Journal of breast cancer research最新文献

Investigating the role of HSP90 in cancer cell phenotypic plasticity. 研究 HSP90 在癌细胞表型可塑性中的作用。

Journal of breast cancer research Pub Date : 2024-01-01 DOI: 10.46439/breastcancer.4.021

Vincent Sollars, Alexandria Chapman, Nicole R Liang, Seth Myers

{"title":"Investigating the role of HSP90 in cancer cell phenotypic plasticity.","authors":"Vincent Sollars, Alexandria Chapman, Nicole R Liang, Seth Myers","doi":"10.46439/breastcancer.4.021","DOIUrl":"10.46439/breastcancer.4.021","url":null,"abstract":"\"What are the mechanisms driving tumor evolution under the selective pressure of chemotherapeutics?\" The emerging importance of epigenetic gene regulation in cancer progression necessitates not only our understanding of which genes are potential targets but also what mechanisms are employed in targeting those genes. Understanding the mechanisms that promote the evolution of the normal genome and epigenome is central to understanding how cancer cells adapt to chemotherapy. Our previous investigations have shown that heat shock protein 90 (HSP90) has a critical role in epigenetic gene regulation through histone acetylation and phenotypic plasticity. We recently extended these results in an A549 lung cancer model to test the role of HSP90 in the plasticity of cells regarding multi-drug resistance and epithelial-to-mesenchymal transition phenotypes. HSP90 is over-expressed in multiple cancers with poor prognosis. We propose that inhibition of HSP90 results in lower phenotypic plasticity of cancer cells making them more susceptible to chemotherapeutic intervention. Here we review the context of our results in the broader field of evolution of these phenotypes.","PeriodicalId":73629,"journal":{"name":"Journal of breast cancer research","volume":"4 1","pages":"5-10"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11448696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metastatic breast cancer-derived exosomes and osteoclast-mediated bone metastasis 转移性乳腺癌来源的外泌体和破骨细胞介导的骨转移

Journal of breast cancer research Pub Date : 2023-09-06 DOI: 10.46439/breastcancer.3.019

Manh Tien Tran

引用次数: 0

A new population screening program for BRCA mutations in Israel – Attitudes and barriers among Ashkenazi Jewish women 以色列BRCA突变的新人群筛查项目——德系犹太妇女的态度和障碍

Journal of breast cancer research Pub Date : 2023-05-06 DOI: 10.46439/breastcancer.2.011

Amar S, Lieberman S, Biderman A, Lahad A, Feinsilver T

{"title":"A new population screening program for BRCA mutations in Israel – Attitudes and barriers among Ashkenazi Jewish women","authors":"Amar S, Lieberman S, Biderman A, Lahad A, Feinsilver T","doi":"10.46439/breastcancer.2.011","DOIUrl":"https://doi.org/10.46439/breastcancer.2.011","url":null,"abstract":"Israeli Jewish women of Ashkenazi ancestry have a high BRCA mutation carrier rate. Therefore, recently, Israel included free genetic testing among all Jewish women with Ashkenazi ancestry, 25 yrs. and older in its public health system. The aim of this study was to assess the intention of eligible women to be tested for BRCA mutations, and to find factors that may affect their decision.\u0000\u0000We distributed an online survey to a panel of participants in a commercial research institute. The survey included socio-demographic characteristics, attitudes towards preventive actions, views related to benefits and limitations of performing the BRCA test, worry regarding cancer morbidity, knowledge about breast cancer morbidity and hereditary breast cancer genetics. The survey concluded with a question regarding the woman’s interest in undergoing the BRCA test.\u0000\u0000The results showed that among the 506 respondents, 250 (49%) were interested in BRCA testing, 42 (8%) objected and 214 (43%) were undecided. In comparing the undecided to the other groups, we found that most presented a positive attitude towards screening tests and preventive medicine, they showed acceptable knowledge about the proposed test, and yet were interested in learning and further expanding the knowledge and the consequences of doing the test. Most respondents of all groups expressed concern of breast cancer morbidity and were reluctant to perform the test for reasons of reducing uncertainty, implications for children and implications for their own health.\u0000\u0000Within all groups, many women expressed their desire to consult with a medical professional about the test. We conclude that aiming to improve the performance of BRCA genetic testing, women need a thorough explanation about its implications. The main way to inform them would be by medical professionals, especially in primary care. This implies that front line nurses and physicians need to become more knowledgeable and committed to this subject.","PeriodicalId":73629,"journal":{"name":"Journal of breast cancer research","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81971319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Tumor grade as a novel predictor of outcomes in medullary thyroid cancer 肿瘤分级作为一种新的预测甲状腺髓样癌预后的指标

Journal of breast cancer research Pub Date : 2023-05-06 DOI: 10.46439/breastcancer.3.017

Aradhya Nigam, B. Untch, A. Shaha

{"title":"Tumor grade as a novel predictor of outcomes in medullary thyroid cancer","authors":"Aradhya Nigam, B. Untch, A. Shaha","doi":"10.46439/breastcancer.3.017","DOIUrl":"https://doi.org/10.46439/breastcancer.3.017","url":null,"abstract":"The recent development of the International Medullary Thyroid Cancer Grading System (IMTCGS) provided clinicians with a tool to predict for disease outcomes after undergoing resection based on histologic features. However, its impact on the clinical management of patients is still under investigation. Utilizing the IMTCGS, we evaluated the association of grade with postoperative surveillance markers. High-grade tumors, when compared to low-grade, had a significantly more rapid calcitonin doubling time with a vast majority of high-grade patients having doubling times <2 years. While these findings reaffirmed the poor recurrence and mortality outcomes observed in high-grade patients, we found that high-grade patients with rapid calcitonin doubling times were particularly at risk for poor local control and survival outcomes.These findings demonstrate the importance of close clinical follow-up of patients with high-grade disease and further support the determination tumor grade and calcitonin doubling times in MTC patients after resection. In addition, the study supports the use of MTC grading as an important variable for future management of MTC patients. This could lay the foundation for better understanding of neuroendocrine carcinomas of the breast.","PeriodicalId":73629,"journal":{"name":"Journal of breast cancer research","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80422003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Loss of breast reconstruction services during the COVID-19 pandemic: Negative impact on patient quality of life and wellbeing 2019冠状病毒病大流行期间乳房重建服务的丧失:对患者生活质量和福祉的负面影响

Journal of breast cancer research Pub Date : 2023-05-06 DOI: 10.46439/breastcancer.2.012

Jenna Shepherd, Mairi Fuller, Sue Rodwell, Rachel Moir, Beatrix Elsberger, Yazan A. Masannat

引用次数: 0

Advances in shared decision-making for breast cancer screening in Spain 西班牙乳腺癌筛查共同决策的进展

Journal of breast cancer research Pub Date : 2023-05-06 DOI: 10.46439/breastcancer.2.013

María José Hernández-Leal, M. Pérez-Lacasta, M. Carles-Lavila

引用次数: 0

Neoangiogenesis and immune-regulation: Two armour of VEGF in the tumor microenvironment 新生血管生成与免疫调节:VEGF在肿瘤微环境中的两种作用

Journal of breast cancer research Pub Date : 2023-05-06 DOI: 10.46439/breastcancer.2.015

Subhanki Dhar, Tania Sarkar, G. Sa

引用次数: 0

Oncologist well-being in the era of COVID-19: A call to action COVID-19时代肿瘤学家的福祉:行动呼吁

Journal of breast cancer research Pub Date : 2023-05-06 DOI: 10.46439/breastcancer.2.010

A. Chichura, K. Yao

引用次数: 0

NTRK fusions: A novel diagnostic and therapeutic methodology for cancer NTRK融合:一种新的癌症诊断和治疗方法

Journal of breast cancer research Pub Date : 2023-05-06 DOI: 10.46439/breastcancer.3.016

Rishika Singh, Nupur Singh, G. Vidal

引用次数: 0

Sentinel lymph node biopsy in early breast cancer: A brief review 早期乳腺癌前哨淋巴结活检:简要回顾

Journal of breast cancer research Pub Date : 2023-05-06 DOI: 10.46439/breastcancer.2.014

S. Kadam, Tejaswini Kadam

引用次数: 0