Joint diseases and related surgery最新文献

{"title":"Efficacy and safety of hollow pedicle screw-anchored bone cement combined with posterior long-segment fixation for Stage III Kümmell's disease.","authors":"Dongjie Kan, Jinghuai Wang, Guoyong Qiao, Yanan Chen, Dongping Han","doi":"10.52312/jdrs.2024.1834","DOIUrl":"10.52312/jdrs.2024.1834","url":null,"abstract":"<p><strong>Objectives: </strong>The study aimed to evaluate the efficacy and safety of hollow pedicle screw-anchored bone cement combined with posterior long-segment fixation (LSF) for the treatment of Stage III Kümmell's disease.</p><p><strong>Patients and methods: </strong>The study retrospectively analyzed 23 patients (18 females, 5 males; mean age: 70.1±6.2 years; range, 58 to 80 years) with Stage III Kümmell's disease who underwent hollow pedicle screw-anchored bone cement combined with posterior LSF between March 2017 and April 2020. The clinical efficacy was evaluated using the Visual Analog scale (VAS), the Oswestry Disability Index (ODI), anterior vertebral height, kyphotic Cobb angle, and neurological function by Frankel classification. Complications, operation time, intraoperative blood loss, and complications were obtained from the hospital records. Data recorded at three time intervals (before the surgery, early postoperative period, and the last follow-up) were compared.</p><p><strong>Results: </strong>The mean follow-up time was 20.8±6.1 months. The mean operation time was 102±16.5 min, and the mean intraoperative blood loss was 225±41.3 mL. The VAS, ODI, anterior vertebral heights, and local kyphosis angle showed statistically significant differences between preoperative and postoperative values, as well as the preoperative and the final follow-up values (p<0.05). However, the differences between postoperative and final follow-up values were not statistically significant (p>0.05). Six patients (26%) had mild preoperative neurological deficits and normalized neurological function at the final follow-up evaluation. Asymptomatic leakage of cement occurred in five (22%) cases. There was no fixation failure (rod breakage or screw loosening).</p><p><strong>Conclusion: </strong>Hollow pedicle screw-anchored bone cement combined with posterior LSF is a safe and effective surgical option for the treatment of Stage III Kümmell's disease.</p>","PeriodicalId":73560,"journal":{"name":"Joint diseases and related surgery","volume":"36 1","pages":"15-23"},"PeriodicalIF":1.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of ChatGPT-4o's answers to questions about hip arthroscopy from the patient perspective.","authors":"Gökhan Ayık, Niyazi Ercan, Yunus Demirtaş, Tuğrul Yıldırım, Gökhan Çakmak","doi":"10.52312/jdrs.2025.1961","DOIUrl":"10.52312/jdrs.2025.1961","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the responses provided by ChatGPT-4o to the most frequently asked questions by patients regarding hip arthroscopy.</p><p><strong>Materials and methods: </strong>In this cross-sectional survey study, a new Google account without a search history was created to determine the 20 most frequently asked questions about hip arthroscopy via Google. These questions were asked to a new ChatGPT-4o account on June 1, 2024, and the responses were recorded. Ten orthopedic surgeons specializing in sports surgery rated the responses using a rating scale to assess relevance, accuracy, clarity, and completeness. The responses were scored on a scale from 1 to 5, with 1 being the worst and 5 being the best. The interrater reliability assessed via the intraclass correlation coefficient (ICC).</p><p><strong>Results: </strong>The lowest score given by the surgeons for any response was 4/5 in each subcategory. The highest mean scores were in accuracy and clarity, followed by relevance, with completeness receiving the lowest scores. The overall mean score was 4.49±0.16. Interrater reliability showed insufficient overall agreement (ICC=0.004, p=0.383), with the highest agreement in clarity (ICC=0.039, p=0.131) and the lowest in accuracy (ICC=-0.019, p=0.688).</p><p><strong>Conclusion: </strong>The study confirms our hypothesis that ChatGPT-4o provides above-average quality responses to frequently asked questions about hip arthroscopy, as evidenced by the high scores in relevance, accuracy, clarity, and completeness. However, it is still advisable to consult orthopedic specialists on the subject, incorporating ChatGPT's suggestions during the final decision-making process.</p>","PeriodicalId":73560,"journal":{"name":"Joint diseases and related surgery","volume":"36 1","pages":"193-199"},"PeriodicalIF":1.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is casting superior to plate fixation in metacarpal shaft fractures?","authors":"Orhun Eray Bozkurt, Ugur Bezirgan, Erdinc Acar, Osman Talha Nergizal, Ebru Dumlupinar, Mehmet Armangil","doi":"10.52312/jdrs.2025.1983","DOIUrl":"10.52312/jdrs.2025.1983","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to compare the outcomes and conduct a cost analysis between plate screw fixation and conservative treatment.</p><p><strong>Patients and methods: </strong>The retrospective study was conducted with 36 patients (32 males, 4 females; mean age: 30.3±13.4 years; range, 16 to 65 years) between May 2019 and July 2023. The patients were divided into two groups: those who underwent surgery with miniplate fixation (n=21) and those who were conservatively managed (n=15). The differences in postoperative shortening and angulation were compared between these groups. Additionally, the patients' postoperative functional scores, complication rates, examination findings, and cost analyses were compared.</p><p><strong>Results: </strong>The per-patient cost in the surgical group was higher than in the conservatively treated group (€246.96 vs. €45.07; p<0.001). While postoperative shortening and angulation were more pronounced in the nonoperative group, the other clinical parameters and functional scores were improved. The return-to-work time was longer in the nonoperative group due to prolonged immobilization.</p><p><strong>Conclusion: </strong>Nonoperative splint treatment for metacarpal shaft fractures shows better radiological and clinical outcomes than surgery, except for angulation and shortening, which have limited impact on function. Due to higher costs in surgical cases, nonoperative treatment is more cost-effective. Larger, randomized trials are needed to confirm these findings.</p>","PeriodicalId":73560,"journal":{"name":"Joint diseases and related surgery","volume":"36 1","pages":"182-192"},"PeriodicalIF":1.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical treatment of coronal plane hamate fractures: Clinical and radiological outcomes.","authors":"Serkan Aykut, Güray Altun, Mehmet Baydar, Kahraman Öztürk, İlyas Kar","doi":"10.52312/jdrs.2025.1997","DOIUrl":"10.52312/jdrs.2025.1997","url":null,"abstract":"<p><strong>Objectives: </strong>In this study, we present our extensive case series on hamatometacarpal fracture-dislocations treated with open reduction and internal fixation and share our treatment strategies and outcomes.</p><p><strong>Patients and methods: </strong>Between March 2014 and November 2022, a total of 17 male patients (mean age: 28.6±7.9 years; range, 18 to 49 years) with isolated hamate fracture or a fracture involving the base of the fourth and/or fifth metacarpals who underwent surgery and were followed for a minimum duration of 12 months were retrospectively analyzed. Mechanism of injury, type of hamate fracture, presence of associated metacarpal fracture-dislocations, demographic data, time to surgery, postoperative duration of immobilization and complications were noted. Functional assessment was performed using Disabilities of the Arm, Shoulder, and Hand (DASH) scoring and grip strength was evaluated using a hand dynamometer.</p><p><strong>Results: </strong>The mean follow-up was 5.8±2.2 (range, 2 to 8) years. All patients were male, with fractures on the dominant side, and the primary mechanism of injury was punching a hard surface. Surgical fixation primarily involved a single screw, with Kirschner wires used for metacarpal stabilization. The mean time to return to work was 61±22 (range, 35 to 90) days. The mean grip strength of the injured and uninjured side was 40.5±3.6 kg and 42.1±3.5 kg, respectively (p=0.415). The mean DASH score at the final follow-up was 5.6±4.8. All patients achieved clinical union, with no malunions, and full range of motion was restored. Two cases of ulnar nerve neuropraxia fully resolved.</p><p><strong>Conclusion: </strong>The surgical treatment of coronal plane hamate fractures associated with the fourth and fifth metacarpal base fracture-dislocations can provide good functional recovery in these complex fractures.</p>","PeriodicalId":73560,"journal":{"name":"Joint diseases and related surgery","volume":"36 1","pages":"164-173"},"PeriodicalIF":1.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hidden blood loss in percutaneous endoscopic lumbar discectomy via the posterolateral approach.","authors":"Jin-Wang Liu, Shao-Xing Li, Fei Wang, Yun Yang, Hua Yu","doi":"10.52312/jdrs.2025.2065","DOIUrl":"10.52312/jdrs.2025.2065","url":null,"abstract":"<p><strong>Objectives: </strong>The study aimed to evaluate the hidden blood loss (HBL) and its possible risk factors in patients with lumbar disc herniation undergoing percutaneous endoscopic lumbar discectomy (PELD) via posterolateral approach.</p><p><strong>Patients and methods: </strong>The clinical data of 170 lumbar disc herniation patients (101 males, 69 females; mean age: 57.7±18.0 years; range, 19 to 87 years) treated with PELD via posterolateral approach between January 2021 and January 2023 were retrospectively analyzed. Demographic characteristics, laboratory data, and surgery-related clinical data of the patients were collected, including age, sex, height, weight, body mass index, albumin, blood glucose, hemoglobin (Hb), hematocrit (Hct), American Society of Anesthesiologists (ASA) score, surgical time, number of puncture, and the need for foramenoplasty. Hidden blood loss was calculated, and multiple linear regression analysis was performed to identify risk factors.</p><p><strong>Results: </strong>The mean Hb in patients with preoperative anemia was 115.8±8.6 g/L. The mean postoperative Hb loss and Hct loss were 7.0±4.5 g/L and 0.02±0.01%, respectively. The mean number of punctures (1-3 punctures vs. >3 punctures) was 2.4±0.7 and 4.6±0.6, respectively. Satisfactory localization was achieved within three punctures in nearly 60% of the patients. More than half (55.3%) of the patients underwent foraminoplasty. The mean surgical time was 110.9±32.0 min. The mean HBL was 178.4±66.5 mL. The mean follow-up time was 6.9±2.2 months. When comparing the preoperative and postoperative incidence of anemia, we found that the incidence of anemia was significantly associated with HBL (p<0.001). Multiple linear regression analysis showed that HBL was positively correlated with the number of punctures, foraminoplasty, and surgical time.</p><p><strong>Conclusion: </strong>Our results suggest that the number of punctures, foraminoplasty, and surgical time are independent risk factors for HBL after PELD via posterolateral approach. Therefore, HBL should not be ignored in patients with these risk factors to ensure patients' safety in the perioperative period.</p>","PeriodicalId":73560,"journal":{"name":"Joint diseases and related surgery","volume":"36 1","pages":"56-64"},"PeriodicalIF":1.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative analysis of protective Kirschner wire diameters in lateral opening wedge distal femoral osteotomy: A finite element study.","authors":"Alican Baris, Emre Özmen, Esra Circi, Serdar Yuksel, Ozan Beytemür","doi":"10.52312/jdrs.2025.1806","DOIUrl":"10.52312/jdrs.2025.1806","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to investigate quantitatively the protective effect of a 1.6-mm or a 2.5-mm Kirschner wire (K-wire) on the medial hinge at different gap distances through finite element analysis (FEA) and to establish whether using a 2.5-mm K-wire can offer benefits compared to a 1.6-mm in preventing medial hinge fractures.</p><p><strong>Materials and methods: </strong>Between June 2024 and July 2024, three different models simulating a lateral opening wedge (LOW) osteotomy of the distal femur were created from a femoral computed tomography (CT) scan of a 36-year-old male patient: no K-wire (Model I), 1.6-mm K-wire (Model II), and 2.5-mm K-wire (Model III). Finite element analysis was performed to simulate 7- to 13-mm gaps at the osteotomy site. Loads, principal stress, strain, and equivalent stress were analyzed around the medial hinge.</p><p><strong>Results: </strong>Model I required 123.0±5.2 N, Model II required 181.7±12.2 N, and Model III required 228.7±13.6 N (p<0.001). Cracked shell elements were the lowest in Model II and the highest in Model I. While the average equivalent/yield stress ratio was not significantly lower in Model II compared to Model III (87.0±10.9% vs. 92.7±12.1%), the maximum equivalent/yield stress ratio values in Model II were significantly lower than both Model I and Model III (1206.2±138.3% vs. 1836.2±165.4% and 1689.1±404.0%, respectively), suggesting a superior dispersion of forces.</p><p><strong>Conclusion: </strong>Using a 1.6-mm K-wire during LOW osteotomy of the distal femur provides a balance between structural reinforcement and stress distribution, significantly improving stability and reducing the risk of medial hinge fractures compared to a 2.5-mm K-wire or no K-wire. The 1.6-mm K-wire optimizes stress dispersion, making it the preferred choice for surgical planning in lateral opening wedge distal femoral osteotomy.</p>","PeriodicalId":73560,"journal":{"name":"Joint diseases and related surgery","volume":"36 1","pages":"97-106"},"PeriodicalIF":1.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential impact of obstetric history on postmenopausal fragility fracture risk: A reassessment of the Fracture Risk Assessment Tool.","authors":"Aydan Sezgin, Huriye Güvenç Saçıntı, Elşad Osmanlı, Kübra Mangır, Koray Görkem Saçıntı, Erdem Aras Sezgin","doi":"10.52312/jdrs.2025.1995","DOIUrl":"10.52312/jdrs.2025.1995","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the impact of integrating obstetric parameters into the Fracture Risk Assessment Tool (FRAX) on the precision of risk assessment.</p><p><strong>Patients and methods: </strong>In this retrospective study, patients who experienced postmenopausal fragility fractures of the distal radius, proximal femur, or lumbar vertebrae between January 1, 2021, and December 31, 2023, were included. Obstetric histories, along with standard FRAX parameters, were obtained by phone interviews. Based on the FRAX major osteoporotic fracture risk score calculated without bone mineral density, patients were classified into high-, intermediate-, and low-risk group categories. Differences in age at menarche, age at menopause, lactation duration, gravidity, and parity were analyzed across risk categories.</p><p><strong>Results: </strong>A total of 328 patients (mean age: 64.5±5.8 years; range, 55 to 75 years) were included. The mean FRAX score was 16±8.8 (range, 3 to 58), and 85, 191, and 52 patients were classified as high-, intermediate-, and low-risk, respectively. A positive correlation was observed between FRAX scores and both later age at menarche and earlier menopause (p<0.001 and p=0.008, respectively). The mean age at menopause was significantly different between the high- and low-risk groups (46.4 vs. 49.3 years, p=0.016). The intermediate-risk group was also evaluated, showing no significant differences in obstetric parameters compared to the low-risk group (p>0.05).</p><p><strong>Conclusion: </strong>Although late menarche is not explicitly included in FRAX, its association with higher fracture risk was evident. The established influence of early menopause on FRAX scores supports its role in fracture risk estimation. However, the inclusion of additional obstetric parameters did not enhance the predictive accuracy of FRAX in this cohort.</p>","PeriodicalId":73560,"journal":{"name":"Joint diseases and related surgery","volume":"36 1","pages":"142-147"},"PeriodicalIF":1.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors and rates of revision amputation following ischemic lower major limb amputations: A 10-year retrospective analysis.","authors":"Eşref Selçuk, Murat Erem, Savaş Yıldırım, Cem Çopuroğlu, Mert Çiftdemir, Doğukan Erkal","doi":"10.52312/jdrs.2025.2030","DOIUrl":"10.52312/jdrs.2025.2030","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the rates and risk factors associated with revision amputation following ischemic lower major limb amputations, focusing on cases related to peripheral arterial disease.</p><p><strong>Patients and methods: </strong>This retrospective study included 253 patients (174 males, 79 females; mean age: 73.1±12.2 years; range, 44 to 99 years) who underwent ischemic foot amputation between December 2012 and December 2022. Eligible patients were over 18 years old and had major lower extremity amputations due to peripheral arterial disease or chronic arterial occlusion. Exclusions were made for amputations due to diabetic foot conditions, trauma, tumors, or osteomyelitis and minor lower extremity amputations.</p><p><strong>Results: </strong>Above-knee amputations were the most common type of amputation, accounting for 56.5% (n=143) of cases. Revision amputations occurred in 27.3% (n=69) of patients, with significantly higher rates in those with open wounds at first admission (chi-square [χ² ]=9.81, p=0.002). Patients with occlusion at the popliteal artery level had a higher rate of revision amputation following below-knee amputation (p=0.034). Each additional year of age decreased the likelihood of revision amputation by 2.3% (p=0.049). Vacuum-assisted closure therapy was associated with higher revision rates (χ² =22.71, p<0.001). Patients who developed infections (n=40) had a significantly higher rate of revision amputations (n=26, p<0.001). Elevated preoperative C-reactive protein levels were also correlated with an increased risk of revision (p=0.006).</p><p><strong>Conclusion: </strong>Patients with ischemic lower limb amputations, particularly those presenting with open wounds, are at higher risk for revision amputation. Elevated preoperative C-reactive protein levels, infections, age, and the initial level of amputation significantly impact the likelihood of reamputation.</p>","PeriodicalId":73560,"journal":{"name":"Joint diseases and related surgery","volume":"36 1","pages":"174-181"},"PeriodicalIF":1.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy- and lactation-related bone fragility: The hidden risk.","authors":"Mustafa Ünal, Koray Görkem Saçıntı, Erdem Aras Sezgin","doi":"10.52312/jdrs.2024.1957","DOIUrl":"10.52312/jdrs.2024.1957","url":null,"abstract":"<p><p>Pregnancy and lactation significantly alter bone homeostasis, potentially leading to impaired bone quality and mineralization due to the increased metabolic demands of the developing offspring. While most women with osteopenia during these periods experience a return to baseline bone density after weaning, some may remain at risk for fractures, particularly in cancellous bone. There are inconsistencies in current reports on fracture risk and appropriate treatment strategies. In this review, we discuss the existing evidence on the diagnosis, clinical presentation, and approaches for preventing and managing bone fragility in this unique population.</p>","PeriodicalId":73560,"journal":{"name":"Joint diseases and related surgery","volume":"36 1","pages":"210-213"},"PeriodicalIF":1.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of supplementation with type 1 and type 3 collagen peptide and type 2 hydrolyzed collagen on osteoarthritis-related pain, quality of life, and physical function: A double-blind, randomized, placebo-controlled study.","authors":"Ahmet Serhat Genç, Ali Kerim Yılmaz, Berna Anıl, Esra Korkmaz Salkılıç, Enes Akdemir, Aykut Sancaklı, Ahmet Mor, Egemen Ermiş, Lale Saka Baraz, Nizamettin Güzel, Lokman Kehribar","doi":"10.52312/jdrs.2025.1965","DOIUrl":"10.52312/jdrs.2025.1965","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to assess the effect of Naturagen® 4 Joint product, containing type 1, 2, and 3 collagen, on pain associated with osteoarthritis (OA) and to evaluate its effects on quality of life and physical functioning.</p><p><strong>Patients and methods: </strong>This double-blind, randomized, placebo-controlled clinical study included a total of 31 patients (8 males, 23 females; mean age: 53.5±9.1 years; range, 35 to 65 years) with Grade 2-3 OA according to the Kellgren-Lawrence (KL) classification system between June 2023 and November 2023. The patients were divided into two groups: a collagen group (n=16) and a placebo group (n=15). The Visual Analog Scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Knee Injury and Osteoarthritis Outcome Score (KOOS-PS), Oxford Knee Score (OKS), Tampa Scale for Kinesiophobia (TSK), Short Form Health Survey (SF-12), Foot Function Index (FFI), Timed Up and Go (TUG), 6-Min Walking Test (6MWT), Five Repetition Sit to Stand Test (5STS), Stair Climbing Test (SCT), and Berg Balance Scale (BBS) were used. All tests were performed before and after eight weeks of collagen supplementation.</p><p><strong>Results: </strong>Eight weeks of collagen supplementation yielded notable enhancements across all osteoarthritis-related pain and quality of life scales evaluated, including VAS, WOMAC, KOOS-PS, OKS, TSK, SF-12, and FFI scores (p<0.05). In functional evaluations, there were significant positive effects of collagen use in BBS and 6MWT results (p<0.05). In TUG, 5STS, and SCT tests, no significant difference was found between the groups (p>0.05).</p><p><strong>Conclusion: </strong>Our study results suggest that the eight-week collagen-based supplement exerts a favorable effect on pain and quality of life levels, as well as some functional test results.</p>","PeriodicalId":73560,"journal":{"name":"Joint diseases and related surgery","volume":"36 1","pages":"85-96"},"PeriodicalIF":1.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}