Journal of cancer & allied specialties最新文献_第9页

HYBRID SCINTIGRAPHY OF RARE SPLENIC HAMARTOMA 罕见脾错构瘤的杂交闪烁成像

Journal of cancer & allied specialties Pub Date : 2018-12-31 DOI: 10.37029/jcas.v4i4.212

Mairah Razi, H. Bashir, Z. Faruqui

引用次数: 0

MR ENTEROGRAPHY: AN EMERGENT TECHNIQUE FOR CHARACTERIZATION OF SMALL BOWEL LESIONS IN ONCOLOGICAL AND NON-ONCOLOGY DISEASES 磁共振肠造影:一种新兴技术，用于表征肿瘤和非肿瘤疾病中的小肠病变

Journal of cancer & allied specialties Pub Date : 2018-12-31 DOI: 10.37029/JCAS.V4I4.208

W. Ahmad, Iram Zaheer, I. Niazi, K. A. Mufti

引用次数: 0

INDOLEAMINE 2,3 DIOXYGENASE AS AN IMMUNOTHERAPEUTIC TARGET BRINGS A NEW HOPE FOR CANCER PATIENTS 吲哚胺2,3双加氧酶作为免疫治疗靶点，给癌症患者带来了新的希望

Journal of cancer & allied specialties Pub Date : 2018-09-30 DOI: 10.37029/JCAS.V4I3.175

K. Asghar, A. Loya

{"title":"INDOLEAMINE 2,3 DIOXYGENASE AS AN IMMUNOTHERAPEUTIC TARGET BRINGS A NEW HOPE FOR CANCER PATIENTS","authors":"K. Asghar, A. Loya","doi":"10.37029/JCAS.V4I3.175","DOIUrl":"https://doi.org/10.37029/JCAS.V4I3.175","url":null,"abstract":"Therapeutic manipulation of immune system in cancer has been an extensive area of research in the field of oncoimmunology. Immunotherapy helps the immune system to combat against cancer. Tumour cells take an edge of immunosuppressive mechanisms and inhibit antitumour immune responses. Indoleamine 2,3 dioxygenase (IDO) is an immunosuppressive enzyme which is involved in tumour immune escape mechanism in various cancers. IDO can degrade the tryptophan into kynurenines and has an ability to enhance the immune tolerance through mammalian target of rapamycin pathway general control nonderepressible 2 (GCN2) pathway and induction of regulatory T (T-regs) cells. IDO-induced T-regs suppress the local immune responses in the tumour microenvironment and promote metastasis. IDO overexpression in various cancers is associated with poor prognosis. Several preclinical and clinical trials have been proceeding and recommend that IDO inhibitor may be an influential tool against a wide range of cancers. IDO inhibitors as adjuvant therapeutic agents may also have clinical implications. Thus, IDO has the potential to be used as an immunotherapeutic target. This review discusses the promising role of IDO in cancer and its implication in immunotherapy.Key words: Breast cancer, colorectal cancer, haematological malignancies, immunotherapy, indoleamine 2,3-dioxygenase, pancreatic cancer, prostate cancer","PeriodicalId":73631,"journal":{"name":"Journal of cancer & allied specialties","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82679433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY IN A KNOWN THYMOMA PATIENT 胸腺瘤患者的进行性多灶性脑白质病

Journal of cancer & allied specialties Pub Date : 2018-09-30 DOI: 10.37029/jcas.v4i3.191

A. Iqbal, M. Naveed

引用次数: 0

PNEUMATOSIS INTESTINALIS - A RARE CLINICAL FINDING REQUIRING MULTIMODALITY TREATMENT 肠肺病-一种罕见的临床发现，需要多模式治疗

Journal of cancer & allied specialties Pub Date : 2018-09-30 DOI: 10.37029/JCAS.V4I3.193

N. Urooj, M. Janjua, A. Malik, S. Khattak, A. Syed

引用次数: 0

CARDIO-ONCOLOGY – THE NEW KID ON THE BLOCK 心脏肿瘤科，新来的

Journal of cancer & allied specialties Pub Date : 2018-09-30 DOI: 10.37029/JCAS.V4I3.200

Ahmed Awais, I. Vaziri, B. George

引用次数: 0

COMPARISON OF DOCUMENTED PATIENT CARE BEFORE AND AFTER IMPLEMENTATION OF END OF LIFE CARE PATHWAY FOR TERMINALLY ILL PATIENTS AT SHAUKAT KHANUM MEMORIAL CANCER HOSPITAL AND RESEARCH CENTRE shaukat khanum纪念癌症医院和研究中心实施临终关怀路径之前和之后记录的患者护理的比较

Journal of cancer & allied specialties Pub Date : 2018-09-30 DOI: 10.37029/JCAS.V4I3.196

Irum Ghafoor, Haroon Hafeez, Farhat Naz, Muhammad Abu Baker

{"title":"COMPARISON OF DOCUMENTED PATIENT CARE BEFORE AND AFTER IMPLEMENTATION OF END OF LIFE CARE PATHWAY FOR TERMINALLY ILL PATIENTS AT SHAUKAT KHANUM MEMORIAL CANCER HOSPITAL AND RESEARCH CENTRE","authors":"Irum Ghafoor, Haroon Hafeez, Farhat Naz, Muhammad Abu Baker","doi":"10.37029/JCAS.V4I3.196","DOIUrl":"https://doi.org/10.37029/JCAS.V4I3.196","url":null,"abstract":"Purpose: Shaukat Khanum Memorial Cancer Hospital and Research Cancer primarily deals with cancer patients and has various departments which provide best-integrated lifesaving care. However, when patients who have been given all possible medical and oncological treatment still progress their disease, they are then referred for best supportive care to palliative care department. The aim of this paper was to audit documented care for palliative patients before and after implementation of end of life care (ELC) pathway.Materials and Methods: We used a retrospective method to audit 45 terminally ill patients over a period of 3 months. Then, a re-audit was done over a period of 3 months and data were collected for patients who were started on SKM-ELC pathway.Results: Results show that the implementation of ELC pathway, 67% of the patients were not prescribed PRN medications for symptom control, 20% of the patients were not reviewed for the need of assisted nutrition and for 20% of the patient’s primary team were not even notified that the patient is dying. After the ELC pathway implementation, it was found that 100% of patients were reviewed for PRN medications and assisted nutrition. Oncologists were timely notified that the patient is dying.Conclusion: In summary, we can say that implantation of ELC pathway has significantly improved documented patients care in all aspects.Key words: Cancer, care for dying, end of life care, goals of care pathway","PeriodicalId":73631,"journal":{"name":"Journal of cancer & allied specialties","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90287969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Journal of cancer & allied specialties Pub Date : 2018-09-30 DOI: 10.37029/JCAS.V4I3.194

Nasira Hayat, S. Hafi, F. Badar, I. Ahmed

{"title":"HEALTH-RELATED QUALITY OF LIFE (HRQoL) ASSESSMENT FOLLOWING RADICAL CYSTECTOMY IN POPULATION OF A SOUTH ASIAN COUNTRY","authors":"Nasira Hayat, S. Hafi, F. Badar, I. Ahmed","doi":"10.37029/JCAS.V4I3.194","DOIUrl":"https://doi.org/10.37029/JCAS.V4I3.194","url":null,"abstract":"Purpose: Radical cystectomy is carried out for muscle invasive bladder (BL) cancer, which greatly affects the quality of life. The objective of our study was to assess the health-related quality of life (HRQoL) in patients following radicalcystectomy.Methods: A retrospective review was done in patients that underwent radical cystectomy between July 2009 and November 2014 at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan. HRQoLassessments of 34 patients done during clinical psychology review were included in this study. HRQoL was assessed using functional assessment of cancer therapy-BL questionnaire.Results: Low scores were observed in physical well-being and emotional well-being domains with mean scores of 7.32 and 7.97, respectively. Patients scored high on social and family well-being, functional well-being and additionalconcerns, with mean scores of 24.9, 17.24 and 21.73, respectively.Conclusions: Psychological evaluation and rehabilitation should be an integral part of surveillance after radical cystectomy.Key words: Bladder cancer, functional assessment of cancer therapy-bladder, health-related quality of life, radicalcystectomy, South Asian","PeriodicalId":73631,"journal":{"name":"Journal of cancer & allied specialties","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85351541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retracted: Diagnostic Dilemma of a Diaphragmatic Hernia 收缩:膈疝的诊断困境

Journal of cancer & allied specialties Pub Date : 2018-09-17 DOI: 10.37029/jcas.v4i3.327

S. Yahya, S. Zafar, H. Babar

引用次数: 0

GERM CELL TUMOURS OF THE OVARY IN CHILDREN AND ADOLESCENTS: A CLINICAL STUDY OF 109 PATIENTS IN A SPECIALIZED CANCER CENTRE 儿童和青少年卵巢生殖细胞肿瘤:109名癌症专科中心患者的临床研究

Journal of cancer & allied specialties Pub Date : 2018-07-01 DOI: 10.37029/JCAS.V4I2.99

I. Nasir, M. F. Shah, A. Malik, A. Anwer, A.-A. Syed, A. Qazi

{"title":"GERM CELL TUMOURS OF THE OVARY IN CHILDREN AND ADOLESCENTS: A CLINICAL STUDY OF 109 PATIENTS IN A SPECIALIZED CANCER CENTRE","authors":"I. Nasir, M. F. Shah, A. Malik, A. Anwer, A.-A. Syed, A. Qazi","doi":"10.37029/JCAS.V4I2.99","DOIUrl":"https://doi.org/10.37029/JCAS.V4I2.99","url":null,"abstract":"Objective: Paediatric ovarian germ cell tumours (GCTs) are rare tumours withmalignant tumours extremely rare.Methods: All the paediatric patients who received treatment for histology proven ovarian GCT at Shaukat Khanum Memorial Cancer Hospital from January 2006 to December 2014 were retrospectively reviewed. Patients over the age of 18 years were excluded from the study. A total of 109 patients were included in the study. A set of parameters were identified to record initial clinical presentation and examination, imaging and laboratory investigations including tumour marker levels. Decisions of multidisciplinary team meetings, surgical treatment, neo adjuvant, adjuvant chemotherapy and radiation data retrieved. Data analysiscarried out using SPSS 20.Results: In total 109 girls presented to our hospital during the study period, most of them above the age of 5 years, with dysgerminoma being the most common followed by yolk sac tumour. Most of the patients received treatment outside our hospital and were referred here for chemoradiotherapy. Fertility preserving surgery was the most commonly performed surgical procedure with a mean follow-up of 50.4 months and >75% overall 5-year survival.Conclusion: Regardless of histologic types, the outcomes of GCT can be improved with a multidisciplinary approach.Key words: Dysgerminomas, germ cell tumours, ovarian tumours","PeriodicalId":73631,"journal":{"name":"Journal of cancer & allied specialties","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86272338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0