, Peiran Yang, Jing Wang, H. Dai","doi":"10.46439/immunol.2.015","DOIUrl":"https://doi.org/10.46439/immunol.2.015","url":null,"abstract":"","PeriodicalId":73643,"journal":{"name":"Journal of cellular and molecular immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75266992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insight into the application of nicotinamide mononucleotide (NMN) to age-related disorders 烟酰胺单核苷酸(NMN)在年龄相关疾病中的应用
Journal of cellular and molecular immunology Pub Date : 2023-05-06 DOI: 10.46439/immunol.2.014
Masaki Igarashi, T. Yamauchi
{"title":"Insight into the application of nicotinamide mononucleotide (NMN) to age-related disorders","authors":"Masaki Igarashi, T. Yamauchi","doi":"10.46439/immunol.2.014","DOIUrl":"https://doi.org/10.46439/immunol.2.014","url":null,"abstract":"Numerous animal studies have shown that the decrease in the tissue Nicotinamide Adenine Dinucleotide (NAD+) levels during aging are closely related to age-related physiological decline and that the administration of NAD+ precursors restore NAD+ levels and promotes health and prolongs lifespan. Therefore, in order to demonstrate whether NAD+ supplementation by NAD+ precursors mitigate age-related physiological dysfunction including muscle weakness in older men. We conducted a placebo-controlled, randomized, double-blind, parallel-group study in which Nicotinamide mononucleotide (NMN) was administered to healthy older men for 12 weeks. In this commentary, we overview reported human NAD+-related clinical trials including our NMN study.","PeriodicalId":73643,"journal":{"name":"Journal of cellular and molecular immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77014095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune checkpoint inhibitor therapy-associated myocarditis – Toward identification of an immune signature that can improve diagnosis 免疫检查点抑制剂治疗相关的心肌炎——鉴别一种可以提高诊断的免疫标记
Journal of cellular and molecular immunology Pub Date : 2023-02-21 DOI: 10.46439/immunol.2.013
{"title":"Immune checkpoint inhibitor therapy-associated myocarditis – Toward identification of an immune signature that can improve diagnosis","authors":"","doi":"10.46439/immunol.2.013","DOIUrl":"https://doi.org/10.46439/immunol.2.013","url":null,"abstract":"","PeriodicalId":73643,"journal":{"name":"Journal of cellular and molecular immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75300345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BRCA1 and BRCA2 mutation variants in early breast cancer confer added prognostic information 早期乳腺癌的BRCA1和BRCA2突变变异提供了额外的预后信息
Journal of cellular and molecular immunology Pub Date : 2023-02-21 DOI: 10.46439/immunol.2.012
{"title":"BRCA1 and BRCA2 mutation variants in early breast cancer confer added prognostic information","authors":"","doi":"10.46439/immunol.2.012","DOIUrl":"https://doi.org/10.46439/immunol.2.012","url":null,"abstract":"","PeriodicalId":73643,"journal":{"name":"Journal of cellular and molecular immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91198534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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